ARP10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARP10_HUMAN
• UniProt AC: Q9NZ32
• Protein Name: Actin-related protein 10
• Gene Name: ACTR10
• Organism: Homo sapiens (Human).
• Sequence Length: 417
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Sequence: MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKRAGMPKPVRVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVIIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTSVAKEQSLPSVMGSVPEGVLEDIKARTCFVSDLKRGLKIQAAKFNIDGNNERPSPPPNVDYPLDGEKILHILGSIRDSVVEILFEQDNEEQSVATLILDSLIQCPIDTRKQLAENLVVIGGTSMLPGFLHRLLAEIRYLVEKPKYKKALGTKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKEYYNQTGRIPDWCSLNNPPLEMMFDVGKTQPPLMKRAFSTEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPLYEGLGSGG ----CCCCCCCCCCC	11.33	21945579
4	Nitration	----MPLYEGLGSGG ----CCCCCCCCCCC	11.33	-
9	Phosphorylation	PLYEGLGSGGEKTAV CCCCCCCCCCCCEEE	48.98	46158761
14	Phosphorylation	LGSGGEKTAVVIDLG CCCCCCCEEEEEECH	22.00	46158767
26	Ubiquitination	DLGEAFTKCGFAGET ECHHHHHHCCCCCCC	26.38	-
27	S-nitrosylation	LGEAFTKCGFAGETG CHHHHHHCCCCCCCC	5.01	24105792
44	Ubiquitination	CIIPSVIKRAGMPKP CCHHHHHHHCCCCCC	33.76	-
57	Phosphorylation	KPVRVVQYNINTEEL CCEEEEEEECCHHHH	13.34	6907845
65	Phosphorylation	NINTEELYSYLKEFI ECCHHHHHHHHHHHH	9.88	110759479
67	Phosphorylation	NTEELYSYLKEFIHI CHHHHHHHHHHHHHH	14.29	6907865
76	Phosphorylation	KEFIHILYFRHLLVN HHHHHHHHHHHHHCC	9.66	24114839
97	S-nitrosylation	VIIESVLCPSHFRET EEEEEEECCHHHHHH	2.81	24105792
141	S-palmitoylation	NSAMVLDCGYRESLV CCEEEECCCCCHHCE	4.51	29575903
152	Phosphorylation	ESLVLPIYEGIPVLN HHCEEEEECCCCEEE	13.23	83437
169	Ubiquitination	GALPLGGKALHKELE CCCCCCHHHHHHHHH	46.07	-
173	Ubiquitination	LGGKALHKELETQLL CCHHHHHHHHHHHHH	65.92	-
187	Phosphorylation	LEQCTVDTSVAKEQS HHHCCCCHHHHCCCC	22.29	46158773
188	Phosphorylation	EQCTVDTSVAKEQSL HHCCCCHHHHCCCCC	18.66	46158755
199	Sulfoxidation	EQSLPSVMGSVPEGV CCCCCHHCCCCCCCH	3.77	30846556
201	Phosphorylation	SLPSVMGSVPEGVLE CCCHHCCCCCCCHHH	19.19	113334129
211	Ubiquitination	EGVLEDIKARTCFVS CCHHHHHHHCCCCHH	44.10	21906983
221	Ubiquitination	TCFVSDLKRGLKIQA CCCHHHHHHCCEEEE	49.78	-
221	2-Hydroxyisobutyrylation	TCFVSDLKRGLKIQA CCCHHHHHHCCEEEE	49.78	-
221	Acetylation	TCFVSDLKRGLKIQA CCCHHHHHHCCEEEE	49.78	25825284
225	Ubiquitination	SDLKRGLKIQAAKFN HHHHHCCEEEEEEEE	35.28	-
225	Malonylation	SDLKRGLKIQAAKFN HHHHHCCEEEEEEEE	35.28	26320211
230	Ubiquitination	GLKIQAAKFNIDGNN CCEEEEEEEECCCCC	41.79	2190698
241	Phosphorylation	DGNNERPSPPPNVDY CCCCCCCCCCCCCCC	57.15	23401153
339	Ubiquitination	YKKALGTKTFRIHTP HHHHHCCCEEEECCC	43.82	-
375	Ubiquitination	LGSRSVSKEYYNQTG HCCCCCCHHHHCCCC	47.80	21906983
377	Phosphorylation	SRSVSKEYYNQTGRI CCCCCHHHHCCCCCC	16.08	119489
389	Phosphorylation	GRIPDWCSLNNPPLE CCCCCHHHCCCCCCC	29.85	26074081
404	Phosphorylation	MMFDVGKTQPPLMKR CCEECCCCCCCHHHH	40.14	26074081
410	Ubiquitination	KTQPPLMKRAFSTEK CCCCCHHHHHHCCCC	48.54	-
414	Phosphorylation	PLMKRAFSTEK---- CHHHHHHCCCC----	34.37	30266825
415	Phosphorylation	LMKRAFSTEK----- HHHHHHCCCC-----	41.14	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARP10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARP10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARP10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCTN4_HUMAN	DCTN4	physical	22939629
LMNB1_HUMAN	LMNB1	physical	22863883
RABE1_HUMAN	RABEP1	physical	22863883
ACTZ_HUMAN	ACTR1A	physical	26344197
DCTN4_HUMAN	DCTN4	physical	26344197
DCTN2_HUMAN	DCTN2	physical	27173435
DCTN1_HUMAN	DCTN1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.