| UniProt ID | MEPCE_HUMAN | |
|---|---|---|
| UniProt AC | Q7L2J0 | |
| Protein Name | 7SK snRNA methylphosphate capping enzyme | |
| Gene Name | MEPCE | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 689 | |
| Subcellular Localization | ||
| Protein Description | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.. | |
| Protein Sequence | MIEMAAEKEPFLVPAPPPPLKDESGGGGGPTVPPHQEAASGELRGGTERGPGRCAPSAGSPAAAVGRESPGAAATSSSGPQAQQHRGGGPQAQSHGEARLSDPPGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGKRRNSCNVGGGGGGFKHPAFKRRRRVNSDCDSVLPSNFLLGGNIFDPLNLNSLLDEEVSRTLNAETPKSSPLPAKGRDPVEILIPKDITDPLSLNTCTDEGHVVLASPLKTGRKRHRHRGQHHQQQQAAGGSESHPVPPTAPLTPLLHGEGASQQPRHRGQNRDAPQPYELNTAINCRDEVVSPLPSALQGPSGSLSAPPAASVISAPPSSSSRHRKRRRTSSKSEAGARGGGQGSKEKGRGSWGGRHHHHHPLPAAGFKKQQRKFQYGNYCKYYGYRNPSCEDGRLRVLKPEWFRGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIRHYLSEELRLPPQTLEGDPGAEGEEGTTTVRKRSCFPASLTASRGPIAAPQVPLDGADTSVFPNNVVFVTGNYVLDRDDLVEAQTPEYDVVLCLSLTKWVHLNWGDEGLKRMFRRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNYYRIQLKPEQFSSYLTSPDVGFSSYELVATPHNTSKGFQRPVYLFHKARSPSH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MIEMAAEK -------CCCCCCCC | 5.44 | 19413330 | |
| 21 | Sumoylation | PAPPPPLKDESGGGG CCCCCCCCCCCCCCC | 66.28 | - | |
| 57 | Phosphorylation | GPGRCAPSAGSPAAA CCCCCCCCCCCCCCC | 27.08 | 29255136 | |
| 60 | Phosphorylation | RCAPSAGSPAAAVGR CCCCCCCCCCCCCCC | 15.87 | 29255136 | |
| 69 | Phosphorylation | AAAVGRESPGAAATS CCCCCCCCCCCCCCC | 27.55 | 29255136 | |
| 75 | Phosphorylation | ESPGAAATSSSGPQA CCCCCCCCCCCCHHH | 25.15 | 23927012 | |
| 76 | Phosphorylation | SPGAAATSSSGPQAQ CCCCCCCCCCCHHHH | 20.13 | 30278072 | |
| 77 | Phosphorylation | PGAAATSSSGPQAQQ CCCCCCCCCCHHHHC | 34.65 | 30278072 | |
| 78 | Phosphorylation | GAAATSSSGPQAQQH CCCCCCCCCHHHHCC | 55.02 | 30278072 | |
| 86 | Methylation | GPQAQQHRGGGPQAQ CHHHHCCCCCCCCHH | 40.91 | - | |
| 94 | Phosphorylation | GGGPQAQSHGEARLS CCCCCHHCCCCCCCC | 36.15 | 29523821 | |
| 101 | Phosphorylation | SHGEARLSDPPGRAA CCCCCCCCCCCCCCC | 42.38 | 23401153 | |
| 117 | Methylation | PDVGEERRGGGGTEL CCCCCCCCCCCCCCC | 51.92 | - | |
| 122 | Phosphorylation | ERRGGGGTELGPPAP CCCCCCCCCCCCCCC | 31.17 | 28555341 | |
| 136 | Phosphorylation | PPRPRNGYQPHRPPG CCCCCCCCCCCCCCC | 23.55 | 27642862 | |
| 148 | Acetylation | PPGGGGGKRRNSCNV CCCCCCCCCCCCCCC | 52.00 | 25953088 | |
| 152 | Phosphorylation | GGGKRRNSCNVGGGG CCCCCCCCCCCCCCC | 12.78 | 29255136 | |
| 158 | Ubiquitination | NSCNVGGGGGGFKHP CCCCCCCCCCCCCCH | 26.16 | 29967540 | |
| 163 | Ubiquitination | GGGGGGFKHPAFKRR CCCCCCCCCHHHHCC | 52.53 | 29967540 | |
| 163 | Acetylation | GGGGGGFKHPAFKRR CCCCCCCCCHHHHCC | 52.53 | 25953088 | |
| 166 | Ubiquitination | GGGFKHPAFKRRRRV CCCCCCHHHHCCCCC | 23.47 | 21890473 | |
| 175 | Phosphorylation | KRRRRVNSDCDSVLP HCCCCCCCCCCCCCC | 36.44 | 25159151 | |
| 179 | Phosphorylation | RVNSDCDSVLPSNFL CCCCCCCCCCCCCCE | 31.70 | 25159151 | |
| 183 | Phosphorylation | DCDSVLPSNFLLGGN CCCCCCCCCCEECCC | 35.73 | 28464451 | |
| 199 | Phosphorylation | FDPLNLNSLLDEEVS CCCCCHHHHCCHHHH | 33.21 | 22115753 | |
| 206 | Phosphorylation | SLLDEEVSRTLNAET HHCCHHHHHHHCCCC | 23.87 | 26074081 | |
| 208 | Phosphorylation | LDEEVSRTLNAETPK CCHHHHHHHCCCCCC | 19.50 | 30266825 | |
| 213 | Phosphorylation | SRTLNAETPKSSPLP HHHHCCCCCCCCCCC | 33.34 | 19664994 | |
| 215 | Ubiquitination | TLNAETPKSSPLPAK HHCCCCCCCCCCCCC | 71.62 | 33845483 | |
| 216 | Phosphorylation | LNAETPKSSPLPAKG HCCCCCCCCCCCCCC | 38.09 | 19664994 | |
| 217 | Phosphorylation | NAETPKSSPLPAKGR CCCCCCCCCCCCCCC | 36.26 | 22167270 | |
| 222 | Ubiquitination | KSSPLPAKGRDPVEI CCCCCCCCCCCCCEE | 53.17 | 29967540 | |
| 233 | Ubiquitination | PVEILIPKDITDPLS CCEEECCCCCCCCCC | 55.56 | 29967540 | |
| 236 | Phosphorylation | ILIPKDITDPLSLNT EECCCCCCCCCCCCC | 41.52 | 23927012 | |
| 240 | Phosphorylation | KDITDPLSLNTCTDE CCCCCCCCCCCCCCC | 25.59 | 23927012 | |
| 243 | Phosphorylation | TDPLSLNTCTDEGHV CCCCCCCCCCCCCCE | 23.29 | 23927012 | |
| 244 | Glutathionylation | DPLSLNTCTDEGHVV CCCCCCCCCCCCCEE | 4.37 | 22555962 | |
| 245 | Phosphorylation | PLSLNTCTDEGHVVL CCCCCCCCCCCCEEE | 34.74 | 23401153 | |
| 254 | Phosphorylation | EGHVVLASPLKTGRK CCCEEEECCCCCCCC | 26.97 | 29255136 | |
| 257 | Ubiquitination | VVLASPLKTGRKRHR EEEECCCCCCCCHHC | 52.93 | 29967540 | |
| 258 | Phosphorylation | VLASPLKTGRKRHRH EEECCCCCCCCHHCC | 50.32 | 25159151 | |
| 266 | Methylation | GRKRHRHRGQHHQQQ CCCHHCCCCHHHHHH | 46.56 | - | |
| 279 | Phosphorylation | QQQAAGGSESHPVPP HHHHCCCCCCCCCCC | 34.70 | 23927012 | |
| 281 | Phosphorylation | QAAGGSESHPVPPTA HHCCCCCCCCCCCCC | 34.49 | 23927012 | |
| 287 | Phosphorylation | ESHPVPPTAPLTPLL CCCCCCCCCCCCCCC | 34.53 | 23401153 | |
| 291 | Phosphorylation | VPPTAPLTPLLHGEG CCCCCCCCCCCCCCC | 15.72 | 23401153 | |
| 300 | Phosphorylation | LLHGEGASQQPRHRG CCCCCCCCCCCCCCC | 39.96 | 29255136 | |
| 304 | Methylation | EGASQQPRHRGQNRD CCCCCCCCCCCCCCC | 28.00 | - | |
| 316 | Phosphorylation | NRDAPQPYELNTAIN CCCCCCCCCCCCHHC | 28.00 | 28796482 | |
| 330 | Phosphorylation | NCRDEVVSPLPSALQ CCCCCCCCCCCHHHC | 26.37 | 29255136 | |
| 334 | Phosphorylation | EVVSPLPSALQGPSG CCCCCCCHHHCCCCC | 49.66 | 29255136 | |
| 340 | Phosphorylation | PSALQGPSGSLSAPP CHHHCCCCCCCCCCC | 48.08 | 29255136 | |
| 342 | Phosphorylation | ALQGPSGSLSAPPAA HHCCCCCCCCCCCCH | 24.40 | 29255136 | |
| 344 | Phosphorylation | QGPSGSLSAPPAASV CCCCCCCCCCCCHHH | 40.19 | 29255136 | |
| 350 | Phosphorylation | LSAPPAASVISAPPS CCCCCCHHHCCCCCC | 23.30 | 25850435 | |
| 353 | Phosphorylation | PPAASVISAPPSSSS CCCHHHCCCCCCCCH | 32.35 | 20873877 | |
| 357 | Phosphorylation | SVISAPPSSSSRHRK HHCCCCCCCCHHHHH | 41.62 | 20873877 | |
| 358 | Phosphorylation | VISAPPSSSSRHRKR HCCCCCCCCHHHHHH | 37.80 | 20873877 | |
| 359 | Phosphorylation | ISAPPSSSSRHRKRR CCCCCCCCHHHHHHH | 35.41 | 20873877 | |
| 360 | Phosphorylation | SAPPSSSSRHRKRRR CCCCCCCHHHHHHHC | 33.77 | 20873877 | |
| 369 | Phosphorylation | HRKRRRTSSKSEAGA HHHHHCCCCCHHHCC | 33.68 | 28176443 | |
| 370 | Phosphorylation | RKRRRTSSKSEAGAR HHHHCCCCCHHHCCC | 39.32 | 28176443 | |
| 372 | Phosphorylation | RRRTSSKSEAGARGG HHCCCCCHHHCCCCC | 34.33 | 28176443 | |
| 377 | Methylation | SKSEAGARGGGQGSK CCHHHCCCCCCCCCC | 43.29 | - | |
| 384 | Methylation | RGGGQGSKEKGRGSW CCCCCCCCCCCCCCC | 70.98 | - | |
| 390 | Phosphorylation | SKEKGRGSWGGRHHH CCCCCCCCCCCCCCC | 22.61 | 26055452 | |
| 412 | Acetylation | GFKKQQRKFQYGNYC CCHHHHHHHHCCCCC | 32.26 | 26051181 | |
| 412 | Ubiquitination | GFKKQQRKFQYGNYC CCHHHHHHHHCCCCC | 32.26 | 29967540 | |
| 418 | Phosphorylation | RKFQYGNYCKYYGYR HHHHCCCCCHHCCCC | 5.97 | 22817900 | |
| 438 | Ubiquitination | DGRLRVLKPEWFRGR CCCEEECCCHHHCCC | 37.73 | - | |
| 521 | Phosphorylation | TTTVRKRSCFPASLT CCEEEECCCCCCCCE | 24.12 | 28555341 | |
| 526 | Phosphorylation | KRSCFPASLTASRGP ECCCCCCCCEECCCC | 26.87 | 28555341 | |
| 582 | Phosphorylation | YDVVLCLSLTKWVHL CCEEEEEECCEEECC | 32.75 | 24719451 | |
| 627 | Ubiquitination | WSSYGKRKTLTETIY CCCCCCCCCHHHHHH | 51.91 | 29967540 | |
| 628 | Phosphorylation | SSYGKRKTLTETIYK CCCCCCCCHHHHHHH | 42.84 | - | |
| 630 | Phosphorylation | YGKRKTLTETIYKNY CCCCCCHHHHHHHHH | 35.99 | 30631047 | |
| 632 | Phosphorylation | KRKTLTETIYKNYYR CCCCHHHHHHHHHEE | 25.11 | 30631047 | |
| 635 | Acetylation | TLTETIYKNYYRIQL CHHHHHHHHHEEEEC | 34.32 | 25953088 | |
| 635 | Ubiquitination | TLTETIYKNYYRIQL CHHHHHHHHHEEEEC | 34.32 | 21890473 | |
| 635 | Ubiquitination | TLTETIYKNYYRIQL CHHHHHHHHHEEEEC | 34.32 | 21890473 | |
| 643 | Sumoylation | NYYRIQLKPEQFSSY HHEEEECCHHHHHHH | 30.08 | 28112733 | |
| 661 | Phosphorylation | PDVGFSSYELVATPH CCCCCCCEEEEECCC | 16.45 | 22817900 | |
| 666 | Phosphorylation | SSYELVATPHNTSKG CCEEEEECCCCCCCC | 20.01 | 25627689 | |
| 686 | Phosphorylation | YLFHKARSPSH---- EEEECCCCCCC---- | 35.30 | 20068231 | |
| 688 | Phosphorylation | FHKARSPSH------ EECCCCCCC------ | 42.97 | 20068231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MEPCE_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MEPCE_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MEPCE_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-60; THR-213; SER-216; SER-217 AND THR-291, ANDMASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-213; SER-216 ANDSER-254, AND MASS SPECTROMETRY. | |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-60; THR-213; SER-216; SER-217 AND THR-291, ANDMASS SPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-69; THR-213;SER-216; SER-217 AND SER-254, AND MASS SPECTROMETRY. | |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-60; SER-69;SER-101; SER-152; SER-175; SER-216; SER-217; SER-254; SER-330 ANDSER-390, AND MASS SPECTROMETRY. | |
| "Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69; SER-175 AND SER-179,AND MASS SPECTROMETRY. | |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-213 AND SER-217, ANDMASS SPECTROMETRY. | |
| "A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND MASSSPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69 AND SER-175, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-213, AND MASSSPECTROMETRY. | |
| "Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-661, AND MASSSPECTROMETRY. | |
