dbPTM

ARI5B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARI5B_HUMAN
UniProt AC	Q14865
Protein Name	AT-rich interactive domain-containing protein 5B
Gene Name	ARID5B
Organism	Homo sapiens (Human).
Sequence Length	1188
Subcellular Localization	Nucleus .
Protein Description	Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer..
Protein Sequence	MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGFHAGPVKTEALGRNGQKEALLKYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSFSGVKDSNNNSDGKAVAKVKCEARSALTKPKNNHNCKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKPQDAAEVSSEQEKEQETLISQKSIPEPLPAADMKKKIEGYQEFSAKPLASRVDPEKDNETDQGSNSEKVAEEAGEKGPTPPLPSAPLAPEKDSALVPGASKQPLTSPSALVDSKQESKLCCFTESPESEPQEASFPSFPTTQPPLANQNETEDDKLPAMADYIANCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIARDDLCSSLSQTHHGQSTDHMAVSRPSVIQHVQSFRSKPSEERKTINDIFKHEKLSRSDPHRCSFSKHHLNPLADSYVLKQEIQEGKDKLLEKRALPHSHMPSFLADFYSSPHLHSLYRHTEHHLHNEQTSKYPSRDMYRESENSSFPSHRHQEKLHVNYLTSLHLQDKKSAAAEAPTDDQPTDLSLPKNPHKPTGKVLGLAHSTTGPQESKGISQFQVLGSQSRDCHPKACRVSPMTMSGPKKYPESLSRSGKPHHVRLENFRKMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPSKEVSGKEKASEQESEGSKAAHGGHSGGGSEGHKLPLSSPIFPGLYSGSLCNSGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAAINPQAAFPSSQLSSVHPSTKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Ubiquitination	YIFYKAFQFHLEGKP CHHEEEEEHHHCCCC	29.70	30230243
32	Ubiquitination	FQFHLEGKPRILSLG EEHHHCCCCEEEEEC	23.03	-
67	Ubiquitination	LWEERTSRQLLSSSK HHHHHHHHHHHHCCC	30.47	29967540
74	Ubiquitination	RQLLSSSKLYFLPED HHHHHCCCEEECCCC	49.51	21963094
105	Sumoylation	VSEKVIVKLEDLVKW EECEEEEEHHHHHHH	34.73	-
105	Sumoylation	VSEKVIVKLEDLVKW EECEEEEEHHHHHHH	34.73	17000644
111	Ubiquitination	VKLEDLVKWVHSDFS EEHHHHHHHHHCCHH	51.28	29967540
119	Ubiquitination	WVHSDFSKWRCGFHA HHHCCHHHCCCEEEC	38.36	-
130	Sumoylation	GFHAGPVKTEALGRN EEECCCCCHHHHCCC	43.72	-
130	Sumoylation	GFHAGPVKTEALGRN EEECCCCCHHHHCCC	43.72	17000644
130	Ubiquitination	GFHAGPVKTEALGRN EEECCCCCHHHHCCC	43.72	29967540
131	Phosphorylation	FHAGPVKTEALGRNG EECCCCCHHHHCCCC	27.07	-
140	Ubiquitination	ALGRNGQKEALLKYR HHCCCCHHHHHHHHH	46.48	29967540
145	Acetylation	GQKEALLKYRQSTLN CHHHHHHHHHHHHHH	38.96	30590455
145	Ubiquitination	GQKEALLKYRQSTLN CHHHHHHHHHHHHHH	38.96	29967540
150	Phosphorylation	LLKYRQSTLNSGLNF HHHHHHHHHHCCCCH	22.94	28555341
158	Ubiquitination	LNSGLNFKDVLKEKA HHCCCCHHHHHHHHH	45.94	29967540
162	Ubiquitination	LNFKDVLKEKADLGE CCHHHHHHHHHCCCC	57.95	-
192	Ubiquitination	CRYRSMLKRIQDKPS HHHHHHHHHHCCCCC	38.52	24816145
264	Phosphorylation	PCPQRRDSFSGVKDS CCCCCCCCCCCCCCC	21.35	23401153
266	Phosphorylation	PQRRDSFSGVKDSNN CCCCCCCCCCCCCCC	46.78	29255136
269	Ubiquitination	RDSFSGVKDSNNNSD CCCCCCCCCCCCCCC	59.99	30230243
271	Phosphorylation	SFSGVKDSNNNSDGK CCCCCCCCCCCCCCC	35.42	23312004
275	Phosphorylation	VKDSNNNSDGKAVAK CCCCCCCCCCCEEEE	50.27	23186163
284	Sumoylation	GKAVAKVKCEARSAL CCEEEEEEHHHHHHC	26.17	-
284	Sumoylation	GKAVAKVKCEARSAL CCEEEEEEHHHHHHC	26.17	17000644
289	Phosphorylation	KVKCEARSALTKPKN EEEHHHHHHCCCCCC	34.38	24275569
310	Ubiquitination	VSNEEKPKVAIGEEC CCCCCCCCEEECHHH	56.20	29967540
336	"N6,N6-dimethyllysine"	YKYMKERKTPIERIP HHHHHHCCCCHHHCC	60.80	-
336	Methylation	YKYMKERKTPIERIP HHHHHHCCCCHHHCC	60.80	21532585
358	Ubiquitination	NLWTMFQAAQKLGGY CHHHHHHHHHHHCCC	10.70	24816145
363	Ubiquitination	FQAAQKLGGYETITA HHHHHHHCCCCHHHH	43.61	21963094
365	Phosphorylation	AAQKLGGYETITARR HHHHHCCCCHHHHHH	14.22	-
386	Ubiquitination	DELGGNPGSTSAATC HHHCCCCCCCHHHHH	47.78	29967540
400	Ubiquitination	CTRRHYERLILPYER HHHHHHHHHEECHHH	21.62	29967540
410	Sumoylation	LPYERFIKGEEDKPL ECHHHHCCCCCCCCC	58.52	-
410	Sumoylation	LPYERFIKGEEDKPL ECHHHHCCCCCCCCC	58.52	17000644
417	Ubiquitination	KGEEDKPLPPIKPRK CCCCCCCCCCCCCCC	10.97	29967540
435	Ubiquitination	SSQENENKTKVSGTK CCCCCCCCCCCCCCH	43.47	24816145
445	Sumoylation	VSGTKRIKHEIPKSK CCCCHHHHHCCCCCH	38.94	-
445	Sumoylation	VSGTKRIKHEIPKSK CCCCHHHHHCCCCCH	38.94	17000644
451	Ubiquitination	IKHEIPKSKKEKENA HHHCCCCCHHHHHCC	43.54	29967540
468	Phosphorylation	PQDAAEVSSEQEKEQ CCCHHHHCHHHHHHH	21.47	25627689
469	Phosphorylation	QDAAEVSSEQEKEQE CCHHHHCHHHHHHHH	48.77	30576142
476	Ubiquitination	SEQEKEQETLISQKS HHHHHHHHHHHHCCC	46.82	29967540
483	Phosphorylation	ETLISQKSIPEPLPA HHHHHCCCCCCCCCH	35.42	28555341
494	Sumoylation	PLPAADMKKKIEGYQ CCCHHHHHHHHCCHH	52.00	28112733
496	Sumoylation	PAADMKKKIEGYQEF CHHHHHHHHCCHHHH	40.24	-
496	Sumoylation	PAADMKKKIEGYQEF CHHHHHHHHCCHHHH	40.24	28112733
504	Phosphorylation	IEGYQEFSAKPLASR HCCHHHHCCCCCHHC	34.33	-
506	Acetylation	GYQEFSAKPLASRVD CHHHHCCCCCHHCCC	39.09	26051181
510	Phosphorylation	FSAKPLASRVDPEKD HCCCCCHHCCCCCCC	40.29	26503514
534	Ubiquitination	EKVAEEAGEKGPTPP HHHHHHHHHCCCCCC	40.19	22817900
535	Ubiquitination	KVAEEAGEKGPTPPL HHHHHHHHCCCCCCC	62.98	22817900
539	Phosphorylation	EAGEKGPTPPLPSAP HHHHCCCCCCCCCCC	46.32	29255136
544	Phosphorylation	GPTPPLPSAPLAPEK CCCCCCCCCCCCCCC	50.64	26074081
547	Ubiquitination	PPLPSAPLAPEKDSA CCCCCCCCCCCCCCC	14.36	29967540
551	Acetylation	SAPLAPEKDSALVPG CCCCCCCCCCCCCCC	56.79	26051181
553	Phosphorylation	PLAPEKDSALVPGAS CCCCCCCCCCCCCCC	34.27	26074081
560	Phosphorylation	SALVPGASKQPLTSP CCCCCCCCCCCCCCH	37.43	26074081
560	Ubiquitination	SALVPGASKQPLTSP CCCCCCCCCCCCCCH	37.43	29967540
565	Phosphorylation	GASKQPLTSPSALVD CCCCCCCCCHHHCCC	45.32	30266825
566	Phosphorylation	ASKQPLTSPSALVDS CCCCCCCCHHHCCCC	25.25	30266825
568	Phosphorylation	KQPLTSPSALVDSKQ CCCCCCHHHCCCCCC	33.72	30266825
573	Phosphorylation	SPSALVDSKQESKLC CHHHCCCCCCCCCEE	28.85	26074081
577	Phosphorylation	LVDSKQESKLCCFTE CCCCCCCCCEECEEC	28.56	26074081
612	Ubiquitination	LANQNETEDDKLPAM CCCCCCCCCCCHHHH	59.02	21963094
629	Sumoylation	YIANCTVKVDQLGSD HHHHCEEEHHHCCCH	23.18	-
629	Sumoylation	YIANCTVKVDQLGSD HHHHCEEEHHHCCCH	23.18	17000644
629	Ubiquitination	YIANCTVKVDQLGSD HHHHCEEEHHHCCCH	23.18	29967540
635	Phosphorylation	VKVDQLGSDDIHNAL EEHHHCCCHHHHHHH	40.48	21712546
643	Ubiquitination	DDIHNALKQTPKVLV HHHHHHHHHCCCEEE	50.11	29967540
645	Phosphorylation	IHNALKQTPKVLVVQ HHHHHHHCCCEEEEE	24.40	30576142
649	Ubiquitination	LKQTPKVLVVQSFDM HHHCCCEEEEEECCC	3.79	29967540
650	Ubiquitination	KQTPKVLVVQSFDMF HHCCCEEEEEECCCC	4.05	29967540
653	Phosphorylation	PKVLVVQSFDMFKDK CCEEEEEECCCCCCC	16.17	22964224
660	Ubiquitination	SFDMFKDKDLTGPMN ECCCCCCCCCCCCCC	56.05	29967540
669	Ubiquitination	LTGPMNENHGLNYTP CCCCCCCCCCCCCCC	29.53	29967540
673	Ubiquitination	MNENHGLNYTPLLYS CCCCCCCCCCCCCCC	43.13	29967540
674	Phosphorylation	NENHGLNYTPLLYSR CCCCCCCCCCCCCCC	18.12	27642862
675	Phosphorylation	ENHGLNYTPLLYSRG CCCCCCCCCCCCCCC	13.34	25159151
677	Ubiquitination	HGLNYTPLLYSRGNP CCCCCCCCCCCCCCC	5.59	29967540
679	Phosphorylation	LNYTPLLYSRGNPGI CCCCCCCCCCCCCCC	12.19	27642862
680	Phosphorylation	NYTPLLYSRGNPGIM CCCCCCCCCCCCCCC	33.41	24719451
688	Phosphorylation	RGNPGIMSPLAKKKL CCCCCCCCHHHHHHH	18.16	25159151
692	Ubiquitination	GIMSPLAKKKLLSQV CCCCHHHHHHHHHCC	59.11	29967540
693	Ubiquitination	IMSPLAKKKLLSQVS CCCHHHHHHHHHCCC	42.94	-
694	Ubiquitination	MSPLAKKKLLSQVSG CCHHHHHHHHHCCCC	54.69	29967540
695	Ubiquitination	SPLAKKKLLSQVSGA CHHHHHHHHHCCCCC	8.37	21963094
700	Phosphorylation	KKLLSQVSGASLSSS HHHHHCCCCCCCCCC	22.47	28857561
703	Phosphorylation	LSQVSGASLSSSYPY HHCCCCCCCCCCCCC	32.10	28857561
705	Phosphorylation	QVSGASLSSSYPYGS CCCCCCCCCCCCCCC	18.10	27251275
706	Phosphorylation	VSGASLSSSYPYGSP CCCCCCCCCCCCCCC	38.90	28348404
707	Phosphorylation	SGASLSSSYPYGSPP CCCCCCCCCCCCCCC	27.10	28348404
708	Phosphorylation	GASLSSSYPYGSPPP CCCCCCCCCCCCCCC	11.47	28348404
712	Phosphorylation	SSSYPYGSPPPLISK CCCCCCCCCCCCCCC	28.52	30576142
719	Ubiquitination	SPPPLISKKKLIARD CCCCCCCCCCEEECH	47.11	29967540
723	Ubiquitination	LISKKKLIARDDLCS CCCCCCEEECHHHHH	3.97	29967540
724	Ubiquitination	ISKKKLIARDDLCSS CCCCCEEECHHHHHH	21.20	29967540
745	Ubiquitination	GQSTDHMAVSRPSVI CCCCCCCCCCCHHHH	7.85	29967540
757	Phosphorylation	SVIQHVQSFRSKPSE HHHHHHHHHHCCCHH	22.87	23312004
757	Ubiquitination	SVIQHVQSFRSKPSE HHHHHHHHHHCCCHH	22.87	29967540
767	Sumoylation	SKPSEERKTINDIFK CCCHHHCCCHHHHHH	57.97	28112733
768	Phosphorylation	KPSEERKTINDIFKH CCHHHCCCHHHHHHH	31.10	28555341
770	Ubiquitination	SEERKTINDIFKHEK HHHCCCHHHHHHHHH	41.37	29967540
774	Sumoylation	KTINDIFKHEKLSRS CCHHHHHHHHHHCCC	51.71	-
774	Sumoylation	KTINDIFKHEKLSRS CCHHHHHHHHHHCCC	51.71	17000644
774	Ubiquitination	KTINDIFKHEKLSRS CCHHHHHHHHHHCCC	51.71	-
777	Ubiquitination	NDIFKHEKLSRSDPH HHHHHHHHHCCCCCC	52.02	-
778	Ubiquitination	DIFKHEKLSRSDPHR HHHHHHHHCCCCCCC	4.72	21963094
781	Phosphorylation	KHEKLSRSDPHRCSF HHHHHCCCCCCCCCC	52.71	28555341
783	Ubiquitination	EKLSRSDPHRCSFSK HHHCCCCCCCCCCCH	20.33	22817900
783 (in isoform 2)	Ubiquitination	-	20.33	21906983
784	Ubiquitination	KLSRSDPHRCSFSKH HHCCCCCCCCCCCHH	48.66	22817900
787	Phosphorylation	RSDPHRCSFSKHHLN CCCCCCCCCCHHHCC	32.29	27251275
789	Phosphorylation	DPHRCSFSKHHLNPL CCCCCCCCHHHCCHH	18.13	32645325
790	Ubiquitination	PHRCSFSKHHLNPLA CCCCCCCHHHCCHHH	32.79	29967540
795	Ubiquitination	FSKHHLNPLADSYVL CCHHHCCHHHHHHHH	34.97	29967540
803	Sumoylation	LADSYVLKQEIQEGK HHHHHHHHHHHHHCH	35.52	-
803	Sumoylation	LADSYVLKQEIQEGK HHHHHHHHHHHHHCH	35.52	17000644
803	Ubiquitination	LADSYVLKQEIQEGK HHHHHHHHHHHHHCH	35.52	29967540
810	Sumoylation	KQEIQEGKDKLLEKR HHHHHHCHHHHHHHH	51.44	28112733
827	Ubiquitination	PHSHMPSFLADFYSS CCCCCHHHHHHHHCC	5.56	29967540
855	Ubiquitination	LHNEQTSKYPSRDMY CCCCCCCCCCCHHHH	65.65	21963094
856	Phosphorylation	HNEQTSKYPSRDMYR CCCCCCCCCCHHHHH	13.25	-
858	Phosphorylation	EQTSKYPSRDMYRES CCCCCCCCHHHHHCC	37.51	-
878	Ubiquitination	PSHRHQEKLHVNYLT CCHHHHHHHHHHHHH	37.00	-
892	Ubiquitination	TSLHLQDKKSAAAEA HHHHCCCHHHHCCCC	35.35	29967540
893	Sumoylation	SLHLQDKKSAAAEAP HHHCCCHHHHCCCCC	54.33	-
893	Sumoylation	SLHLQDKKSAAAEAP HHHCCCHHHHCCCCC	54.33	28112733
893	Ubiquitination	SLHLQDKKSAAAEAP HHHCCCHHHHCCCCC	54.33	29967540
912	Ubiquitination	PTDLSLPKNPHKPTG CCCCCCCCCCCCCCC	84.29	29967540
916	Sumoylation	SLPKNPHKPTGKVLG CCCCCCCCCCCCEEE	45.60	28112733
916	Ubiquitination	SLPKNPHKPTGKVLG CCCCCCCCCCCCEEE	45.60	29967540
920	Sumoylation	NPHKPTGKVLGLAHS CCCCCCCCEEEEEEC	36.44	28112733
920	Ubiquitination	NPHKPTGKVLGLAHS CCCCCCCCEEEEEEC	36.44	29967540
935	Sumoylation	TTGPQESKGISQFQV CCCCCCCCCCCCEEE	60.56	-
935	Sumoylation	TTGPQESKGISQFQV CCCCCCCCCCCCEEE	60.56	28112733
935	Ubiquitination	TTGPQESKGISQFQV CCCCCCCCCCCCEEE	60.56	29967540
944	Ubiquitination	ISQFQVLGSQSRDCH CCCEEEECCCCCCCC	25.45	21963094
945	Phosphorylation	SQFQVLGSQSRDCHP CCEEEECCCCCCCCC	22.33	28555341
949	Ubiquitination	VLGSQSRDCHPKACR EECCCCCCCCCCCCE	40.08	22817900
950	Ubiquitination	LGSQSRDCHPKACRV ECCCCCCCCCCCCEE	6.02	22817900
958	Phosphorylation	HPKACRVSPMTMSGP CCCCCEECCCCCCCC	6.93	25159151
963	Phosphorylation	RVSPMTMSGPKKYPE EECCCCCCCCCCCCH	42.66	25159151
966	Ubiquitination	PMTMSGPKKYPESLS CCCCCCCCCCCHHHC	69.35	29967540
967	Ubiquitination	MTMSGPKKYPESLSR CCCCCCCCCCHHHCC	69.99	29967540
968	Phosphorylation	TMSGPKKYPESLSRS CCCCCCCCCHHHCCC	20.54	29083192
971	Phosphorylation	GPKKYPESLSRSGKP CCCCCCHHHCCCCCC	27.43	24719451
973	Phosphorylation	KKYPESLSRSGKPHH CCCCHHHCCCCCCCE	33.41	29083192
975	Phosphorylation	YPESLSRSGKPHHVR CCHHHCCCCCCCEEE	48.03	29083192
988	Sumoylation	VRLENFRKMEGMVHP EEHHHHHHHHCCCHH	36.85	28112733
988	Ubiquitination	VRLENFRKMEGMVHP EEHHHHHHHHCCCHH	36.85	29967540
1000	Sumoylation	VHPILHRKMSPQNIG CHHHHCCCCCHHHCC	32.74	28112733
1000	Ubiquitination	VHPILHRKMSPQNIG CHHHHCCCCCHHHCC	32.74	29967540
1002	Phosphorylation	PILHRKMSPQNIGAA HHHCCCCCHHHCCCC	26.77	25159151
1013	Sumoylation	IGAARPIKRSLEDLD CCCCCCCCCCHHHCC	38.32	-
1013	Sumoylation	IGAARPIKRSLEDLD CCCCCCCCCCHHHCC	38.32	28112733
1013	Ubiquitination	IGAARPIKRSLEDLD CCCCCCCCCCHHHCC	38.32	29967540
1026	Acetylation	LDLVIAGKKARAVSP CCEEEECCCEEECCC	33.95	25953088
1026	Ubiquitination	LDLVIAGKKARAVSP CCEEEECCCEEECCC	33.95	22817900
1026 (in isoform 1)	Ubiquitination	-	33.95	21906983
1027	Acetylation	DLVIAGKKARAVSPL CEEEECCCEEECCCC	42.03	20167786
1027	Ubiquitination	DLVIAGKKARAVSPL CEEEECCCEEECCCC	42.03	22817900
1032	Phosphorylation	GKKARAVSPLDPSKE CCCEEECCCCCCCCC	20.82	23401153
1037	Phosphorylation	AVSPLDPSKEVSGKE ECCCCCCCCCCCCCH	40.91	23403867
1038	Ubiquitination	VSPLDPSKEVSGKEK CCCCCCCCCCCCCHH	68.47	29967540
1041	Phosphorylation	LDPSKEVSGKEKASE CCCCCCCCCCHHCCH	45.28	23927012
1045	Ubiquitination	KEVSGKEKASEQESE CCCCCCHHCCHHCCC	61.78	-
1051	Phosphorylation	EKASEQESEGSKAAH HHCCHHCCCCCCCCC	47.13	24719451
1054	Phosphorylation	SEQESEGSKAAHGGH CHHCCCCCCCCCCCC	18.31	24719451
1055	Sumoylation	EQESEGSKAAHGGHS HHCCCCCCCCCCCCC	61.52	28112733
1070	Sumoylation	GGGSEGHKLPLSSPI CCCCCCCCCCCCCCC	63.76	28112733
1070	Ubiquitination	GGGSEGHKLPLSSPI CCCCCCCCCCCCCCC	63.76	29967540
1075	Phosphorylation	GHKLPLSSPIFPGLY CCCCCCCCCCCCCCC	29.69	21815630
1102	Phosphorylation	LPAGYSHSLQYLKNQ CCCCHHHHHHHHCCC	15.95	28555341
1110	Ubiquitination	LQYLKNQTVLSPLMQ HHHHCCCCCCHHHHC	32.57	21963094
1113	Phosphorylation	LKNQTVLSPLMQPLA HCCCCCCHHHHCHHH	16.20	21712546
1132	Phosphorylation	VMQRGIFTSPTNSQQ HHHCCCCCCCCCHHH	31.69	22199227
1133	Phosphorylation	MQRGIFTSPTNSQQL HHCCCCCCCCCHHHH	20.98	21532585
1135	Phosphorylation	RGIFTSPTNSQQLYR CCCCCCCCCHHHHHH	47.47	22199227
1137	Phosphorylation	IFTSPTNSQQLYRHL CCCCCCCHHHHHHHH	23.06	23186163
1148	Phosphorylation	YRHLAAATPVGSSYG HHHHHHHCCCCCCHH	17.49	24043423
1152	Phosphorylation	AAATPVGSSYGDLLH HHHCCCCCCHHHHHH	22.18	24043423
1153	Phosphorylation	AATPVGSSYGDLLHN HHCCCCCCHHHHHHC	27.49	24043423
1154	Phosphorylation	ATPVGSSYGDLLHNS HCCCCCCHHHHHHCC	19.16	24043423
1161	Phosphorylation	YGDLLHNSIYPLAAI HHHHHHCCCCCHHCC	16.86	24043423
1163	Phosphorylation	DLLHNSIYPLAAINP HHHHCCCCCHHCCCC	7.63	24043423
1176	Phosphorylation	NPQAAFPSSQLSSVH CCCCCCCHHHHHCCC	25.02	24043423
1177	Phosphorylation	PQAAFPSSQLSSVHP CCCCCCHHHHHCCCC	35.06	24043423
1180	Phosphorylation	AFPSSQLSSVHPSTK CCCHHHHHCCCCCCC	23.76	24043423
1181	Phosphorylation	FPSSQLSSVHPSTKL CCHHHHHCCCCCCCC	32.79	24043423
1185	Phosphorylation	QLSSVHPSTKL---- HHHCCCCCCCC----	24.24	24043423
1186	Phosphorylation	LSSVHPSTKL----- HHCCCCCCCC-----	40.59	24043423
1187	Ubiquitination	SSVHPSTKL------ HCCCCCCCC------	57.44	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARI5B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
336	K	Methylation		21532585
Methylation at Lys-336 prevents DNA-binding.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARI5B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ARI5B_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
	Note=Defects in ARID5B may be a cause of susceptibility to coronary atherosclerosis in the Japanese population.
613065
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARI5B_HUMAN

Related Literatures of Post-Translational Modification

Methylation
Reference	PubMed
"PKA-dependent regulation of the histone lysine demethylase complexPHF2-ARID5B."; Baba A., Ohtake F., Okuno Y., Yokota K., Okada M., Imai Y., Ni M.,Meyer C.A., Igarashi K., Kanno J., Brown M., Kato S.; Nat. Cell Biol. 13:668-675(2011). Cited for: FUNCTION, INTERACTION WITH PHF2, IDENTIFICATION BY MASS SPECTROMETRY,TISSUE SPECIFICITY, DNA-BINDING, IDENTIFICATION IN THE PHF2-ARID5BCOMPLEX, METHYLATION AT LYS-336, AND MUTAGENESIS OF LYS-336.	21532585 [Abstract]
Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1002, AND MASSSPECTROMETRY.	17081983 [Abstract]

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