LDHD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LDHD_HUMAN
• UniProt AC: Q86WU2
• Protein Name: Probable D-lactate dehydrogenase, mitochondrial
• Gene Name: LDHD {ECO:0000312|HGNC:HGNC:19708}
• Organism: Homo sapiens (Human).
• Sequence Length: 507
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESVHRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMDRILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRYGTMRDNVLNLEVVLPDGRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYNLTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIEFLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEAEERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVGHVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEVGAVGVETMRQLKAVLDPQGLMNPGKVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Acetylation	RDFVEALKAVVGGSH HHHHHHHHHHHCCCC	46.30	-
42	Phosphorylation	LKAVVGGSHVSTAAV HHHHHCCCCCCHHHH	18.13	24114839
45	Phosphorylation	VVGGSHVSTAAVVRE HHCCCCCCHHHHHHH	13.60	24114839
46	Phosphorylation	VGGSHVSTAAVVREQ HCCCCCCHHHHHHHH	19.97	24114839
163	Phosphorylation	VDPGADASLCGMAAT CCCCCCHHHCCHHCC	25.41	-
315	Acetylation	DACNRYSKLNCLVAP HHHHHHHHHCCEECC	34.48	-
358	Acetylation	ASDFSWAKEAEERSR CCCCHHHHHHHHHHC	51.72	-
358	Succinylation	ASDFSWAKEAEERSR CCCCHHHHHHHHHHC	51.72	-
358	Succinylation	ASDFSWAKEAEERSR CCCCHHHHHHHHHHC	51.72	-
445	Acetylation	AEELGRVKAFAEQLG HHHHHHHHHHHHHHH	36.10	-
472	Acetylation	EHGIGMGKRQLLQEE CCCCCCCHHHHHHHH	28.25	-
487	Phosphorylation	VGAVGVETMRQLKAV HHCCHHHHHHHHHHH	18.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LDHD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LDHD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LDHD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MARK2_HUMAN	MARK2	physical	26496610
MYH4_HUMAN	MYH4	physical	26496610
RPOM_HUMAN	POLRMT	physical	26496610
RL30_HUMAN	RPL30	physical	26496610
SPAG1_HUMAN	SPAG1	physical	26496610
ELOB_HUMAN	TCEB2	physical	26496610
VRK2_HUMAN	VRK2	physical	26496610
ZKSC1_HUMAN	ZKSCAN1	physical	26496610
ZW10_HUMAN	ZW10	physical	26496610
CNOT8_HUMAN	CNOT8	physical	26496610
SPF30_HUMAN	SMNDC1	physical	26496610
CE164_HUMAN	CEP164	physical	26496610
DHX30_HUMAN	DHX30	physical	26496610
FBX28_HUMAN	FBXO28	physical	26496610
NIPBL_HUMAN	NIPBL	physical	26496610
FA98A_HUMAN	FAM98A	physical	26496610
CKAP2_HUMAN	CKAP2	physical	26496610
ACAD8_HUMAN	ACAD8	physical	26496610
RGAP1_HUMAN	RACGAP1	physical	26496610
REPI1_HUMAN	REPIN1	physical	26496610
NOP53_HUMAN	GLTSCR2	physical	26496610
RT21_HUMAN	MRPS21	physical	26496610
UBR7_HUMAN	UBR7	physical	26496610
MA7D1_HUMAN	MAP7D1	physical	26496610
ZCCHV_HUMAN	ZC3HAV1	physical	26496610
SUGP1_HUMAN	SUGP1	physical	26496610
BCORL_HUMAN	BCORL1	physical	26496610
SPA5L_HUMAN	SPATA5L1	physical	26496610
RPAP3_HUMAN	RPAP3	physical	26496610
MAGT1_HUMAN	MAGT1	physical	26496610
ZGPAT_HUMAN	ZGPAT	physical	26496610
SP14L_HUMAN	SP140L	physical	26496610
CGAS_HUMAN	MB21D1	physical	26496610
SOGA1_HUMAN	SOGA1	physical	26496610
RL22L_HUMAN	RPL22L1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.