dbPTM

BCORL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BCORL_HUMAN
UniProt AC	Q5H9F3
Protein Name	BCL-6 corepressor-like protein 1
Gene Name	BCORL1
Organism	Homo sapiens (Human).
Sequence Length	1711
Subcellular Localization	Nucleus .
Protein Description	Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor..
Protein Sequence	MISTAPLYSGVHNWTSSDRIRMCGINEERRAPLSDEESTTGDCQHFGSQEFCVSSSFSKVELTAVGSGSNARGADPDGSATEKLGHKSEDKPDDPQPKMDYAGNVAEAEGFLVPLSSPGDGLKLPASDSAEASNSRADCSWTPLNTQMSKQVDCSPAGVKALDSRQGVGEKNTFILATLGTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARPLTSDSKLVSLEVNRLPCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPLDLSSKSNRQKLPLPNQRKTPPMPVLTPVHTSSKALLSTVLSRSQRTTQAAGGNVTSCLGSTSSPFVIFPEIVRNGDPSTWVKNSTALISTIPGTYVGVANPVPASLLLNKDPNLGLNRDPRHLPKQEPISIIDQGEPKGTGATCGKKGSQAGAEGQPSTVKRYTPARIAPGLPGCQTKELSLWKPTGPANIYPRCSVNGKPTSTQVLPVGWSPYHQASLLSIGISSAGQLTPSQGAPIRPTSVVSEFSGVPSLSSSEAVHGLPEGQPRPGGSFVPEQDPVTKNKTCRIAAKPYEEQVNPVLLTLSPQTGTLALSVQPSGGDIRMNQGPEESESHLCSDSTPKMEGPQGACGLKLAGDTKPKNQVLATYMSHELVLATPQNLPKMPELPLLPHDSHPKELILDVVPSSRRGSSTERPQLGSQVDLGRVKMEKVDGDVVFNLATCFRADGLPVAPQRGQAEVRAKAGQARVKQESVGVFACKNKWQPDDVTESLPPKKMKCGKEKDSEEQQLQPQAKAVVRSSHRPKCRKLPSDPQESTKKSPRGASDSGKEHNGVRGKHKHRKPTKPESQSPGKRADSHEEGSLEKKAKSSFRDFIPVVLSTRTRSQSGSICSSFAGMADSDMGSQEVFPTEEEEEVTPTPAKRRKVRKTQRDTQYRSHHAQDKSLLSQGRRHLWRAREMPWRTEAARQMWDTNEEEEEEEEEGLLKRKKRRRQKSRKYQTGEYLTEQEDEQRRKGRADLKARKQKTSSSQSLEHRLRNRNLLLPNKVQGISDSPNGFLPNNLEEPACLENSEKPSGKRKCKTKHMATVSEEAKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDTMKRFLSDHLSDLQGRAEGDPGVSWDFYSSSVLEEKDGFACDLLHNPPGSSDQEGDDPMEEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERPGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVEFQSCNS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MISTAPLYSG -----CCCCCCCCCC	30.31	23663014
4	Phosphorylation	----MISTAPLYSGV ----CCCCCCCCCCC	37.66	23663014
8	Phosphorylation	MISTAPLYSGVHNWT CCCCCCCCCCCCCCC	11.43	23663014
9	Phosphorylation	ISTAPLYSGVHNWTS CCCCCCCCCCCCCCC	41.86	23663014
15	Phosphorylation	YSGVHNWTSSDRIRM CCCCCCCCCCHHEEE	24.54	23663014
16	Phosphorylation	SGVHNWTSSDRIRMC CCCCCCCCCHHEEEC	23.12	23663014
17	Phosphorylation	GVHNWTSSDRIRMCG CCCCCCCCHHEEECC	24.43	23663014
34	Phosphorylation	EERRAPLSDEESTTG HHHCCCCCCCCCCCC	41.75	28348404
38	Phosphorylation	APLSDEESTTGDCQH CCCCCCCCCCCCCCC	29.26	28348404
39	Phosphorylation	PLSDEESTTGDCQHF CCCCCCCCCCCCCCC	37.77	28348404
40	Phosphorylation	LSDEESTTGDCQHFG CCCCCCCCCCCCCCC	40.06	28348404
48	Phosphorylation	GDCQHFGSQEFCVSS CCCCCCCCCEEEEEC	26.12	17525332
55	Phosphorylation	SQEFCVSSSFSKVEL CCEEEEECCCCEEEE	18.27	-
56	Phosphorylation	QEFCVSSSFSKVELT CEEEEECCCCEEEEE	26.49	24719451
69	Phosphorylation	LTAVGSGSNARGADP EEEECCCCCCCCCCC	29.07	24670416
79	Phosphorylation	RGADPDGSATEKLGH CCCCCCCHHHHHCCC	39.12	25332170
81	Phosphorylation	ADPDGSATEKLGHKS CCCCCHHHHHCCCCC	35.04	29396449
116	Phosphorylation	EGFLVPLSSPGDGLK CCEEEECCCCCCCCC	28.54	27251275
127	O-linked_Glycosylation	DGLKLPASDSAEASN CCCCCCCCCCCCHHC	30.11	30059200
127	Phosphorylation	DGLKLPASDSAEASN CCCCCCCCCCCCHHC	30.11	-
129	Phosphorylation	LKLPASDSAEASNSR CCCCCCCCCCHHCCC	26.05	-
142	Phosphorylation	SRADCSWTPLNTQMS CCCCCCCCCCCCHHC	11.12	28555341
155	Phosphorylation	MSKQVDCSPAGVKAL HCCCCCCCHHHHHHH	17.20	25159151
416	Phosphorylation	APIPASFSLSRVCFP CCCCCCCCCHHCEEC	23.96	24945436
496	Phosphorylation	CLPGVLASPELRSYP CCCCCCCCHHHHCCC	18.10	30266825
529	Phosphorylation	EVNRLPCTSPSGSTT EECCCCCCCCCCCCC	41.55	25850435
530	Phosphorylation	VNRLPCTSPSGSTTT ECCCCCCCCCCCCCC	24.64	25850435
532	Phosphorylation	RLPCTSPSGSTTTQP CCCCCCCCCCCCCCC	45.18	25850435
534	Phosphorylation	PCTSPSGSTTTQPAP CCCCCCCCCCCCCCC	27.24	25850435
535	Phosphorylation	CTSPSGSTTTQPAPD CCCCCCCCCCCCCCC	37.07	25850435
536	Phosphorylation	TSPSGSTTTQPAPDG CCCCCCCCCCCCCCC	25.73	25850435
537	Phosphorylation	SPSGSTTTQPAPDGV CCCCCCCCCCCCCCC	32.42	25850435
572	Phosphorylation	QPLLPAPSGSSAPPH CCCCCCCCCCCCCCC	54.11	22210691
585	Phosphorylation	PHPAKMPSGTEQQTE CCCCCCCCCCCCCCC	55.65	27251275
587	Phosphorylation	PAKMPSGTEQQTEGT CCCCCCCCCCCCCCC	34.65	27251275
591	Phosphorylation	PSGTEQQTEGTSVTF CCCCCCCCCCCEEEE	35.76	30266825
594	Phosphorylation	TEQQTEGTSVTFSPL CCCCCCCCEEEECCC	17.50	30266825
595	Phosphorylation	EQQTEGTSVTFSPLK CCCCCCCEEEECCCC	29.98	23401153
597	Phosphorylation	QTEGTSVTFSPLKSP CCCCCEEEECCCCCC	20.40	23401153
599	Phosphorylation	EGTSVTFSPLKSPPQ CCCEEEECCCCCCHH	21.69	30266825
603	Phosphorylation	VTFSPLKSPPQLERE EEECCCCCCHHHHHH	49.88	21815630
613	Phosphorylation	QLEREMASPPECSEM HHHHHCCCCCCHHCC	39.41	25159151
618	Phosphorylation	MASPPECSEMPLDLS CCCCCCHHCCCCCCC	34.96	27134283
625	Phosphorylation	SEMPLDLSSKSNRQK HCCCCCCCCCCCCCC	35.07	22964224
626	Phosphorylation	EMPLDLSSKSNRQKL CCCCCCCCCCCCCCC	47.61	22964224
628	Phosphorylation	PLDLSSKSNRQKLPL CCCCCCCCCCCCCCC	38.91	22964224
641	Phosphorylation	PLPNQRKTPPMPVLT CCCCCCCCCCCCCCC	34.51	25159151
648	Phosphorylation	TPPMPVLTPVHTSSK CCCCCCCCCCCCCHH	24.41	-
652	O-linked_Glycosylation	PVLTPVHTSSKALLS CCCCCCCCCHHHHHH	34.62	30059200
652	Phosphorylation	PVLTPVHTSSKALLS CCCCCCCCCHHHHHH	34.62	-
659	Phosphorylation	TSSKALLSTVLSRSQ CCHHHHHHHHHHHHH	19.81	21712546
663	Phosphorylation	ALLSTVLSRSQRTTQ HHHHHHHHHHHCCCC	26.08	21712546
747	Sumoylation	RDPRHLPKQEPISII CCCCCCCCCCCCEEE	73.90	-
747	Sumoylation	RDPRHLPKQEPISII CCCCCCCCCCCCEEE	73.90	28112733
806	Acetylation	TKELSLWKPTGPANI CCEECCCCCCCCCCC	37.69	26051181
816	Methylation	GPANIYPRCSVNGKP CCCCCCCCCEECCCC	14.36	-
824	O-linked_Glycosylation	CSVNGKPTSTQVLPV CEECCCCCCCEEECC	48.14	30059200
834	O-linked_Glycosylation	QVLPVGWSPYHQASL EEECCCCCHHHHHHH	15.06	30059200
855	O-linked_Glycosylation	SAGQLTPSQGAPIRP CCCCCCCCCCCCCCC	35.69	30059200
913	Acetylation	KTCRIAAKPYEEQVN CCCEEECCCHHHHCC	38.83	26051181
925	Phosphorylation	QVNPVLLTLSPQTGT HCCCEEEEECCCCCE	22.49	25627689
927	Phosphorylation	NPVLLTLSPQTGTLA CCEEEEECCCCCEEE	15.10	25159151
930	Phosphorylation	LLTLSPQTGTLALSV EEEECCCCCEEEEEE	35.20	25627689
932	Phosphorylation	TLSPQTGTLALSVQP EECCCCCEEEEEEEC	16.55	25627689
961	Phosphorylation	ESHLCSDSTPKMEGP HHCCCCCCCCCCCCC	30.25	25627689
962	Phosphorylation	SHLCSDSTPKMEGPQ HCCCCCCCCCCCCCC	31.73	25159151
1016	Phosphorylation	LPLLPHDSHPKELIL CCCCCCCCCCHHHHE	38.36	25159151
1028	Phosphorylation	LILDVVPSSRRGSST HHEEECCCCCCCCCC	25.52	21815630
1029	Phosphorylation	ILDVVPSSRRGSSTE HEEECCCCCCCCCCC	21.67	20873877
1033	Phosphorylation	VPSSRRGSSTERPQL CCCCCCCCCCCCCCC	32.07	23401153
1034	Phosphorylation	PSSRRGSSTERPQLG CCCCCCCCCCCCCCC	36.79	25159151
1035	Phosphorylation	SSRRGSSTERPQLGS CCCCCCCCCCCCCCC	37.40	26055452
1042	Phosphorylation	TERPQLGSQVDLGRV CCCCCCCCCCCCCCC	35.31	24732914
1092	Sumoylation	KAGQARVKQESVGVF HHCCCEECEEEEEEE	42.68	-
1092	Sumoylation	KAGQARVKQESVGVF HHCCCEECEEEEEEE	42.68	28112733
1102	Acetylation	SVGVFACKNKWQPDD EEEEEEECCCCCCCC	59.12	25953088
1153	Phosphorylation	PKCRKLPSDPQESTK CCCCCCCCCCCCCCC	72.81	30108239
1158	Phosphorylation	LPSDPQESTKKSPRG CCCCCCCCCCCCCCC	40.04	24732914
1159	Phosphorylation	PSDPQESTKKSPRGA CCCCCCCCCCCCCCC	41.56	24732914
1162	Phosphorylation	PQESTKKSPRGASDS CCCCCCCCCCCCCCC	22.76	24123876
1167	Phosphorylation	KKSPRGASDSGKEHN CCCCCCCCCCCCCCC	34.82	23312004
1169	Phosphorylation	SPRGASDSGKEHNGV CCCCCCCCCCCCCCC	49.63	23312004
1186	Phosphorylation	KHKHRKPTKPESQSP CCCCCCCCCCCCCCC	63.37	29449344
1190	Phosphorylation	RKPTKPESQSPGKRA CCCCCCCCCCCCCCC	44.48	30576142
1192	Phosphorylation	PTKPESQSPGKRADS CCCCCCCCCCCCCCC	44.92	25849741
1199	Phosphorylation	SPGKRADSHEEGSLE CCCCCCCCCCCCCHH	31.64	25159151
1204	Phosphorylation	ADSHEEGSLEKKAKS CCCCCCCCHHHHHHH	36.31	25159151
1212	Phosphorylation	LEKKAKSSFRDFIPV HHHHHHHHHHHHHHH	24.48	28555341
1225	Phosphorylation	PVVLSTRTRSQSGSI HHHEECCCCCCCCCC	34.46	-
1227	Phosphorylation	VLSTRTRSQSGSICS HEECCCCCCCCCCCH	28.25	-
1229	Phosphorylation	STRTRSQSGSICSSF ECCCCCCCCCCCHHH	35.44	30576142
1242	Phosphorylation	SFAGMADSDMGSQEV HHCCCCCCCCCCCCC	21.69	30576142
1252	Phosphorylation	GSQEVFPTEEEEEVT CCCCCCCCCCCCCCC	44.56	22210691
1259	Phosphorylation	TEEEEEVTPTPAKRR CCCCCCCCCCHHHHH	25.40	22210691
1261	Phosphorylation	EEEEVTPTPAKRRKV CCCCCCCCHHHHHHC	26.89	22210691
1271	Phosphorylation	KRRKVRKTQRDTQYR HHHHCHHHHHHHHHH	20.48	-
1314	Phosphorylation	AARQMWDTNEEEEEE HHHHHHCCCHHHHHH	29.08	29978859
1363	Ubiquitination	KGRADLKARKQKTSS HHHHHHHHHHHHCCC	31.06	23000965
1370	Phosphorylation	ARKQKTSSSQSLEHR HHHHHCCCHHHHHHH	37.31	-
1393	Phosphorylation	PNKVQGISDSPNGFL CCCCCCCCCCCCCCC	38.57	25627689
1395	Phosphorylation	KVQGISDSPNGFLPN CCCCCCCCCCCCCCC	17.30	25159151
1395	Ubiquitination	KVQGISDSPNGFLPN CCCCCCCCCCCCCCC	17.30	23000965
1431	Phosphorylation	TKHMATVSEEAKDVV CCCCEECCHHHHHHH	25.93	28674151
1431 (in isoform 3)	Phosphorylation	-	25.93	25627689
1444	Acetylation	VVLYCLQKDSEDVNH HHHHEEECCCCCCCC	50.72	30587179
1445 (in isoform 3)	Phosphorylation	-	44.28	29083192
1447 (in isoform 3)	Phosphorylation	-	75.90	29116813
1450 (in isoform 3)	Phosphorylation	-	36.48	30266825
1452 (in isoform 3)	Phosphorylation	-	33.40	26657352
1457	Phosphorylation	NHRDNAGYTALHEAC CCCCCCCHHHHHHHH	6.09	26471730
1457 (in isoform 3)	Phosphorylation	-	6.09	27732954
1458	Phosphorylation	HRDNAGYTALHEACS CCCCCCHHHHHHHHH	23.09	26471730
1461 (in isoform 3)	Phosphorylation	-	20.39	23927012
1463 (in isoform 3)	Phosphorylation	-	5.95	25159151
1465 (in isoform 3)	Phosphorylation	-	40.66	24247654
1467 (in isoform 3)	Phosphorylation	-	18.49	25262027
1469 (in isoform 3)	Phosphorylation	-	18.91	23911959
1470 (in isoform 3)	Phosphorylation	-	36.55	25262027
1474 (in isoform 3)	Phosphorylation	-	4.10	27732954
1476 (in isoform 3)	Phosphorylation	-	3.96	25159151
1478 (in isoform 3)	Phosphorylation	-	40.41	27732954
1493	Neddylation	AQDGTRPVHDAVVND CCCCCCCCCHHHCCC	6.02	32015554
1493	Ubiquitination	AQDGTRPVHDAVVND CCCCCCCCCHHHCCC	6.02	23000965
1493 (in isoform 3)	Ubiquitination	-	6.02	21890473
1533	Phosphorylation	MKLASSDTMKRFLSD HHHCCHHHHHHHHHH	26.92	29759185
1539	Phosphorylation	DTMKRFLSDHLSDLQ HHHHHHHHHHHHHHC	21.92	28555341
1543	Phosphorylation	RFLSDHLSDLQGRAE HHHHHHHHHHCHHHC	32.62	-
1556	O-linked_Glycosylation	AEGDPGVSWDFYSSS HCCCCCCCCCEECCC	27.18	30059200
1649	Phosphorylation	RFPHFEITTMPKAEF HCCCCEEEECCHHHH	15.16	22210691
1662	Phosphorylation	EFYRQVASSQLLTPA HHHHHHHHHCCCCCC	21.54	26714015
1663	Phosphorylation	FYRQVASSQLLTPAE HHHHHHHHCCCCCCC	18.34	26714015
1667	Phosphorylation	VASSQLLTPAERPGG HHHHCCCCCCCCCCC	29.10	27174698
1679	Phosphorylation	PGGLDDRSPPGSSET CCCCCCCCCCCCCCC	42.30	19691289
1683	Phosphorylation	DDRSPPGSSETVELV CCCCCCCCCCCEEEE	30.67	27174698
1684	Phosphorylation	DRSPPGSSETVELVR CCCCCCCCCCEEEEE	43.11	27174698
1686	Phosphorylation	SPPGSSETVELVRYE CCCCCCCCEEEEEEC	22.64	27174698
1702	Phosphorylation	DLLRLLGSEVEFQSC HHHHHHCCEEEEECC	38.14	29759185
1711	Phosphorylation	VEFQSCNS------- EEEECCCC-------	46.02	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BCORL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BCORL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BCORL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTBP1_HUMAN	CTBP1	physical	17379597
HDAC4_HUMAN	HDAC4	physical	17379597
HDAC5_HUMAN	HDAC5	physical	17379597
HDAC7_HUMAN	HDAC7	physical	17379597

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BCORL_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613; SER-1033 ANDSER-1162, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND MASSSPECTROMETRY.	17525332 [Abstract]