DCTN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCTN3_HUMAN
• UniProt AC: O75935
• Protein Name: Dynactin subunit 3
• Gene Name: DCTN3 {ECO:0000312|EMBL:CAG46687.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 186
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cleavage furrow . Midbody . Localizes to punctate cytoplasmic structures and to the centrosome d
• Protein Description: Together with dynein may be involved in spindle assembly and cytokinesis..
• Protein Sequence: MAGLTDLQRLQARVEELERWVYGPGGARGSRKVADGLVKVQVALGNISSKRERVKILYKKIEDLIKYLDPEYIDRIAIPDASKLQFILAEEQFILSQVALLEQVNALVPMLDSAHIKAVPEHAARLQRLAQIHIQQQDQCVEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAATQVKPAEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGLTDLQR ------CCCCHHHHH	23.00	22814378
5	Phosphorylation	---MAGLTDLQRLQA ---CCCCHHHHHHHH	33.47	24043423
22	Phosphorylation	EELERWVYGPGGARG HHHHHHHHCCCCCCC	15.62	29496907
30	Phosphorylation	GPGGARGSRKVADGL CCCCCCCHHHHCCCC	24.31	24719451
32	Ubiquitination	GGARGSRKVADGLVK CCCCCHHHHCCCCEE	43.39	21906983
32 (in isoform 2)	Ubiquitination	-	43.39	21890473
32 (in isoform 1)	Ubiquitination	-	43.39	21890473
32 (in isoform 3)	Ubiquitination	-	43.39	21890473
50 (in isoform 2)	Ubiquitination	-	52.03	21890473
50 (in isoform 1)	Ubiquitination	-	52.03	21890473
50	Acetylation	ALGNISSKRERVKIL CCCCCCCHHHHHHHH	52.03	25953088
50 (in isoform 3)	Ubiquitination	-	52.03	21890473
50	Ubiquitination	ALGNISSKRERVKIL CCCCCCCHHHHHHHH	52.03	21890473
55 (in isoform 3)	Ubiquitination	-	32.96	-
55	Ubiquitination	SSKRERVKILYKKIE CCHHHHHHHHHHHHH	32.96	-
60 (in isoform 3)	Ubiquitination	-	37.46	-
60	Ubiquitination	RVKILYKKIEDLIKY HHHHHHHHHHHHHHH	37.46	-
66	Ubiquitination	KKIEDLIKYLDPEYI HHHHHHHHHCCHHHH	47.24	-
66 (in isoform 3)	Ubiquitination	-	47.24	-
67	Phosphorylation	KIEDLIKYLDPEYID HHHHHHHHCCHHHHH	14.89	30576142
72	Phosphorylation	IKYLDPEYIDRIAIP HHHCCHHHHHHHCCC	17.32	28152594
75	Methylation	LDPEYIDRIAIPDAS CCHHHHHHHCCCCHH	15.64	-
83 (in isoform 3)	Ubiquitination	-	48.29	-
120 (in isoform 3)	Ubiquitination	-	32.30	-
128 (in isoform 3)	Ubiquitination	-	36.26	-
148	Ubiquitination	VEITEESKALLEEYN ECCCHHHHHHHHHHH	46.46	-
154	Phosphorylation	SKALLEEYNKTTMLL HHHHHHHHHHHHHHH	16.75	22817900
156	Ubiquitination	ALLEEYNKTTMLLSK HHHHHHHHHHHHHHH	44.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCTN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCTN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCTN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYLT3_HUMAN	DYNLT3	physical	22939629
ARP10_HUMAN	ACTR10	physical	22863883
ACTZ_HUMAN	ACTR1A	physical	22863883
DCTN2_HUMAN	DCTN2	physical	22863883
FLNB_HUMAN	FLNB	physical	22863883
CCAR2_HUMAN	CCAR2	physical	22863883
LEO1_HUMAN	LEO1	physical	22863883
LMNB1_HUMAN	LMNB1	physical	22863883
TB182_HUMAN	TNKS1BP1	physical	22863883
DCTN1_HUMAN	DCTN1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330