dbPTM

ARI1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARI1B_HUMAN
UniProt AC	Q8NFD5
Protein Name	AT-rich interactive domain-containing protein 1B
Gene Name	ARID1B
Organism	Homo sapiens (Human).
Sequence Length	2236
Subcellular Localization	Nucleus .
Protein Description	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically. [PubMed: 14982958]
Protein Sequence	MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAHNAGAAA ------CCCCHHHHH	18.88	19413330
15	Phosphorylation	AAAAGTHSAKSGGSE HHHHCCCHHCCCCCH	36.91	24719451
21	Phosphorylation	HSAKSGGSEAALKEG CHHCCCCCHHHHHCC	27.82	24719451
68	Acetylation	TGLLPNHKLKTVGEA CCCCCCCCCCCCCCC	59.32	25953088
181	Acetylation	PGPPLLSKPGDEDDA CCCCCCCCCCCCCCC	53.65	26051181
369	Phosphorylation	SAGYGVLSSPRQQGG CCCCCCCCCCCCCCC	35.57	17081983
370	Phosphorylation	AGYGVLSSPRQQGGG CCCCCCCCCCCCCCC	21.68	17081983
389	Phosphorylation	PGGGGAASLSKAAAG CCCCHHHHHHHHHHC	32.42	24425749
404	Methylation	SAAGGFQRFAGQNQH CCCCCHHHHCCCCCC	22.56	-
413	Phosphorylation	AGQNQHPSGATPTLN CCCCCCCCCCCCCHH	38.65	22199227
416	Phosphorylation	NQHPSGATPTLNQLL CCCCCCCCCCHHHHH	21.97	22199227
418	Phosphorylation	HPSGATPTLNQLLTS CCCCCCCCHHHHHHC	33.70	22199227
424	Phosphorylation	PTLNQLLTSPSPMMR CCHHHHHHCCCHHHH	47.38	22199227
425	Phosphorylation	TLNQLLTSPSPMMRS CHHHHHHCCCHHHHH	24.29	22199227
427	Phosphorylation	NQLLTSPSPMMRSYG HHHHHCCCHHHHHCC	25.79	22199227
483	Phosphorylation	GKDMGAQYAAASPAW CHHHHHHHHHHCHHH	9.55	21945579
487	Phosphorylation	GAQYAAASPAWAAAQ HHHHHHHCHHHHHHH	15.49	21945579
497	Phosphorylation	WAAAQQRSHPAMSPG HHHHHHHCCCCCCCC	29.50	23927012
502	Phosphorylation	QRSHPAMSPGTPGPT HHCCCCCCCCCCCCC	23.45	23401153
505	Phosphorylation	HPAMSPGTPGPTMGR CCCCCCCCCCCCCCC	28.58	30266825
509	Phosphorylation	SPGTPGPTMGRSQGS CCCCCCCCCCCCCCC	37.87	23927012
513	Phosphorylation	PGPTMGRSQGSPMDP CCCCCCCCCCCCCCC	32.91	28102081
516	Phosphorylation	TMGRSQGSPMDPMVM CCCCCCCCCCCCCHH	14.93	25159151
525	Dimethylation	MDPMVMKRPQLYGMG CCCCHHCCCCCCCCC	13.20	-
525	Methylation	MDPMVMKRPQLYGMG CCCCHHCCCCCCCCC	13.20	-
529	Phosphorylation	VMKRPQLYGMGSNPH HHCCCCCCCCCCCCC	10.38	24043423
533	Phosphorylation	PQLYGMGSNPHSQPQ CCCCCCCCCCCCCCC	37.99	24043423
537	Phosphorylation	GMGSNPHSQPQQSSP CCCCCCCCCCCCCCC	44.83	24043423
542	Phosphorylation	PHSQPQQSSPYPGGS CCCCCCCCCCCCCCC	28.21	24043423
543	Phosphorylation	HSQPQQSSPYPGGSY CCCCCCCCCCCCCCC	24.90	24043423
545	Phosphorylation	QPQQSSPYPGGSYGP CCCCCCCCCCCCCCC	19.23	24043423
549	Phosphorylation	SSPYPGGSYGPPGPQ CCCCCCCCCCCCCCC	32.60	24043423
550	Phosphorylation	SPYPGGSYGPPGPQR CCCCCCCCCCCCCCC	36.61	24043423
557	Asymmetric dimethylarginine	YGPPGPQRYPIGIQG CCCCCCCCCCCCCCC	42.18	-
557	Methylation	YGPPGPQRYPIGIQG CCCCCCCCCCCCCCC	42.18	24129315
558	Phosphorylation	GPPGPQRYPIGIQGR CCCCCCCCCCCCCCC	8.24	24043423
565	Dimethylation	YPIGIQGRTPGAMAG CCCCCCCCCCCCCCC	22.75	-
565	Methylation	YPIGIQGRTPGAMAG CCCCCCCCCCCCCCC	22.75	-
585	Phosphorylation	QQMPPQYGQQGVSGY HHCCCCCCCCCCCCC	14.21	32142685
588	Phosphorylation	PPQYGQQGVSGYCQQ CCCCCCCCCCCCCCC	13.99	32142685
632	Phosphorylation	YQPQQDMSQEGYGTR CCCCCCCCCCCCCCC	33.11	18077418
645	Phosphorylation	TRSQPPLAPGKPNHE CCCCCCCCCCCCCHH	19.30	18077418
663	Phosphorylation	LIQQERPSSLPDLSG HHHHHCCCCCCCCCC	51.21	26074081
664	Phosphorylation	IQQERPSSLPDLSGS HHHHCCCCCCCCCCC	46.75	26074081
677	Phosphorylation	GSIDDLPTGTEATLS CCHHCCCCCCHHHHH	65.12	-
738	Phosphorylation	VGSNQSRSGPISPAS CCCCCCCCCCCCCCC	54.92	23401153
742	Phosphorylation	QSRSGPISPASIPGS CCCCCCCCCCCCCCC	19.97	28464451
745	Phosphorylation	SGPISPASIPGSQMP CCCCCCCCCCCCCCC	32.47	30108239
749	Phosphorylation	SPASIPGSQMPPQPP CCCCCCCCCCCCCCC	20.25	26074081
758	Phosphorylation	MPPQPPGSQSESSSH CCCCCCCCCCCCCCC	35.99	26074081
760	Phosphorylation	PQPPGSQSESSSHPA CCCCCCCCCCCCCCC	40.94	26074081
762	Phosphorylation	PPGSQSESSSHPALS CCCCCCCCCCCCCCC	42.25	26074081
763	Phosphorylation	PGSQSESSSHPALSQ CCCCCCCCCCCCCCC	28.72	26074081
764	Phosphorylation	GSQSESSSHPALSQS CCCCCCCCCCCCCCC	42.65	26074081
769	Phosphorylation	SSSHPALSQSPMPQE CCCCCCCCCCCCCCC	30.62	26074081
771	Phosphorylation	SHPALSQSPMPQERG CCCCCCCCCCCCCCC	21.57	26074081
825	Phosphorylation	FQQSNSSGTYGPQMS CCCCCCCCCCCCCHH	23.83	32142685
838	Phosphorylation	MSQYGPQGNYSRPPA HHHCCCCCCCCCCCC	37.87	32142685
858	Phosphorylation	SASYSGPGPGMGISA CCCCCCCCCCCCCCC	34.61	32645325
862	Phosphorylation	SGPGPGMGISANNQM CCCCCCCCCCCCCCC	19.33	32142685
867	Phosphorylation	GMGISANNQMHGQGP CCCCCCCCCCCCCCC	40.02	33259812
888	Phosphorylation	VPLGRMPSAGMQNRP CCCCCCCCCCCCCCC	28.28	-
904	Phosphorylation	PGNMSSMTPSSPGMS CCCCCCCCCCCCCCC	23.20	22210691
906	Phosphorylation	NMSSMTPSSPGMSQQ CCCCCCCCCCCCCCC	39.74	27251275
907	Phosphorylation	MSSMTPSSPGMSQQG CCCCCCCCCCCCCCC	27.03	28348404
924	Phosphorylation	GMGPPMPTVNRKAQE CCCCCCCCCCHHHHH	24.94	22210691
943	Phosphorylation	VMQAAANSAQSRQGS HHHHHHHHHHHHCCC	23.98	28555341
946	Phosphorylation	AAANSAQSRQGSFPG HHHHHHHHHCCCCCC	26.70	-
1005	Phosphorylation	VGLADMMSPGESKLP HCCHHCCCCCCCCCC	24.10	26074081
1009	Phosphorylation	DMMSPGESKLPLPLK HCCCCCCCCCCCCCC	45.46	26074081
1016	Acetylation	SKLPLPLKADGKEEG CCCCCCCCCCCCCCC	42.36	25953088
1016	Sumoylation	SKLPLPLKADGKEEG CCCCCCCCCCCCCCC	42.36	17000644
1020	Acetylation	LPLKADGKEEGTPQP CCCCCCCCCCCCCCC	53.81	26051181
1024	Phosphorylation	ADGKEEGTPQPESKS CCCCCCCCCCCCCCC	23.25	29396449
1034	Phosphorylation	PESKSKKSSSSTTTG CCCCCCCCCCCCCCH	38.91	21060948
1036	Phosphorylation	SKSKKSSSSTTTGEK CCCCCCCCCCCCHHH	38.50	-
1037	Phosphorylation	KSKKSSSSTTTGEKI CCCCCCCCCCCHHHH	31.55	-
1040	Phosphorylation	KSSSSTTTGEKITKV CCCCCCCCHHHHHHH	43.35	-
1043	Acetylation	SSTTTGEKITKVYEL CCCCCHHHHHHHEEC	57.95	26051181
1048	Phosphorylation	GEKITKVYELGNEPE HHHHHHHEECCCCHH	13.64	30257219
1063	Phosphorylation	RKLWVDRYLTFMEER HHHHHHHHHHHHHHH	12.96	29691806
1065	Phosphorylation	LWVDRYLTFMEERGS HHHHHHHHHHHHHCC	16.41	29691806
1072	Phosphorylation	TFMEERGSPVSSLPA HHHHHHCCCCHHCCC	28.49	30266825
1075	Phosphorylation	EERGSPVSSLPAVGK HHHCCCCHHCCCCCC	29.55	27251275
1076	Phosphorylation	ERGSPVSSLPAVGKK HHCCCCHHCCCCCCC	38.31	29449344
1081 (in isoform 3)	Phosphorylation	-	34.08	28450419
1082	Acetylation	SSLPAVGKKPLDLFR HHCCCCCCCCHHHHH	44.62	25953088
1083 (in isoform 3)	Phosphorylation	-	44.90	23911959
1084 (in isoform 3)	Phosphorylation	-	34.29	28450419
1085	Phosphorylation	PAVGKKPLDLFRLYV CCCCCCCHHHHHHHH	14.18	-
1091	Phosphorylation	PLDLFRLYVCVKEIG CHHHHHHHHHHHHHC	6.37	-
1091 (in isoform 3)	Phosphorylation	-	6.37	-
1114	Phosphorylation	KKWRELATNLNVGTS HHHHHHHHHCCCCCC	53.52	20068231
1120	Phosphorylation	ATNLNVGTSSSAASS HHHCCCCCCHHHHHH	22.58	28787133
1121	Phosphorylation	TNLNVGTSSSAASSL HHCCCCCCHHHHHHH	19.16	20068231
1122	Phosphorylation	NLNVGTSSSAASSLK HCCCCCCHHHHHHHH	24.67	20068231
1123	Phosphorylation	LNVGTSSSAASSLKK CCCCCCHHHHHHHHH	27.85	20068231
1126	Phosphorylation	GTSSSAASSLKKQYI CCCHHHHHHHHHHHH	35.60	20068231
1127	Phosphorylation	TSSSAASSLKKQYIQ CCHHHHHHHHHHHHH	39.21	20068231
1169	Phosphorylation	QPKLQPPSPANSGSL CCCCCCCCCCCCCCC	43.24	26074081
1173	Phosphorylation	QPPSPANSGSLQGPQ CCCCCCCCCCCCCCC	31.68	26074081
1175	Phosphorylation	PSPANSGSLQGPQTP CCCCCCCCCCCCCCC	19.83	26074081
1181	Phosphorylation	GSLQGPQTPQSTGSN CCCCCCCCCCCCCCC	26.82	26074081
1182	Phosphorylation	SLQGPQTPQSTGSNS CCCCCCCCCCCCCCC	22.37	-
1184	Phosphorylation	QGPQTPQSTGSNSMA CCCCCCCCCCCCCCC	35.62	27251275
1185	Phosphorylation	GPQTPQSTGSNSMAE CCCCCCCCCCCCCCC	39.11	27251275
1189	Phosphorylation	PQSTGSNSMAEVPGD CCCCCCCCCCCCCCC	22.52	20068231
1197	Ubiquitination	MAEVPGDLKPPTPAS CCCCCCCCCCCCCCC	12.74	21890473
1201	Phosphorylation	PGDLKPPTPASTPHG CCCCCCCCCCCCCCC	39.76	22210691
1211	Phosphorylation	STPHGQMTPMQGGRS CCCCCCCCCCCCCCC	14.02	-
1218	Phosphorylation	TPMQGGRSSTISVHD CCCCCCCCCEEEECC	34.80	23401153
1219	Phosphorylation	PMQGGRSSTISVHDP CCCCCCCCEEEECCC	28.53	20068231
1220	Phosphorylation	MQGGRSSTISVHDPF CCCCCCCEEEECCCC	20.65	20068231
1222	Phosphorylation	GGRSSTISVHDPFSD CCCCCEEEECCCCCC	17.31	20068231
1228	Phosphorylation	ISVHDPFSDVSDSSF EEECCCCCCCCCCCC	42.35	27080861
1231	Phosphorylation	HDPFSDVSDSSFPKR CCCCCCCCCCCCCCC	36.44	27080861
1233	Phosphorylation	PFSDVSDSSFPKRNS CCCCCCCCCCCCCCC	26.77	27080861
1234	Phosphorylation	FSDVSDSSFPKRNSM CCCCCCCCCCCCCCC	51.03	27080861
1240	Phosphorylation	SSFPKRNSMTPNAPY CCCCCCCCCCCCCCC	28.24	25159151
1241	Phosphorylation	SFPKRNSMTPNAPYQ CCCCCCCCCCCCCCC	9.13	20068231
1242	Phosphorylation	FPKRNSMTPNAPYQQ CCCCCCCCCCCCCCC	17.14	25159151
1247	Phosphorylation	SMTPNAPYQQGMSMP CCCCCCCCCCCCCCC	15.85	28450419
1252	Phosphorylation	APYQQGMSMPDVMGR CCCCCCCCCCCCCCC	33.71	27080861
1253	Phosphorylation	PYQQGMSMPDVMGRM CCCCCCCCCCCCCCC	2.14	20068231
1255	Phosphorylation	QQGMSMPDVMGRMPY CCCCCCCCCCCCCCC	34.10	20068231
1259	Methylation	SMPDVMGRMPYEPNK CCCCCCCCCCCCCCC	12.57	-
1272	Methylation	NKDPFGGMRKVPGSS CCCCCCCCCCCCCCC	3.71	-
1287	Ubiquitination	EPFMTQGQMPNSSMQ CCCCCCCCCCCCHHH	34.05	21890473
1340	Phosphorylation	YPGQGPPSGQPPYGG CCCCCCCCCCCCCCC	53.87	28555341
1360	Methylation	YPQQPNYKRHMDGMY CCCCCCCCCCCCCCC	42.33	-
1361	Methylation	PQQPNYKRHMDGMYG CCCCCCCCCCCCCCC	21.72	-
1367	Phosphorylation	KRHMDGMYGPPAKRH CCCCCCCCCCCCCCC	31.82	-
1373	Methylation	MYGPPAKRHEGDMYN CCCCCCCCCCCCCCC	34.88	-
1374	Methylation	YGPPAKRHEGDMYNM CCCCCCCCCCCCCCC	42.56	-
1379	Phosphorylation	KRHEGDMYNMQYSSQ CCCCCCCCCCCCHHH	16.54	24043423
1383	Phosphorylation	GDMYNMQYSSQQQEM CCCCCCCCHHHHHHH	10.26	24043423
1384	Phosphorylation	DMYNMQYSSQQQEMY CCCCCCCHHHHHHHH	12.55	24043423
1385	Phosphorylation	MYNMQYSSQQQEMYN CCCCCCHHHHHHHHH	27.37	24043423
1391	Phosphorylation	SSQQQEMYNQYGGSY HHHHHHHHHHCCCCC	9.81	24043423
1394	Phosphorylation	QQEMYNQYGGSYSGP HHHHHHHCCCCCCCC	21.59	24043423
1397	Phosphorylation	MYNQYGGSYSGPDRR HHHHCCCCCCCCCCC	16.26	24043423
1398	Phosphorylation	YNQYGGSYSGPDRRP HHHCCCCCCCCCCCC	22.41	24043423
1399	Phosphorylation	NQYGGSYSGPDRRPI HHCCCCCCCCCCCCC	45.61	24043423
1400	Ubiquitination	QYGGSYSGPDRRPIQ HCCCCCCCCCCCCCC	21.64	21890473
1415	Phosphorylation	GQYPYPYSRERMQGP CCCCCCCCCCCCCCC	24.14	25003641
1472	Phosphorylation	RQGPGGPTQAPPYPG CCCCCCCCCCCCCCC	40.41	28787133
1490	Ubiquitination	TDDMMVPDQRINHES CCCCCCCCCCCCCHH	38.69	21890473
1497	Phosphorylation	DQRINHESQWPSHVS CCCCCCHHHCCCCHH	29.96	19664995
1501	Phosphorylation	NHESQWPSHVSQRQP CCHHHCCCCHHHCCC	33.30	20068231
1509	Phosphorylation	HVSQRQPYMSSSASM CHHHCCCCCCCCCCC	10.99	24043423
1511	Phosphorylation	SQRQPYMSSSASMQP HHCCCCCCCCCCCCC	18.46	24043423
1512	Phosphorylation	QRQPYMSSSASMQPI HCCCCCCCCCCCCCC	17.25	24043423
1542	Phosphorylation	NHISRAPSPASFQRS CCHHCCCCHHHHHHH	31.92	23401153
1545	Phosphorylation	SRAPSPASFQRSLEN HCCCCHHHHHHHHHH	25.87	30266825
1549	Phosphorylation	SPASFQRSLENRMSP CHHHHHHHHHHCCCC	29.29	22199227
1553	Methylation	FQRSLENRMSPSKSP HHHHHHHCCCCCCCC	19.99	-
1555	Phosphorylation	RSLENRMSPSKSPFL HHHHHCCCCCCCCCC	23.84	25159151
1557	Phosphorylation	LENRMSPSKSPFLPS HHHCCCCCCCCCCCC	38.16	30266825
1559	Phosphorylation	NRMSPSKSPFLPSMK HCCCCCCCCCCCCCC	25.81	30266825
1562	Phosphorylation	SPSKSPFLPSMKMQK CCCCCCCCCCCCEEE	3.31	-
1564	Phosphorylation	SKSPFLPSMKMQKVM CCCCCCCCCCEEECC	32.93	23927012
1566	Acetylation	SPFLPSMKMQKVMPT CCCCCCCCEEECCCC	42.38	25953088
1566	Methylation	SPFLPSMKMQKVMPT CCCCCCCCEEECCCC	42.38	-
1568	Phosphorylation	FLPSMKMQKVMPTVP CCCCCCEEECCCCCC	29.67	32645325
1569	Acetylation	LPSMKMQKVMPTVPT CCCCCEEECCCCCCH	36.68	26051181
1570	Phosphorylation	PSMKMQKVMPTVPTS CCCCEEECCCCCCHH	2.90	-
1572	Phosphorylation	MKMQKVMPTVPTSQV CCEEECCCCCCHHHC	32.98	20068231
1573	Phosphorylation	KMQKVMPTVPTSQVT CEEECCCCCCHHHCC	22.48	23879269
1577	O-linked_Glycosylation	VMPTVPTSQVTGPPP CCCCCCHHHCCCCCC	19.31	20305658
1577	Phosphorylation	VMPTVPTSQVTGPPP CCCCCCHHHCCCCCC	19.31	-
1579	Acetylation	PTVPTSQVTGPPPQP CCCCHHHCCCCCCCC	7.18	19608861
1616	Acetylation	QRRKITSKDIVTPEA HCCCCCCCCCCCHHH	42.71	23749302
1629	Acetylation	EAWRVMMSLKSGLLA HHHHHHHHHHCCHHH	17.98	-
1638	Phosphorylation	KSGLLAESTWALDTI HCCHHHCCCCCCCCE	24.52	32645325
1651	Phosphorylation	TINILLYDDSTVATF CEEEEEECCCCEEEE	43.27	32645325
1655	Phosphorylation	LLYDDSTVATFNLSQ EEECCCCEEEEEHHH	5.67	32142685
1660	Phosphorylation	STVATFNLSQLSGFL CCEEEEEHHHHHHHH	2.78	33259812
1691	Phosphorylation	ILMEYEVGDPSQKAL HHHHCCCCCHHHHHH	29.22	32645325
1695	Phosphorylation	YEVGDPSQKALDHNA CCCCCHHHHHHCCCC	40.19	32142685
1700	Phosphorylation	PSQKALDHNAARKDD HHHHHHCCCCCCCCC	27.03	33259812
1710	Phosphorylation	ARKDDSQSLADDSGK CCCCCCCCCCCCCCC	29.49	30576142
1715	Phosphorylation	SQSLADDSGKEEEDA CCCCCCCCCCCHHHH	52.92	21815630
1728	Phosphorylation	DAECIDDDEEDEEDE HHHCCCCCCCCCCCH	58.39	19651622
1739	Phosphorylation	EEDEEEDSEKTESDE CCCHHHHHHHCCCHH	44.25	30576142
1742	Phosphorylation	EEEDSEKTESDEKSS HHHHHHHCCCHHHHC	36.35	23312004
1744	Phosphorylation	EDSEKTESDEKSSIA HHHHHCCCHHHHCEE	57.19	23312004
1748	Phosphorylation	KTESDEKSSIALTAP HCCCHHHHCEEEECC	25.57	30266825
1749	Phosphorylation	TESDEKSSIALTAPD CCCHHHHCEEEECCC	23.97	30266825
1753	Phosphorylation	EKSSIALTAPDAAAD HHHCEEEECCCHHCC	27.42	29255136
1770	Acetylation	EKPKQASKFDKLPIK CCCCCCCCCCCCCEE	61.67	25953088
1773	Acetylation	KQASKFDKLPIKIVK CCCCCCCCCCEEEEE	60.33	26051181
1777	Acetylation	KFDKLPIKIVKKNNL CCCCCCEEEEEECCE	39.24	19608861
1777	Ubiquitination	KFDKLPIKIVKKNNL CCCCCCEEEEEECCE	39.24	29967540
1780	Acetylation	KLPIKIVKKNNLFVV CCCEEEEEECCEEEE	53.94	7678637
1790	Acetylation	NLFVVDRSDKLGRVQ CEEEEECCCCCCCCE	34.33	19608861
1790	Ubiquitination	NLFVVDRSDKLGRVQ CEEEEECCCCCCCCE	34.33	19608861
1830	Ubiquitination	SKMEIPPRRRPPPPL HCCCCCCCCCCCCCC	41.72	29967540
1830 (in isoform 3)	Ubiquitination	-	41.72	-
1838	Phosphorylation	RRPPPPLSSAGRKKE CCCCCCCCCCCCCHH	24.74	23898821
1839	Phosphorylation	RPPPPLSSAGRKKEQ CCCCCCCCCCCCHHC	42.28	23898821
1858	Acetylation	DSEEQQEKSIIATID CCHHHHHHHHEEHHH	42.49	7675419
1859	O-linked_Glycosylation	SEEQQEKSIIATIDD CHHHHHHHHEEHHHH	20.62	20305658
1859	Phosphorylation	SEEQQEKSIIATIDD CHHHHHHHHEEHHHH	20.62	27732954
1863	O-linked_Glycosylation	QEKSIIATIDDVLSA HHHHHEEHHHHHHHC	17.96	20305658
1863	Phosphorylation	QEKSIIATIDDVLSA HHHHHEEHHHHHHHC	17.96	29449344
1869	Phosphorylation	ATIDDVLSARPGALP EHHHHHHHCCCCCCC	23.29	25022875
1887	Phosphorylation	NPGPQTESSKFPFGI CCCCCCCCCCCCCCH	42.06	-
1898	Acetylation	PFGIQQAKSHRNIKL CCCHHHHHHHCCCCC	42.32	25953088
1904	Acetylation	AKSHRNIKLLEDEPR HHHHCCCCCCCCCCC	51.04	25953088
1904	Ubiquitination	AKSHRNIKLLEDEPR HHHHCCCCCCCCCCC	51.04	29967540
1912	Phosphorylation	LLEDEPRSRDETPLC CCCCCCCCCCCCCCH	55.59	23898821
1917	Ubiquitination	PRSRDETPLCTIAHW CCCCCCCCCHHHHHH	24.32	29967540
1941	Phosphorylation	CVSNIVRSLSFVPGN HHHHHHHHHCCCCCC	19.92	-
1943	Phosphorylation	SNIVRSLSFVPGNDA HHHHHHHCCCCCCHH	25.99	-
1953	Phosphorylation	PGNDAEMSKHPGLVL CCCHHHHHCCHHHEE	21.22	-
1957	Ubiquitination	AEMSKHPGLVLILGK HHHHCCHHHEEHHHH	28.30	29967540
2011	Phosphorylation	LEVLRDNTLVTLANI HHHHCCCCEEEEEEC	27.22	-
2028	Phosphorylation	QLDLSAYTESICLPI CCCHHHHCHHHHHHH	23.99	-
2064	Phosphorylation	VGPNSVLSPQRLVLE CCCCCCCCHHHHHHH	19.48	24719451
2072	Phosphorylation	PQRLVLETLCKLSIQ HHHHHHHHHHHCCCC	33.04	-
2097	Ubiquitination	PPFSRQEKFYATLVR CCCCHHHHHHHHHHH	35.02	23000965
2097 (in isoform 1)	Ubiquitination	-	35.02	21890473
2110	Ubiquitination	VRYVGDRKNPVCREM HHHHCCCCCHHHHHH	71.05	21890473
2110 (in isoform 2)	Ubiquitination	-	71.05	21890473
2117	Ubiquitination	KNPVCREMSMALLSN CCHHHHHHHHHHHHH	1.39	21890473
2118	Phosphorylation	NPVCREMSMALLSNL CHHHHHHHHHHHHHH	8.99	23612710
2124	Ubiquitination	MSMALLSNLAQGDAL HHHHHHHHHHHHHHH	39.09	21890473
2150	Ubiquitination	IGNLISFLEDGVTMA HHHHHHHHHCCCCHH	4.72	21890473
2150 (in isoform 3)	Ubiquitination	-	4.72	21890473
2167	Ubiquitination	QQSQHNLMHMQPPPL HHHHHCCCCCCCCCC	2.76	21890473
2177	Ubiquitination	QPPPLEPPSVDMMCR CCCCCCCCCHHHHHH	37.29	21890473
2187	Ubiquitination	DMMCRAAKALLAMAR HHHHHHHHHHHHHHC	38.28	23000965
2187 (in isoform 1)	Ubiquitination	-	38.28	21890473
2200	Phosphorylation	ARVDENRSEFLLHEG HCCCCCHHHHEEECC	44.26	23403867
2200	Ubiquitination	ARVDENRSEFLLHEG HCCCCCHHHHEEECC	44.26	21890473
2200 (in isoform 2)	Ubiquitination	-	44.26	21890473
2207	Ubiquitination	SEFLLHEGRLLDISI HHHEEECCCHHHHHH	18.13	21890473
2214	Ubiquitination	GRLLDISISAVLNSL CCHHHHHHHHHHHHH	2.91	21890473
2220	Ubiquitination	SISAVLNSLVASVIC HHHHHHHHHHHHHHH	21.76	21890473
2240	Ubiquitination	IGQL----------- HCCC-----------		21890473
2240 (in isoform 3)	Ubiquitination	-		21890473
2257	Ubiquitination	---------------------------- ----------------------------		21890473
2267	Ubiquitination	-------------------------------------- --------------------------------------		21890473
2277	Ubiquitination	------------------------------------------------ ------------------------------------------------		21890473
2310	Ubiquitination	--------------------------------------------------------------------------------- ---------------------------------------------------------------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ARID1B	Q8NFD5	PMID:20086098

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARI1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARI1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMCA4_HUMAN	SMARCA4	physical	11988099
SMCA2_HUMAN	SMARCA2	physical	12200431
SMCA4_HUMAN	SMARCA4	physical	12200431
CUL2_HUMAN	CUL2	physical	20086098
SMRC2_HUMAN	SMARCC2	physical	20086098
SMRC1_HUMAN	SMARCC1	physical	20086098
SMCA4_HUMAN	SMARCA4	physical	20086098
H2B2E_HUMAN	HIST2H2BE	physical	20086098
ELOC_HUMAN	TCEB1	physical	20086098
RBX1_HUMAN	RBX1	physical	20086098
ARI1A_HUMAN	ARID1A	physical	15170388
SMCA4_HUMAN	SMARCA4	physical	15170388
SMCA1_HUMAN	SMARCA1	physical	21118156
SMCA4_HUMAN	SMARCA4	physical	21118156
SMRC2_HUMAN	SMARCC2	physical	21118156
SMRC1_HUMAN	SMARCC1	physical	21118156
SMRD1_HUMAN	SMARCD1	physical	21118156
ANM5_HUMAN	PRMT5	physical	21118156
SMCA2_HUMAN	SMARCA2	physical	22939629
SMCA4_HUMAN	SMARCA4	physical	22939629
SMRC1_HUMAN	SMARCC1	physical	22939629
SNF5_HUMAN	SMARCB1	physical	22939629
SMRC2_HUMAN	SMARCC2	physical	22939629
SMRD1_HUMAN	SMARCD1	physical	22939629
SMCE1_HUMAN	SMARCE1	physical	22939629
ARI1A_HUMAN	ARID1A	physical	26344197
BCL7A_HUMAN	BCL7A	physical	26344197
BCL7B_HUMAN	BCL7B	physical	26344197
BCL7C_HUMAN	BCL7C	physical	26344197
SMCA2_HUMAN	SMARCA2	physical	26344197
SMCA4_HUMAN	SMARCA4	physical	26344197
SMCE1_HUMAN	SMARCE1	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614562	Mental retardation, autosomal dominant 12 (MRD12)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARI1B_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1566 AND LYS-1777, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-516; SER-1555 ANDSER-1559, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1555, AND MASSSPECTROMETRY.	19690332 [Abstract]