dbPTM

BCL7C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BCL7C_HUMAN
UniProt AC	Q8WUZ0
Protein Name	B-cell CLL/lymphoma 7 protein family member C
Gene Name	BCL7C
Organism	Homo sapiens (Human).
Sequence Length	217
Subcellular Localization
Protein Description	May play an anti-apoptotic role..
Protein Sequence	MAGRTVRAETRSRAKDDIKKVMATIEKVRRWEKRWVTVGDTSLRIFKWVPVVDPQEEERRRAGGGAERSRGRERRGRGASPRGGGPLILLDLNDENSNQSFHSEGSLQKGTEPSPGGTPQPSRPVSPAGPPEGVPEEAQPPRLGQERDPGGITAGSTDEPPMLTKEEPVPELLEAEAPEAYPVFEPVPPVPEAAQGDTEDSEGAPPLKRICPNAPDP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	RWVTVGDTSLRIFKW CEEEECCCEEEEEEE	24.59	-
69	Phosphorylation	AGGGAERSRGRERRG CCCCCHHHHCCCCCC	30.50	-
80	Phosphorylation	ERRGRGASPRGGGPL CCCCCCCCCCCCCCE	20.25	23090842
82	Methylation	RGRGASPRGGGPLIL CCCCCCCCCCCCEEE	54.62	-
97	Phosphorylation	LDLNDENSNQSFHSE EECCCCCCCCCCCCC	33.91	23401153
100	Phosphorylation	NDENSNQSFHSEGSL CCCCCCCCCCCCCCC	29.22	30278072
103	Phosphorylation	NSNQSFHSEGSLQKG CCCCCCCCCCCCCCC	41.46	30278072
106	Phosphorylation	QSFHSEGSLQKGTEP CCCCCCCCCCCCCCC	24.47	21712546
111	Phosphorylation	EGSLQKGTEPSPGGT CCCCCCCCCCCCCCC	52.32	29255136
114	Phosphorylation	LQKGTEPSPGGTPQP CCCCCCCCCCCCCCC	29.91	29255136
118	Phosphorylation	TEPSPGGTPQPSRPV CCCCCCCCCCCCCCC	25.35	29255136
122	Phosphorylation	PGGTPQPSRPVSPAG CCCCCCCCCCCCCCC	43.92	29255136
126	Phosphorylation	PQPSRPVSPAGPPEG CCCCCCCCCCCCCCC	16.24	29255136
153	Phosphorylation	ERDPGGITAGSTDEP CCCCCCCCCCCCCCC	28.39	23663014
156	Phosphorylation	PGGITAGSTDEPPML CCCCCCCCCCCCCCC	30.16	23401153
157	Phosphorylation	GGITAGSTDEPPMLT CCCCCCCCCCCCCCC	43.39	30266825
162	Sulfoxidation	GSTDEPPMLTKEEPV CCCCCCCCCCCCCCC	12.42	21406390
164	Phosphorylation	TDEPPMLTKEEPVPE CCCCCCCCCCCCCHH	30.11	30266825
198	Phosphorylation	PEAAQGDTEDSEGAP CHHHCCCCCCCCCCC	48.82	27251275
201	Phosphorylation	AQGDTEDSEGAPPLK HCCCCCCCCCCCCHH	31.53	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BCL7C_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BCL7C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BCL7C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARI1A_HUMAN	ARID1A	physical	18809673
ARID2_HUMAN	ARID2	physical	18809673
SMCA4_HUMAN	SMARCA4	physical	18809673
SMRC1_HUMAN	SMARCC1	physical	18809673
BRD7_HUMAN	BRD7	physical	18809673
SMRD1_HUMAN	SMARCD1	physical	18809673
SMCE1_HUMAN	SMARCE1	physical	18809673
REQU_HUMAN	DPF2	physical	18809673
ACL6A_HUMAN	ACTL6A	physical	18809673
SNF5_HUMAN	SMARCB1	physical	18809673
ACTB_HUMAN	ACTB	physical	18809673
A4_HUMAN	APP	physical	21832049
ARI1A_HUMAN	ARID1A	physical	26344197
REQU_HUMAN	DPF2	physical	26344197
SMCA4_HUMAN	SMARCA4	physical	26344197
SNF5_HUMAN	SMARCB1	physical	26344197
SMRC1_HUMAN	SMARCC1	physical	26344197
SMRC2_HUMAN	SMARCC2	physical	26344197
SMRD2_HUMAN	SMARCD2	physical	26344197
SSXT_HUMAN	SS18	physical	26344197
DPF3_HUMAN	DPF3	physical	28514442
PHAR2_HUMAN	PHACTR2	physical	28514442
BRD7_HUMAN	BRD7	physical	28514442
BRD9_HUMAN	BRD9	physical	28514442
PHAR4_HUMAN	PHACTR4	physical	28514442
BICRA_HUMAN	GLTSCR1	physical	28514442
SMRC2_HUMAN	SMARCC2	physical	28514442
BICRL_HUMAN	GLTSCR1L	physical	28514442
SMRD1_HUMAN	SMARCD1	physical	28514442
INO80_HUMAN	INO80	physical	28514442
SPIR1_HUMAN	SPIRE1	physical	28514442
ARI1B_HUMAN	ARID1B	physical	28514442
PB1_HUMAN	PBRM1	physical	28514442
ARID2_HUMAN	ARID2	physical	28514442
CIZ1_HUMAN	CIZ1	physical	28514442
SMRD3_HUMAN	SMARCD3	physical	28514442
DPF1_HUMAN	DPF1	physical	28514442
REQU_HUMAN	DPF2	physical	28514442
SMCA2_HUMAN	SMARCA2	physical	28514442
SMRD2_HUMAN	SMARCD2	physical	28514442
IN80C_HUMAN	INO80C	physical	28514442
ADSV_HUMAN	SCIN	physical	28514442
IN80B_HUMAN	INO80B	physical	28514442
GELS_HUMAN	GSN	physical	28514442
SMCA4_HUMAN	SMARCA4	physical	28514442
BCL7B_HUMAN	BCL7B	physical	28514442
PHF10_HUMAN	PHF10	physical	28514442
ARP5_HUMAN	ACTR5	physical	28514442
NFRKB_HUMAN	NFRKB	physical	28514442
ARP8_HUMAN	ACTR8	physical	28514442
SMCE1_HUMAN	SMARCE1	physical	28514442
SNF5_HUMAN	SMARCB1	physical	28514442
CAP2_HUMAN	CAP2	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
SMRC1_HUMAN	SMARCC1	physical	28514442
ARI1A_HUMAN	ARID1A	physical	28514442
ACL6B_HUMAN	ACTL6B	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442
MYO1B_HUMAN	MYO1B	physical	28514442
CAP1_HUMAN	CAP1	physical	28514442
SSXT_HUMAN	SS18	physical	28514442
TWF2_HUMAN	TWF2	physical	28514442
INT14_HUMAN	VWA9	physical	28514442
LIMA1_HUMAN	LIMA1	physical	28514442
WDR54_HUMAN	WDR54	physical	28514442
ACL6A_HUMAN	ACTL6A	physical	28514442
S11IP_HUMAN	STK11IP	physical	28514442
TWF1_HUMAN	TWF1	physical	28514442
ARP10_HUMAN	ACTR10	physical	28514442
FBX30_HUMAN	FBXO30	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BCL7C_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97; SER-100; THR-111;THR-118; SER-122 AND SER-126, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-111; SER-114; THR-118AND SER-126, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-111; SER-114; THR-118AND SER-126, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-111; SER-114; SER-122AND SER-126, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97; SER-100; SER-103 ANDSER-106, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-118; SER-126 ANDSER-156, AND MASS SPECTROMETRY.	15302935 [Abstract]