| UniProt ID | PRP39_HUMAN | |
|---|---|---|
| UniProt AC | Q86UA1 | |
| Protein Name | Pre-mRNA-processing factor 39 | |
| Gene Name | PRPF39 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 669 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Involved in pre-mRNA splicing.. | |
| Protein Sequence | MQNSHMDEYRNSSNGSTGNSSEVVVEHPTDFSTEIMNVTEMEQSPDDSPNVNASTEETEMASAVDLPVTLTETEANFPPEYEKFWKTVENNPQDFTGWVYLLQYVEQENHLMAARKAFDRFFIHYPYCYGYWKKYADLEKRHDNIKPSDEVYRRGLQAIPLSVDLWIHYINFLKETLDPGDPETNNTIRGTFEHAVLAAGTDFRSDRLWEMYINWENEQGNLREVTAIYDRILGIPTQLYSHHFQRFKEHVQNNLPRDLLTGEQFIQLRRELASVNGHSGDDGPPGDDLPSGIEDITDPAKLITEIENMRHRIIEIHQEMFNYNEHEVSKRWTFEEGIKRPYFHVKPLEKAQLKNWKEYLEFEIENGTHERVVVLFERCVISCALYEEFWIKYAKYMENHSIEGVRHVFSRACTIHLPKKPMVHMLWAAFEEQQGNINEARNILKTFEECVLGLAMVRLRRVSLERRHGNLEEAEHLLQDAIKNAKSNNESSFYAVKLARHLFKIQKNLPKSRKVLLEAIERDKENTKLYLNLLEMEYSGDLKQNEENILNCFDKAVHGSLPIKMRITFSQRKVEFLEDFGSDVNKLLNAYDEHQTLLKEQDSLKRKAENGSEEPEEKKAHTEDTTSSSTQMIDGDLQANQAVYNYSAWYQYNYQNPWNYGQYYPPPPT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 39 | Phosphorylation | STEIMNVTEMEQSPD CCEECCHHHCCCCCC | 25.30 | 24275569 | |
| 44 | Phosphorylation | NVTEMEQSPDDSPNV CHHHCCCCCCCCCCC | 19.59 | 14702039 | |
| 48 | Phosphorylation | MEQSPDDSPNVNAST CCCCCCCCCCCCCCH | 26.25 | 24275569 | |
| 191 | Phosphorylation | TNNTIRGTFEHAVLA CCCCCCCHHHHHHHH | 18.92 | - | |
| 248 | Ubiquitination | SHHFQRFKEHVQNNL HHHHHHHHHHHHHCC | 49.45 | - | |
| 261 | Phosphorylation | NLPRDLLTGEQFIQL CCCHHHCCHHHHHHH | 46.07 | - | |
| 346 | Acetylation | KRPYFHVKPLEKAQL CCCCCCCCCCCHHHC | 35.00 | 19608861 | |
| 346 | Ubiquitination | KRPYFHVKPLEKAQL CCCCCCCCCCCHHHC | 35.00 | 32015554 | |
| 350 | Ubiquitination | FHVKPLEKAQLKNWK CCCCCCCHHHCCCHH | 49.46 | 29967540 | |
| 463 | Phosphorylation | MVRLRRVSLERRHGN HHHHHHHHHHHHCCC | 23.77 | 24719451 | |
| 512 | Phosphorylation | IQKNLPKSRKVLLEA HHHCCCHHHHHHHHH | 35.08 | - | |
| 555 | Ubiquitination | NILNCFDKAVHGSLP HHHHHHHHHHCCCCC | 31.86 | 29967540 | |
| 560 | Phosphorylation | FDKAVHGSLPIKMRI HHHHHCCCCCEEEEE | 18.98 | - | |
| 586 | Ubiquitination | DFGSDVNKLLNAYDE HHCHHHHHHHHHHHH | 54.95 | 29967540 | |
| 599 | Ubiquitination | DEHQTLLKEQDSLKR HHHHHHHHHHHHHHH | 57.34 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRP39_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRP39_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRP39_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KCD15_HUMAN | KCTD15 | physical | 28514442 | |
| ZN318_HUMAN | ZNF318 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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