CFA58_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CFA58_HUMAN
• UniProt AC: Q5T655
• Protein Name: Cilia- and flagella-associated protein 58 {ECO:0000312|HGNC:HGNC:26676}
• Gene Name: CFAP58 {ECO:0000312|HGNC:HGNC:26676}
• Organism: Homo sapiens (Human).
• Sequence Length: 872
• Subcellular Localization: Cell projection, cilium .
• Protein Sequence: MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNKDTAPMDNTFLMVKPNGPGFTGGGFPLRSTKMTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	LHAVMKKSYDNEKRL HHHHHHHCCCCHHHH		24719451
63	Acetylation	NEKRLMAKCRELNAE CHHHHHHHHHHCCCE		8082863
85	Phosphorylation	VATALKLSQDDQTTI HHHHHHCCCCCHHHH		25954137
90	Phosphorylation	KLSQDDQTTIASLKK HCCCCCHHHHHHHHH		25954137
91	Phosphorylation	LSQDDQTTIASLKKE CCCCCHHHHHHHHHH		25954137
94	Phosphorylation	DDQTTIASLKKEIEK CCHHHHHHHHHHHHH		25954137
138	Phosphorylation	TKLVEQGSGLSMDQH HHHHHCCCCCCCCCC		28509920
141	Phosphorylation	VEQGSGLSMDQHSNI HHCCCCCCCCCCCCH		28509920
167	Phosphorylation	KERDQLLSEVVKLRE HHHHHHHHHHHHHHH		23403867
220	Acetylation	REFRKKEKLEKELKQ HHHHHHHHHHHHHHH		7290037
223	Acetylation	RKKEKLEKELKQIQA HHHHHHHHHHHHHHH		7290047
248	Acetylation	ALQQYVQKSKEELQK HHHHHHHHCHHHHHH		12435355
391	Ubiquitination	RERDILNKNMLKAVN HHHHHCCHHHHHHHH		-
425	Acetylation	EGEIQNYKDEAQKQR HHHHHHCCHHHHHHH		25038526
615	Phosphorylation	SERDILGSQLVRRND HHHHHCCHHHHHCCH		30266825
661	Ubiquitination	ILRLEIKKLRREKGI HHHHHHHHHHHHCCC		-
692	Acetylation	HMQRELLKERTRCRA HHHHHHHHHHHHHHH		11794805
754	Ubiquitination	KELLLQEKEKLYMEL HHHHHHHHHHHHHHH		29967540
783	Phosphorylation	QLKLYRRTLHDKKQQ HHHHHHHHHCCHHHH		23898821
795	Phosphorylation	KQQLKVLSSELNMYE HHHHHHHHHHHCCHH		30622161
796	Phosphorylation	QQLKVLSSELNMYEV HHHHHHHHHHCCHHH		30622161
801	Phosphorylation	LSSELNMYEVQSKEY HHHHHCCHHHHCCHH		25693802
825	Acetylation	ELQNLKKKYLAQKRK HHHHHHHHHHHHHHH		90505

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CFA58_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CFA58_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CFA58_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.