dbPTM

MTD2L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MTD2L_HUMAN
UniProt AC	Q9H903
Protein Name	Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
Gene Name	MTHFD2L
Organism	Homo sapiens (Human).
Sequence Length	347
Subcellular Localization	Mitochondrion inner membrane Peripheral membrane protein Matrix side.
Protein Description
Protein Sequence	MTVPVRGFSLLRGRLGRAPALGRSTAPSVRAPGEPGSAFRGFRSSGVRHEAIIISGTEMAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPKDVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVTGKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKKIIY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Acetylation	ISGTEMAKHIQKEIQ EECHHHHHHHHHHHH	39.67	25953088
65	Acetylation	EMAKHIQKEIQRGVE HHHHHHHHHHHHHHH	57.07	25953088
65	Ubiquitination	EMAKHIQKEIQRGVE HHHHHHHHHHHHHHH	57.07	-
73	Phosphorylation	EIQRGVESWVSLGNR HHHHHHHHHHHCCCC	30.30	26852163
76	Phosphorylation	RGVESWVSLGNRRPH HHHHHHHHCCCCCCC	25.05	26852163
201	Phosphorylation	VWEIIKRTGIQTFGK HHHHHHHHCCCCCCC	33.37	-
320	Phosphorylation	KKKAGFITPVPGGVG HHHCCEEECCCCCCC	18.90	-
330	Phosphorylation	PGGVGPMTVAMLLKN CCCCCHHHHHHHHHH	14.30	29396449
343	Acetylation	KNTLLAAKKIIY--- HHHHHHHHHHCC---	38.61	25953088
343	Succinylation	KNTLLAAKKIIY--- HHHHHHHHHHCC---	38.61	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MTD2L_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MTD2L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MTD2L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CYTS_HUMAN	CST4	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MTD2L_HUMAN

Related Literatures of Post-Translational Modification