Z385A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: Z385A_HUMAN
• UniProt AC: Q96PM9
• Protein Name: Zinc finger protein 385A
• Gene Name: ZNF385A
• Organism: Homo sapiens (Human).
• Sequence Length: 386
• Subcellular Localization: Cytoplasm . Nucleus, nucleolus . Cell projection, dendrite. Detected in dendrites of Purkinje cells and hippocampal neurons..
• Protein Description: RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation..
• Protein Sequence: MILGSLSRAGPLPLLRQPPIMQPPLDLKQILPFPLEPAPTLGLFSNYSTMDPVQKAVLSHTFGGPLLKTKRPVISCNICQIRFNSQSQAEAHYKGNRHARRVKGIEAAKTRGREPGVREPGDPAPPGSTPTNGDGVAPRPVSMENGLGPAPGSPEKQPGSPSPPSIPETGQGVTKGEGGTPAPASLPGGSKEEEEKAKRLLYCALCKVAVNSLSQLEAHNKGTKHKTILEARSGLGPIKAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNSEVQLKQHISSRRHRDGVAGKPNPLLSRHKKSRGAGELAGTLTFSKELPKSLAGGLLPSPLAVAAVMAAAAGSPLSLRPAPAAPLLQGPPITHPLLHPAPGPIRTAHGPILFSPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Methylation	MILGSLSRAGPLPLL CCCCCCCCCCCCCHH	34.65	115388177
110	Phosphorylation	KGIEAAKTRGREPGV CCHHHHHHCCCCCCC	26.09	-
142	Phosphorylation	GVAPRPVSMENGLGP CCCCCCCCCCCCCCC	51.66	29449344
153	Phosphorylation	GLGPAPGSPEKQPGS CCCCCCCCCCCCCCC	3.72	29255136
160	Phosphorylation	SPEKQPGSPSPPSIP CCCCCCCCCCCCCCC	27.43	30278072
162	Phosphorylation	EKQPGSPSPPSIPET CCCCCCCCCCCCCCC	16.48	30278072
165	Phosphorylation	PGSPSPPSIPETGQG CCCCCCCCCCCCCCC	33.75	25850435
169	Phosphorylation	SPPSIPETGQGVTKG CCCCCCCCCCCCCCC	33.34	28985074
174	Phosphorylation	PETGQGVTKGEGGTP CCCCCCCCCCCCCCC	66.93	29449344
180	Phosphorylation	VTKGEGGTPAPASLP CCCCCCCCCCCCCCC	3.83	21815630
185	Phosphorylation	GGTPAPASLPGGSKE CCCCCCCCCCCCCHH	2.31	29396449
248	Phosphorylation	YPRLGPPTPGEPEAP CCCCCCCCCCCCCCC	6.76	25159151
282	Phosphorylation	QLKQHISSRRHRDGV HHHHHHHHCCCCCCC	38.98	-
303	Phosphorylation	LLSRHKKSRGAGELA HHHHCCCCCCCHHHC	6.83	28555341
314	Phosphorylation	GELAGTLTFSKELPK HHHCCEEEECCCCCH	4.65	28555341
316	Phosphorylation	LAGTLTFSKELPKSL HCCEEEECCCCCHHH	5.75	28555341
344	Phosphorylation	VMAAAAGSPLSLRPA HHHHHCCCCCCCCCC	16.25	27251275
384	Phosphorylation	AHGPILFSPY----- CCCCCEECCC-----		25394399
386	Phosphorylation	GPILFSPY------- CCCEECCC-------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of Z385A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of Z385A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of Z385A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of Z385A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.