| UniProt ID | CGAS_HUMAN | |
|---|---|---|
| UniProt AC | Q8N884 | |
| Protein Name | Cyclic GMP-AMP synthase {ECO:0000303|PubMed:23258413} | |
| Gene Name | CGAS {ECO:0000312|HGNC:HGNC:21367} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 522 | |
| Subcellular Localization |
Cytoplasm, cytosol . Upon transfection with dsDNA forms punctate structures that co-localize with DNA and Beclin-1 (BECN1) (PubMed:26048138). (Microbial infection) Upon infection with virulent M.tuberculosis forms aggregates with dsDNA, non-vir |
|
| Protein Description | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. [PubMed: 23258413] | |
| Protein Sequence | MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSRQKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGSCRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MQPWHGKA -------CCCCCHHH | - | ||
| 7 | Methylation | -MQPWHGKAMQRASE -CCCCCHHHHHHHHH | 19608861 | ||
| 7 | Acetylation | -MQPWHGKAMQRASE -CCCCCHHHHHHHHH | 19608861 | ||
| 13 | Phosphorylation | GKAMQRASEAGATAP HHHHHHHHHHCCCCC | 25159151 | ||
| 18 | Phosphorylation | RASEAGATAPKASAR HHHHHCCCCCHHHHC | 20860994 | ||
| 37 | Phosphorylation | APMDPTESPAAPEAA CCCCCCCCCCCCHHH | - | ||
| 50 | Acetylation | AALPKAGKFGPARKS HHCCCCCCCCCCCCC | 19608861 | ||
| 64 | Phosphorylation | SGSRQKKSAPDTQER CCCCCCCCCCCCCCC | 24732914 | ||
| 68 | Phosphorylation | QKKSAPDTQERPPVR CCCCCCCCCCCCCCH | 24732914 | ||
| 77 | Phosphorylation | ERPPVRATGARAKKA CCCCCHHHCHHHHCC | 28555341 | ||
| 82 | Methylation | RATGARAKKAPQRAQ HHHCHHHHCCCCCCC | - | ||
| 91 | Phosphorylation | APQRAQDTQPSDATS CCCCCCCCCCCCCCC | 29214152 | ||
| 116 | Phosphorylation | AAREPALSRAGSCRQ HHCCCHHHCCCCHHH | 20068231 | ||
| 120 | Phosphorylation | PALSRAGSCRQRGAR CHHHCCCCHHHCCCC | 20068231 | ||
| 129 | Phosphorylation | RQRGARCSTKPRPPP HHCCCCCCCCCCCCC | 21712546 | ||
| 131 | Acetylation | RGARCSTKPRPPPGP CCCCCCCCCCCCCCC | 26051181 | ||
| 143 | Phosphorylation | PGPWDVPSPGLPVSA CCCCCCCCCCCCCCC | 25159151 | ||
| 163 | Phosphorylation | RDAAPGASKLRAVLE CCCCCCHHHHHHHHH | 22210691 | ||
| 164 | Ubiquitination | DAAPGASKLRAVLEK CCCCCHHHHHHHHHH | 29967540 | ||
| 171 | Acetylation | KLRAVLEKLKLSRDD HHHHHHHHHCCCHHH | 26051181 | ||
| 173 | Ubiquitination | RAVLEKLKLSRDDIS HHHHHHHCCCHHHHH | 29967540 | ||
| 175 | Phosphorylation | VLEKLKLSRDDISTA HHHHHCCCHHHHHHH | - | ||
| 181 | Phosphorylation | LSRDDISTAAGMVKG CCHHHHHHHHHHHHH | - | ||
| 198 | Acetylation | DHLLLRLKCDSAFRG HHHHHHHHCCCCCCC | - | ||
| 198 | Ubiquitination | DHLLLRLKCDSAFRG HHHHHHHHCCCCCCC | 33845483 | ||
| 201 | Phosphorylation | LLRLKCDSAFRGVGL HHHHHCCCCCCCCEE | - | ||
| 210 | Deamidation | FRGVGLLNTGSYYEH CCCCEECCCCCCEEE | 30092200 | ||
| 215 | Phosphorylation | LLNTGSYYEHVKISA ECCCCCCEEEEEECC | 30356214 | ||
| 221 | Phosphorylation | YYEHVKISAPNEFDV CEEEEEECCCCCEEE | - | ||
| 231 | Sumoylation | NEFDVMFKLEVPRIQ CCEEEEEEEECCCEE | - | ||
| 231 | Sumoylation | NEFDVMFKLEVPRIQ CCEEEEEEEECCCEE | - | ||
| 248 | Phosphorylation | EYSNTRAYYFVKFKR ECCCCEEEEEEEECC | 22817900 | ||
| 263 | Phosphorylation | NPKENPLSQFLEGEI CCCCCCHHHHHHHHH | - | ||
| 282 | Ubiquitination | KMLSKFRKIIKEEIN HHHHHHHHHHHHHHH | 29967540 | ||
| 285 | Sumoylation | SKFRKIIKEEINDIK HHHHHHHHHHHHCCC | - | ||
| 285 | Ubiquitination | SKFRKIIKEEINDIK HHHHHHHHHHHHCCC | 29967540 | ||
| 285 | Acetylation | SKFRKIIKEEINDIK HHHHHHHHHHHHCCC | 26051181 | ||
| 285 | Sumoylation | SKFRKIIKEEINDIK HHHHHHHHHHHHCCC | - | ||
| 286 | Formation of an isopeptide bond | KFRKIIKEEINDIKD HHHHHHHHHHHCCCC | - | ||
| 286 | 5-glutamyl polyglutamate | KFRKIIKEEINDIKD HHHHHHHHHHHCCCC | - | ||
| 292 | Ubiquitination | KEEINDIKDTDVIMK HHHHHCCCCCCHHHH | 29967540 | ||
| 292 | Acetylation | KEEINDIKDTDVIMK HHHHHCCCCCCHHHH | - | ||
| 294 | Phosphorylation | EINDIKDTDVIMKRK HHHCCCCCCHHHHCC | 20068231 | ||
| 301 | Methylation | TDVIMKRKRGGSPAV CCHHHHCCCCCCCCH | 23644510 | ||
| 305 | Phosphorylation | MKRKRGGSPAVTLLI HHCCCCCCCCHHEEE | 25159151 | ||
| 313 | Phosphorylation | PAVTLLISEKISVDI CCHHEEEECCCCEEE | 24719451 | ||
| 314 | Formation of an isopeptide bond | AVTLLISEKISVDIT CHHEEEECCCCEEEE | - | ||
| 347 | Ubiquitination | IQNWLSAKVRKQLRL HHHHHHHHHHHHHCC | 22817900 | ||
| 347 | Ubiquitination | IQNWLSAKVRKQLRL HHHHHHHHHHHHHCC | 21890473 | ||
| 347 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 347 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 350 | Ubiquitination | WLSAKVRKQLRLKPF HHHHHHHHHHCCCCE | 22817900 | ||
| 355 | Ubiquitination | VRKQLRLKPFYLVPK HHHHHCCCCEEECCC | 22817900 | ||
| 355 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 355 | Ubiquitination | VRKQLRLKPFYLVPK HHHHHCCCCEEECCC | 21890473 | ||
| 355 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 355 | Acetylation | VRKQLRLKPFYLVPK HHHHHCCCCEEECCC | - | ||
| 362 | Methylation | KPFYLVPKHAKEGNG CCEEECCCCCCCCCC | - | ||
| 365 | Ubiquitination | YLVPKHAKEGNGFQE EECCCCCCCCCCCCC | 29967540 | ||
| 374 | Phosphorylation | GNGFQEETWRLSFSH CCCCCCEEEEEEHHH | 29083192 | ||
| 378 | Phosphorylation | QEETWRLSFSHIEKE CCEEEEEEHHHHHHH | 28674419 | ||
| 384 | Ubiquitination | LSFSHIEKEILNNHG EEHHHHHHHHHHCCC | 30799039 | ||
| 384 | Sumoylation | LSFSHIEKEILNNHG EEHHHHHHHHHHCCC | 30799039 | ||
| 384 | Acetylation | LSFSHIEKEILNNHG EEHHHHHHHHHHCCC | 30799039 | ||
| 389 | Deamidation | IEKEILNNHGKSKTC HHHHHHHCCCCCCCC | 30092200 | ||
| 392 | Ubiquitination | EILNNHGKSKTCCEN HHHHCCCCCCCCCCC | 30799039 | ||
| 392 | Acetylation | EILNNHGKSKTCCEN HHHHCCCCCCCCCCC | 20167786 | ||
| 394 | Sumoylation | LNNHGKSKTCCENKE HHCCCCCCCCCCCCC | 30799039 | ||
| 394 | Acetylation | LNNHGKSKTCCENKE HHCCCCCCCCCCCCC | 20167786 | ||
| 411 | Ubiquitination | CCRKDCLKLMKYLLE HCHHHHHHHHHHHHH | 23000965 | ||
| 411 | Acetylation | CCRKDCLKLMKYLLE HCHHHHHHHHHHHHH | 26051181 | ||
| 414 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 414 | Acetylation | KDCLKLMKYLLEQLK HHHHHHHHHHHHHHH | 19608861 | ||
| 414 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 414 | Ubiquitination | KDCLKLMKYLLEQLK HHHHHHHHHHHHHHH | 21890473 | ||
| 414 | Ubiquitination | KDCLKLMKYLLEQLK HHHHHHHHHHHHHHH | 23000965 | ||
| 415 | Phosphorylation | DCLKLMKYLLEQLKE HHHHHHHHHHHHHHH | 19664995 | ||
| 421 | Ubiquitination | KYLLEQLKERFKDKK HHHHHHHHHHHCCHH | 29967540 | ||
| 432 | Acetylation | KDKKHLDKFSSYHVK CCHHHHHHHHHHHHH | 26051181 | ||
| 432 | Ubiquitination | KDKKHLDKFSSYHVK CCHHHHHHHHHHHHH | 29967540 | ||
| 439 | Acetylation | KFSSYHVKTAFFHVC HHHHHHHHEEEEEHH | 26051181 | ||
| 451 | Deamidation | HVCTQNPQDSQWDRK EHHHCCCCCCCCCHH | 30092200 | ||
| 454 | Deamidation | TQNPQDSQWDRKDLG HCCCCCCCCCHHHHH | 30092200 | ||
| 479 | Sumoylation | LQCLRTEKLENYFIP HHHHHHHHHHHHCCC | - | ||
| 479 | Sumoylation | LQCLRTEKLENYFIP HHHHHHHHHHHHCCC | - | ||
| 479 | Acetylation | LQCLRTEKLENYFIP HHHHHHHHHHHHCCC | - | ||
| 501 | Ubiquitination | NLIDKRSKEFLTKQI CCCCHHHHHHHHHHH | 22817900 | ||
| 506 | Ubiquitination | RSKEFLTKQIEYERN HHHHHHHHHHHHHHC | 22817900 | ||
| 506 | Ubiquitination | RSKEFLTKQIEYERN HHHHHHHHHHHHHHC | 21890473 | ||
| 506 (in isoform 1) | Ubiquitination | - | 21890473 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CGAS_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ZN593_HUMAN | ZNF593 | physical | 28514442 | |
| RN185_HUMAN | RNF185 | physical | 28273161 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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