MCR_HUMAN - dbPTM
MCR_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MCR_HUMAN
UniProt AC P08235
Protein Name Mineralocorticoid receptor
Gene Name NR3C2
Organism Homo sapiens (Human).
Sequence Length 984
Subcellular Localization Cytoplasm. Nucleus. Endoplasmic reticulum membrane
Peripheral membrane protein. Cytoplasmic and nuclear in the absence of ligand
nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Protein Description Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels..
Protein Sequence METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAIVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNAENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----METKGYHSLP
-----CCCCCCCCCC		28.5928270605
6Phosphorylation--METKGYHSLPEGL
--CCCCCCCCCCCCC		6.9828270605
8PhosphorylationMETKGYHSLPEGLDM
CCCCCCCCCCCCCCH		36.8228270605
23PhosphorylationERRWGQVSQAVERSS
HHHHHHHHHHHHHHC		12.44-
29PhosphorylationVSQAVERSSLGPTER
HHHHHHHHCCCCCCC		19.1922210691
30PhosphorylationSQAVERSSLGPTERT
HHHHHHHCCCCCCCC		43.5022210691
89SumoylationGILTSDIKTELESKE
CCCCHHHHHHHHHHH		40.72-
89SumoylationGILTSDIKTELESKE
CCCCHHHHHHHHHHH		40.72-
111PhosphorylationSMGLYMDSVRDADYS
HCCCHHHHHHHCCCC		11.52-
127PhosphorylationEQQNQQGSMSPAKIY
HHHHCCCCCCHHHHH		16.2624719451
129PhosphorylationQNQQGSMSPAKIYQN
HHCCCCCCHHHHHHC		24.3323403867
134PhosphorylationSMSPAKIYQNVEQLV
CCCHHHHHHCHHHHH		8.0429978859
168PhosphorylationLRSFMSDSGSSVNGG
CHHHHCCCCCCCCHH		33.01-
183PhosphorylationVMRAIVKSPIMCHEK
HHHHHHCCCEECCCC		14.5728857561
196PhosphorylationEKSPSVCSPLNMTSS
CCCCCCCCCCCCCCC		30.21-
227PhosphorylationFGSFPVHSPITQGTP
CCCCCCCCCCCCCCC		20.45-
238PhosphorylationQGTPLTCSPNAENRG
CCCCCCCCCCCCCCC		18.89-
248PhosphorylationAENRGSRSHSPAHAS
CCCCCCCCCCCCCHH		29.9822777824
250PhosphorylationNRGSRSHSPAHASNV
CCCCCCCCCCCHHCC		25.6528857561
255PhosphorylationSHSPAHASNVGSPLS
CCCCCCHHCCCCCCC		23.3728857561
259PhosphorylationAHASNVGSPLSSPLS
CCHHCCCCCCCCCHH		20.5622777824
262PhosphorylationSNVGSPLSSPLSSMK
HCCCCCCCCCHHHCC		33.0427732954
263PhosphorylationNVGSPLSSPLSSMKS
CCCCCCCCCHHHCCC		37.2327732954
266PhosphorylationSPLSSPLSSMKSSIS
CCCCCCHHHCCCCCC		31.6027080861
267PhosphorylationPLSSPLSSMKSSISS
CCCCCHHHCCCCCCC		37.6027080861
270PhosphorylationSPLSSMKSSISSPPS
CCHHHCCCCCCCCCC		25.0223312004
271PhosphorylationPLSSMKSSISSPPSH
CHHHCCCCCCCCCCC		22.4428985074
273PhosphorylationSSMKSSISSPPSHCS
HHCCCCCCCCCCCCC		38.4523312004
274PhosphorylationSMKSSISSPPSHCSV
HCCCCCCCCCCCCCC		38.8823312004
277PhosphorylationSSISSPPSHCSVKSP
CCCCCCCCCCCCCCC		40.2729978859
280PhosphorylationSSPPSHCSVKSPVSS
CCCCCCCCCCCCCCC		27.4428985074
283PhosphorylationPSHCSVKSPVSSPNN
CCCCCCCCCCCCCCC		28.5120363803
286PhosphorylationCSVKSPVSSPNNVTL
CCCCCCCCCCCCEEE		43.3829978859
287PhosphorylationSVKSPVSSPNNVTLR
CCCCCCCCCCCEEEC		31.7020363803
292PhosphorylationVSSPNNVTLRSSVSS
CCCCCCEEECEECCC		20.6929978859
298PhosphorylationVTLRSSVSSPANINN
EEECEECCCCCCCCC		32.3328348404
299PhosphorylationTLRSSVSSPANINNS
EECEECCCCCCCCCC		26.3522798277
311PhosphorylationNNSRCSVSSPSNTNN
CCCCCCCCCCCCCCC		21.9028348404
312PhosphorylationNSRCSVSSPSNTNNR
CCCCCCCCCCCCCCC		30.1428348404
361PhosphorylationTLRDVVPSPDTQEKG
CHHHCCCCCCCCCCC		24.6523403867
399SumoylationLNIVQYIKPEPDGAF
EEEEEECCCCCCCCC		38.09-
399SumoylationLNIVQYIKPEPDGAF
EEEEEECCCCCCCCC		38.09-
424PhosphorylationINSDSSFSVPIKQES
CCCCCCCCCEECCCC		29.00-
428SumoylationSSFSVPIKQESTKHS
CCCCCEECCCCCCCC		41.78-
428SumoylationSSFSVPIKQESTKHS
CCCCCEECCCCCCCC		41.78-
459PhosphorylationFMDGSYFSFMDDKDY
CCCCCEEEECCCCCC		16.07-
464AcetylationYFSFMDDKDYYSLSG
EEEECCCCCCEECCC		43.2868537
494SumoylationSGFPVGIKQEPDDGS
CCCCCEEEECCCCCC		42.55-
494SumoylationSGFPVGIKQEPDDGS
CCCCCEEEECCCCCC		42.55-
532PhosphorylationYRIGAQGTISLSRSA
EEECCCCEEEECHHH		8.70-
534PhosphorylationIGAQGTISLSRSARD
ECCCCEEEECHHHCC		21.8224719451
536PhosphorylationAQGTISLSRSARDQS
CCCEEEECHHHCCCC		19.8722210691
543PhosphorylationSRSARDQSFQHLSSF
CHHHCCCCCHHHHCC		31.0322210691
680UbiquitinationRKSKKLGKLKGIHEE
HHHHHHHCCCCCCCC		58.42-
703PhosphorylationPPPPPPQSPEEGTTY
CCCCCCCCCCCCCEE		39.8026657352
708PhosphorylationPQSPEEGTTYIAPAK
CCCCCCCCEEEECCC		21.5028348404
709PhosphorylationQSPEEGTTYIAPAKE
CCCCCCCEEEECCCC		24.6428348404
710PhosphorylationSPEEGTTYIAPAKEP
CCCCCCEEEECCCCC		8.5728348404
735PhosphorylationSTISRALTPSPVMVL
HHHHCCCCCCCEEEE		22.2728348404
737PhosphorylationISRALTPSPVMVLEN
HHCCCCCCCEEEEEC		25.5428348404
761PhosphorylationYDSSKPDTAENLLST
CCCCCCCHHHHHHHH		44.38-
815PhosphorylationCLSSFALSWRSYKHT
HHHHHHHHHHHCCCC		19.6024719451
843PhosphorylationNEEKMHQSAMYELCQ
CHHHHHHHHHHHHHH		10.58-
953SumoylationFRESHALKVEFPAML
HHHHHCCCCCCCHHH		40.27-
953SumoylationFRESHALKVEFPAML
HHHHHCCCCCCCHHH		40.27-
970UbiquitinationIISDQLPKVESGNAK
HHHHCCCCCCCCCCC		68.19-
977UbiquitinationKVESGNAKPLYFHRK
CCCCCCCCCCEECCC		39.28-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
111SPhosphorylationKinaseCSNK2A1P68400
GPS
459SPhosphorylationKinaseCSNK2A1P68400
GPS
843SPhosphorylationKinaseULK1O75385
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MCR_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MCR_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GCR_HUMANNR3C1physical
11154266
PROX1_HUMANPROX1physical
15604093
UBC9_HUMANUBE2Iphysical
17314004
SUMO1_HUMANSUMO1physical
17314004
NRIP1_HUMANNRIP1physical
10935545
TIF1A_HUMANTRIM24physical
10935545
CHIP_HUMANSTUB1physical
20661446
FKBP5_HUMANFKBP5physical
20661446
FKBP4_HUMANFKBP4physical
20661446
PPP5_HUMANPPP5Cphysical
20661446
DNJC7_HUMANDNAJC7physical
20661446
PPID_HUMANPPIDphysical
20661446
AIP_HUMANAIPphysical
20661446
RXRA_HUMANRXRAphysical
21988832
PRAF1_HUMANRABAC1physical
21988832
PRS8_HUMANPSMC5physical
15604093
NCOA1_HUMANNCOA1physical
10935545
NCOA1_HUMANNCOA1physical
15604093
CBP_HUMANCREBBPphysical
25707758
EP300_HUMANEP300physical
25707758
KAT2B_HUMANKAT2Bphysical
25707758
PP1A_HUMANPPP1CAphysical
28454724
Drug and Disease Associations
Kegg Disease
H00243 Hyperkalemic distal renal tubular acidosis (RTA type 4), including: Pseudohypoaldosteronism type I
H00603 Hypertension exacerbated in pregnancy
OMIM Disease
177735Pseudohypoaldosteronism 1, autosomal dominant (PHA1A)
605115Early-onset hypertension with severe exacerbation in pregnancy (EOHSEP)
Kegg Drug
D00443 Spironolactone (JP16/USP/INN); Aldactone (TN)
D01115 Eplerenone (JAN/USAN/INN); Inspra (TN)
D01943 Potassium canrenoate (JP16); Canrenoate potassium (USAN); Soldactone (TN)
D03363 Canrenone (USAN)
D03698 Desoxycorticosterone acetate (USP); Doca (TN)
D03699 Desoxycorticosterone pivalate (USP); Percorten (TN)
D03792 Dicirenone (USAN)
D03917 Drospirenone (JAN/USP/INN)
D05020 Mexrenoate potassium (USAN); Mexrenoate potassium dihydrate
D05640 Prorenoate potassium (USAN/INN)
D07792 Desoxycortone (INN); Desoxycorticosterone
DrugBank
DB01395Drospirenone
DB00700Eplerenone
DB01023Felodipine
DB00687Fludrocortisone
DB00588Fluticasone Propionate
DB00393Nimodipine
DB00396Progesterone
DB00421Spironolactone
Regulatory Network of MCR_HUMAN

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Related Literatures of Post-Translational Modification

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