dbPTM

K2C6C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	K2C6C_HUMAN
UniProt AC	P48668
Protein Name	Keratin, type II cytoskeletal 6C
Gene Name	KRT6C
Organism	Homo sapiens (Human).
Sequence Length	564
Subcellular Localization
Protein Description
Protein Sequence	MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCASLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNVSVVQSTISSGYGGASGVGSGLGLGGGSSYSYGSGLGIGGGFSSSSGRAIGGGLSSVGGGSSTIKYTTTSSSSRKSYKH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASTSTTIR ------CCCCCCCCC	22.86	-
3	Phosphorylation	-----MASTSTTIRS -----CCCCCCCCCC	22.92	21955146
4	Phosphorylation	----MASTSTTIRSH ----CCCCCCCCCCC	22.13	21955146
5	Phosphorylation	---MASTSTTIRSHS ---CCCCCCCCCCCC	22.51	20860994
6	Phosphorylation	--MASTSTTIRSHSS --CCCCCCCCCCCCC	26.74	21955146
7	Phosphorylation	-MASTSTTIRSHSSS -CCCCCCCCCCCCCC	17.73	21955146
10	Phosphorylation	STSTTIRSHSSSRRG CCCCCCCCCCCCCCC	24.70	21955146
12	Phosphorylation	STTIRSHSSSRRGFS CCCCCCCCCCCCCCC	31.12	21955146
13	Phosphorylation	TTIRSHSSSRRGFSA CCCCCCCCCCCCCCC	23.57	21955146
14	Phosphorylation	TIRSHSSSRRGFSAN CCCCCCCCCCCCCCC	29.07	21955146
19	Phosphorylation	SSSRRGFSANSARLP CCCCCCCCCCCCCCC	29.39	25394399
22	Phosphorylation	RRGFSANSARLPGVS CCCCCCCCCCCCCCC	17.93	25394399
29	Phosphorylation	SARLPGVSRSGFSSI CCCCCCCCCCCCCEE	27.00	25247763
31	Phosphorylation	RLPGVSRSGFSSISV CCCCCCCCCCCEEEE	36.36	23927012
34	Phosphorylation	GVSRSGFSSISVSRS CCCCCCCCEEEEECC	30.22	23927012
35	Phosphorylation	VSRSGFSSISVSRSR CCCCCCCEEEEECCC	19.34	27251275
37	Phosphorylation	RSGFSSISVSRSRGS CCCCCEEEEECCCCC	18.91	28355574
39	Phosphorylation	GFSSISVSRSRGSGG CCCEEEEECCCCCCC	20.11	27251275
41	Phosphorylation	SSISVSRSRGSGGLG CEEEEECCCCCCCCC	33.22	26657352
42	Methylation	SISVSRSRGSGGLGG EEEEECCCCCCCCCC	42.03	-
44	Phosphorylation	SVSRSRGSGGLGGAC EEECCCCCCCCCCCC	28.69	27966365
58	Phosphorylation	CGGAGFGSRSLYGLG CCCCCCCCCCCCCCC	19.21	25394399
60	Phosphorylation	GAGFGSRSLYGLGGS CCCCCCCCCCCCCCC	27.86	28355574
62	Phosphorylation	GFGSRSLYGLGGSKR CCCCCCCCCCCCCCE	16.14	23927012
67	Phosphorylation	SLYGLGGSKRISIGG CCCCCCCCCEEEECC	19.57	28355574
71	Phosphorylation	LGGSKRISIGGGSCA CCCCCEEEECCCCEE	21.15	25394399
76	Phosphorylation	RISIGGGSCAISGGY EEEECCCCEEECCCC	12.03	26356563
80	Phosphorylation	GGGSCAISGGYGSRA CCCCEEECCCCCCCC	13.98	25394399
83	Phosphorylation	SCAISGGYGSRAGGS CEEECCCCCCCCCCC	18.56	23927012
85	Phosphorylation	AISGGYGSRAGGSYG EECCCCCCCCCCCCC	15.52	25394399
146	Phosphorylation	TVNQSLLTPLNLQID EECHHHHCCCCCCCC	30.90	-
168	Ubiquitination	AEEREQIKTLNNKFA HHHHHHHHHHHHHHH	46.80	21906983
169	Phosphorylation	EEREQIKTLNNKFAS HHHHHHHHHHHHHHH	36.03	27251275
173	Sumoylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
173	Ubiquitination	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	21963094
173	Acetylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	132995
173	Sumoylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
173	Methylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	132995
173	Neddylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	32015554
176	Phosphorylation	TLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	28355574
180	Acetylation	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	7705779
180	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	21906983
189	Ubiquitination	RFLEQQNKVLDTKWT HHHHHHHCHHHHHHH	39.58	16196087
194	Methylation	QNKVLDTKWTLLQEQ HHCHHHHHHHHHHHH	37.54	-
196	Phosphorylation	KVLDTKWTLLQEQGT CHHHHHHHHHHHHCC	21.10	24719451
205	Phosphorylation	LQEQGTKTVRQNLEP HHHHCCHHHHHHHHH	22.28	24719451
217	Phosphorylation	LEPLFEQYINNLRRQ HHHHHHHHHHHHHHH	9.83	-
227	Phosphorylation	NLRRQLDSIVGERGR HHHHHHHHHHCHHHH	27.97	28355574
237	Phosphorylation	GERGRLDSELRNMQD CHHHHHHHHHHHHHH	43.02	28355574
252	Neddylation	LVEDLKNKYEDEINK HHHHHHHHHHHHHHH	48.72	32015554
252	Ubiquitination	LVEDLKNKYEDEINK HHHHHHHHHHHHHHH	48.72	21906983
252	Methylation	LVEDLKNKYEDEINK HHHHHHHHHHHHHHH	48.72	-
253	Phosphorylation	VEDLKNKYEDEINKR HHHHHHHHHHHHHHH	37.70	-
259	Ubiquitination	KYEDEINKRTAAENE HHHHHHHHHHHHHCC	57.71	29901268
259	Methylation	KYEDEINKRTAAENE HHHHHHHHHHHHHCC	57.71	-
261	Phosphorylation	EDEINKRTAAENEFV HHHHHHHHHHHCCCE	31.65	29083192
278	Phosphorylation	KKDVDAAYMNKVELQ EHHHCHHHHCHHHHH	11.71	21253578
290	Phosphorylation	ELQAKADTLTDEINF HHHHCCCHHHHHHHH	36.10	27966365
302	Phosphorylation	INFLRALYDAELSQM HHHHHHHHHHHHHHC	16.48	20860994
307	Phosphorylation	ALYDAELSQMQTHIS HHHHHHHHHCCCCCC	18.34	20860994
311	Phosphorylation	AELSQMQTHISDTSV HHHHHCCCCCCCCEE	18.81	20860994
316	Phosphorylation	MQTHISDTSVVLSMD CCCCCCCCEEEEECC	19.34	20860994
332	Phosphorylation	NRNLDLDSIIAEVKA CCCCCHHHHHHHHHH	24.16	26657352
341	Phosphorylation	IAEVKAQYEEIAQRS HHHHHHHHHHHHHHH	22.01	26356563
348	Phosphorylation	YEEIAQRSRAEAESW HHHHHHHHHHHHHHH	24.62	24719451
356	Phosphorylation	RAEAESWYQTKYEEL HHHHHHHHHHHHHHH	18.65	26267517
358	Phosphorylation	EAESWYQTKYEELQV HHHHHHHHHHHHHHH	21.64	19060867
360	Phosphorylation	ESWYQTKYEELQVTA HHHHHHHHHHHHHHC	20.30	22817900
366	Phosphorylation	KYEELQVTAGRHGDD HHHHHHHHCCCCCCH	15.50	-
393	Phosphorylation	RMIQRLRSEIDHVKK HHHHHHHHHHHHHHH	43.42	27251275
404	Phosphorylation	HVKKQCASLQAAIAD HHHHHHHHHHHHHHC	28.74	-
426	Acetylation	ALKDAKNKLEGLEDA HHHHHHHHHHCHHHH	47.40	7462033
448	Phosphorylation	LARLLKEYQELMNVK HHHHHHHHHHHHCCH	13.00	20068231
464	Phosphorylation	ALDVEIATYRKLLEG HHHHHHHHHHHHHCC	29.53	29083192
465	Phosphorylation	LDVEIATYRKLLEGE HHHHHHHHHHHHCCC	9.20	29083192
467	Ubiquitination	VEIATYRKLLEGEEC HHHHHHHHHHCCCCC	47.19	22817900
475	Methylation	LLEGEECRLNGEGVG HHCCCCCCCCCCCCC	34.17	-
540	Phosphorylation	RAIGGGLSSVGGGSS CEECCCCCCCCCCCC	26.67	23927012
541	Phosphorylation	AIGGGLSSVGGGSST EECCCCCCCCCCCCE	29.80	25394399
546	Phosphorylation	LSSVGGGSSTIKYTT CCCCCCCCCEEEEEE	27.81	27966365
547	Phosphorylation	SSVGGGSSTIKYTTT CCCCCCCCEEEEEEC	37.11	28731282
548	Phosphorylation	SVGGGSSTIKYTTTS CCCCCCCEEEEEECC	24.16	25394399
550	Methylation	GGGSSTIKYTTTSSS CCCCCEEEEEECCCC	36.31	-
551	Phosphorylation	GGSSTIKYTTTSSSS CCCCEEEEEECCCCC	12.88	19534553
552	Phosphorylation	GSSTIKYTTTSSSSR CCCEEEEEECCCCCC	20.70	19060867
553	Phosphorylation	SSTIKYTTTSSSSRK CCEEEEEECCCCCCC	22.91	28348404
554	Phosphorylation	STIKYTTTSSSSRKS CEEEEEECCCCCCCC	20.86	28348404
555	Phosphorylation	TIKYTTTSSSSRKSY EEEEEECCCCCCCCC	26.57	28348404
556	Phosphorylation	IKYTTTSSSSRKSYK EEEEECCCCCCCCCC	30.18	24719451
557	Phosphorylation	KYTTTSSSSRKSYKH EEEECCCCCCCCCCC	33.65	28348404
558	Phosphorylation	YTTTSSSSRKSYKH- EEECCCCCCCCCCC-	45.75	28348404
561	Phosphorylation	TSSSSRKSYKH---- CCCCCCCCCCC----	38.00	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of K2C6C_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of K2C6C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of K2C6C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of K2C6C_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615735	Palmoplantar keratoderma, non-epidermolytic, focal or diffuse (PPKNEFD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of K2C6C_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphorylation of human keratin 8 in vivo at conserved head domainserine 23 and at epidermal growth factor-stimulated tail domain serine431."; Ku N.-O., Omary M.B.; J. Biol. Chem. 272:7556-7564(1997). Cited for: PHOSPHORYLATION AT SER-60.	9054461 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-341, AND MASSSPECTROMETRY.	18083107 [Abstract]