FBSL_HUMAN - dbPTM
FBSL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FBSL_HUMAN
UniProt AC Q9HCM7
Protein Name Fibrosin-1-like protein
Gene Name FBRSL1
Organism Homo sapiens (Human).
Sequence Length 1045
Subcellular Localization
Protein Description
Protein Sequence MEAKVRPSRRSRAQRDRGRRREAARDARAQSPSSGDEPEPSPGKENAGLRGAPPRGAAPAPRTARPPRRRRRESSSQEEEVIDGFAIASFSTLEALEKDMALKPHERKEKWERRLIKKPRESETCPPAEPSENRRPLEAGSPGQDLEPACDGARKVPLQPSKQMKVTVSKGGDRDSDDDSVLEATSSRDPLSDSSAHAVSGRGYSCDSESGPDDKASVGSEKLFAPGTDKGPALEKSEAKAGPVPKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPGSRANPLVKKEPPAPHRHTPQPPPPQPRGLLPTHVPASLGAFAGHSQAAANGLHGLSRSSSAPLGLGKHVSLSPHGPGPHLSTSHLALRSQAQHQLHAAMFAAPPTLPPPPALPASSLVLPGHPADHELLRQELNTRFLVQSAERPGASLGPGALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGLPPTPPAAPPPFDKYAPKLDSPYFRHSSVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGARDSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAWNRLHRAPPSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKESRSPAKEEAAKMPARASPPHSKAAPGDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERLGAPGFAWEPFRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERLRGELERARAPHLPPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPPLVTAAGPPTPPGPPRSRTTPLGGLGPGEARDYSPSRNPPEVEAR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
31PhosphorylationARDARAQSPSSGDEP
HHHHHHHCCCCCCCC		26.2627794612
33PhosphorylationDARAQSPSSGDEPEP
HHHHHCCCCCCCCCC		52.8023663014
34PhosphorylationARAQSPSSGDEPEPS
HHHHCCCCCCCCCCC		54.3627794612
41PhosphorylationSGDEPEPSPGKENAG
CCCCCCCCCCCCCCC		44.6223663014
63PhosphorylationGAAPAPRTARPPRRR
CCCCCCCCCCCCCHH		26.4220363803
74PhosphorylationPRRRRRESSSQEEEV
CCHHCCCCCCCCHHH		33.2127282143
75PhosphorylationRRRRRESSSQEEEVI
CHHCCCCCCCCHHHH		31.1527282143
76PhosphorylationRRRRESSSQEEEVID
HHCCCCCCCCHHHHH		51.3827282143
122PhosphorylationLIKKPRESETCPPAE
HCCCCCCCCCCCCCC		39.2130108239
124PhosphorylationKKPRESETCPPAEPS
CCCCCCCCCCCCCCC		39.3230108239
131PhosphorylationTCPPAEPSENRRPLE
CCCCCCCCCCCCCCC		38.7223401153
141PhosphorylationRRPLEAGSPGQDLEP
CCCCCCCCCCCCCCC		32.6730266825
162UbiquitinationKVPLQPSKQMKVTVS
CCCCCCCCCEEEEEE		62.1832015554
170UbiquitinationQMKVTVSKGGDRDSD
CEEEEEECCCCCCCC		63.68-
176PhosphorylationSKGGDRDSDDDSVLE
ECCCCCCCCCCCHHH		43.7820873877
180PhosphorylationDRDSDDDSVLEATSS
CCCCCCCCHHHHCCC		35.2828985074
185PhosphorylationDDSVLEATSSRDPLS
CCCHHHHCCCCCCCC		20.1923312004
186PhosphorylationDSVLEATSSRDPLSD
CCHHHHCCCCCCCCC		30.3523312004
187PhosphorylationSVLEATSSRDPLSDS
CHHHHCCCCCCCCCC		36.0323312004
192PhosphorylationTSSRDPLSDSSAHAV
CCCCCCCCCCCCCCC		40.6123663014
194PhosphorylationSRDPLSDSSAHAVSG
CCCCCCCCCCCCCCC		26.5023663014
195PhosphorylationRDPLSDSSAHAVSGR
CCCCCCCCCCCCCCC		29.1223663014
200PhosphorylationDSSAHAVSGRGYSCD
CCCCCCCCCCCCCCC		24.4527732954
204PhosphorylationHAVSGRGYSCDSESG
CCCCCCCCCCCCCCC		12.5528985074
205PhosphorylationAVSGRGYSCDSESGP
CCCCCCCCCCCCCCC		17.8024114839
208PhosphorylationGRGYSCDSESGPDDK
CCCCCCCCCCCCCCC		37.6824114839
210PhosphorylationGYSCDSESGPDDKAS
CCCCCCCCCCCCCCC		60.6224114839
253PhosphorylationKVSGLERSRELSAES
CCCCCHHHHCCCHHH		22.26-
264PhosphorylationSAESFLPTASPAPHA
CHHHHCCCCCCCCCC		41.7525627689
266PhosphorylationESFLPTASPAPHAAP
HHHCCCCCCCCCCCC		24.8725627689
288SumoylationSRANPLVKKEPPAPH
CCCCCCCCCCCCCCC		60.13-
288SumoylationSRANPLVKKEPPAPH
CCCCCCCCCCCCCCC		60.13-
298PhosphorylationPPAPHRHTPQPPPPQ
CCCCCCCCCCCCCCC		24.4721210654
338PhosphorylationGLHGLSRSSSAPLGL
CCCCCCCCCCCCCCC		25.8528450419
339PhosphorylationLHGLSRSSSAPLGLG
CCCCCCCCCCCCCCC		29.4328450419
340PhosphorylationHGLSRSSSAPLGLGK
CCCCCCCCCCCCCCC		34.8425159151
350PhosphorylationLGLGKHVSLSPHGPG
CCCCCCCCCCCCCCC		23.8927080861
352PhosphorylationLGKHVSLSPHGPGPH
CCCCCCCCCCCCCCC		13.8227080861
408UbiquitinationGHPADHELLRQELNT
CCCCCHHHHHHHHHH		4.2421890473
411UbiquitinationADHELLRQELNTRFL
CCHHHHHHHHHHHHH		60.5421890473
436MethylationLGPGALLRAEFHQHQ
CCCCHHHHHHHHCCC		32.68-
466UbiquitinationTFAPFPAGLPPTPPA
CCCCCCCCCCCCCCC		38.6721890473
484UbiquitinationPFDKYAPKLDSPYFR
CHHHCCCCCCCCCCC		57.6721890473
487PhosphorylationKYAPKLDSPYFRHSS
HCCCCCCCCCCCCCC		31.7521815630
489PhosphorylationAPKLDSPYFRHSSVS
CCCCCCCCCCCCCCC		19.7323186163
506UbiquitinationPSFPPAIPGLPTLLP
CCCCCCCCCCCCCCC		40.1321890473
507UbiquitinationSFPPAIPGLPTLLPH
CCCCCCCCCCCCCCC		37.8721890473
520PhosphorylationPHPGPFGSLQGAFQP
CCCCCCCCCCCCCCC		20.2125332170
610UbiquitinationYRHQQKIKEMQLDPH
HHHHHHHHHCCCCHH		54.9229967540
618UbiquitinationEMQLDPHKLEVGAKL
HCCCCHHHCCCCCEE		52.2929967540
630MethylationAKLDLFGRPPAPGVF
CEEECCCCCCCCCCC		27.05-
721PhosphorylationIFAPKEGSSVHGLPS
EECCCCCCCCCCCCC		30.2223186163
722PhosphorylationFAPKEGSSVHGLPSP
ECCCCCCCCCCCCCH		29.0523186163
728PhosphorylationSSVHGLPSPHEAWNR
CCCCCCCCHHHHHHH		43.8820873877
751UbiquitinationPAPPPWPKSVDAERV
CCCCCCCCCCCHHHH		60.2829967540
782UbiquitinationQERDLLEKTRLLSRA
HHHHHHHHHHHHHHC		38.6329967540
787PhosphorylationLEKTRLLSRASPATP
HHHHHHHHHCCCCCC		30.3223312004
790PhosphorylationTRLLSRASPATPAGH
HHHHHHCCCCCCCCC		17.6029255136
793PhosphorylationLSRASPATPAGHPVS
HHHCCCCCCCCCCCH		19.6325159151
800PhosphorylationTPAGHPVSGLLLRAQ
CCCCCCCHHHHHHHH		28.3326074081
808PhosphorylationGLLLRAQSELGRSGA
HHHHHHHHHHHCCCC		33.5323312004
813PhosphorylationAQSELGRSGAPAERE
HHHHHHCCCCCCHHH		37.1922210691
828PhosphorylationAEPRVKESRSPAKEE
CCCCHHCCCCHHHHH		32.1324719451
830PhosphorylationPRVKESRSPAKEEAA
CCHHCCCCHHHHHHH		38.1926657352
844O-linked_GlycosylationAKMPARASPPHSKAA
HCCCCCCCCCCCCCC		33.1530379171
844PhosphorylationAKMPARASPPHSKAA
HCCCCCCCCCCCCCC		33.1525159151
848PhosphorylationARASPPHSKAAPGDV
CCCCCCCCCCCCCCC		29.7523403867
849"N6,N6-dimethyllysine"RASPPHSKAAPGDVK
CCCCCCCCCCCCCCC		45.60-
849UbiquitinationRASPPHSKAAPGDVK
CCCCCCCCCCCCCCC		45.60-
849MethylationRASPPHSKAAPGDVK
CCCCCCCCCCCCCCC		45.60-
858MethylationAPGDVKVKEERGEDE
CCCCCCCEECCCCCC		48.41-
858SumoylationAPGDVKVKEERGEDE
CCCCCCCEECCCCCC		48.4128112733
858"N6,N6-dimethyllysine"APGDVKVKEERGEDE
CCCCCCCEECCCCCC		48.41-
936PhosphorylationRDREPHGYSPERLRG
CCCCCCCCCHHHHHH		20.3021712546
937PhosphorylationDREPHGYSPERLRGE
CCCCCCCCHHHHHHH		25.5229255136
977PhosphorylationALHFPRLSPAALHNG
CCCCCCCCHHHHHCC		17.4830266825
989PhosphorylationHNGLLARTPPAAAAL
HCCCCCCCCHHHHHH		28.1929255136
1004PhosphorylationGAPPPLVTAAGPPTP
CCCCCEEECCCCCCC		20.6229255136
1010PhosphorylationVTAAGPPTPPGPPRS
EECCCCCCCCCCCCC		45.2929255136
1017PhosphorylationTPPGPPRSRTTPLGG
CCCCCCCCCCCCCCC		39.4928450419
1019PhosphorylationPGPPRSRTTPLGGLG
CCCCCCCCCCCCCCC		33.7328348404
1020PhosphorylationGPPRSRTTPLGGLGP
CCCCCCCCCCCCCCC		18.5319276368
1033PhosphorylationGPGEARDYSPSRNPP
CCCCCCCCCCCCCCC		19.5423927012
1034PhosphorylationPGEARDYSPSRNPPE
CCCCCCCCCCCCCCC		22.2325159151
1036PhosphorylationEARDYSPSRNPPEVE
CCCCCCCCCCCCCCC		38.4630266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FBSL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FBSL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FBSL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FBSL_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FBSL_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-989 AND THR-1010, ANDMASS SPECTROMETRY.

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