S2543_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S2543_HUMAN
• UniProt AC: Q8WUT9
• Protein Name: Solute carrier family 25 member 43
• Gene Name: SLC25A43
• Organism: Homo sapiens (Human).
• Sequence Length: 341
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Sequence: MATWRRDGRLTGGQRLLCAGLAGTLSLSLTAPLELATVLAQVGVVRGHARGPWATGHRVWRAEGLRALWKGNAVACLRLFPCSAVQLAAYRKFVVLFTDDLGHISQWSSIMAGSLAGMVSTIVTYPTDLIKTRLIMQNILEPSYRGLLHAFSTIYQQEGFLALYRGVSLTVVGALPFSAGSLLVYMNLEKIWNGPRDQFSLPQNFANVCLAAAVTQTLSFPFETVKRKMQAQSPYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLKIVPYFGIMFSTFEFCKRICLYQNGYILSPLSYKLTPGVDQSLQPQELRELKKFFKTRKPKPKKPTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	Phosphorylation	RKFVVLFTDDLGHIS HCEEEEEECCCCHHH	25.17	-
120	Phosphorylation	GSLAGMVSTIVTYPT HHHHHHHHHHHHCCH	11.97	28122231
121	Phosphorylation	SLAGMVSTIVTYPTD HHHHHHHHHHHCCHH	14.20	28122231
124	Phosphorylation	GMVSTIVTYPTDLIK HHHHHHHHCCHHHHH	21.67	28122231
125	Phosphorylation	MVSTIVTYPTDLIKT HHHHHHHCCHHHHHH	8.01	28122231
127	Phosphorylation	STIVTYPTDLIKTRL HHHHHCCHHHHHHHH	32.78	28122231
168	Phosphorylation	LALYRGVSLTVVGAL HHHHCCCEEEEEECC	22.58	29978859
170	Phosphorylation	LYRGVSLTVVGALPF HHCCCEEEEEECCCC	12.97	29978859
178	Phosphorylation	VVGALPFSAGSLLVY EEECCCCCCCCEEEE	29.76	29978859
181	Phosphorylation	ALPFSAGSLLVYMNL CCCCCCCCEEEEECH	20.46	29978859
185	Phosphorylation	SAGSLLVYMNLEKIW CCCCEEEEECHHHHH	4.73	29978859
258	Acetylation	DCFRQIVKAQGVLGL HHHHHHHHHHCCHHH	36.30	7712397
270	Phosphorylation	LGLWNGLTANLLKIV HHHHCCHHHHHHHHH	18.20	-
300	Phosphorylation	ICLYQNGYILSPLSY HHHHCCCEEECCCCC	13.26	26074081
303	Phosphorylation	YQNGYILSPLSYKLT HCCCEEECCCCCCCC	17.78	26074081
306	Phosphorylation	GYILSPLSYKLTPGV CEEECCCCCCCCCCC	24.49	26074081
307	Phosphorylation	YILSPLSYKLTPGVD EEECCCCCCCCCCCC	20.07	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S2543_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S2543_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S2543_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRSR2_HUMAN	PROSER2	physical	28514442
NDEL1_HUMAN	NDEL1	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.