dbPTM

DHX57_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DHX57_HUMAN
UniProt AC	Q6P158
Protein Name	Putative ATP-dependent RNA helicase DHX57
Gene Name	DHX57
Organism	Homo sapiens (Human).
Sequence Length	1386
Subcellular Localization
Protein Description	Probable ATP-binding RNA helicase..
Protein Sequence	MSSSVRRKGKPGKGGGKGSSRGGRGGRSHASKSHGSGGGGGGGGGGGGGNRKASSRIWDDGDDFCIFSESRRPSRPSNSNISKGESRPKWKPKAKVPLQTLHMTSENQEKVKALLRDLQEQDADAGSERGLSGEEEDDEPDCCNDERYWPAGQEPSLVPDLDPLEYAGLASVEPYVPEFTVSPFAVQKLSRYGFNTERCQAVLRMCDGDVGASLEHLLTQCFSETFGERMKISEAVNQISLDECMEQRQEEAFALKSICGEKFIERIQNRVWTIGLELEYLTSRFRKSKPKESTKNVQENSLEICKFYLKGNCKFGSKCRFKHEVPPNQIVGRIERSVDDSHLNAIEDASFLYELEIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEFLYDKALTFAETSEPVVYSLITLLEEESEIVKLLTNTHHKYSDPPVNFLPVPSRTRINNPACHKTVIPNNSFVSNQIPEVEKASESEESDEDDGPAPVIVENESYVNLKKKISKRYDWQAKSVHAENGKICKQFRMKQASRQFQSILQERQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQGVSHIIVDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSCPVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQLDFKQLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSVFSRLIEPPHTDSLRASKIRLRDLGALTPDERLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLQAYKGWQLSTKEGVRASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFAREGLRAREIEKRAQGGDGVLDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSAELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGEFVVSLDDGWIRFVAASHQVAELVKELRCELDQLLQDKIKNPSIDLCTCPRGSRIISTIVKLVTTQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	GSSRGGRGGRSHASK CCCCCCCCCCCCCCC	38.86	33259812
25 (in isoform 1)	Phosphorylation	-	38.86	-
28	Phosphorylation	RGGRGGRSHASKSHG CCCCCCCCCCCCCCC	27.04	23090842
30 (in isoform 1)	Phosphorylation	-	21.65	-
31	Phosphorylation	RGGRSHASKSHGSGG CCCCCCCCCCCCCCC	29.30	20363803
33	Phosphorylation	GRSHASKSHGSGGGG CCCCCCCCCCCCCCC	30.50	23090842
36	Phosphorylation	HASKSHGSGGGGGGG CCCCCCCCCCCCCCC	28.92	23090842
51	Methylation	GGGGGGNRKASSRIW CCCCCCCCCCCCCCC	38.91	-
54	Phosphorylation	GGGNRKASSRIWDDG CCCCCCCCCCCCCCC	24.16	22210691
74	Phosphorylation	FSESRRPSRPSNSNI EECCCCCCCCCCCCC	55.82	23927012
77	Phosphorylation	SRRPSRPSNSNISKG CCCCCCCCCCCCCCC	52.35	29496963
79	Phosphorylation	RPSRPSNSNISKGES CCCCCCCCCCCCCCC	39.62	23927012
82	Phosphorylation	RPSNSNISKGESRPK CCCCCCCCCCCCCCC	38.57	27251275
104	Phosphorylation	PLQTLHMTSENQEKV CCCEEECCCCCHHHH	23.34	28348404
105	Phosphorylation	LQTLHMTSENQEKVK CCEEECCCCCHHHHH	27.29	28857561
127	Phosphorylation	EQDADAGSERGLSGE HHHCCCCCCCCCCCC	26.33	29255136
132	Phosphorylation	AGSERGLSGEEEDDE CCCCCCCCCCCCCCC	47.16	23401153
154	Ubiquitination	RYWPAGQEPSLVPDL CCCCCCCCCCCCCCC	35.62	29967540
190	Phosphorylation	PFAVQKLSRYGFNTE HHHHHHHHHCCCCHH	30.41	24719451
193	Ubiquitination	VQKLSRYGFNTERCQ HHHHHHCCCCHHHHH	14.28	32015554
256	Ubiquitination	QEEAFALKSICGEKF HHHHHHHHHHHCHHH	34.05	29967540
273	Phosphorylation	RIQNRVWTIGLELEY HHHHHHHHHHHHHHH	11.43	27732954
280	Phosphorylation	TIGLELEYLTSRFRK HHHHHHHHHHHHHHH	28.09	27732954
282	Phosphorylation	GLELEYLTSRFRKSK HHHHHHHHHHHHHCC	19.56	27732954
283	Phosphorylation	LELEYLTSRFRKSKP HHHHHHHHHHHHCCC	27.16	27732954
293	Phosphorylation	RKSKPKESTKNVQEN HHCCCCHHCCCCHHC	51.30	26270265
294	Phosphorylation	KSKPKESTKNVQENS HCCCCHHCCCCHHCH	27.94	26270265
295	Ubiquitination	SKPKESTKNVQENSL CCCCHHCCCCHHCHH	65.48	32015554
301	Phosphorylation	TKNVQENSLEICKFY CCCCHHCHHHHHHHH	26.99	26270265
373 (in isoform 1)	Phosphorylation	-	12.82	-
375 (in isoform 1)	Phosphorylation	-	12.59	-
377	Phosphorylation	PLVAFYSTNENLPLA CEEEEEECCCCCCCH	34.86	-
378 (in isoform 1)	Phosphorylation	-	30.16	-
396	Ubiquitination	ISEFLYDKALTFAET HHHHHHHHHHHHHHC	31.57	-
444	Phosphorylation	VNFLPVPSRTRINNP CCCCCCCCCCCCCCC	46.66	26552605
456	Phosphorylation	NNPACHKTVIPNNSF CCCCCCCCCCCCCCC	10.45	21406692
462	Phosphorylation	KTVIPNNSFVSNQIP CCCCCCCCCHHCCCC	33.39	21406692
465	Phosphorylation	IPNNSFVSNQIPEVE CCCCCCHHCCCCCHH	22.47	21406692
475	Phosphorylation	IPEVEKASESEESDE CCCHHHCCCCCCCCC	53.36	17081983
477	Phosphorylation	EVEKASESEESDEDD CHHHCCCCCCCCCCC	44.14	25159151
480	Phosphorylation	KASESEESDEDDGPA HCCCCCCCCCCCCCC	42.10	25159151
495	Phosphorylation	PVIVENESYVNLKKK CEEEECCCEECHHHH	46.06	21406692
496	Phosphorylation	VIVENESYVNLKKKI EEEECCCEECHHHHH	6.28	21406692
512	Methylation	KRYDWQAKSVHAENG HCCCCHHCCHHHHCC	37.60	-
533	Ubiquitination	RMKQASRQFQSILQE HHHHHHHHHHHHHHH	37.93	24816145
536	Phosphorylation	QASRQFQSILQERQS HHHHHHHHHHHHHHC	26.93	28857561
552	Phosphorylation	PAWEERETILNLLRK CCHHHHHHHHHHHHH	36.67	20068231
605	Phosphorylation	CTQPRRISAISVAER ECCCCHHHHHHHHHH	20.10	28450419
608	Phosphorylation	PRRISAISVAERVAK CCHHHHHHHHHHHHH	18.26	28450419
635	Ubiquitination	QIRLESVKSSATRLL EEEHHHHHCCHHHHH	48.23	24816145
639	Phosphorylation	ESVKSSATRLLYCTT HHHHCCHHHHHHHHH	24.65	-
688	Ubiquitination	LLVLKDIVSQRPGLQ HHHHHHHHHCCCCHH	5.98	32015554
699	Ubiquitination	PGLQVILMSATLNAE CCHHHEEEECCCCHH	1.43	29967540
741	Phosphorylation	DAIAVTRYVLQDGSP HHHHHHHHHHHCCCH	8.99	-
747	Phosphorylation	RYVLQDGSPYMRSMK HHHHHCCCHHHHHHH	22.58	20068231
749	Phosphorylation	VLQDGSPYMRSMKQI HHHCCCHHHHHHHHH	13.57	20068231
752	Phosphorylation	DGSPYMRSMKQISKE CCCHHHHHHHHHCHH	17.50	20068231
757	Phosphorylation	MRSMKQISKEKLKAR HHHHHHHCHHHHHHH	32.06	26074081
790	Ubiquitination	LQDQDSVKDAVPDQQ ECCCCHHHHCCCHHH	43.87	32015554
801	Ubiquitination	PDQQLDFKQLLARYK CHHHCCHHHHHHHHC	39.44	29967540
813	Phosphorylation	RYKGVSKSVIKTMSI HHCCCCHHHHHHHCC	22.90	29083192
817	Phosphorylation	VSKSVIKTMSIMDFE CCHHHHHHHCCCCHH	12.67	22210691
819	Phosphorylation	KSVIKTMSIMDFEKV HHHHHHHCCCCHHHC	21.72	22210691
869	Phosphorylation	MLYEQLQSNSLFNNR HHHHHHHHCCCCCCC	36.66	24043423
871	Phosphorylation	YEQLQSNSLFNNRRS HHHHHHCCCCCCCCC	39.32	24043423
1002	Ubiquitination	QRVPLEQLCLRIKIL HCCCHHHHHHHHHHH	1.85	29967540
1030	Phosphorylation	RLIEPPHTDSLRASK HHCCCCCCCCCCHHH	32.81	22817900
1032	Phosphorylation	IEPPHTDSLRASKIR CCCCCCCCCCHHHCC	22.40	22817900
1034	Ubiquitination	PPHTDSLRASKIRLR CCCCCCCCHHHCCHH	40.54	32015554
1036	Phosphorylation	HTDSLRASKIRLRDL CCCCCCHHHCCHHHH	23.37	22817900
1104	Malonylation	FVSPWDKKEEANQKK CCCCCCHHHHHHHHH	59.31	26320211
1104	Acetylation	FVSPWDKKEEANQKK CCCCCCHHHHHHHHH	59.31	26051181
1104	Ubiquitination	FVSPWDKKEEANQKK CCCCCCHHHHHHHHH	59.31	29967540
1135	Ubiquitination	YKGWQLSTKEGVRAS HCCCCCCCHHHHHHH	41.53	29967540
1136	Ubiquitination	KGWQLSTKEGVRASY CCCCCCCHHHHHHHH	49.44	32015554
1142	Phosphorylation	TKEGVRASYNYCRQN CHHHHHHHHHHHHHH	11.89	-
1152	Phosphorylation	YCRQNFLSGRVLQEM HHHHHCCCHHHHHHH	22.03	24719451
1163	2-Hydroxyisobutyrylation	LQEMASLKRQFTELL HHHHHHHHHHHHHHH	41.48	-
1237	Ubiquitination	SPEGKFQKTSTGAVR CCCCCCEECCCCCEE	47.80	29967540
1256	Ubiquitination	SAELKFVTKNDGYVH CEEEEEEECCCCEEE	27.54	29967540
1261	Phosphorylation	FVTKNDGYVHIHPSS EEECCCCEEEECHHH	7.54	-
1267	Phosphorylation	GYVHIHPSSVNYQVR CEEEECHHHCCEEEE	32.53	-
1271	Phosphorylation	IHPSSVNYQVRHFDS ECHHHCCEEEECCCC	13.26	-
1358	Ubiquitination	LDQLLQDKIKNPSID HHHHHHHHHHCCCCC	42.49	29967540
1373	Phosphorylation	LCTCPRGSRIISTIV CCCCCCCHHHHHHHH	22.91	28509920
1377	Phosphorylation	PRGSRIISTIVKLVT CCCHHHHHHHHHHHH	15.09	28509920
1378	Phosphorylation	RGSRIISTIVKLVTT CCHHHHHHHHHHHHC	21.27	28509920
1384	Phosphorylation	STIVKLVTTQ----- HHHHHHHHCC-----	29.89	28509920
1385	Phosphorylation	TIVKLVTTQ------ HHHHHHHCC------	25.46	28509920

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DHX57_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DHX57_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DHX57_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
SESN2_HUMAN	SESN2	physical	28514442
APOD_HUMAN	APOD	physical	28514442
ZDH17_HUMAN	ZDHHC17	physical	28514442
CLUS_HUMAN	CLU	physical	28514442
RS2_HUMAN	RPS2	physical	28514442
RSSA_HUMAN	RPSA	physical	28514442
TTL12_HUMAN	TTLL12	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
SRC_HUMAN	SRC	physical	28514442
H14_HUMAN	HIST1H1E	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
EF1A2_HUMAN	EEF1A2	physical	28514442
UBB_HUMAN	UBB	physical	28514442
GLMN_HUMAN	GLMN	physical	28514442
RS14_HUMAN	RPS14	physical	28514442
MUCL1_HUMAN	MUCL1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DHX57_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127 AND SER-132, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127; SER-132; SER-475;SER-477 AND SER-480, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127; SER-475; SER-477AND SER-480, AND MASS SPECTROMETRY.	17081983 [Abstract]