| UniProt ID | DFFB_HUMAN | |
|---|---|---|
| UniProt AC | O76075 | |
| Protein Name | DNA fragmentation factor subunit beta | |
| Gene Name | DFFB | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 338 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.. | |
| Protein Sequence | MLQKPKSVKLRALRSPRKFGVAGRSCQEVLRKGCLRFQLPERGSRLCLYEDGTELTEDYFPSVPDNAELVLLTLGQAWQGYVSDIRRFLSAFHEPQVGLIQAAQQLLCDEQAPQRQRLLADLLHNVSQNIAAETRAEDPPWFEGLESRFQSKSGYLRYSCESRIRSYLREVSSYPSTVGAEAQEEFLRVLGSMCQRLRSMQYNGSYFDRGAKGGSRLCTPEGWFSCQGPFDMDSCLSRHSINPYSNRESRILFSTWNLDHIIEKKRTIIPTLVEAIKEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLNCDPSRIYKPQTRLKRKQPVRKRQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Phosphorylation | VKLRALRSPRKFGVA CCCHHCCCCCCCCCC | 29.88 | 17081983 | |
| 152 | Ubiquitination | LESRFQSKSGYLRYS HHHHHHCCCCCHHHH | 36.80 | 21906983 | |
| 152 (in isoform 1) | Ubiquitination | - | 36.80 | 21890473 | |
| 152 (in isoform 2) | Ubiquitination | - | 36.80 | 21906983 | |
| 158 | Phosphorylation | SKSGYLRYSCESRIR CCCCCHHHHHHHHHH | 18.31 | - | |
| 264 | Ubiquitination | NLDHIIEKKRTIIPT CHHHHHHHHHCHHHH | 36.83 | 2190698 | |
| 264 (in isoform 1) | Ubiquitination | - | 36.83 | 21890473 | |
| 265 | Ubiquitination | LDHIIEKKRTIIPTL HHHHHHHHHCHHHHH | 41.82 | - | |
| 277 | Ubiquitination | PTLVEAIKEQDGREV HHHHHHHHHCCCCCC | 57.27 | - | |
| 308 | Acetylation | LVHIVCHKKTTHKLN EEEEEEECCCCCCCC | 46.84 | 25953088 | |
| 319 | Phosphorylation | HKLNCDPSRIYKPQT CCCCCCHHHCCCCCC | 20.33 | - | |
| 322 | Phosphorylation | NCDPSRIYKPQTRLK CCCHHHCCCCCCCCC | 18.59 | - | |
| 323 | Ubiquitination | CDPSRIYKPQTRLKR CCHHHCCCCCCCCCC | 28.42 | - | |
| 326 | Phosphorylation | SRIYKPQTRLKRKQP HHCCCCCCCCCCCCC | 46.63 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DFFB_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DFFB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DFFB_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TOP2A_HUMAN | TOP2A | physical | 10959840 | |
| A4_HUMAN | APP | physical | 21832049 | |
| NUBP1_HUMAN | NUBP1 | physical | 22939629 | |
| MARCS_HUMAN | MARCKS | physical | 22939629 | |
| DFFA_HUMAN | DFFA | physical | 15572351 | |
| PTN13_HUMAN | PTPN13 | physical | 28514442 | |
| UBB_HUMAN | UBB | physical | 28514442 | |
| LRC15_HUMAN | LRRC15 | physical | 28514442 | |
| PKN2_HUMAN | PKN2 | physical | 28514442 | |
| KAPCB_HUMAN | PRKACB | physical | 28514442 | |
| NFH_HUMAN | NEFH | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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