| UniProt ID | DPF1_HUMAN | |
|---|---|---|
| UniProt AC | Q92782 | |
| Protein Name | Zinc finger protein neuro-d4 | |
| Gene Name | DPF1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 380 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).. | |
| Protein Sequence | MGGLSARPTAGRTDPAGTCWGQDPGSKMATVIPGPLSLGEDFYREAIEHCRSYNARLCAERSLRLPFLDSQTGVAQNNCYIWMEKTHRGPGLAPGQIYTYPARCWRKKRRLNILEDPRLRPCEYKIDCEAPLKKEGGLPEGPVLEALLCAETGEKKIELKEEETIMDCQKQQLLEFPHDLEVEDLEDDIPRRKNRAKGKAYGIGGLRKRQDTASLEDRDKPYVCDKFYKELAWVPEAQRKHTAKKAPDGTVIPNGYCDFCLGGSKKTGCPEDLISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECKSCSLCGTSENDGASWAGLTPQDQLLFCDDCDRGYHMYCLSPPMAEPPEGSWSCHLCLRHLKEKASAYITLT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 62 | Phosphorylation | ARLCAERSLRLPFLD HHHHHHHHCCCCCCC | 14.89 | - | |
| 70 | Phosphorylation | LRLPFLDSQTGVAQN CCCCCCCCCCCCEEC | 31.61 | - | |
| 72 | Phosphorylation | LPFLDSQTGVAQNNC CCCCCCCCCCEECCE | 37.26 | - | |
| 133 | Sumoylation | IDCEAPLKKEGGLPE EECCCCCCCCCCCCC | 47.95 | - | |
| 133 | Sumoylation | IDCEAPLKKEGGLPE EECCCCCCCCCCCCC | 47.95 | 28112733 | |
| 155 | Acetylation | LCAETGEKKIELKEE HHCCCCCCEEEECCC | 61.47 | 30588295 | |
| 156 | Sumoylation | CAETGEKKIELKEEE HCCCCCCEEEECCCE | 36.79 | 28112733 | |
| 156 (in isoform 3) | Phosphorylation | - | 36.79 | 27732954 | |
| 157 (in isoform 3) | Phosphorylation | - | 12.73 | 27732954 | |
| 159 (in isoform 3) | Phosphorylation | - | 10.88 | 27732954 | |
| 160 | Sumoylation | GEKKIELKEEETIMD CCCEEEECCCEEHHH | 50.74 | 28112733 | |
| 160 (in isoform 3) | Phosphorylation | - | 50.74 | 27732954 | |
| 162 (in isoform 3) | Phosphorylation | - | 59.87 | 27732954 | |
| 208 | Acetylation | YGIGGLRKRQDTASL CCCCCCHHCCCCCCC | 60.50 | 20167786 | |
| 238 (in isoform 2) | Phosphorylation | - | 53.98 | 27732954 | |
| 239 (in isoform 2) | Phosphorylation | - | 39.51 | 27732954 | |
| 241 (in isoform 2) | Phosphorylation | - | 32.99 | 27732954 | |
| 242 (in isoform 2) | Phosphorylation | - | 43.11 | 27732954 | |
| 242 | Phosphorylation | PEAQRKHTAKKAPDG HHHHHHCCCCCCCCC | 43.11 | 24719451 | |
| 244 (in isoform 2) | Phosphorylation | - | 51.10 | 27732954 | |
| 267 | Phosphorylation | CLGGSKKTGCPEDLI ECCCCCCCCCCHHHH | 47.99 | 22210691 | |
| 286 | Phosphorylation | CGRSGHPSCLQFTVN CCCCCCCCCEEEEEC | 23.06 | 24719451 | |
| 374 | O-linked_Glycosylation | RHLKEKASAYITLT- HHHHHHHEEEEECC- | 32.45 | 30379171 | |
| 380 | O-linked_Glycosylation | ASAYITLT------- HEEEEECC------- | 28.10 | 30379171 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DPF1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DPF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DPF1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SMCA2_HUMAN | SMARCA2 | physical | 22334708 | |
| SMCA4_HUMAN | SMARCA4 | physical | 22334708 | |
| SMRC1_HUMAN | SMARCC1 | physical | 22334708 | |
| TF65_HUMAN | RELA | physical | 22334708 | |
| NFKB1_HUMAN | NFKB1 | physical | 22334708 | |
| SMCE1_HUMAN | SMARCE1 | physical | 22939629 | |
| SNF5_HUMAN | SMARCB1 | physical | 22939629 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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