dbPTM

CEP57_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CEP57_HUMAN
UniProt AC	Q86XR8
Protein Name	Centrosomal protein of 57 kDa
Gene Name	CEP57
Organism	Homo sapiens (Human).
Sequence Length	500
Subcellular Localization	Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Description	Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1..
Protein Sequence	MAAASVSAASGSHLSNSFAEPSRSNGSMVRHSSSPYVVYPSDKPFLNSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSLCWDY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAAASVSAASGS ---CCCCCCCCCCCC	16.33	27251275
7	O-linked_Glycosylation	-MAAASVSAASGSHL -CCCCCCCCCCCCCC	18.67	29485866
7	Phosphorylation	-MAAASVSAASGSHL -CCCCCCCCCCCCCC	18.67	29255136
10	Phosphorylation	AASVSAASGSHLSNS CCCCCCCCCCCCCCC	40.31	29255136
12	Phosphorylation	SVSAASGSHLSNSFA CCCCCCCCCCCCCCC	20.82	29255136
13 (in isoform 4)	Phosphorylation	-	36.48	26503514
13 (in isoform 5)	Phosphorylation	-	36.48	26503514
15	Phosphorylation	AASGSHLSNSFAEPS CCCCCCCCCCCCCCC	25.63	29255136
17	Phosphorylation	SGSHLSNSFAEPSRS CCCCCCCCCCCCCCC	23.58	29255136
22	Phosphorylation	SNSFAEPSRSNGSMV CCCCCCCCCCCCCCC	39.59	29255136
32	Phosphorylation	NGSMVRHSSSPYVVY CCCCCCCCCCCEEEC	23.19	30108239
33	Phosphorylation	GSMVRHSSSPYVVYP CCCCCCCCCCEEECC	29.25	25849741
34	Phosphorylation	SMVRHSSSPYVVYPS CCCCCCCCCEEECCC	24.22	25849741
34	Ubiquitination	SMVRHSSSPYVVYPS CCCCCCCCCEEECCC	24.22	29967540
36	Phosphorylation	VRHSSSPYVVYPSDK CCCCCCCEEECCCCC	12.42	30576142
39	Phosphorylation	SSSPYVVYPSDKPFL CCCCEEECCCCCCCC	6.23	29496907
41	Phosphorylation	SPYVVYPSDKPFLNS CCEEECCCCCCCCCC	40.35	28634298
43	Ubiquitination	YVVYPSDKPFLNSDL EEECCCCCCCCCCCC	41.84	29967540
44	Phosphorylation	VVYPSDKPFLNSDLR EECCCCCCCCCCCCC	43.90	33259812
47	Ubiquitination	PSDKPFLNSDLRRSP CCCCCCCCCCCCCCC	33.58	29967540
48	Phosphorylation	SDKPFLNSDLRRSPS CCCCCCCCCCCCCCC	39.92	23312004
53	Phosphorylation	LNSDLRRSPSKPTLA CCCCCCCCCCCCCCC	27.39	22617229
55	Phosphorylation	SDLRRSPSKPTLAYP CCCCCCCCCCCCCCC	53.14	23401153
56	Ubiquitination	DLRRSPSKPTLAYPE CCCCCCCCCCCCCCC	45.46	29967540
58	Phosphorylation	RRSPSKPTLAYPESN CCCCCCCCCCCCCCH	27.97	30278072
61	Phosphorylation	PSKPTLAYPESNSRA CCCCCCCCCCCHHHH	15.62	30108239
64	Phosphorylation	PTLAYPESNSRAIFS CCCCCCCCHHHHHHH	35.28	23312004
66	Phosphorylation	LAYPESNSRAIFSAL CCCCCCHHHHHHHHH	32.16	23312004
70	Ubiquitination	ESNSRAIFSALKNLQ CCHHHHHHHHHHHHH	3.22	29967540
74	Ubiquitination	RAIFSALKNLQDKIR HHHHHHHHHHHHHHH	56.16	-
79	Ubiquitination	ALKNLQDKIRRLELE HHHHHHHHHHHHHHH	25.75	29967540
86	Ubiquitination	KIRRLELERIQAEES HHHHHHHHHHHHHHH	38.06	23000965
86 (in isoform 4)	Ubiquitination	-	38.06	21890473
95	Ubiquitination	IQAEESVKTLSRETI HHHHHHHHHHCHHHH	53.69	23000965
95 (in isoform 1)	Ubiquitination	-	53.69	21890473
95 (in isoform 2)	Ubiquitination	-	53.69	21890473
95 (in isoform 3)	Ubiquitination	-	53.69	21890473
96	Phosphorylation	QAEESVKTLSRETIE HHHHHHHHHCHHHHH	28.01	-
96	Ubiquitination	QAEESVKTLSRETIE HHHHHHHHHCHHHHH	28.01	29967540
97	Ubiquitination	AEESVKTLSRETIEY HHHHHHHHCHHHHHH	3.63	29967540
101	Phosphorylation	VKTLSRETIEYKKVL HHHHCHHHHHHHHHH	20.28	-
104	Phosphorylation	LSRETIEYKKVLDEQ HCHHHHHHHHHHHHH	16.56	-
105	Ubiquitination	SRETIEYKKVLDEQI CHHHHHHHHHHHHHH	24.50	29967540
106	Ubiquitination	RETIEYKKVLDEQIQ HHHHHHHHHHHHHHH	47.32	29967540
110	Ubiquitination	EYKKVLDEQIQEREN HHHHHHHHHHHHHHH	45.48	29967540
115	Ubiquitination	LDEQIQERENSKNEE HHHHHHHHHHCCCHH	31.83	29967540
118	Phosphorylation	QIQERENSKNEESKH HHHHHHHCCCHHHHH	31.91	30576142
119	Ubiquitination	IQERENSKNEESKHN HHHHHHCCCHHHHHH	78.82	29967540
124	Ubiquitination	NSKNEESKHNQELTS HCCCHHHHHHHHHHH	50.26	29967540
130	Ubiquitination	SKHNQELTSQLLAAE HHHHHHHHHHHHHHH	17.42	29967540
136	Ubiquitination	LTSQLLAAENKCNLL HHHHHHHHHHHHCHH	22.36	29967540
139	Ubiquitination	QLLAAENKCNLLEKQ HHHHHHHHHCHHHHH	18.92	29967540
145	Ubiquitination	NKCNLLEKQLEYMRN HHHCHHHHHHHHHHH	61.22	29967540
146	Ubiquitination	KCNLLEKQLEYMRNM HHCHHHHHHHHHHHH	30.10	29967540
149	Phosphorylation	LLEKQLEYMRNMIKH HHHHHHHHHHHHHHH	15.23	22817900
155	Ubiquitination	EYMRNMIKHAEMERT HHHHHHHHHHHHHHH	26.45	29967540
158	Ubiquitination	RNMIKHAEMERTSVL HHHHHHHHHHHHHHH	41.10	21890473
158 (in isoform 4)	Ubiquitination	-	41.10	21890473
167	Ubiquitination	ERTSVLEKQVSLERE HHHHHHHHHHHHHHH	52.41	23000965
167 (in isoform 1)	Ubiquitination	-	52.41	21890473
167 (in isoform 2)	Ubiquitination	-	52.41	21890473
167 (in isoform 3)	Ubiquitination	-	52.41	21890473
170	Phosphorylation	SVLEKQVSLERERQH HHHHHHHHHHHHHHH	23.24	24719451
179	Ubiquitination	ERERQHDQTHVQSQL HHHHHHCHHHHHHHH	31.23	29967540
188	Ubiquitination	HVQSQLEKLDLLEQE HHHHHHHHHHHHHHH	56.76	29967540
189	Ubiquitination	VQSQLEKLDLLEQEY HHHHHHHHHHHHHHH	4.02	29967540
198	Ubiquitination	LLEQEYNKLTTMQAL HHHHHHHHHHHHHHH	46.43	29967540
199	Ubiquitination	LEQEYNKLTTMQALA HHHHHHHHHHHHHHH	4.25	29967540
200	Phosphorylation	EQEYNKLTTMQALAE HHHHHHHHHHHHHHH	23.10	20860994
201	Phosphorylation	QEYNKLTTMQALAEK HHHHHHHHHHHHHHH	20.09	29083192
208	Ubiquitination	TMQALAEKKMQELEA HHHHHHHHHHHHHHH	48.19	29967540
209	Ubiquitination	MQALAEKKMQELEAK HHHHHHHHHHHHHHH	37.00	22505724
216	Ubiquitination	KMQELEAKLHEEEQE HHHHHHHHHHHHHHH	40.79	29967540
221	Ubiquitination	EAKLHEEEQERKRMQ HHHHHHHHHHHHHHH	55.55	29967540
225	Ubiquitination	HEEEQERKRMQAKAA HHHHHHHHHHHHHHH	52.01	29967540
230	Ubiquitination	ERKRMQAKAAELQTG HHHHHHHHHHHHHHH	31.10	29967540
239	Ubiquitination	AELQTGLETNRLIFE HHHHHHHHHCCCCCC	45.44	22505724
248	Ubiquitination	NRLIFEDKATPCVPN CCCCCCCCCCCCCCC	47.14	22505724
250	Phosphorylation	LIFEDKATPCVPNAR CCCCCCCCCCCCCHH	23.98	28555341
264	Phosphorylation	RRIKKKKSKPPEKKS HHHHCCCCCCCCCCC	60.31	26657352
265	Sumoylation	RIKKKKSKPPEKKSS HHHCCCCCCCCCCCC	73.75	-
265	Acetylation	RIKKKKSKPPEKKSS HHHCCCCCCCCCCCC	73.75	12433715
265	Sumoylation	RIKKKKSKPPEKKSS HHHCCCCCCCCCCCC	73.75	-
269	Acetylation	KKSKPPEKKSSRNYF CCCCCCCCCCCCCCC	64.82	12433725
293	Ubiquitination	LGDMPFVAGKSTSPS CCCCCCCCCCCCCHH	21.78	29967540
308	Ubiquitination	HAVVANVQLVLHLMK HHHHHHHHHHHHHHH	26.17	29967540
310	Ubiquitination	VVANVQLVLHLMKQH HHHHHHHHHHHHHHH	1.44	29967540
319	Ubiquitination	HLMKQHSKALCNDRV HHHHHHHHHHHCCCC	43.16	29967540
325	Ubiquitination	SKALCNDRVINSIPL HHHHHCCCCHHHHHH	19.75	29967540
334	Ubiquitination	INSIPLAKQVSSRGG HHHHHHHHHHHCCCC	59.94	29967540
347	Phosphorylation	GGKSKKLSVTPPSSN CCCCCCCCCCCCCCC	32.59	28450419
349	Phosphorylation	KSKKLSVTPPSSNGI CCCCCCCCCCCCCCC	26.55	28450419
352	Phosphorylation	KLSVTPPSSNGINEE CCCCCCCCCCCCCHH	37.32	28450419
353	Phosphorylation	LSVTPPSSNGINEEL CCCCCCCCCCCCHHH	44.86	28450419
361	Phosphorylation	NGINEELSEVLQTLQ CCCCHHHHHHHHHHH	29.01	28450419
368	Ubiquitination	SEVLQTLQDEFGQMS HHHHHHHHHHHHCCC	52.13	29967540
370	Ubiquitination	VLQTLQDEFGQMSFD HHHHHHHHHHCCCCC	38.42	29967540
385	Ubiquitination	HQQLAKLIQESPTVE HHHHHHHHHHCCCCC	4.15	29967540
387	Ubiquitination	QLAKLIQESPTVELK HHHHHHHHCCCCCHH	52.25	29967540
388	Phosphorylation	LAKLIQESPTVELKD HHHHHHHCCCCCHHH	14.97	28348404
390	Phosphorylation	KLIQESPTVELKDKL HHHHHCCCCCHHHHH	35.57	19691289
391	Ubiquitination	LIQESPTVELKDKLE HHHHCCCCCHHHHHH	10.34	29967540
394	Acetylation	ESPTVELKDKLECEL HCCCCCHHHHHHHHH	39.03	25038526
394	Ubiquitination	ESPTVELKDKLECEL HCCCCCHHHHHHHHH	39.03	29967540
396	Acetylation	PTVELKDKLECELEA CCCCHHHHHHHHHHH	44.60	25038526
396	Ubiquitination	PTVELKDKLECELEA CCCCHHHHHHHHHHH	44.60	29967540
402	Ubiquitination	DKLECELEALVGRME HHHHHHHHHHHHHHH	20.05	29967540
408	Ubiquitination	LEALVGRMEAKANQI HHHHHHHHHHHHHHH	4.90	29967540
411	Ubiquitination	LVGRMEAKANQITKV HHHHHHHHHHHHHHH	34.27	29967540
417	Ubiquitination	AKANQITKVRKYQAQ HHHHHHHHHHHHHHH	41.49	29967540
420	Ubiquitination	NQITKVRKYQAQLEK HHHHHHHHHHHHHHH	44.71	29967540
436	Ubiquitination	KLEKQKKELKATKKT HHHHHHHHHHHHHHH	63.64	29967540
450	Ubiquitination	TLDEERNSSSRSGIT HHHHHHHHCCCCCCC	35.59	29967540
452	Phosphorylation	DEERNSSSRSGITGT HHHHHHCCCCCCCCC	30.22	28787133
453	Ubiquitination	EERNSSSRSGITGTT HHHHHCCCCCCCCCC	40.63	29967540
462	Ubiquitination	GITGTTNKKDFMKLR CCCCCCCHHHHHHCC	52.18	29967540
463	Ubiquitination	ITGTTNKKDFMKLRP CCCCCCHHHHHHCCC	59.26	-
467	Ubiquitination	TNKKDFMKLRPGEKR CCHHHHHHCCCCHHH	41.14	29967540
473	Acetylation	MKLRPGEKRRKNLQL HHCCCCHHHHHHHHH	64.52	30587629
476	Ubiquitination	RPGEKRRKNLQLLKD CCCHHHHHHHHHHHH	67.07	29967540
493	Phosphorylation	SIQNSLQSSSLCWDY HHHHHHHHCCCCCCC	27.47	27251275
494	Phosphorylation	IQNSLQSSSLCWDY- HHHHHHHCCCCCCC-	17.86	27251275
495	Phosphorylation	QNSLQSSSLCWDY-- HHHHHHCCCCCCC--	32.56	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CEP57_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CEP57_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CEP57_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
ABR_HUMAN	ABR	physical	23443559
ACTS_HUMAN	ACTA1	physical	23443559
ATD3A_HUMAN	ATAD3A	physical	23443559
ATPG_HUMAN	ATP5C1	physical	23443559
PRC2C_HUMAN	PRRC2C	physical	23443559
CCD33_HUMAN	CCDC33	physical	23443559
CCDC8_HUMAN	CCDC8	physical	23443559
CEAM1_HUMAN	CEACAM1	physical	23443559
CE170_HUMAN	CEP170	physical	23443559
CE290_HUMAN	CEP290	physical	23443559
CLH2_HUMAN	CLTCL1	physical	23443559
CPNE7_HUMAN	CPNE7	physical	23443559
CPVL_HUMAN	CPVL	physical	23443559
CYTA_HUMAN	CSTA	physical	23443559
RS18_HUMAN	RPS18	physical	23443559
DDB1_HUMAN	DDB1	physical	23443559
DHX15_HUMAN	DHX15	physical	23443559
EF1A2_HUMAN	EEF1A2	physical	23443559
CSK21_HUMAN	CSNK2A1	physical	23443559
DSC1_HUMAN	DSC1	physical	23443559
FABP5_HUMAN	FABP5	physical	23443559
RL23_HUMAN	RPL23	physical	23443559
MIP18_HUMAN	FAM96B	physical	23443559
FBLN5_HUMAN	FBLN5	physical	23443559
FRIH_HUMAN	FTH1	physical	23443559
FRIL_HUMAN	FTL	physical	23443559
MOGS_HUMAN	MOGS	physical	23443559
GGYF2_HUMAN	GIGYF2	physical	23443559
GRWD1_HUMAN	GRWD1	physical	23443559
HINT3_HUMAN	HINT3	physical	23443559
ROA2_HUMAN	HNRNPA2B1	physical	23443559
HNRPU_HUMAN	HNRNPU	physical	23443559
HNRL2_HUMAN	HNRNPUL2	physical	23443559
HORN_HUMAN	HRNR	physical	23443559
HS90A_HUMAN	HSP90AA1	physical	23443559
HS71L_HUMAN	HSPA1L	physical	23443559
HSP72_HUMAN	HSPA2	physical	23443559
GRP78_HUMAN	HSPA5	physical	23443559
GRP75_HUMAN	HSPA9	physical	23443559
HSPB1_HUMAN	HSPB1	physical	23443559
IQGA1_HUMAN	IQGAP1	physical	23443559
IRS4_HUMAN	IRS4	physical	23443559
LRCH3_HUMAN	LRCH3	physical	23443559
LSM3_HUMAN	LSM3	physical	23443559
LY65B_HUMAN	LY6G5B	physical	23443559
LYSC_HUMAN	LYZ	physical	23443559
MARK2_HUMAN	MARK2	physical	23443559
MCM7_HUMAN	MCM7	physical	23443559
MMRN1_HUMAN	MMRN1	physical	23443559
RM40_HUMAN	MRPL40	physical	23443559
RM49_HUMAN	MRPL49	physical	23443559
RT11_HUMAN	MRPS11	physical	23443559
RT23_HUMAN	MRPS23	physical	23443559
RT07_HUMAN	MRPS7	physical	23443559
MYL6B_HUMAN	MYL6B	physical	23443559
KPB1_HUMAN	PHKA1	physical	23443559
KPB2_HUMAN	PHKA2	physical	23443559
RPAB3_HUMAN	POLR2H	physical	23443559
IASPP_HUMAN	PPP1R13L	physical	23443559
PRP19_HUMAN	PRPF19	physical	23443559
MRRP1_HUMAN	TRMT10C	physical	23443559
RL11_HUMAN	RPL11	physical	23443559
RL22_HUMAN	RPL22	physical	23443559
RL30_HUMAN	RPL30	physical	23443559
RL38_HUMAN	RPL38	physical	23443559
RLA2_HUMAN	RPLP2	physical	23443559
RS11_HUMAN	RPS11	physical	23443559
RS14_HUMAN	RPS14	physical	23443559
RS15A_HUMAN	RPS15A	physical	23443559
RS16_HUMAN	RPS16	physical	23443559
RS17_HUMAN	RPS17	physical	23443559
RS23_HUMAN	RPS23	physical	23443559
RS25_HUMAN	RPS25	physical	23443559
RS3_HUMAN	RPS3	physical	23443559
RS3A_HUMAN	RPS3A	physical	23443559
RS4X_HUMAN	RPS4X	physical	23443559
RS7_HUMAN	RPS7	physical	23443559
S10AD_HUMAN	S100A13	physical	23443559
SPTN1_HUMAN	SPTAN1	physical	23443559
SSBP_HUMAN	SSBP1	physical	23443559
SPT6H_HUMAN	SUPT6H	physical	23443559
TBCD4_HUMAN	TBC1D4	physical	23443559
TITIN_HUMAN	TTN	physical	23443559
TBA4A_HUMAN	TUBA4A	physical	23443559
UBB_HUMAN	UBB	physical	23443559
UBR4_HUMAN	UBR4	physical	23443559
DCAF7_HUMAN	DCAF7	physical	23443559
1433E_HUMAN	YWHAE	physical	23443559
Z385A_HUMAN	ZNF385A	physical	23443559
RBP1_HUMAN	RALBP1	physical	25416956
TFP11_HUMAN	TFIP11	physical	25416956
GCC1_HUMAN	GCC1	physical	25416956
CEP63_HUMAN	CEP63	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614114	Mosaic variegated aneuploidy syndrome 2 (MVA2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CEP57_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53 AND SER-388, AND MASSSPECTROMETRY.	19007248 [Abstract]