KC1G3_HUMAN - dbPTM
KC1G3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KC1G3_HUMAN
UniProt AC Q9Y6M4
Protein Name Casein kinase I isoform gamma-3
Gene Name CSNK1G3
Organism Homo sapiens (Human).
Sequence Length 447
Subcellular Localization Cytoplasm.
Protein Description Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity)..
Protein Sequence MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETKCCCFFKRRKRKTIQRHK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MENKKKDK
-------CCCCCCCC		13.2922814378
11PhosphorylationKKKDKDKSDDRMARP
CCCCCCCCCCCCCCC		55.68-
29PhosphorylationSGHNTRGTGSSSSGV
CCCCCCCCCCCCCCE		30.5121955146
29 (in isoform 3)Phosphorylation-30.5118669648
31PhosphorylationHNTRGTGSSSSGVLM
CCCCCCCCCCCCEEE		27.2126055452
31 (in isoform 3)Phosphorylation-27.2118669648
32PhosphorylationNTRGTGSSSSGVLMV
CCCCCCCCCCCEEEE		29.8426055452
33PhosphorylationTRGTGSSSSGVLMVG
CCCCCCCCCCEEEEC		32.5830576142
34PhosphorylationRGTGSSSSGVLMVGP
CCCCCCCCCEEEECC		34.5626055452
34 (in isoform 3)Phosphorylation-34.5618669648
48UbiquitinationPNFRVGKKIGCGNFG
CCCCCCCEECCCCCC		38.1033845483
48 (in isoform 2)Ubiquitination-38.10-
48 (in isoform 2)Malonylation-38.1026320211
51UbiquitinationRVGKKIGCGNFGELR
CCCCEECCCCCCEEE		4.6024816145
61UbiquitinationFGELRLGKNLYTNEY
CCEEECCCCCCCCCE		48.66-
63UbiquitinationELRLGKNLYTNEYVA
EEECCCCCCCCCEEE		6.7733845483
64PhosphorylationLRLGKNLYTNEYVAI
EECCCCCCCCCEEEE		19.5328152594
65PhosphorylationRLGKNLYTNEYVAIK
ECCCCCCCCCEEEEE		25.4128152594
68PhosphorylationKNLYTNEYVAIKLEP
CCCCCCCEEEEEEEE		9.3928152594
78PhosphorylationIKLEPMKSRAPQLHL
EEEEECCCCCCCHHE		27.6728787133
85UbiquitinationSRAPQLHLEYRFYKQ
CCCCCHHEEHHHHHH		9.3432015554
87PhosphorylationAPQLHLEYRFYKQLG
CCCHHEEHHHHHHHC		16.6320071362
89UbiquitinationQLHLEYRFYKQLGSG
CHHEEHHHHHHHCCC		9.7624816145
90PhosphorylationLHLEYRFYKQLGSGD
HHEEHHHHHHHCCCC		6.7120071362
91MethylationHLEYRFYKQLGSGDG
HEEHHHHHHHCCCCC		36.01-
95PhosphorylationRFYKQLGSGDGIPQV
HHHHHHCCCCCCCEE		42.1623532336
101UbiquitinationGSGDGIPQVYYFGPC
CCCCCCCEEEEECCC		33.6433845483
103PhosphorylationGDGIPQVYYFGPCGK
CCCCCEEEEECCCHH		6.4523532336
123UbiquitinationLELLGPSLEDLFDLC
HHHHCCCHHHHHHHH		7.1732015554
140UbiquitinationTFSLKTVLMIAIQLI
CCCHHHHHHHHHHHH		2.1923000965
145UbiquitinationTVLMIAIQLISRMEY
HHHHHHHHHHHCCHH		24.5823000965
150UbiquitinationAIQLISRMEYVHSKN
HHHHHHCCHHHHHCC		3.3027667366
160PhosphorylationVHSKNLIYRDVKPEN
HHHCCEECCCCCCHH		12.15-
164UbiquitinationNLIYRDVKPENFLIG
CEECCCCCCHHEEEC		51.4024816145
176UbiquitinationLIGRPGNKTQQVIHI
EECCCCCCHHHEEEE		54.3433845483
178UbiquitinationGRPGNKTQQVIHIID
CCCCCCHHHEEEEEE		36.8323000965
183UbiquitinationKTQQVIHIIDFGLAK
CHHHEEEEEEECCCH		1.9123000965
188UbiquitinationIHIIDFGLAKEYIDP
EEEEEECCCHHHCCH		6.5927667366
189UbiquitinationHIIDFGLAKEYIDPE
EEEEECCCHHHCCHH		11.7424816145
192PhosphorylationDFGLAKEYIDPETKK
EECCCHHHCCHHHHC		15.21-
198UbiquitinationEYIDPETKKHIPYRE
HHCCHHHHCCCCCCC		40.4632015554
198 (in isoform 2)Ubiquitination-40.46-
201UbiquitinationDPETKKHIPYREHKS
CHHHHCCCCCCCCCC		4.3833845483
215PhosphorylationSLTGTARYMSINTHL
CCCCCCEEEEHHHHC		7.8629496907
223UbiquitinationMSINTHLGKEQSRRD
EEHHHHCCCCHHHHH		24.6932015554
248UbiquitinationYFLRGSLPWQGLKAD
HHHHCCCCCCCCCHH		24.0421963094
253UbiquitinationSLPWQGLKADTLKER
CCCCCCCCHHHHHHH		51.5523000965
253 (in isoform 6)Phosphorylation-51.5530266825
253 (in isoform 2)Ubiquitination-51.5521890473
253UbiquitinationSLPWQGLKADTLKER
CCCCCCCCHHHHHHH		51.5521890473
253UbiquitinationSLPWQGLKADTLKER
CCCCCCCCHHHHHHH		51.5521890473
253UbiquitinationSLPWQGLKADTLKER
CCCCCCCCHHHHHHH		51.5521890473
253 (in isoform 1)Ubiquitination-51.5521890473
253 (in isoform 3)Ubiquitination-51.5521890473
254 (in isoform 6)Phosphorylation-21.7730266825
255 (in isoform 6)Phosphorylation-51.4930266825
256PhosphorylationWQGLKADTLKERYQK
CCCCCHHHHHHHHHH		44.5917192257
258UbiquitinationGLKADTLKERYQKIG
CCCHHHHHHHHHHHC		42.0923000965
261PhosphorylationADTLKERYQKIGDTK
HHHHHHHHHHHCCCC		18.4322817900
261 (in isoform 6)Phosphorylation-18.4323663014
263UbiquitinationTLKERYQKIGDTKRA
HHHHHHHHHCCCCCC		39.4627667366
265 (in isoform 6)Phosphorylation-43.5030108239
269 (in isoform 6)Phosphorylation-45.8727732954
274 (in isoform 6)Phosphorylation-30.5527732954
277 (in isoform 6)Phosphorylation-4.9227732954
278UbiquitinationTPIEVLCENFPEMAT
CHHHHHHCCCHHHHH		58.7223000965
283UbiquitinationLCENFPEMATYLRYV
HHCCCHHHHHHHHHH		3.2523000965
285UbiquitinationENFPEMATYLRYVRR
CCCHHHHHHHHHHHH		23.0621963094
288UbiquitinationPEMATYLRYVRRLDF
HHHHHHHHHHHHHCH		19.9327667366
290 (in isoform 5)Phosphorylation-2.0230266825
291 (in isoform 5)Phosphorylation-25.2230266825
292 (in isoform 5)Phosphorylation-28.6830266825
298 (in isoform 5)Phosphorylation-37.7223663014
302 (in isoform 5)Phosphorylation-43.2930108239
306UbiquitinationPDYDYLRKLFTDLFD
CCHHHHHHHHHHHHC		45.41-
306 (in isoform 5)Phosphorylation-45.4127732954
306 (in isoform 2)Ubiquitination-45.41-
311 (in isoform 5)Phosphorylation-4.3427732954
314 (in isoform 5)Phosphorylation-27.2827732954
332PhosphorylationWIGKQLPTPVGAVQQ
CCCCCCCCCCCCCCC		38.9223312004
344PhosphorylationVQQDPALSSNREAHQ
CCCCCHHHCCHHHHH		27.8930266825
345PhosphorylationQQDPALSSNREAHQH
CCCCHHHCCHHHHHH		40.5330266825
360UbiquitinationRDKMQQSKNQSADHR
HHHHHHHHHHCHHHH		55.4521963094
361UbiquitinationDKMQQSKNQSADHRA
HHHHHHHHHCHHHHH		46.4121963094
361 (in isoform 3)Ubiquitination-46.4121890473
365 (in isoform 3)Phosphorylation-36.7330266825
366 (in isoform 3)Phosphorylation-22.4630266825
366 (in isoform 4)Phosphorylation-22.4630266825
367 (in isoform 3)Phosphorylation-26.9230266825
367 (in isoform 4)Phosphorylation-26.9230266825
368 (in isoform 4)Phosphorylation-14.9730266825
373 (in isoform 3)Phosphorylation-43.8823663014
374 (in isoform 4)Phosphorylation-47.2423663014
377 (in isoform 3)Phosphorylation-21.2030108239
378 (in isoform 4)Phosphorylation-32.2130108239
381 (in isoform 3)Phosphorylation-18.6627732954
382 (in isoform 4)Phosphorylation-14.3827732954
385UbiquitinationHHLRAHLAADRHGGS
HHHHHHHHHCCCCCE		9.4621963094
386UbiquitinationHLRAHLAADRHGGSV
HHHHHHHHCCCCCEE		22.2621963094
386 (in isoform 3)Phosphorylation-22.2627732954
387 (in isoform 4)Phosphorylation-37.1927732954
389 (in isoform 3)Phosphorylation-45.5827732954
390 (in isoform 4)Phosphorylation-30.8527732954
392PhosphorylationAADRHGGSVQVVSST
HHCCCCCEEEEEECC		17.61-
397PhosphorylationGGSVQVVSSTNGELN
CCEEEEEECCCCCCC		32.3718691976
398PhosphorylationGSVQVVSSTNGELNT
CEEEEEECCCCCCCC		17.8118691976
399PhosphorylationSVQVVSSTNGELNTD
EEEEEECCCCCCCCC		39.4718691976
399UbiquitinationSVQVVSSTNGELNTD
EEEEEECCCCCCCCC		39.4729901268
405PhosphorylationSTNGELNTDDPTAGR
CCCCCCCCCCCCCCC		55.1723090842
413PhosphorylationDDPTAGRSNAPITAP
CCCCCCCCCCCCCCC		36.1029255136
413 (in isoform 2)Phosphorylation-36.1027732954
418PhosphorylationGRSNAPITAPTEVEV
CCCCCCCCCCCEEEE		26.0629255136
418 (in isoform 2)Phosphorylation-26.0627732954
421PhosphorylationNAPITAPTEVEVMDE
CCCCCCCCEEEECCC		50.6429255136
421 (in isoform 2)Phosphorylation-50.6427732954
429PhosphorylationEVEVMDETKCCCFFK
EEEECCCCCEEEEEH		25.7222167270
430UbiquitinationVEVMDETKCCCFFKR
EEECCCCCEEEEEHH		24.1929901268
436UbiquitinationTKCCCFFKRRKRKTI
CCEEEEEHHHCCHHH		30.9229967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KC1G3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KC1G3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KC1G3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DBND2_HUMANDBNDD2physical
16618118
KC1G3_HUMANCSNK1G3physical
18082144
UBXN7_HUMANUBXN7physical
26389662
KC1G1_HUMANCSNK1G1physical
28514442
AN13D_HUMANANKRD13Dphysical
28514442
AN13A_HUMANANKRD13Aphysical
28514442
UBB_HUMANUBBphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KC1G3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-29; SER-32; THR-256;SER-344; SER-397; SER-398; THR-399 AND SER-413, AND MASS SPECTROMETRY.

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