TYB4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TYB4_HUMAN
• UniProt AC: P62328
• Protein Name: Thymosin beta-4
• Gene Name: TMSB4X
• Organism: Homo sapiens (Human).
• Sequence Length: 44
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.; Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase..
• Protein Sequence: MSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDKPDMAE ------CCCCCCHHH	55.10	29255136
2	Acetylation	------MSDKPDMAE ------CCCCCCHHH	55.10	20068231
4	Methylation	----MSDKPDMAEIE ----CCCCCCHHHHH	35.29	19608861
4	Acetylation	----MSDKPDMAEIE ----CCCCCCHHHHH	35.29	19608861
4	Trimethylation	----MSDKPDMAEIE ----CCCCCCHHHHH	35.29	-
4	Ubiquitination	----MSDKPDMAEIE ----CCCCCCHHHHH	35.29	19608861
12	Acetylation	PDMAEIEKFDKSKLK CCHHHHHHHCHHHHC	65.60	19608861
12	Ubiquitination	PDMAEIEKFDKSKLK CCHHHHHHHCHHHHC	65.60	19608861
12	Succinylation	PDMAEIEKFDKSKLK CCHHHHHHHCHHHHC	65.60	23954790
12	Sumoylation	PDMAEIEKFDKSKLK CCHHHHHHHCHHHHC	65.60	28112733
15	Acetylation	AEIEKFDKSKLKKTE HHHHHHCHHHHCCCC	53.26	12433517
15	Ubiquitination	AEIEKFDKSKLKKTE HHHHHHCHHHHCCCC	53.26	-
16	Phosphorylation	EIEKFDKSKLKKTET HHHHHCHHHHCCCCC	45.10	28464451
17	Acetylation	IEKFDKSKLKKTETQ HHHHCHHHHCCCCCC	70.80	19809627
19	Acetylation	KFDKSKLKKTETQEK HHCHHHHCCCCCCCC	62.48	-
20	Ubiquitination	FDKSKLKKTETQEKN HCHHHHCCCCCCCCC	63.13	-
21	Phosphorylation	DKSKLKKTETQEKNP CHHHHCCCCCCCCCC	42.55	30266825
23	Phosphorylation	SKLKKTETQEKNPLP HHHCCCCCCCCCCCC	47.46	23401153
26	Acetylation	KKTETQEKNPLPSKE CCCCCCCCCCCCCHH	54.79	19608861
26	Ubiquitination	KKTETQEKNPLPSKE CCCCCCCCCCCCCHH	54.79	21906983
31	Phosphorylation	QEKNPLPSKETIEQE CCCCCCCCHHHHHHH	51.29	23401153
32	Ubiquitination	EKNPLPSKETIEQEK CCCCCCCHHHHHHHH	57.86	19608861
32	Acetylation	EKNPLPSKETIEQEK CCCCCCCHHHHHHHH	57.86	19608861
32	Succinylation	EKNPLPSKETIEQEK CCCCCCCHHHHHHHH	57.86	23954790
34	Phosphorylation	NPLPSKETIEQEKQA CCCCCHHHHHHHHHH	33.28	29255136
39	Acetylation	KETIEQEKQAGES-- HHHHHHHHHHCCC--	45.18	19608861
39	Ubiquitination	KETIEQEKQAGES-- HHHHHHHHHHCCC--	45.18	21906983
44	Phosphorylation	QEKQAGES------- HHHHHCCC-------	44.60	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TYB4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TYB4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TYB4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTS_HUMAN	ACTA1	physical	11812134
ACTG_HUMAN	ACTG1	physical	8617195
MLH1_HUMAN	MLH1	physical	20706999
TRIP6_HUMAN	TRIP6	physical	25416956
PNMA1_HUMAN	PNMA1	physical	25416956
RBPMS_HUMAN	RBPMS	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-4; LYS-12; LYS-26; LYS-32AND LYS-39, AND MASS SPECTROMETRY.
PubMed: 19608861