KC1G1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KC1G1_HUMAN
• UniProt AC: Q9HCP0
• Protein Name: Casein kinase I isoform gamma-1
• Gene Name: CSNK1G1
• Organism: Homo sapiens (Human).
• Sequence Length: 422
• Subcellular Localization: Cytoplasm.
• Protein Description: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN..
• Protein Sequence: MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRPSQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQRHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	EKDERQRTTKPMAQR HHHHHHHCCCCHHHH	30.73	-
15	Phosphorylation	KDERQRTTKPMAQRS HHHHHHCCCCHHHHH	35.03	-
22	Phosphorylation	TKPMAQRSAHCSRPS CCCHHHHHHHCCCCC	15.41	27422710
26	Phosphorylation	AQRSAHCSRPSGSSS HHHHHHCCCCCCCCC	37.04	29449344
29	Phosphorylation	SAHCSRPSGSSSSSG HHHCCCCCCCCCCCC	50.63	27422710
31	Phosphorylation	HCSRPSGSSSSSGVL HCCCCCCCCCCCCEE	31.24	21712546
32	Phosphorylation	CSRPSGSSSSSGVLM CCCCCCCCCCCCEEE	37.45	29449344
33	Phosphorylation	SRPSGSSSSSGVLMV CCCCCCCCCCCEEEE	30.16	28555341
34	Phosphorylation	RPSGSSSSSGVLMVG CCCCCCCCCCEEEEC	32.81	29449344
35	Phosphorylation	PSGSSSSSGVLMVGP CCCCCCCCCEEEECC	34.56	29449344
49	Ubiquitination	PNFRVGKKIGCGNFG CCCCCCCEECCCCCC	38.10	-
62	Ubiquitination	FGELRLGKNLYTNEY CCEEECCCCCCCCCE	48.66	-
65	Phosphorylation	LRLGKNLYTNEYVAI EECCCCCCCCCEEEE	19.53	28152594
66	Phosphorylation	RLGKNLYTNEYVAIK ECCCCCCCCCEEEEE	25.41	28152594
69	Phosphorylation	KNLYTNEYVAIKLEP CCCCCCCEEEEEEEE	9.39	28152594
88	Phosphorylation	APQLHLEYRFYKQLG CCCHHHHHHHHHHHC	16.63	20071362
91	Phosphorylation	LHLEYRFYKQLGSAG HHHHHHHHHHHCCCC	6.71	20071362
96	Phosphorylation	RFYKQLGSAGEGLPQ HHHHHHCCCCCCCCE	41.51	-
135	Phosphorylation	LFDLCDRTFTLKTVL HHHHHCCCCHHHHHH	14.02	20068231
137	Phosphorylation	DLCDRTFTLKTVLMI HHHCCCCHHHHHHHH	27.08	-
140	Phosphorylation	DRTFTLKTVLMIAIQ CCCCHHHHHHHHHHH	23.22	-
162	Phosphorylation	VHSKNLIYRDVKPEN HHHCCEECCCCCHHH	12.15	-
166	Ubiquitination	NLIYRDVKPENFLIG CEECCCCCHHHEEEE	51.40	-
194	Phosphorylation	DFGLAKEYIDPETKK ECCCCHHHCCHHHHC	15.21	-
217	Phosphorylation	SLTGTARYMSINTHL CCCCCCEEEEHHHHC	7.86	29496907
255	Ubiquitination	SLPWQGLKADTLKER CCCCCCCCHHHHHHH	51.55	21890473
255 (in isoform 1)	Ubiquitination	-	51.55	21890473
255 (in isoform 2)	Ubiquitination	-	51.55	21890473
255	Ubiquitination	SLPWQGLKADTLKER CCCCCCCCHHHHHHH	51.55	-
258	Phosphorylation	WQGLKADTLKERYQK CCCCCHHHHHHHHHH	44.59	17192257
263	Phosphorylation	ADTLKERYQKIGDTK HHHHHHHHHHHCCCC	18.43	18083107
265	Ubiquitination	TLKERYQKIGDTKRN HHHHHHHHHCCCCCC	39.46	-
273	Phosphorylation	IGDTKRNTPIEALCE HCCCCCCCHHHHHHH	29.67	24114839
288	Phosphorylation	NFPEEMATYLRYVRR CCCHHHHHHHHHHHH	23.06	22210691
289	Phosphorylation	FPEEMATYLRYVRRL CCHHHHHHHHHHHHC	4.61	24114839
309	Phosphorylation	PDYEYLRTLFTDLFE CCHHHHHHHHHHHHH	24.51	-
317	Ubiquitination	LFTDLFEKKGYTFDY HHHHHHHHCCCEEEE	44.13	2190698
317 (in isoform 1)	Ubiquitination	-	44.13	21890473
317 (in isoform 2)	Ubiquitination	-	44.13	21890473
344	Phosphorylation	VGSVHVDSGASAITR CEEEEECCCCCEECC	34.86	17192257
347	Phosphorylation	VHVDSGASAITRESH EEECCCCCEECCCCC	24.59	18691976
361	Phosphorylation	HTHRDRPSQQQPLRN CCCCCCCHHCCCCHH	41.33	21082442
373	Phosphorylation	LRNQVVSSTNGELNV CHHHHHHCCCCCCCC	17.81	23663014
374	Phosphorylation	RNQVVSSTNGELNVD HHHHHHCCCCCCCCC	39.47	23663014
411	Ubiquitination	AKCCCFFKRKRKKTA HEEEEEEHHHCHHHH	36.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KC1G1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KC1G1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KC1G1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDCP_HUMAN	C2orf44	physical	21900206
IKZF1_HUMAN	IKZF1	physical	21900206
F219A_HUMAN	FAM219A	physical	21900206
MKRN1_HUMAN	MKRN1	physical	21900206
RUN3B_HUMAN	RUNDC3B	physical	21900206
A4_HUMAN	APP	physical	21832049
TRAF6_HUMAN	TRAF6	physical	24442433
TF65_HUMAN	RELA	physical	24442433
CEP76_HUMAN	CEP76	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KC1G2_HUMAN	CSNK1G2	physical	26186194
KC1G2_HUMAN	CSNK1G2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344 AND SER-361, ANDMASS SPECTROMETRY.
PubMed: 18691976