DCTN6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCTN6_HUMAN
• UniProt AC: O00399
• Protein Name: Dynactin subunit 6
• Gene Name: DCTN6
• Organism: Homo sapiens (Human).
• Sequence Length: 190
• Subcellular Localization: Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore .
• Protein Sequence: MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Phosphorylation	NAYPDNITPDTEDPE ECCCCCCCCCCCCCC	22.74	26074081
74	Phosphorylation	PDNITPDTEDPEPKP CCCCCCCCCCCCCCC	43.41	26074081
110	Ubiquitination	DNNVIESKAYVGRNV CCCEECCCCCCCCCE	30.83	21906983
168	Sulfoxidation	TLQLDFLMKILPNYH EEHHHHHHHHCCCCH	2.27	21406390
169	Ubiquitination	LQLDFLMKILPNYHH EHHHHHHHHCCCCHH	43.15	30230243
178	Ubiquitination	LPNYHHLKKTMKGSS CCCCHHHHHHCCCCC	41.67	29967540
184	Phosphorylation	LKKTMKGSSTPVKN- HHHHCCCCCCCCCC-	26.06	24719451
185	Phosphorylation	KKTMKGSSTPVKN-- HHHCCCCCCCCCC--	45.45	24719451
186	Phosphorylation	KTMKGSSTPVKN--- HHCCCCCCCCCC---	33.52	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
186	T	Phosphorylation	Kinase	CDK1	P06493	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
186	T	Phosphorylation	Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.	23455152

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCTN6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RSSA_HUMAN	RPSA	physical	21988832
DCTN5_HUMAN	DCTN5	physical	26344197
ACTY_HUMAN	ACTR1B	physical	28514442
DCTN1_HUMAN	DCTN1	physical	28514442
DCTN2_HUMAN	DCTN2	physical	28514442
ARP10_HUMAN	ACTR10	physical	28514442
CAZA2_HUMAN	CAPZA2	physical	28514442
DCTN5_HUMAN	DCTN5	physical	28514442
ZBT43_HUMAN	ZBTB43	physical	28514442
DCTN4_HUMAN	DCTN4	physical	28514442
ACTZ_HUMAN	ACTR1A	physical	28514442
DCTN3_HUMAN	DCTN3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.