K2C71_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C71_HUMAN
• UniProt AC: Q3SY84
• Protein Name: Keratin, type II cytoskeletal 71
• Gene Name: KRT71
• Organism: Homo sapiens (Human).
• Sequence Length: 523
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle..
• Protein Sequence: MSRQFTCKSGAAAKGGFSGCSAVLSGGSSSSFRAGSKGLSGGFGSRSLYSLGGVRSLNVASGSGKSGGYGFGRGRASGFAGSMFGSVALGPVCPTVCPPGGIHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRNVRDVVEDYKKRYEEEINKRTAAENEFVLLKKDVDAAYANKVELQAKVESMDQEIKFFRCLFEAEITQIQSHISDMSVILSMDNNRNLDLDSIIDEVRTQYEEIALKSKAEAEALYQTKFQELQLAAGRHGDDLKNTKNEISELTRLIQRIRSEIENVKKQASNLETAIADAEQRGDNALKDARAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGEFPSPVSISIISSTSGGSVYGFRPSMVSGGYVANSSNCISGVCSVRGGEGRSRGSANDYKDTLGKGSSLSAPSKKTSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	SRQFTCKSGAAAKGG CCCCCCCCCCCCCCC	35.49	-
18	Phosphorylation	AAAKGGFSGCSAVLS CCCCCCCCCCCEEEC	42.01	-
21	Phosphorylation	KGGFSGCSAVLSGGS CCCCCCCCEEECCCC	25.57	-
25	Phosphorylation	SGCSAVLSGGSSSSF CCCCEEECCCCCCCC	34.21	-
36	Phosphorylation	SSSFRAGSKGLSGGF CCCCCCCCCCCCCCC	23.67	20363803
40	Phosphorylation	RAGSKGLSGGFGSRS CCCCCCCCCCCCCCC	45.60	20363803
45	Phosphorylation	GLSGGFGSRSLYSLG CCCCCCCCCCCHHCC	19.21	20363803
50	Phosphorylation	FGSRSLYSLGGVRSL CCCCCCHHCCCEEEE	26.32	-
56	Phosphorylation	YSLGGVRSLNVASGS HHCCCEEEEEECCCC	23.14	24719451
65	Ubiquitination	NVASGSGKSGGYGFG EECCCCCCCCCCCCC	47.85	21963094
66	Phosphorylation	VASGSGKSGGYGFGR ECCCCCCCCCCCCCC	40.76	24719451
69	Phosphorylation	GSGKSGGYGFGRGRA CCCCCCCCCCCCCCC	16.89	24719451
140	Ubiquitination	QIKALNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
143	Phosphorylation	ALNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	28355574
147	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	21906983
147	Acetylation	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	7705945
186	Phosphorylation	PILEGYISNLRKQLE HHHHHHHHHHHHHHH	22.71	24719451
204	Phosphorylation	GDRVRLDSELRNVRD CCCCCCCHHHHCHHH	43.02	28355574
220	Phosphorylation	VEDYKKRYEEEINKR HHHHHHHHHHHHHHH	36.25	24670416
228	Phosphorylation	EEEINKRTAAENEFV HHHHHHHCCCCCCEE	31.65	-
257	Phosphorylation	ELQAKVESMDQEIKF HHHHHHHHHHHHHHH	30.55	20860994
315	Phosphorylation	YEEIALKSKAEAEAL HHHHHHHCHHHHHHH	37.64	22210691
323	Phosphorylation	KAEAEALYQTKFQEL HHHHHHHHHHHHHHH	22.60	22817900
325	Phosphorylation	EAEALYQTKFQELQL HHHHHHHHHHHHHHH	21.92	-
360	Phosphorylation	RLIQRIRSEIENVKK HHHHHHHHHHHHHHH	40.32	20860994
370	Phosphorylation	ENVKKQASNLETAIA HHHHHHHHCHHHHHH	39.18	20068231
415	Phosphorylation	LARMLREYQELMSLK HHHHHHHHHHHHHHH	10.80	28348404
420	Phosphorylation	REYQELMSLKLALDM HHHHHHHHHHHHHHH	34.67	-
431	Phosphorylation	ALDMEIATYRKLLES HHHHHHHHHHHHHHC	29.53	28348404
444	Phosphorylation	ESEECRMSGEFPSPV HCCHHHHCCCCCCCE	18.80	24043423
449	Phosphorylation	RMSGEFPSPVSISII HHCCCCCCCEEEEEE	43.16	24043423
452	Phosphorylation	GEFPSPVSISIISST CCCCCCEEEEEEECC	17.63	24043423
454	Phosphorylation	FPSPVSISIISSTSG CCCCEEEEEEECCCC	13.33	24043423
457	Phosphorylation	PVSISIISSTSGGSV CEEEEEEECCCCCCE	26.37	24043423
458	Phosphorylation	VSISIISSTSGGSVY EEEEEEECCCCCCEE	19.04	24043423
459	Phosphorylation	SISIISSTSGGSVYG EEEEEECCCCCCEEE	25.30	24043423
460	Phosphorylation	ISIISSTSGGSVYGF EEEEECCCCCCEEEE	43.00	24043423
463	Phosphorylation	ISSTSGGSVYGFRPS EECCCCCCEEEEEHH	18.72	24043423
465	Phosphorylation	STSGGSVYGFRPSMV CCCCCCEEEEEHHHE	16.55	24043423
510	Acetylation	DYKDTLGKGSSLSAP CCCCCCCCCCCCCCC	59.75	7683103
515	Phosphorylation	LGKGSSLSAPSKKTS CCCCCCCCCCCCCCC	39.83	28258704

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C71_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2C71_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C71_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C40_HUMAN	KRT40	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615896: Hypotrichosis 13 (HYPT13)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.