| UniProt ID | CAND1_HUMAN | |
|---|---|---|
| UniProt AC | Q86VP6 | |
| Protein Name | Cullin-associated NEDD8-dissociated protein 1 | |
| Gene Name | CAND1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1230 | |
| Subcellular Localization | Cytoplasm . Nucleus . Predominantly cytoplasmic. | |
| Protein Description | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.. | |
| Protein Sequence | MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCMGQIICNLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVPILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDLLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEYLPFVLQEITSQPKRQYLLLHSLKEIISSASVVGLKPYVENIWALLLKHCECAEEGTRNVVAECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLEDPDLNVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKDSSSTNLESMDTS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MASASYHIS ------CCCHHHHHH | 25.71 | 22223895 | |
| 3 | Phosphorylation | -----MASASYHISN -----CCCHHHHHHH | 29.61 | 25159151 | |
| 5 | Phosphorylation | ---MASASYHISNLL ---CCCHHHHHHHHH | 18.10 | 25159151 | |
| 6 | Phosphorylation | --MASASYHISNLLE --CCCHHHHHHHHHH | 11.68 | 25159151 | |
| 9 | Phosphorylation | ASASYHISNLLEKMT CCHHHHHHHHHHHHC | 14.23 | 20068231 | |
| 12 | Ubiquitination | SYHISNLLEKMTSSD HHHHHHHHHHHCCCC | 7.51 | 22817900 | |
| 14 | 2-Hydroxyisobutyrylation | HISNLLEKMTSSDKD HHHHHHHHHCCCCCC | 47.66 | - | |
| 14 | Acetylation | HISNLLEKMTSSDKD HHHHHHHHHCCCCCC | 47.66 | 23236377 | |
| 14 | Ubiquitination | HISNLLEKMTSSDKD HHHHHHHHHCCCCCC | 47.66 | 21890473 | |
| 14 (in isoform 1) | Ubiquitination | - | 47.66 | 21890473 | |
| 14 (in isoform 2) | Ubiquitination | - | 47.66 | 21890473 | |
| 16 | Phosphorylation | SNLLEKMTSSDKDFR HHHHHHHCCCCCCCH | 35.83 | 20068231 | |
| 16 | Ubiquitination | SNLLEKMTSSDKDFR HHHHHHHCCCCCCCH | 35.83 | 33845483 | |
| 17 | Phosphorylation | NLLEKMTSSDKDFRF HHHHHHCCCCCCCHH | 32.80 | 24719451 | |
| 18 | Phosphorylation | LLEKMTSSDKDFRFM HHHHHCCCCCCCHHH | 39.24 | 20068231 | |
| 20 | 2-Hydroxyisobutyrylation | EKMTSSDKDFRFMAT HHHCCCCCCCHHHHH | 61.79 | - | |
| 20 | Neddylation | EKMTSSDKDFRFMAT HHHCCCCCCCHHHHH | 61.79 | 32015554 | |
| 20 | Ubiquitination | EKMTSSDKDFRFMAT HHHCCCCCCCHHHHH | 61.79 | 21890473 | |
| 20 (in isoform 1) | Ubiquitination | - | 61.79 | 21890473 | |
| 20 (in isoform 2) | Ubiquitination | - | 61.79 | 21890473 | |
| 24 | Ubiquitination | SSDKDFRFMATNDLM CCCCCCHHHHHHHHH | 3.84 | 22817900 | |
| 27 | Ubiquitination | KDFRFMATNDLMTEL CCCHHHHHHHHHHHH | 19.92 | 23000965 | |
| 31 | Ubiquitination | FMATNDLMTELQKDS HHHHHHHHHHHHHCC | 2.82 | 23000965 | |
| 32 | Phosphorylation | MATNDLMTELQKDSI HHHHHHHHHHHHCCC | 40.62 | 24719451 | |
| 36 | Ubiquitination | DLMTELQKDSIKLDD HHHHHHHHCCCCCCC | 67.10 | 23000965 | |
| 38 | Phosphorylation | MTELQKDSIKLDDDS HHHHHHCCCCCCCHH | 28.76 | 22496350 | |
| 40 | Ubiquitination | ELQKDSIKLDDDSER HHHHCCCCCCCHHHH | 50.22 | 21906983 | |
| 40 (in isoform 1) | Ubiquitination | - | 50.22 | 21890473 | |
| 40 (in isoform 2) | Ubiquitination | - | 50.22 | 21890473 | |
| 48 | Ubiquitination | LDDDSERKVVKMILK CCCHHHHHHHHHHHH | 47.53 | 22817900 | |
| 51 | Acetylation | DSERKVVKMILKLLE HHHHHHHHHHHHHHH | 24.18 | 25953088 | |
| 51 | Ubiquitination | DSERKVVKMILKLLE HHHHHHHHHHHHHHH | 24.18 | 23000965 | |
| 51 (in isoform 1) | Ubiquitination | - | 24.18 | 21890473 | |
| 51 (in isoform 2) | Ubiquitination | - | 24.18 | 21890473 | |
| 55 | Acetylation | KVVKMILKLLEDKNG HHHHHHHHHHHCCCC | 39.85 | 19608861 | |
| 55 | Ubiquitination | KVVKMILKLLEDKNG HHHHHHHHHHHCCCC | 39.85 | 23000965 | |
| 55 (in isoform 1) | Ubiquitination | - | 39.85 | 21890473 | |
| 55 (in isoform 2) | Ubiquitination | - | 39.85 | 21890473 | |
| 60 | 2-Hydroxyisobutyrylation | ILKLLEDKNGEVQNL HHHHHHCCCCCHHHH | 58.43 | - | |
| 60 | Acetylation | ILKLLEDKNGEVQNL HHHHHHCCCCCHHHH | 58.43 | 23954790 | |
| 60 | Ubiquitination | ILKLLEDKNGEVQNL HHHHHHCCCCCHHHH | 58.43 | 23000965 | |
| 60 (in isoform 1) | Ubiquitination | - | 58.43 | 21890473 | |
| 60 (in isoform 2) | Ubiquitination | - | 58.43 | 21890473 | |
| 66 | Ubiquitination | DKNGEVQNLAVKCLG CCCCCHHHHHHHHHH | 34.83 | 29967540 | |
| 70 | Ubiquitination | EVQNLAVKCLGPLVS CHHHHHHHHHHHHHH | 20.38 | - | |
| 75 | Ubiquitination | AVKCLGPLVSKVKEY HHHHHHHHHHHHHHH | 6.88 | 29967540 | |
| 95 | Sulfoxidation | VDTLCTNMLSDKEQL HHHHHHHCCCCHHHH | 1.72 | 30846556 | |
| 98 (in isoform 3) | Ubiquitination | - | 55.33 | 21890473 | |
| 99 | Acetylation | CTNMLSDKEQLRDIS HHHCCCCHHHHHHHH | 43.94 | 26822725 | |
| 99 | Ubiquitination | CTNMLSDKEQLRDIS HHHCCCCHHHHHHHH | 43.94 | 21890473 | |
| 107 | Phosphorylation | EQLRDISSIGLKTVI HHHHHHHHCCCEEHH | 22.47 | 20068230 | |
| 108 | Ubiquitination | QLRDISSIGLKTVIG HHHHHHHCCCEEHHC | 6.30 | 21890473 | |
| 132 | Acetylation | ALAANVCKKITGRLT HHHHHHHHHHHCHHH | 42.82 | 25953088 | |
| 132 | Ubiquitination | ALAANVCKKITGRLT HHHHHHHHHHHCHHH | 42.82 | 21890473 | |
| 132 (in isoform 1) | Ubiquitination | - | 42.82 | 21890473 | |
| 132 (in isoform 2) | Ubiquitination | - | 42.82 | 21890473 | |
| 135 | Phosphorylation | ANVCKKITGRLTSAI HHHHHHHHCHHHHHH | 25.73 | 29514088 | |
| 139 | Phosphorylation | KKITGRLTSAIAKQE HHHHCHHHHHHHCCC | 18.10 | 29514088 | |
| 140 | Phosphorylation | KITGRLTSAIAKQED HHHCHHHHHHHCCCC | 23.44 | 29514088 | |
| 149 | Phosphorylation | IAKQEDVSVQLEALD HHCCCCCHHHHHHHH | 19.23 | 24043423 | |
| 163 | Phosphorylation | DIMADMLSRQGGLLV HHHHHHHHHCCCEEC | 18.87 | 24043423 | |
| 216 (in isoform 3) | Ubiquitination | - | 35.46 | 21890473 | |
| 222 | Ubiquitination | IEHLLSELSKNDSMS HHHHHHHHCCCCCCC | 8.74 | 22053931 | |
| 227 | Phosphorylation | SELSKNDSMSTTRTY HHHCCCCCCCCHHHH | 24.83 | 24043423 | |
| 229 | Phosphorylation | LSKNDSMSTTRTYIQ HCCCCCCCCHHHHHH | 30.49 | 24043423 | |
| 229 | Ubiquitination | LSKNDSMSTTRTYIQ HCCCCCCCCHHHHHH | 30.49 | 32015554 | |
| 230 | Phosphorylation | SKNDSMSTTRTYIQC CCCCCCCCHHHHHHH | 16.20 | 24043423 | |
| 231 | Phosphorylation | KNDSMSTTRTYIQCI CCCCCCCHHHHHHHH | 17.44 | 24043423 | |
| 231 | Ubiquitination | KNDSMSTTRTYIQCI CCCCCCCHHHHHHHH | 17.44 | 22053931 | |
| 233 | Phosphorylation | DSMSTTRTYIQCIAA CCCCCHHHHHHHHHH | 23.92 | 28152594 | |
| 234 | Phosphorylation | SMSTTRTYIQCIAAI CCCCHHHHHHHHHHH | 5.91 | 28152594 | |
| 238 | Ubiquitination | TRTYIQCIAAISRQA HHHHHHHHHHHHHHH | 1.34 | 32015554 | |
| 246 (in isoform 3) | Ubiquitination | - | 11.41 | 21890473 | |
| 255 | Acetylation | RIGEYLEKIIPLVVK HHHHHHHHHHHHHHH | 43.25 | 25038526 | |
| 255 | Ubiquitination | RIGEYLEKIIPLVVK HHHHHHHHHHHHHHH | 43.25 | 22053931 | |
| 255 (in isoform 1) | Ubiquitination | - | 43.25 | 21890473 | |
| 255 (in isoform 2) | Ubiquitination | - | 43.25 | 21890473 | |
| 262 | Ubiquitination | KIIPLVVKFCNVDDD HHHHHHHHHCCCCHH | 36.40 | 32015554 | |
| 281 | Phosphorylation | YCIQAFESFVRRCPK HHHHHHHHHHHHCCC | 23.69 | - | |
| 295 | Phosphorylation | KEVYPHVSTIINICL CHHHCCHHHHHHHHH | 15.74 | 20058876 | |
| 296 | Phosphorylation | EVYPHVSTIINICLK HHHCCHHHHHHHHHH | 25.45 | 20058876 | |
| 313 | Phosphorylation | TYDPNYNYDDEDEDE CCCCCCCCCCCCCCC | 17.89 | 28348404 | |
| 322 | Ubiquitination | DEDEDENAMDADGGD CCCCCCCCCCCCCCC | 8.66 | 33845483 | |
| 331 | Ubiquitination | DADGGDDDDQGSDDE CCCCCCCCCCCCCCC | 55.67 | 33845483 | |
| 335 | Phosphorylation | GDDDDQGSDDEYSDD CCCCCCCCCCCCCCC | 35.93 | 28348404 | |
| 339 | Phosphorylation | DQGSDDEYSDDDDMS CCCCCCCCCCCHHHH | 25.13 | 22210691 | |
| 340 | Phosphorylation | QGSDDEYSDDDDMSW CCCCCCCCCCHHHHH | 32.30 | 17192257 | |
| 340 | Ubiquitination | QGSDDEYSDDDDMSW CCCCCCCCCCHHHHH | 32.30 | 21890473 | |
| 346 | Phosphorylation | YSDDDDMSWKVRRAA CCCCHHHHHHHHHHH | 30.64 | 22210691 | |
| 349 | Ubiquitination | DDDMSWKVRRAAAKC CHHHHHHHHHHHHHH | 3.99 | 21890473 | |
| 355 | 2-Hydroxyisobutyrylation | KVRRAAAKCLDAVVS HHHHHHHHHHHHHHH | 30.51 | - | |
| 355 | Acetylation | KVRRAAAKCLDAVVS HHHHHHHHHHHHHHH | 30.51 | 25953088 | |
| 355 | Ubiquitination | KVRRAAAKCLDAVVS HHHHHHHHHHHHHHH | 30.51 | 33845483 | |
| 367 | Sulfoxidation | VVSTRHEMLPEFYKT HHHCCHHHHHHHHHH | 6.55 | 30846556 | |
| 370 | Ubiquitination | TRHEMLPEFYKTVSP CCHHHHHHHHHHHCH | 58.61 | 21890473 | |
| 373 | Ubiquitination | EMLPEFYKTVSPALI HHHHHHHHHHCHHHH | 48.01 | 22817900 | |
| 373 (in isoform 1) | Ubiquitination | - | 48.01 | 21890473 | |
| 373 (in isoform 2) | Ubiquitination | - | 48.01 | 21890473 | |
| 374 | Phosphorylation | MLPEFYKTVSPALIS HHHHHHHHHCHHHHH | 18.16 | 21406692 | |
| 376 | Phosphorylation | PEFYKTVSPALISRF HHHHHHHCHHHHHHH | 15.08 | 21406692 | |
| 379 | Ubiquitination | YKTVSPALISRFKER HHHHCHHHHHHHHHH | 4.08 | 21890473 | |
| 381 | Phosphorylation | TVSPALISRFKEREE HHCHHHHHHHHHHHH | 32.30 | 21406692 | |
| 400 | Phosphorylation | DVFHAYLSLLKQTRP HHHHHHHHHHHCCCC | 20.98 | 24719451 | |
| 403 | Ubiquitination | HAYLSLLKQTRPVQS HHHHHHHHCCCCCCH | 55.72 | 21890473 | |
| 403 (in isoform 1) | Ubiquitination | - | 55.72 | 21890473 | |
| 403 (in isoform 2) | Ubiquitination | - | 55.72 | 21890473 | |
| 470 (in isoform 2) | Phosphorylation | - | 19.98 | 24532841 | |
| 525 | Phosphorylation | QALVPPVVACVGDPF HHHCCCEEEECCCCC | 4.16 | 32142685 | |
| 534 | Phosphorylation | CVGDPFYKITSEALL ECCCCCHHCCHHHHH | 39.63 | 32142685 | |
| 544 | Neddylation | SEALLVTQQLVKVIR HHHHHHHHHHHHHHC | 27.42 | 32015554 | |
| 544 | Ubiquitination | SEALLVTQQLVKVIR HHHHHHHHHHHHHHC | 27.42 | 32015554 | |
| 548 | Ubiquitination | LVTQQLVKVIRPLDQ HHHHHHHHHHCCCCC | 40.30 | - | |
| 553 | Neddylation | LVKVIRPLDQPSSFD HHHHHCCCCCCCCCC | 7.39 | 32015554 | |
| 553 | Ubiquitination | LVKVIRPLDQPSSFD HHHHHCCCCCCCCCC | 7.39 | 32015554 | |
| 557 | Phosphorylation | IRPLDQPSSFDATPY HCCCCCCCCCCCCHH | 37.69 | 25159151 | |
| 558 | Phosphorylation | RPLDQPSSFDATPYI CCCCCCCCCCCCHHH | 33.55 | 25159151 | |
| 562 | Phosphorylation | QPSSFDATPYIKDLF CCCCCCCCHHHHHHH | 20.61 | 23403867 | |
| 562 | Ubiquitination | QPSSFDATPYIKDLF CCCCCCCCHHHHHHH | 20.61 | 32015554 | |
| 564 | Phosphorylation | SSFDATPYIKDLFTC CCCCCCHHHHHHHHH | 19.09 | 23403867 | |
| 566 | Acetylation | FDATPYIKDLFTCTI CCCCHHHHHHHHHHH | 42.40 | 26051181 | |
| 571 | S-nitrosocysteine | YIKDLFTCTIKRLKA HHHHHHHHHHHHHHH | 2.65 | - | |
| 571 | S-nitrosylation | YIKDLFTCTIKRLKA HHHHHHHHHHHHHHH | 2.65 | 19483679 | |
| 574 | Acetylation | DLFTCTIKRLKAADI HHHHHHHHHHHHCCC | 33.26 | 25953088 | |
| 574 | Malonylation | DLFTCTIKRLKAADI HHHHHHHHHHHHCCC | 33.26 | 26320211 | |
| 574 | Ubiquitination | DLFTCTIKRLKAADI HHHHHHHHHHHHCCC | 33.26 | - | |
| 577 | 2-Hydroxyisobutyrylation | TCTIKRLKAADIDQE HHHHHHHHHCCCCHH | 45.63 | - | |
| 577 | Malonylation | TCTIKRLKAADIDQE HHHHHHHHHCCCCHH | 45.63 | 26320211 | |
| 577 | Neddylation | TCTIKRLKAADIDQE HHHHHHHHHCCCCHH | 45.63 | 32015554 | |
| 577 | Ubiquitination | TCTIKRLKAADIDQE HHHHHHHHHCCCCHH | 45.63 | 32015554 | |
| 586 | Acetylation | ADIDQEVKERAISCM CCCCHHHHHHHHHHH | 40.50 | 23749302 | |
| 586 | Ubiquitination | ADIDQEVKERAISCM CCCCHHHHHHHHHHH | 40.50 | 32015554 | |
| 591 | Phosphorylation | EVKERAISCMGQIIC HHHHHHHHHHHHHHH | 9.32 | - | |
| 597 | Ubiquitination | ISCMGQIICNLGDNL HHHHHHHHHHCCCCC | 0.69 | 21890473 | |
| 606 | Ubiquitination | NLGDNLGSDLPNTLQ HCCCCCCCCCCHHHH | 38.86 | 21890473 | |
| 624 | Phosphorylation | ERLKNEITRLTTVKA HHHHHHHHHHHHHHH | 17.28 | 24702127 | |
| 630 | 2-Hydroxyisobutyrylation | ITRLTTVKALTLIAG HHHHHHHHHHHHHCC | 35.27 | - | |
| 630 | Ubiquitination | ITRLTTVKALTLIAG HHHHHHHHHHHHHCC | 35.27 | 22817900 | |
| 630 (in isoform 1) | Ubiquitination | - | 35.27 | 21890473 | |
| 634 | Ubiquitination | TTVKALTLIAGSPLK HHHHHHHHHCCCCCE | 2.35 | 33845483 | |
| 638 | Phosphorylation | ALTLIAGSPLKIDLR HHHHHCCCCCEEECC | 20.31 | 25159151 | |
| 643 | Ubiquitination | AGSPLKIDLRPVLGE CCCCCEEECCCCCCC | 34.73 | 33845483 | |
| 657 | Phosphorylation | EGVPILASFLRKNQR CCHHHHHHHHHHCHH | 22.74 | 24719451 | |
| 658 (in isoform 2) | Ubiquitination | - | 6.77 | 21890473 | |
| 667 | Ubiquitination | RKNQRALKLGTLSAL HHCHHHHHHCHHHHH | 43.84 | 33845483 | |
| 670 | Phosphorylation | QRALKLGTLSALDIL HHHHHHCHHHHHHHH | 28.16 | - | |
| 672 | Phosphorylation | ALKLGTLSALDILIK HHHHCHHHHHHHHHH | 26.99 | - | |
| 723 | Nitration | LTTLAKVYPSSLSKI HHHHHHHCHHHHHHH | 9.18 | - | |
| 723 | Phosphorylation | LTTLAKVYPSSLSKI HHHHHHHCHHHHHHH | 9.18 | 28152594 | |
| 725 | Phosphorylation | TLAKVYPSSLSKISG HHHHHCHHHHHHHCH | 26.65 | 20860994 | |
| 731 | Phosphorylation | PSSLSKISGSILNEL HHHHHHHCHHHHHHH | 30.17 | 20860994 | |
| 733 | Phosphorylation | SLSKISGSILNELIG HHHHHCHHHHHHHHH | 19.67 | 20860994 | |
| 768 | Ubiquitination | ALVVTGTNNLGYMDL HHHHCCCCCCCHHHH | 42.97 | 32015554 | |
| 777 | Ubiquitination | LGYMDLLRMLTGPVY CCHHHHHHHHHCCCC | 25.92 | 32015554 | |
| 778 | Sulfoxidation | GYMDLLRMLTGPVYS CHHHHHHHHHCCCCC | 3.86 | 28183972 | |
| 779 | Ubiquitination | YMDLLRMLTGPVYSQ HHHHHHHHHCCCCCC | 3.96 | 32015554 | |
| 780 | Phosphorylation | MDLLRMLTGPVYSQS HHHHHHHHCCCCCCC | 30.05 | 24667141 | |
| 788 | Ubiquitination | GPVYSQSTALTHKQS CCCCCCCCCCCCCHH | 20.32 | 32015554 | |
| 793 | Ubiquitination | QSTALTHKQSYYSIA CCCCCCCCHHHHHHH | 35.39 | 21890473 | |
| 796 | Phosphorylation | ALTHKQSYYSIAKCV CCCCCHHHHHHHHHH | 9.95 | - | |
| 801 | Ubiquitination | QSYYSIAKCVAALTR HHHHHHHHHHHHHHH | 27.80 | 32015554 | |
| 802 | Ubiquitination | SYYSIAKCVAALTRA HHHHHHHHHHHHHHH | 1.54 | 21890473 | |
| 812 | Ubiquitination | ALTRACPKEGPAVVG HHHHHCCCCCCCHHH | 75.16 | 32015554 | |
| 826 | Acetylation | GQFIQDVKNSRSTDS HHHHHHHHCCCCCHH | 58.45 | 25953088 | |
| 826 | Ubiquitination | GQFIQDVKNSRSTDS HHHHHHHHCCCCCHH | 58.45 | 22817900 | |
| 826 (in isoform 1) | Ubiquitination | - | 58.45 | 21890473 | |
| 828 | Phosphorylation | FIQDVKNSRSTDSIR HHHHHHCCCCCHHHH | 23.14 | 27251275 | |
| 859 | Phosphorylation | SGQLELKSVILEAFS CCCCEEHHHHHHHHC | 27.32 | 28348404 | |
| 866 | Phosphorylation | SVILEAFSSPSEEVK HHHHHHHCCCCHHHH | 48.68 | 20068231 | |
| 867 | Phosphorylation | VILEAFSSPSEEVKS HHHHHHCCCCHHHHH | 26.45 | 20068231 | |
| 869 | Phosphorylation | LEAFSSPSEEVKSAA HHHHCCCCHHHHHHH | 48.62 | 20068231 | |
| 869 (in isoform 2) | Ubiquitination | - | 48.62 | 21890473 | |
| 918 | Phosphorylation | HSLKEIISSASVVGL HHHHHHHHHCCCCCC | 26.05 | - | |
| 919 | Phosphorylation | SLKEIISSASVVGLK HHHHHHHHCCCCCCH | 17.72 | - | |
| 924 | Ubiquitination | ISSASVVGLKPYVEN HHHCCCCCCHHHHHH | 26.31 | 32015554 | |
| 928 | Phosphorylation | SVVGLKPYVENIWAL CCCCCHHHHHHHHHH | 20.86 | 21406692 | |
| 933 | Ubiquitination | KPYVENIWALLLKHC HHHHHHHHHHHHHHC | 7.76 | 32015554 | |
| 957 | Ubiquitination | VVAECLGKLTLIDPE HHHHHHCCCCCCCHH | 25.91 | 32015554 | |
| 959 | Phosphorylation | AECLGKLTLIDPETL HHHHCCCCCCCHHHH | 25.75 | 22210691 | |
| 965 | Phosphorylation | LTLIDPETLLPRLKG CCCCCHHHHHHHHCC | 38.70 | 22210691 | |
| 971 | Acetylation | ETLLPRLKGYLISGS HHHHHHHCCEEECCC | 46.95 | 19608861 | |
| 972 | Ubiquitination | TLLPRLKGYLISGSS HHHHHHCCEEECCCC | 27.37 | 29967540 | |
| 973 | Phosphorylation | LLPRLKGYLISGSSY HHHHHCCEEECCCCC | 10.16 | 28152594 | |
| 976 | Phosphorylation | RLKGYLISGSSYARS HHCCEEECCCCCCCH | 29.99 | 28152594 | |
| 978 | Phosphorylation | KGYLISGSSYARSSV CCEEECCCCCCCHHC | 17.24 | 28152594 | |
| 979 | Phosphorylation | GYLISGSSYARSSVV CEEECCCCCCCHHCE | 26.74 | 28152594 | |
| 980 | Phosphorylation | YLISGSSYARSSVVT EEECCCCCCCHHCEE | 14.02 | 28152594 | |
| 980 | Ubiquitination | YLISGSSYARSSVVT EEECCCCCCCHHCEE | 14.02 | 32015554 | |
| 981 | Ubiquitination | LISGSSYARSSVVTA EECCCCCCCHHCEEE | 13.56 | 29967540 | |
| 984 | Phosphorylation | GSSYARSSVVTAVKF CCCCCCHHCEEEEEE | 18.30 | 18452278 | |
| 989 | Ubiquitination | RSSVVTAVKFTISDH CHHCEEEEEEECCCC | 3.70 | 32015554 | |
| 992 | Phosphorylation | VVTAVKFTISDHPQP CEEEEEEECCCCCCC | 17.54 | 26434776 | |
| 994 | Phosphorylation | TAVKFTISDHPQPID EEEEEECCCCCCCCC | 27.15 | 26434776 | |
| 1004 | Ubiquitination | PQPIDPLLKNCIGDF CCCCCHHHHHHHHHH | 4.57 | 21890473 | |
| 1005 | Acetylation | QPIDPLLKNCIGDFL CCCCHHHHHHHHHHH | 58.41 | 26051181 | |
| 1005 | Ubiquitination | QPIDPLLKNCIGDFL CCCCHHHHHHHHHHH | 58.41 | 29967540 | |
| 1007 | S-nitrosylation | IDPLLKNCIGDFLKT CCHHHHHHHHHHHHH | 3.34 | 22178444 | |
| 1013 | Ubiquitination | NCIGDFLKTLEDPDL HHHHHHHHHCCCCCC | 51.57 | 21890473 | |
| 1037 | 2-Hydroxyisobutyrylation | FNSAAHNKPSLIRDL ECHHHCCCCHHHHHH | 26.56 | - | |
| 1037 | Ubiquitination | FNSAAHNKPSLIRDL ECHHHCCCCHHHHHH | 26.56 | 22817900 | |
| 1037 (in isoform 1) | Ubiquitination | - | 26.56 | 21890473 | |
| 1039 | Ubiquitination | SAAHNKPSLIRDLLD HHHCCCCHHHHHHHH | 37.73 | 24816145 | |
| 1048 | Ubiquitination | IRDLLDTVLPHLYNE HHHHHHHHHHHHCCH | 8.59 | 24816145 | |
| 1068 | Sulfoxidation | ELIREVEMGPFKHTV HHHHHHHCCCCCCCC | 11.31 | 30846556 | |
| 1072 | 2-Hydroxyisobutyrylation | EVEMGPFKHTVDDGL HHHCCCCCCCCCCCC | 41.31 | - | |
| 1072 | Acetylation | EVEMGPFKHTVDDGL HHHCCCCCCCCCCCC | 41.31 | 27452117 | |
| 1072 | Ubiquitination | EVEMGPFKHTVDDGL HHHCCCCCCCCCCCC | 41.31 | 24816145 | |
| 1082 | Methylation | VDDGLDIRKAAFECM CCCCCHHHHHHHHHH | 23.40 | - | |
| 1123 | Ubiquitination | HYDIKMLTFLMLVRL CCHHHHHHHHHHHHH | 15.95 | 33845483 | |
| 1130 | Ubiquitination | TFLMLVRLSTLCPSA HHHHHHHHHCCCHHH | 3.41 | 32015554 | |
| 1132 | Ubiquitination | LMLVRLSTLCPSAVL HHHHHHHCCCHHHHH | 36.65 | 33845483 | |
| 1134 | S-nitrosocysteine | LVRLSTLCPSAVLQR HHHHHCCCHHHHHHH | 2.25 | - | |
| 1134 | S-nitrosylation | LVRLSTLCPSAVLQR HHHHHCCCHHHHHHH | 2.25 | 19483679 | |
| 1135 | Ubiquitination | VRLSTLCPSAVLQRL HHHHCCCHHHHHHHH | 28.56 | 24816145 | |
| 1139 | Ubiquitination | TLCPSAVLQRLDRLV CCCHHHHHHHHHHHH | 2.16 | 32015554 | |
| 1144 | Ubiquitination | AVLQRLDRLVEPLRA HHHHHHHHHHHHHHH | 45.27 | 24816145 | |
| 1152 | Phosphorylation | LVEPLRATCTTKVKA HHHHHHHHCCCHHHH | 12.16 | 28258704 | |
| 1154 | Phosphorylation | EPLRATCTTKVKANS HHHHHHCCCHHHHHH | 25.87 | 28258704 | |
| 1156 | 2-Hydroxyisobutyrylation | LRATCTTKVKANSVK HHHHCCCHHHHHHHH | 24.47 | - | |
| 1156 | Ubiquitination | LRATCTTKVKANSVK HHHHCCCHHHHHHHH | 24.47 | 33845483 | |
| 1161 | Phosphorylation | TTKVKANSVKQEFEK CCHHHHHHHHHHHHC | 35.24 | 28348404 | |
| 1163 | 2-Hydroxyisobutyrylation | KVKANSVKQEFEKQD HHHHHHHHHHHHCHH | 43.88 | - | |
| 1163 | Ubiquitination | KVKANSVKQEFEKQD HHHHHHHHHHHHCHH | 43.88 | 32015554 | |
| 1168 | Acetylation | SVKQEFEKQDELKRS HHHHHHHCHHHHHHH | 69.26 | 22644943 | |
| 1168 | Ubiquitination | SVKQEFEKQDELKRS HHHHHHHCHHHHHHH | 69.26 | 24816145 | |
| 1173 | Acetylation | FEKQDELKRSAMRAV HHCHHHHHHHHHHHH | 42.11 | 19815613 | |
| 1175 | Phosphorylation | KQDELKRSAMRAVAA CHHHHHHHHHHHHHH | 25.48 | - | |
| 1191 | Acetylation | LTIPEAEKSPLMSEF HCCCHHHCCCCHHHH | 65.50 | 19815623 | |
| 1219 | Phosphorylation | FESIQKDSSSTNLES HHHHHCCCCCCCHHH | 32.97 | 20068231 | |
| 1220 | Phosphorylation | ESIQKDSSSTNLESM HHHHCCCCCCCHHHC | 51.84 | 25159151 | |
| 1221 | Phosphorylation | SIQKDSSSTNLESMD HHHCCCCCCCHHHCC | 25.85 | 30576142 | |
| 1222 | Phosphorylation | IQKDSSSTNLESMDT HHCCCCCCCHHHCCC | 45.85 | 20068231 | |
| 1226 | Phosphorylation | SSSTNLESMDTS--- CCCCCHHHCCCC--- | 25.73 | 20873877 | |
| 1227 | Sulfoxidation | SSTNLESMDTS---- CCCCHHHCCCC---- | 4.81 | 21406390 | |
| 1229 | Phosphorylation | TNLESMDTS------ CCHHHCCCC------ | 27.91 | 25159151 | |
| 1230 | Phosphorylation | NLESMDTS------- CHHHCCCC------- | 33.68 | 30108239 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CAND1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CAND1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CAND1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY. | |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-55 AND LYS-971, AND MASSSPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-340, ANDMASS SPECTROMETRY. | |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-624, AND MASSSPECTROMETRY. | |
