UniProt ID | K1C13_HUMAN | |
---|---|---|
UniProt AC | P13646 | |
Protein Name | Keratin, type I cytoskeletal 13 | |
Gene Name | KRT13 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 458 | |
Subcellular Localization | ||
Protein Description | ||
Protein Sequence | MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
7 | Phosphorylation | -MSLRLQSSSASYGG -CCCCCCCCCCCCCC | 30.74 | 25394399 | |
8 | Phosphorylation | MSLRLQSSSASYGGG CCCCCCCCCCCCCCC | 19.57 | - | |
11 | Phosphorylation | RLQSSSASYGGGFGG CCCCCCCCCCCCCCC | 26.68 | 25394399 | |
12 | Phosphorylation | LQSSSASYGGGFGGG CCCCCCCCCCCCCCC | 21.36 | 22817900 | |
27 | Methylation | SCQLGGGRGVSTCST CCCCCCCCCCCCCEE | 45.69 | 24129315 | |
27 (in isoform 3) | Methylation | - | 45.69 | - | |
35 | Methylation | GVSTCSTRFVSGGSA CCCCCEEEEECCCCC | 17.42 | 24129315 | |
50 | Phosphorylation | GGYGGGVSCGFGGGA CCCCCCCCCCCCCCC | 16.28 | - | |
118 | Phosphorylation | LNDRLASYLEKVRAL HHHHHHHHHHHHHHH | 17.17 | - | |
144 | Phosphorylation | RDWHLKQSPASPERD EHHHHCCCCCCCCCC | 22.35 | 28290473 | |
147 | Phosphorylation | HLKQSPASPERDYSP HHCCCCCCCCCCCCC | 30.58 | 28355574 | |
152 | Phosphorylation | PASPERDYSPYYKTI CCCCCCCCCCHHHHH | 20.12 | 23312004 | |
153 | Phosphorylation | ASPERDYSPYYKTIE CCCCCCCCCHHHHHH | 15.66 | 23312004 | |
155 | Phosphorylation | PERDYSPYYKTIEEL CCCCCCCHHHHHHHH | 16.20 | 23312004 | |
156 | Phosphorylation | ERDYSPYYKTIEELR CCCCCCHHHHHHHHH | 12.68 | 23312004 | |
168 | Phosphorylation | ELRDKILTATIENNR HHHHHHHEEEEECCE | 25.81 | 20860994 | |
170 | Phosphorylation | RDKILTATIENNRVI HHHHHEEEEECCEEE | 24.48 | 20860994 | |
194 | Phosphorylation | ADDFRLKYENELALR CHHHHHHHHCHHHHH | 28.69 | 22817900 | |
238 | Phosphorylation | SLNEELAYMKKNHEE HHHHHHHHHHHCCHH | 23.30 | - | |
281 | Phosphorylation | LAEMREQYEAMAERN HHHHHHHHHHHHHHH | 10.82 | - | |
308 | Phosphorylation | AELNKEVSTNTAMIQ HHHCHHCCCCCEEEE | 19.61 | 21406692 | |
309 | Phosphorylation | ELNKEVSTNTAMIQT HHCHHCCCCCEEEEC | 41.59 | 21406692 | |
311 | Phosphorylation | NKEVSTNTAMIQTSK CHHCCCCCEEEECCH | 20.07 | 21406692 | |
316 | Phosphorylation | TNTAMIQTSKTEITE CCCEEEECCHHHHHH | 22.67 | 21406692 | |
317 | Phosphorylation | NTAMIQTSKTEITEL CCEEEECCHHHHHHH | 22.62 | 21406692 | |
327 | Phosphorylation | EITELRRTLQGLEIE HHHHHHHHHHHHHHH | 19.59 | 20068231 | |
337 | Phosphorylation | GLEIELQSQLSMKAG HHHHHHHHHHHHHHC | 45.79 | 20068231 | |
340 | Phosphorylation | IELQSQLSMKAGLEN HHHHHHHHHHHCCCC | 15.59 | 30278072 | |
404 | Phosphorylation | RLEQEIATYRSLLEG HHHHHHHHHHHHHCC | 25.73 | - | |
405 | Phosphorylation | LEQEIATYRSLLEGQ HHHHHHHHHHHHCCC | 6.81 | - | |
416 (in isoform 3) | Acetylation | - | 3.77 | - | |
421 | Phosphorylation | AKMIGFPSSAGSVSP CEEECCCCCCCCCCC | 30.47 | 28176443 | |
422 | Phosphorylation | KMIGFPSSAGSVSPR EEECCCCCCCCCCCC | 36.57 | 28355574 | |
425 | Phosphorylation | GFPSSAGSVSPRSTS CCCCCCCCCCCCCCE | 21.09 | 28176443 | |
427 | Phosphorylation | PSSAGSVSPRSTSVT CCCCCCCCCCCCEEE | 19.12 | 7493031 | |
432 | Phosphorylation | SVSPRSTSVTTTSSA CCCCCCCEEEECCCC | 20.79 | - | |
434 | Phosphorylation | SPRSTSVTTTSSASV CCCCCEEEECCCCEE | 24.91 | - | |
438 | Phosphorylation | TSVTTTSSASVTTTS CEEEECCCCEEEECC | 23.59 | 30576142 | |
444 | Phosphorylation | SSASVTTTSNASGRR CCCEEEECCCCCCCC | 15.60 | 30576142 | |
452 | Phosphorylation | SNASGRRTSDVRRP- CCCCCCCCCCCCCC- | 28.11 | 20363803 | |
453 | Phosphorylation | NASGRRTSDVRRP-- CCCCCCCCCCCCC-- | 32.09 | 20363803 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of K1C13_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of K1C13_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of K1C13_HUMAN !! |
Kegg Disease | ||||||
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There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
615785 | White sponge nevus 2 (WSN2) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425 AND SER-427, ANDMASS SPECTROMETRY. | |
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427, AND MASSSPECTROMETRY. | |
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427, AND MASSSPECTROMETRY. |