GTPB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GTPB2_HUMAN
• UniProt AC: Q9BX10
• Protein Name: GTP-binding protein 2
• Gene Name: GTPBP2 {ECO:0000312|EMBL:CAC36269.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 602
• Protein Sequence: MDSRVSELFGGCCRPGGGPAVGGTLKARGAGSSSGCGGPKGKKKNGRNRGGKANNPPYLPPEAEDGNIEYKLKLVNPSQYRFEHLVTQMKWRLQEGRGEAVYQIGVEDNGLLVGLAEEEMRASLKTLHRMAEKVGADITVLREREVDYDSDMPRKITEVLVRKVPDNQQFLDLRVAVLGNVDSGKSTLLGVLTQGELDNGRGRARLNLFRHLHEIQSGRTSSISFEILGFNSKGEVVNYSDSRTAEEICESSSKMITFIDLAGHHKYLHTTIFGLTSYCPDCALLLVSANTGIAGTTREHLGLALALKVPFFIVVSKIDLCAKTTVERTVRQLERVLKQPGCHKVPMLVTSEDDAVTAAQQFAQSPNVTPIFTLSSVSGESLDLLKVFLNILPPLTNSKEQEELMQQLTEFQVDEIYTVPEVGTVVGGTLSSGICREGDQLVVGPTDDGCFLELRVCSIQRNRSACRVLRAGQAATLALGDFDRALLRKGMVMVSPEMNPTICSVFEAEIVLLFHATTFRRGFQVTVHVGNVRQTAVVEKIHAKDKLRTGEKAVVRFRFLKHPEYLKVGAKLLFREGVTKGIGHVTDVQAITAGEAQANMGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	GGPAVGGTLKARGAG CCCCCCCEEEECCCC	21.11	29083192
26	Methylation	PAVGGTLKARGAGSS CCCCCEEEECCCCCC	35.56	-
26	Ubiquitination	PAVGGTLKARGAGSS CCCCCEEEECCCCCC	35.56	-
28	Methylation	VGGTLKARGAGSSSG CCCEEEECCCCCCCC	33.63	-
32	Phosphorylation	LKARGAGSSSGCGGP EEECCCCCCCCCCCC	22.31	23612710
33	Phosphorylation	KARGAGSSSGCGGPK EECCCCCCCCCCCCC	29.81	28102081
34	Phosphorylation	ARGAGSSSGCGGPKG ECCCCCCCCCCCCCC	39.54	28102081
40	Ubiquitination	SSGCGGPKGKKKNGR CCCCCCCCCCCCCCC	83.25	-
52	Ubiquitination	NGRNRGGKANNPPYL CCCCCCCCCCCCCCC	51.25	-
58	Phosphorylation	GKANNPPYLPPEAED CCCCCCCCCCCCCCC	32.85	-
71	Ubiquitination	EDGNIEYKLKLVNPS CCCCEEEEEEECCHH	26.76	-
125	Ubiquitination	EEMRASLKTLHRMAE HHHHHHHHHHHHHHH	46.69	-
126	Phosphorylation	EMRASLKTLHRMAEK HHHHHHHHHHHHHHH	32.84	28060719
133	Ubiquitination	TLHRMAEKVGADITV HHHHHHHHHCCCEEE	36.11	-
155	Ubiquitination	YDSDMPRKITEVLVR CCCCCCCEEEEEHHE	48.38	-
157	Phosphorylation	SDMPRKITEVLVRKV CCCCCEEEEEHHEEC	24.07	-
220	Phosphorylation	HEIQSGRTSSISFEI HHHHCCCCCEEEEEE	30.28	27251275
221	Phosphorylation	EIQSGRTSSISFEIL HHHCCCCCEEEEEEE	25.06	27251275
222	Phosphorylation	IQSGRTSSISFEILG HHCCCCCEEEEEEEE	22.95	27251275
224	Phosphorylation	SGRTSSISFEILGFN CCCCCEEEEEEEEEC	20.83	27251275
239	Phosphorylation	SKGEVVNYSDSRTAE CCCCEEECCCCCCHH	11.40	27642862
323	Ubiquitination	SKIDLCAKTTVERTV ECHHHHCHHHHHHHH	43.67	-
338	Ubiquitination	RQLERVLKQPGCHKV HHHHHHHCCCCCCCC	52.14	-
561	Ubiquitination	VVRFRFLKHPEYLKV EEEEEECCCHHHHHH	55.17	-
567	Ubiquitination	LKHPEYLKVGAKLLF CCCHHHHHHHHEEHH	37.41	-
571	Ubiquitination	EYLKVGAKLLFREGV HHHHHHHEEHHHCCC	39.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GTPB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GTPB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GTPB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
ANM5_HUMAN	PRMT5	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.