K2C79_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C79_HUMAN
• UniProt AC: Q5XKE5
• Protein Name: Keratin, type II cytoskeletal 79
• Gene Name: KRT79
• Organism: Homo sapiens (Human).
• Sequence Length: 535
• Protein Sequence: MRSSVSRQTYSTKGGFSSNSASGGSGSQARTSFSSVTVSRSSGSGGGAHCGPGTGGFGSRSLYNLGGHKSISVSVAGGALLGRALGGFGFGSRAFMGQGAGRQTFGPACPPGGIQEVTVNQSLLTPLHVEIDPEIQRVRTQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGQNLGVTRNNLEPLFEAYLGSMRSTLDRLQSERGRLDSELRNVQDLVEDFKNKYEDEINKHTAAENEFVVLKKDVDAAYMGRMDLHGKVGTLTQEIDFLQQLYEMELSQVQTHVSNTNVVLSMDNNRNLDLDSIIAEVKAQYELIAQRSRAEAEAWYQTKYEELQVTAGKHGDNLRDTKNEIAELTRTIQRLQGEADAAKKQCQQLQTAIAEAEQRGELALKDAQKKLGDLDVALHQAKEDLTRLLRDYQELMNVKLALDVEIATYRKLLESEESRMSGECPSAVSISVTGNSTTVCGGGAASFGGGISLGGSGGATKGGFSTNVGYSTVKGGPVSAGTSILRKTTTVKTSSQRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MRSSVSRQTY -----CCCCCCCCCC	33.52	21406692
4	Phosphorylation	----MRSSVSRQTYS ----CCCCCCCCCCC	17.47	20363803
6	Phosphorylation	--MRSSVSRQTYSTK --CCCCCCCCCCCCC	22.18	21406692
20	Phosphorylation	KGGFSSNSASGGSGS CCCCCCCCCCCCCCC	26.26	19060867
32	Phosphorylation	SGSQARTSFSSVTVS CCCCCCCEEEEEEEE	19.99	24719451
34	Phosphorylation	SQARTSFSSVTVSRS CCCCCEEEEEEEECC	24.54	-
39	Phosphorylation	SFSSVTVSRSSGSGG EEEEEEEECCCCCCC	19.65	24719451
41	Phosphorylation	SSVTVSRSSGSGGGA EEEEEECCCCCCCCC	31.38	27251275
42	Phosphorylation	SVTVSRSSGSGGGAH EEEEECCCCCCCCCC	35.55	24719451
44	Phosphorylation	TVSRSSGSGGGAHCG EEECCCCCCCCCCCC	35.89	28348404
59	Phosphorylation	PGTGGFGSRSLYNLG CCCCCCCCCCCEECC	19.21	24719451
61	Phosphorylation	TGGFGSRSLYNLGGH CCCCCCCCCEECCCC	36.58	21712546
92	Phosphorylation	LGGFGFGSRAFMGQG HCCCCCCCCCCCCCC	20.41	27251275
147	Ubiquitination	TQEREQIKTLNNKFA HHHHHHHHHHHHHHH	46.80	22817900
148	Phosphorylation	QEREQIKTLNNKFAS HHHHHHHHHHHHHHH	36.03	24719451
152	Neddylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	32015554
152	Ubiquitination	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	21906983
152	Sumoylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
152	Sumoylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
152	Methylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	10929545
152	Acetylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	10929545
155	Phosphorylation	TLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	28355574
159	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	21963094
159	Acetylation	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	7706011
168	Ubiquitination	RFLEQQNKVLETKWA HHHHHHHHHHHHHHH	43.81	16196087
218	Phosphorylation	SERGRLDSELRNVQD HHHCCHHHHHHHHHH	43.02	28355574
231	Ubiquitination	QDLVEDFKNKYEDEI HHHHHHHHHHHHHHH	65.92	22817900
233	Ubiquitination	LVEDFKNKYEDEINK HHHHHHHHHHHHHHH	51.08	22817900
233	Methylation	LVEDFKNKYEDEINK HHHHHHHHHHHHHHH	51.08	-
233	Neddylation	LVEDFKNKYEDEINK HHHHHHHHHHHHHHH	51.08	32015554
234	Phosphorylation	VEDFKNKYEDEINKH HHHHHHHHHHHHHHH	37.70	-
252	Ubiquitination	ENEFVVLKKDVDAAY CCEEEEEECCCCHHH	35.00	23503661
253	Ubiquitination	NEFVVLKKDVDAAYM CEEEEEECCCCHHHH	59.84	23503661
259	Phosphorylation	KKDVDAAYMGRMDLH ECCCCHHHHCCCCCC	11.21	-
302	Phosphorylation	SNTNVVLSMDNNRNL CCCCEEEEECCCCCC	16.69	20860994
313	Phosphorylation	NRNLDLDSIIAEVKA CCCCCHHHHHHHHHH	24.16	26657352
322	Phosphorylation	IAEVKAQYELIAQRS HHHHHHHHHHHHHHH	19.98	20068231
337	Phosphorylation	RAEAEAWYQTKYEEL HHHHHHHHHHHHHHH	17.22	-
341	Phosphorylation	EAWYQTKYEELQVTA HHHHHHHHHHHHHHC	20.30	-
347	Phosphorylation	KYEELQVTAGKHGDN HHHHHHHHCCCCCCC	19.41	21815630
366	Phosphorylation	KNEIAELTRTIQRLQ HHHHHHHHHHHHHHH	19.78	24719451
429	Phosphorylation	LTRLLRDYQELMNVK HHHHHHHHHHHHCHH	9.46	20068231
445	Phosphorylation	ALDVEIATYRKLLES HHHHHHHHHHHHHHC	29.53	26074081
446	Phosphorylation	LDVEIATYRKLLESE HHHHHHHHHHHHHCH	9.20	26074081
452	Phosphorylation	TYRKLLESEESRMSG HHHHHHHCHHHHCCC	46.78	26074081
455	Phosphorylation	KLLESEESRMSGECP HHHHCHHHHCCCCCC	29.27	26074081
458	Phosphorylation	ESEESRMSGECPSAV HCHHHHCCCCCCCCE	30.26	26074081
502	Phosphorylation	GATKGGFSTNVGYST CCCCCCCCCCCCCCE	23.50	27251275
503	Phosphorylation	ATKGGFSTNVGYSTV CCCCCCCCCCCCCEE	31.49	27251275
516	Phosphorylation	TVKGGPVSAGTSILR EECCCCCCCCCCHHC	24.90	20068231
520	Phosphorylation	GPVSAGTSILRKTTT CCCCCCCCHHCCCEE	20.78	24719451
525	Phosphorylation	GTSILRKTTTVKTSS CCCHHCCCEECCCCC	22.67	-
526	Phosphorylation	TSILRKTTTVKTSSQ CCHHCCCEECCCCCC	32.40	-
527	Phosphorylation	SILRKTTTVKTSSQR CHHCCCEECCCCCCC	25.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C79_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2C79_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C79_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of K2C79_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.