PRSR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRSR2_HUMAN
• UniProt AC: Q86WR7
• Protein Name: Proline and serine-rich protein 2
• Gene Name: PROSER2
• Organism: Homo sapiens (Human).
• Sequence Length: 435
• Protein Sequence: MPVTHRKSDASDMNSDTSPSCRLRAFSRGGSLESRSSSSRSRSFTLDDESLKYLTHEEKDVLLFFEETIDSLDEDFEEPVLCDGGVCCLCSPSLEESTSSPSEPEDVIDLVQPAPGAGEAEGLPEGTQAAGPAPAGKEHRKQDAETPPPPDPPAPETLLAPPPLPSTPDPPRRELRAPSPPVEHPRLLRSVPTPLVMAQKISERMAGNEALSPTSPFREGRPGEWRTPAARGPRSGDPGPGPSHPAQPKAPRFPSNIIVTNGAAREPRRTLSRAAVSVQERRAQVLATIHGHAGAFPAAGDAGEGAPGGGSSPERVARGRGLPGPAESLRAGGQAPRGPALANGFPSAHEALKSAPSSFAPAGKSLCFRPGPALPSTRARQSFPGPRQPNGAQDWRRADSLPRPQGITVQFAGRGSSEEARREALRKLGLLRESS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPVTHRKSDAS ----CCCCCCCCCHH		20873877
8	Phosphorylation	MPVTHRKSDASDMNS CCCCCCCCCHHHCCC		23927012
11	Phosphorylation	THRKSDASDMNSDTS CCCCCCHHHCCCCCC		25394399
15	Phosphorylation	SDASDMNSDTSPSCR CCHHHCCCCCCHHHH		25262027
17	Phosphorylation	ASDMNSDTSPSCRLR HHHCCCCCCHHHHHH		23927012
18	Phosphorylation	SDMNSDTSPSCRLRA HHCCCCCCHHHHHHH		23401153
20	Phosphorylation	MNSDTSPSCRLRAFS CCCCCCHHHHHHHHH		23927012
27	Phosphorylation	SCRLRAFSRGGSLES HHHHHHHHCCCCCCC		28355574
28	Methylation	CRLRAFSRGGSLESR HHHHHHHCCCCCCCC		24394805
31	Phosphorylation	RAFSRGGSLESRSSS HHHHCCCCCCCCCCC		23927012
34	Phosphorylation	SRGGSLESRSSSSRS HCCCCCCCCCCCCCC		30576142
36	Phosphorylation	GGSLESRSSSSRSRS CCCCCCCCCCCCCCE		25159151
37	Phosphorylation	GSLESRSSSSRSRSF CCCCCCCCCCCCCEE		23090842
38	Phosphorylation	SLESRSSSSRSRSFT CCCCCCCCCCCCEEE		23090842
39	Phosphorylation	LESRSSSSRSRSFTL CCCCCCCCCCCEEEC		23090842
41	Phosphorylation	SRSSSSRSRSFTLDD CCCCCCCCCEEECCH		29255136
43	Phosphorylation	SSSSRSRSFTLDDES CCCCCCCEEECCHHH		29255136
45	Phosphorylation	SSRSRSFTLDDESLK CCCCCEEECCHHHHH		29255136
50	Phosphorylation	SFTLDDESLKYLTHE EEECCHHHHHHCCHH		28355574
52	Ubiquitination	TLDDESLKYLTHEEK ECCHHHHHHCCHHHC		29967540
53	Phosphorylation	LDDESLKYLTHEEKD CCHHHHHHCCHHHCH		23312004
55	Phosphorylation	DESLKYLTHEEKDVL HHHHHHCCHHHCHHE		23312004
146	Phosphorylation	HRKQDAETPPPPDPP HHCCCCCCCCCCCCC		23401153
157	Phosphorylation	PDPPAPETLLAPPPL CCCCCCCCCCCCCCC		29255136
166	Phosphorylation	LAPPPLPSTPDPPRR CCCCCCCCCCCCCCC		23401153
167	Phosphorylation	APPPLPSTPDPPRRE CCCCCCCCCCCCCCC		29255136
179	Phosphorylation	RRELRAPSPPVEHPR CCCCCCCCCCCCCHH		29255136
190	Phosphorylation	EHPRLLRSVPTPLVM CCHHHHHCCCCHHHH		25159151
193	Phosphorylation	RLLRSVPTPLVMAQK HHHHCCCCHHHHHHH		21815630
212	Phosphorylation	MAGNEALSPTSPFRE HCCCCCCCCCCCCCC		19664994
214	Phosphorylation	GNEALSPTSPFREGR CCCCCCCCCCCCCCC		30266825
215	Phosphorylation	NEALSPTSPFREGRP CCCCCCCCCCCCCCC		29255136
226	Methylation	EGRPGEWRTPAARGP CCCCCCCCCCCCCCC		115488931
227	Phosphorylation	GRPGEWRTPAARGPR CCCCCCCCCCCCCCC		25159151
231	Methylation	EWRTPAARGPRSGDP CCCCCCCCCCCCCCC		115488939
234	Methylation	TPAARGPRSGDPGPG CCCCCCCCCCCCCCC		115488963
235	Phosphorylation	PAARGPRSGDPGPGP CCCCCCCCCCCCCCC		25159151
243	Phosphorylation	GDPGPGPSHPAQPKA CCCCCCCCCCCCCCC		21406692
252	Asymmetric dimethylarginine	PAQPKAPRFPSNIIV CCCCCCCCCCCCEEE		-
252	Methylation	PAQPKAPRFPSNIIV CCCCCCCCCCCCEEE		24129315
255	Phosphorylation	PKAPRFPSNIIVTNG CCCCCCCCCEEEECC		18452278
260	Phosphorylation	FPSNIIVTNGAAREP CCCCEEEECCCCCCH		18452278
277	Phosphorylation	TLSRAAVSVQERRAQ HHHHHHHHHHHHHHH		27535140
288	Phosphorylation	RRAQVLATIHGHAGA HHHHHHHHHHCCCCC		23927012
311	Phosphorylation	EGAPGGGSSPERVAR CCCCCCCCCHHHHHC		22167270
312	Phosphorylation	GAPGGGSSPERVARG CCCCCCCCHHHHHCC		22167270
318	Methylation	SSPERVARGRGLPGP CCHHHHHCCCCCCCC		115488971
320	Methylation	PERVARGRGLPGPAE HHHHHCCCCCCCCHH		12019595
328	Phosphorylation	GLPGPAESLRAGGQA CCCCCHHHHHCCCCC		28348404
330	Methylation	PGPAESLRAGGQAPR CCCHHHHHCCCCCCC		80702007
337	Methylation	RAGGQAPRGPALANG HCCCCCCCCHHHHCC		115488915
364	Ubiquitination	SSFAPAGKSLCFRPG CCCCCCCCCCCCCCC		29967540
365	Phosphorylation	SFAPAGKSLCFRPGP CCCCCCCCCCCCCCC		30576142
369	Methylation	AGKSLCFRPGPALPS CCCCCCCCCCCCCCC		54554835
378	Methylation	GPALPSTRARQSFPG CCCCCCCCHHHCCCC		24129315
380	Methylation	ALPSTRARQSFPGPR CCCCCCHHHCCCCCC		115488923
382	Phosphorylation	PSTRARQSFPGPRQP CCCCHHHCCCCCCCC		27470641
387	Methylation	RQSFPGPRQPNGAQD HHCCCCCCCCCCCCC		80702015
387	Dimethylation	RQSFPGPRQPNGAQD HHCCCCCCCCCCCCC		-
396	Methylation	PNGAQDWRRADSLPR CCCCCCHHHCCCCCC		115488947
397	Methylation	NGAQDWRRADSLPRP CCCCCHHHCCCCCCC		115488955
400	Phosphorylation	QDWRRADSLPRPQGI CCHHHCCCCCCCCCE		23898821
403	Methylation	RRADSLPRPQGITVQ HHCCCCCCCCCEEEE		54554829
408	Phosphorylation	LPRPQGITVQFAGRG CCCCCCEEEEECCCC		24719451
414	Methylation	ITVQFAGRGSSEEAR EEEEECCCCCCHHHH		24129315
421	Methylation	RGSSEEARREALRKL CCCCHHHHHHHHHHH		83445889
434	Phosphorylation	KLGLLRESS------ HHCCHHCCC------		30576142
435	Phosphorylation	LGLLRESS------- HCCHHCCC-------		25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
43	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRSR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRSR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
EPS8_HUMAN	EPS8	physical	21988832
YTDC1_HUMAN	YTHDC1	physical	21988832
PDC10_HUMAN	PDCD10	physical	28514442
STK24_HUMAN	STK24	physical	28514442
STK25_HUMAN	STK25	physical	28514442
STK26_HUMAN	STK26	physical	28514442
ITFG2_HUMAN	ITFG2	physical	28514442
NELFA_HUMAN	NELFA	physical	28514442
RDH13_HUMAN	RDH13	physical	28514442
MTD2L_HUMAN	MTHFD2L	physical	28514442
KPTN_HUMAN	KPTN	physical	28514442
PHF1_HUMAN	PHF1	physical	28514442
VWA8_HUMAN	VWA8	physical	28514442
CDN2C_HUMAN	CDKN2C	physical	28514442
SNX27_HUMAN	SNX27	physical	28514442
INP5K_HUMAN	INPP5K	physical	28514442
GRPE1_HUMAN	GRPEL1	physical	28514442
OBSL1_HUMAN	OBSL1	physical	28514442
TYSY_HUMAN	TYMS	physical	28514442
ANK3_HUMAN	ANK3	physical	28514442
GTPB2_HUMAN	GTPBP2	physical	28514442
KC1G3_HUMAN	CSNK1G3	physical	28514442
BCAT1_HUMAN	BCAT1	physical	28514442
DHYS_HUMAN	DHPS	physical	28514442
GNPAT_HUMAN	GNPAT	physical	28514442
TYK2_HUMAN	TYK2	physical	28514442
CTU2_HUMAN	CTU2	physical	28514442
IPO4_HUMAN	IPO4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.