dbPTM

KDM2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KDM2B_HUMAN
UniProt AC	Q8NHM5
Protein Name	Lysine-specific demethylase 2B
Gene Name	KDM2B
Organism	Homo sapiens (Human).
Sequence Length	1336
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
Protein Sequence	MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26 (in isoform 4)	Phosphorylation	-	51.70	25849741
50	Phosphorylation	RPIDRQRYDENEDLS CCCCHHHCCCCCCCC	21.19	25850435
57	Phosphorylation	YDENEDLSDVEEIVS CCCCCCCCCHHHHHH	52.51	19664994
64	Phosphorylation	SDVEEIVSVRGFSLE CCHHHHHHHCCCCHH	16.26	24719451
69	Phosphorylation	IVSVRGFSLEEKLRS HHHHCCCCHHHHHHH	37.38	26074081
73	Ubiquitination	RGFSLEEKLRSQLYQ CCCCHHHHHHHHHHC	39.56	-
76	Phosphorylation	SLEEKLRSQLYQGDF CHHHHHHHHHHCCCC	34.67	26074081
79	Phosphorylation	EKLRSQLYQGDFVHA HHHHHHHHCCCCHHH	11.65	26074081
94	Phosphorylation	MEGKDFNYEYVQREA CCCCCCCHHHHHHHH	14.50	28796482
111	Ubiquitination	VPLIFREKDGLGIKM CCEEEECCCCCCCCC	53.49	-
117	Ubiquitination	EKDGLGIKMPDPDFT CCCCCCCCCCCCCCC	42.45	-
124	Phosphorylation	KMPDPDFTVRDVKLL CCCCCCCCHHHHHHH	23.24	23403867
129	Ubiquitination	DFTVRDVKLLVGSRR CCCHHHHHHHCCCEE	40.15	-
134	Phosphorylation	DVKLLVGSRRLVDVM HHHHHCCCEEEEEEE	13.52	22817900
145	Phosphorylation	VDVMDVNTQKGTEMS EEEEECCCCCCCEEC	31.35	22817900
147	Ubiquitination	VMDVNTQKGTEMSMS EEECCCCCCCEECHH	66.80	-
149	Phosphorylation	DVNTQKGTEMSMSQF ECCCCCCCEECHHHH	35.23	-
175	Phosphorylation	DKLYNVISLEFSHTK HHHHEEEEEECCCHH	19.98	29978859
179	Phosphorylation	NVISLEFSHTKLEHL EEEEEECCCHHHHHH	22.37	29978859
181	Phosphorylation	ISLEFSHTKLEHLVK EEEECCCHHHHHHHC	35.81	29978859
192 (in isoform 4)	Phosphorylation	-	3.32	-
210	Ubiquitination	WPQHLKEKQTEATNA CHHHHHHHHHHHHHH	62.02	-
212	Phosphorylation	QHLKEKQTEATNAIA HHHHHHHHHHHHHHH	38.36	24719451
215	Phosphorylation	KEKQTEATNAIAEMK HHHHHHHHHHHHHCC	20.96	21406692
222	Ubiquitination	TNAIAEMKYPKVKKY HHHHHHCCCHHHHHE	50.32	-
223	Phosphorylation	NAIAEMKYPKVKKYC HHHHHCCCHHHHHEE	13.63	20068231
229	Phosphorylation	KYPKVKKYCLMSVKG CCHHHHHEEEEECCC	5.77	-
233	Phosphorylation	VKKYCLMSVKGCFTD HHHEEEEECCCCEEE	14.02	24719451
248	Phosphorylation	FHIDFGGTSVWYHVF EEEECCCCEEEEEEE	22.08	24114839
249	Phosphorylation	HIDFGGTSVWYHVFR EEECCCCEEEEEEEC	17.58	24114839
412 (in isoform 4)	Phosphorylation	-	49.97	-
413 (in isoform 4)	Phosphorylation	-	41.09	-
414 (in isoform 4)	Phosphorylation	-	12.88	-
440	Phosphorylation	DRAPKPPTDGSTSPT CCCCCCCCCCCCCCC	62.61	22167270
443	Phosphorylation	PKPPTDGSTSPTSTP CCCCCCCCCCCCCCC	28.64	22167270
443 (in isoform 4)	Phosphorylation	-	28.64	-
444	Phosphorylation	KPPTDGSTSPTSTPS CCCCCCCCCCCCCCC	44.23	22167270
445	Phosphorylation	PPTDGSTSPTSTPSE CCCCCCCCCCCCCCH	28.07	23401153
447	Phosphorylation	TDGSTSPTSTPSEDQ CCCCCCCCCCCCHHH	45.03	22167270
448	Phosphorylation	DGSTSPTSTPSEDQE CCCCCCCCCCCHHHH	41.53	22167270
449	Phosphorylation	GSTSPTSTPSEDQEA CCCCCCCCCCHHHHH	33.06	22167270
451	Phosphorylation	TSPTSTPSEDQEALG CCCCCCCCHHHHHHC	54.62	23927012
466 (in isoform 4)	Phosphorylation	-	3.76	-
472	Phosphorylation	ALRFLKRTLSNESEE HHHHHHHHCCCCCHH	32.71	23927012
474	Phosphorylation	RFLKRTLSNESEESV HHHHHHCCCCCHHHH	37.63	23401153
477	Phosphorylation	KRTLSNESEESVKST HHHCCCCCHHHHHHC	51.41	20164059
480	Phosphorylation	LSNESEESVKSTTLA CCCCCHHHHHHCEEE	30.69	20164059
483	Phosphorylation	ESEESVKSTTLAVDY CCHHHHHHCEEEEEC	25.19	28450419
484	Phosphorylation	SEESVKSTTLAVDYP CHHHHHHCEEEEECC	21.80	28450419
485	Phosphorylation	EESVKSTTLAVDYPK HHHHHHCEEEEECCC	21.58	21815630
490	Phosphorylation	STTLAVDYPKTPTGS HCEEEEECCCCCCCC	10.46	30108239
493	Phosphorylation	LAVDYPKTPTGSPAT EEEECCCCCCCCCCC	22.90	30278072
495	Phosphorylation	VDYPKTPTGSPATEV EECCCCCCCCCCCCC	56.37	29255136
497	Phosphorylation	YPKTPTGSPATEVSA CCCCCCCCCCCCCCC	17.53	29255136
500	Phosphorylation	TPTGSPATEVSAKWT CCCCCCCCCCCCCCC	40.06	29255136
503	Phosphorylation	GSPATEVSAKWTHLT CCCCCCCCCCCCCCC	20.21	21712546
515	Ubiquitination	HLTEFELKGLKALVE CCCHHHHHHHHHHHH	55.81	-
532	Ubiquitination	ESLPENKKCVPEGIE HCCCCCCCCCCCCCC	52.63	-
588	Acetylation	AVGRPKGKLGPASAV CCCCCCCCCCHHHHH	57.29	25953088
593	Phosphorylation	KGKLGPASAVKLAAN CCCCCHHHHHHHHHC	36.41	25159151
596	Acetylation	LGPASAVKLAANRTT CCHHHHHHHHHCCCC	31.93	25953088
602	Phosphorylation	VKLAANRTTAGARRR HHHHHCCCCHHHHHH	22.32	23312004
603	Phosphorylation	KLAANRTTAGARRRR HHHHCCCCHHHHHHH	21.62	23312004
739	Phosphorylation	KRGPGFKYASNLPGS CCCCCCCCCCCCCHH	17.01	22817900
741	Phosphorylation	GPGFKYASNLPGSLL CCCCCCCCCCCHHHH	35.49	22199227
746	Phosphorylation	YASNLPGSLLKEQKM CCCCCCHHHHHHHHC	28.70	22199227
758	Acetylation	QKMNRDNKEGQEPAK HHCCCCCCCCCCCHH	68.46	20167786
765	Acetylation	KEGQEPAKRRSECEE CCCCCCHHHHHHHHH	60.09	20167786
768	Phosphorylation	QEPAKRRSECEEAPR CCCHHHHHHHHHCCC	51.11	30576142
795	Phosphorylation	DGLLRRKSDDVHLRK CCHHCCCCCCCHHHH	36.91	25159151
813	Phosphorylation	YEKPQELSGRKRASS CCCCHHHCCCCCCCC	35.48	24719451
819	Phosphorylation	LSGRKRASSLQTSPG HCCCCCCCCCCCCCC	35.30	30108239
820	Phosphorylation	SGRKRASSLQTSPGS CCCCCCCCCCCCCCC	24.42	28464451
823	Phosphorylation	KRASSLQTSPGSSSH CCCCCCCCCCCCCCC	42.03	21712546
824	Phosphorylation	RASSLQTSPGSSSHL CCCCCCCCCCCCCCC	17.82	28152594
827	Phosphorylation	SLQTSPGSSSHLSPR CCCCCCCCCCCCCCC	31.86	28152594
828	Phosphorylation	LQTSPGSSSHLSPRP CCCCCCCCCCCCCCC	27.91	28152594
829	Phosphorylation	QTSPGSSSHLSPRPP CCCCCCCCCCCCCCC	30.09	30108239
832	Phosphorylation	PGSSSHLSPRPPLGS CCCCCCCCCCCCCCC	17.28	18669648
839	Phosphorylation	SPRPPLGSSLSPWWR CCCCCCCCCCCHHHH	35.47	20873877
840	Phosphorylation	PRPPLGSSLSPWWRS CCCCCCCCCCHHHHH	30.94	20873877
842	Phosphorylation	PPLGSSLSPWWRSSL CCCCCCCCHHHHHHH	22.03	18669648
843 (in isoform 4)	Phosphorylation	-	39.69	-
844 (in isoform 4)	Phosphorylation	-	10.35	-
845 (in isoform 4)	Phosphorylation	-	8.15	-
847	Phosphorylation	SLSPWWRSSLTYFQQ CCCHHHHHHHHHHHH	18.91	23401153
847 (in isoform 4)	Phosphorylation	-	18.91	-
848	Phosphorylation	LSPWWRSSLTYFQQQ CCHHHHHHHHHHHHH	19.02	25159151
850	Phosphorylation	PWWRSSLTYFQQQLK HHHHHHHHHHHHHCC	25.00	27251275
857	Sumoylation	TYFQQQLKPGKEDKL HHHHHHCCCCCCHHH	47.59	28112733
860	Acetylation	QQQLKPGKEDKLFRK HHHCCCCCCHHHHHH	71.86	25953088
884	Acetylation	DRMALANKPLRRFKQ HHHHHCCCHHHHHHC	39.56	26051181
884	Ubiquitination	DRMALANKPLRRFKQ HHHHHCCCHHHHHHC	39.56	-
890	Sumoylation	NKPLRRFKQEPEDEL CCHHHHHHCCCCCCC	52.52	-
890	Methylation	NKPLRRFKQEPEDEL CCHHHHHHCCCCCCC	52.52	-
890	Sumoylation	NKPLRRFKQEPEDEL CCHHHHHHCCCCCCC	52.52	28112733
904	Phosphorylation	LPEAPPKTRESDHSR CCCCCCCCCCCCCCC	45.50	30576142
906 (in isoform 4)	Phosphorylation	-	66.79	-
907	Phosphorylation	APPKTRESDHSRSSS CCCCCCCCCCCCCCC	37.01	28450419
910	Phosphorylation	KTRESDHSRSSSPTA CCCCCCCCCCCCCCC	38.56	30576142
910 (in isoform 4)	Phosphorylation	-	38.56	-
912	Phosphorylation	RESDHSRSSSPTAGP CCCCCCCCCCCCCCC	37.88	29255136
913	Phosphorylation	ESDHSRSSSPTAGPS CCCCCCCCCCCCCCC	38.95	29255136
914	Phosphorylation	SDHSRSSSPTAGPST CCCCCCCCCCCCCCC	27.76	19664994
916	Phosphorylation	HSRSSSPTAGPSTEG CCCCCCCCCCCCCCC	46.31	29255136
920	Phosphorylation	SSPTAGPSTEGAEGP CCCCCCCCCCCCCCH	37.87	22115753
921	Phosphorylation	SPTAGPSTEGAEGPE CCCCCCCCCCCCCHH	41.39	22115753
947	Phosphorylation	RLPNKELSRELSKEL CCCCHHHHHHHHHHH	25.46	20873877
951	Phosphorylation	KELSRELSKELNHEI HHHHHHHHHHHHHHH	21.23	23401153
960 (in isoform 4)	Phosphorylation	-	50.06	-
961	Phosphorylation	LNHEIQRTENSLANE HHHHHHHHHHHHCCC	24.12	28450419
962 (in isoform 4)	Phosphorylation	-	47.19	-
964	Phosphorylation	EIQRTENSLANENQQ HHHHHHHHHCCCCCC	23.72	28450419
975	Phosphorylation	ENQQPIKSEPESEGE CCCCCCCCCCCCCCC	60.13	25159151
979	Phosphorylation	PIKSEPESEGEEPKR CCCCCCCCCCCCCCC	62.71	25159151
1015	Phosphorylation	LRHQLGPSLRSPPRV HHHHHCCCCCCCCCC	34.32	23898821
1018	Phosphorylation	QLGPSLRSPPRVISR HHCCCCCCCCCCCCC	44.54	25159151
1024	Phosphorylation	RSPPRVISRPPPSVS CCCCCCCCCCCCCCC	35.56	23927012
1029	Phosphorylation	VISRPPPSVSPPKCI CCCCCCCCCCCCCCE	40.79	30266825
1031	Phosphorylation	SRPPPSVSPPKCIQM CCCCCCCCCCCCEEE	39.56	29255136
1049	Phosphorylation	VIRPPPISPPPDSLP ECCCCCCCCCCCCCC	36.81	30576142
1054	Phosphorylation	PISPPPDSLPLDDGA CCCCCCCCCCCCCCC	37.35	29978859
1111	Ubiquitination	RIDLNHCKSITPLML EECHHHCCCCCHHHH	37.02	-
1142	Phosphorylation	NISKKQLSWLINRLP CCCHHHHHHHHHHCC	19.83	25247763
1187	Ubiquitination	VQWVEGLKDAQMRDL HHHHCCCCCHHHHHH	62.97	-
1196	Phosphorylation	AQMRDLLSPPTDNRP HHHHHHCCCCCCCCC	35.81	29414761
1231	Methylation	DITDASLRLIIRHMP CCCHHHHHHHHHHHH	22.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KDM2B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KDM2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KDM2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKP1_HUMAN	SKP1	physical	16943429
BCOR_HUMAN	BCOR	physical	16943429
EZH2_HUMAN	EZH2	physical	19202064
JUN_HUMAN	JUN	physical	17704768
CUL1_HUMAN	CUL1	physical	17704768
SKP1_HUMAN	SKP1	physical	17704768
SIN3A_HUMAN	SIN3A	physical	17704768
H31_HUMAN	HIST1H3A	physical	22825849
KDM2B_HUMAN	KDM2B	physical	22825849
UB2D1_HUMAN	UBE2D1	physical	22825849
RING2_HUMAN	RNF2	physical	23395003
PCGF1_HUMAN	PCGF1	physical	23395003
RYBP_HUMAN	RYBP	physical	23395003
RING2_HUMAN	RNF2	physical	25533466
SKP1_HUMAN	SKP1	physical	25533466
BCOR_HUMAN	BCOR	physical	25533466
PCGF1_HUMAN	PCGF1	physical	25533466
GCP60_HUMAN	ACBD3	physical	26344197
SKP1_HUMAN	SKP1	physical	17463251
CUL1_HUMAN	CUL1	physical	26725323
RBX1_HUMAN	RBX1	physical	26725323
SKP1_HUMAN	SKP1	physical	26725323
FOS_HUMAN	FOS	physical	26725323
SKP1_HUMAN	SKP1	physical	28614300

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KDM2B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-474; THR-493; SER-975AND SER-979, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-474 AND SER-497, ANDMASS SPECTROMETRY.	15302935 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-223, AND MASSSPECTROMETRY.	17924679 [Abstract]