SESN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SESN2_HUMAN
• UniProt AC: P58004
• Protein Name: Sestrin-2 {ECO:0000305}
• Gene Name: SESN2 {ECO:0000312|HGNC:HGNC:20746}
• Organism: Homo sapiens (Human).
• Sequence Length: 480
• Subcellular Localization: Cytoplasm .
• Protein Description: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. [PubMed: 18692468]
• Protein Sequence: MIVADSECRAELKDYLRFAPGGVGDSGPGEEQRESRARRGPRGPSAFIPVEEVLREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDADGSPAPQAPTPPSEQSSPPSRDPLNNSGGFESARDVEALMERMQQLQESLLRDEGTSQEEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MIVADSEC -------CCCCCHHH	5.12	22814378
13	Ubiquitination	SECRAELKDYLRFAP HHHHHHHHHHHHHCC	35.51	27667366
26	Phosphorylation	APGGVGDSGPGEEQR CCCCCCCCCCCHHHH	40.74	21815630
45	Phosphorylation	RRGPRGPSAFIPVEE HHCCCCCCCCCCHHH	38.34	-
89	Phosphorylation	VMGLHPDYFTSFWRL HHCCCHHHHHHHHHH	17.13	24248375
91	Phosphorylation	GLHPDYFTSFWRLHY CCCHHHHHHHHHHHH	19.45	24248375
158	Ubiquitination	RAPEKLRKLSEINKL CCHHHHHHHHHHHHH	67.79	29967540
160	Phosphorylation	PEKLRKLSEINKLLA HHHHHHHHHHHHHHH	39.19	24702127
164	Ubiquitination	RKLSEINKLLAHRPW HHHHHHHHHHHCCCC	51.00	29967540
249	Phosphorylation	SRDPLNNSGGFESAR CCCCCCCCCCCHHHH	38.94	30278072
254	Phosphorylation	NNSGGFESARDVEAL CCCCCCHHHHHHHHH	26.75	30278072
271	Phosphorylation	RMQQLQESLLRDEGT HHHHHHHHHHHCCCC	21.53	30108239
274	Methylation	QLQESLLRDEGTSQE HHHHHHHHCCCCCHH	45.27	115916497
278	Phosphorylation	SLLRDEGTSQEEMES HHHHCCCCCHHHHHH	25.78	30108239
279	Phosphorylation	LLRDEGTSQEEMESR HHHCCCCCHHHHHHH	46.59	30108239
285	Phosphorylation	TSQEEMESRFELEKS CCHHHHHHHHHHHHC	40.74	30108239
323	Phosphorylation	VEDPTFGYEDFTRRG EECCCCCCCCCHHCC	14.24	-
374	Phosphorylation	FQAAYSLTYNTIAMH HHHHHHCCHHHHHHH	14.58	22210691
377	Phosphorylation	AYSLTYNTIAMHSGV HHHCCHHHHHHHCCC	10.33	22210691
426	Ubiquitination	RNLKVYIKTVACYPE HCCEEEEEEEEECCH	21.18	29967540
434	Ubiquitination	TVACYPEKTTRRMYN EEEECCHHHHHHHHH	51.17	27667366
470	Phosphorylation	RMQAALLYALRAITR HHHHHHHHHHHHHHH	12.39	18491316

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SESN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SESN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SESN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDX1_HUMAN	PRDX1	physical	15105503
SQSTM_HUMAN	SQSTM1	physical	23274085
RBX1_HUMAN	RBX1	physical	23274085
KEAP1_HUMAN	KEAP1	physical	23274085
ULK1_HUMAN	ULK1	physical	25040165
RBCC1_HUMAN	RB1CC1	physical	25040165
ATG13_HUMAN	ATG13	physical	25040165
SQSTM_HUMAN	SQSTM1	physical	27337507

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.