| UniProt ID | PMEPA_HUMAN | |
|---|---|---|
| UniProt AC | Q969W9 | |
| Protein Name | Protein TMEPAI | |
| Gene Name | PMEPA1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 287 | |
| Subcellular Localization |
Early endosome membrane Single-pass membrane protein. Golgi apparatus membrane Single-pass membrane protein. |
|
| Protein Description | Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. [PubMed: 20129061] | |
| Protein Sequence | MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 (in isoform 2) | Phosphorylation | - | 7.07 | 24043423 | |
| 28 (in isoform 2) | Phosphorylation | - | 40.57 | 24043423 | |
| 30 (in isoform 2) | Phosphorylation | - | 5.41 | 24043423 | |
| 33 (in isoform 2) | Phosphorylation | - | 15.85 | 24043423 | |
| 36 (in isoform 2) | Phosphorylation | - | 2.44 | 24043423 | |
| 39 (in isoform 2) | Phosphorylation | - | 4.66 | 24043423 | |
| 59 | Phosphorylation | MVMVVVITCLLSHYK HHHHHHHHHHHHHHH | 5.86 | 26552605 | |
| 63 | Phosphorylation | VVITCLLSHYKLSAR HHHHHHHHHHHHHHH | 16.30 | 26552605 | |
| 65 | Phosphorylation | ITCLLSHYKLSARSF HHHHHHHHHHHHHHH | 15.39 | 26552605 | |
| 71 | Phosphorylation | HYKLSARSFISRHSQ HHHHHHHHHHHHHCC | 27.01 | 28102081 | |
| 74 | Phosphorylation | LSARSFISRHSQGRR HHHHHHHHHHCCCCC | 23.17 | 28102081 | |
| 77 | Phosphorylation | RSFISRHSQGRRRED HHHHHHHCCCCCHHH | 32.97 | 23898821 | |
| 110 | Phosphorylation | GIPEPQVYAPPRPTD CCCCCCCCCCCCCCC | 14.24 | 27642862 | |
| 137 | Phosphorylation | FHRFQPTYPYLQHEI HHHCCCCCCCCCCCC | 9.14 | 20736484 | |
| 182 | Phosphorylation | QLELNRESVRAPPNR HHHHCHHHCCCCCCC | 17.42 | 26074081 | |
| 190 | Phosphorylation | VRAPPNRTIFDSDLM CCCCCCCCCCCHHHH | 32.41 | 22210691 | |
| 217 | Phosphorylation | SNSGISATCYGSGGR CCCCCCEEEECCCCC | 10.24 | - | |
| 219 | Phosphorylation | SGISATCYGSGGRME CCCCEEEECCCCCCC | 15.24 | 27259358 | |
| 221 | Phosphorylation | ISATCYGSGGRMEGP CCEEEECCCCCCCCC | 16.17 | 22210691 | |
| 231 | Phosphorylation | RMEGPPPTYSEVIGH CCCCCCCCHHHHHCC | 45.51 | 21082442 | |
| 232 | Phosphorylation | MEGPPPTYSEVIGHY CCCCCCCHHHHHCCC | 14.49 | 18083107 | |
| 239 | Phosphorylation | YSEVIGHYPGSSFQH HHHHHCCCCCCCHHH | 12.22 | - | |
| 250 | Phosphorylation | SFQHQQSSGPPSLLE CHHHCCCCCCCCHHC | 51.48 | - | |
| 277 | Ubiquitination | ESAAIWSKEKDKQKG HHHHHCCHHHHHCCC | 54.51 | - | |
| 279 | Ubiquitination | AAIWSKEKDKQKGHP HHHCCHHHHHCCCCC | 74.16 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PMEPA_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PMEPA_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PMEPA_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NEDD4_HUMAN | NEDD4 | physical | 28218281 | |
| HGS_HUMAN | HGS | physical | 28218281 | |
| STAM1_HUMAN | STAM | physical | 28218281 | |
| DCTN6_HUMAN | DCTN6 | physical | 28218281 | |
| DCTN5_HUMAN | DCTN5 | physical | 28218281 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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