ACTZ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACTZ_HUMAN
• UniProt AC: P61163
• Protein Name: Alpha-centractin
• Gene Name: ACTR1A
• Organism: Homo sapiens (Human).
• Sequence Length: 376
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cell cortex .
• Protein Description: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome..
• Protein Sequence: MESYDVIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDIFIGPKAEEHRGLLSIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKNRERAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRIDIAGRDVSRFLRLYLRKEGYDFHSSSEFEIVKAIKERACYLSINPQKDETLETEKAQYYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIHEVLVFAIQKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGARSIHRKTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Sulfoxidation	-------MESYDVIA -------CCCCCEEC	7.52	28465586
1	Acetylation	-------MESYDVIA -------CCCCCEEC	7.52	22223895
3	Phosphorylation	-----MESYDVIANQ -----CCCCCEECCC	25.90	46158779
4	Phosphorylation	----MESYDVIANQP ----CCCCCEECCCC	10.83	26552605
18	Phosphorylation	PVVIDNGSGVIKAGF CEEEECCCCEEECCC	35.82	27251275
22	Ubiquitination	DNGSGVIKAGFAGDQ ECCCCEEECCCCCCC	39.80	-
32	Ubiquitination	FAGDQIPKYCFPNYV CCCCCCCCCCCCCCC	57.17	-
32	Acetylation	FAGDQIPKYCFPNYV CCCCCCCCCCCCCCC	57.17	30586733
33	Phosphorylation	AGDQIPKYCFPNYVG CCCCCCCCCCCCCCC	8.25	29496907
34	S-nitrosylation	GDQIPKYCFPNYVGR CCCCCCCCCCCCCCC	5.96	21278135
34	S-nitrosocysteine	GDQIPKYCFPNYVGR CCCCCCCCCCCCCCC	5.96	-
38	Phosphorylation	PKYCFPNYVGRPKHV CCCCCCCCCCCCCCC	12.43	29496907
43	Ubiquitination	PNYVGRPKHVRVMAG CCCCCCCCCCCCEEC	54.06	-
48	Sulfoxidation	RPKHVRVMAGALEGD CCCCCCCEECCEECC	1.67	21406390
66	Methylation	GPKAEEHRGLLSIRY CCCHHHCCCCEEEEC	40.51	-
72	Methylation	HRGLLSIRYPMEHGI CCCCEEEECCCCCCC	26.57	-
73	Phosphorylation	RGLLSIRYPMEHGIV CCCEEEECCCCCCCC	12.78	28509920
75	Sulfoxidation	LLSIRYPMEHGIVKD CEEEECCCCCCCCCC	4.38	30846556
81	Ubiquitination	PMEHGIVKDWNDMER CCCCCCCCCHHHHHH	55.92	21906983
96	Ubiquitination	IWQYVYSKDQLQTFS HHHHHCCHHHHHCCC	31.63	21890473
171	Phosphorylation	VTHAVPIYEGFAMPH CEEEEEEECCCCCCC	12.15	82491
200	Acetylation	FLRLYLRKEGYDFHS HHHHHHHHCCCCCCC	53.55	26051181
200	Ubiquitination	FLRLYLRKEGYDFHS HHHHHHHHCCCCCCC	53.55	21890473
230	Acetylation	YLSINPQKDETLETE EEECCCCCCCCHHCE	59.81	23954790
230	Malonylation	YLSINPQKDETLETE EEECCCCCCCCHHCE	59.81	26320211
230	Ubiquitination	YLSINPQKDETLETE EEECCCCCCCCHHCE	59.81	-
238	Ubiquitination	DETLETEKAQYYLPD CCCHHCEECEEECCC	48.48	21890473
293	Phosphorylation	SDMDLRRTLFSNIVL CCHHHHHHHHHCEEE	26.22	20071362
296	Phosphorylation	DLRRTLFSNIVLSGG HHHHHHHHCEEECCC	28.85	24719451
301	Phosphorylation	LFSNIVLSGGSTLFK HHHCEEECCCCHHHC	30.16	22199227
304	Phosphorylation	NIVLSGGSTLFKGFG CEEECCCCHHHCCHH	26.01	22199227
305	Phosphorylation	IVLSGGSTLFKGFGD EEECCCCHHHCCHHH	39.22	22199227
308	Ubiquitination	SGGSTLFKGFGDRLL CCCCHHHCCHHHHHH	57.34	2190698
313	Methylation	LFKGFGDRLLSEVKK HHCCHHHHHHHHHHH	37.60	-
319	Ubiquitination	DRLLSEVKKLAPKDV HHHHHHHHHHCCCCC	37.71	-
319	Malonylation	DRLLSEVKKLAPKDV HHHHHHHHHHCCCCC	37.71	26320211
331	Phosphorylation	KDVKIRISAPQERLY CCCEEEEECCHHHHH	24.85	23312004
338	Phosphorylation	SAPQERLYSTWIGGS ECCHHHHHCCCHHHH	15.41	31136907
363	Phosphorylation	MWVSKKEYEEDGARS HHCCHHHHCCCCCCC	33.23	29496907

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACTZ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACTZ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACTZ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUMA1_HUMAN	NUMA1	physical	10504299
DCTN2_HUMAN	DCTN2	physical	22939629
PRS6B_HUMAN	PSMC4	physical	22939629
MYH9_HUMAN	MYH9	physical	22939629
PSMD1_HUMAN	PSMD1	physical	22939629
RRS1_HUMAN	RRS1	physical	22939629
MCM7_HUMAN	MCM7	physical	22939629
ARP10_HUMAN	ACTR10	physical	12857853
ARP10_HUMAN	ACTR10	physical	22863883
LMNB1_HUMAN	LMNB1	physical	22863883
MYCBP_HUMAN	MYCBP	physical	22863883
NU133_HUMAN	NUP133	physical	22863883
DCTN1_HUMAN	DCTN1	physical	26344197
DCTN2_HUMAN	DCTN2	physical	26344197
DCTN5_HUMAN	DCTN5	physical	26344197
PACN3_HUMAN	PACSIN3	physical	26344197
RPB4_HUMAN	POLR2D	physical	26344197
DCTN2_HUMAN	DCTN2	physical	27173435
DCTN1_HUMAN	DCTN1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330