PHAR2_HUMAN - dbPTM
PHAR2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHAR2_HUMAN
UniProt AC O75167
Protein Name Phosphatase and actin regulator 2
Gene Name PHACTR2
Organism Homo sapiens (Human).
Sequence Length 634
Subcellular Localization Isoform 2: Membrane
Lipid-anchor .
Isoform 4: Membrane
Lipid-anchor .
Protein Description
Protein Sequence MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGATAGASHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2 (in isoform 4)Myristoylation-52.3625807930
2 (in isoform 2)Myristoylation-52.3625807930
5 (in isoform 2)Phosphorylation-8.22-
5 (in isoform 4)Phosphorylation-8.22-
12PhosphorylationVDGLDKASIANSDGP
CCCCCHHHHCCCCCC		28.1623403867
16PhosphorylationDKASIANSDGPTAGS
CHHHHCCCCCCCCCC		34.6223927012
20PhosphorylationIANSDGPTAGSQTPP
HCCCCCCCCCCCCCC		49.5323401153
23PhosphorylationSDGPTAGSQTPPFKR
CCCCCCCCCCCCCCC		28.5430266825
25PhosphorylationGPTAGSQTPPFKRKG
CCCCCCCCCCCCCCC		34.3319664994
29MethylationGSQTPPFKRKGKLST
CCCCCCCCCCCCCCH		60.00115974905
31MethylationQTPPFKRKGKLSTIG
CCCCCCCCCCCCHHH		62.07115974913
34 (in isoform 4)Phosphorylation-8.1224719451
35PhosphorylationFKRKGKLSTIGKIFK
CCCCCCCCHHHHHCC		22.8223403867
36PhosphorylationKRKGKLSTIGKIFKP
CCCCCCCHHHHHCCC		44.1523403867
36 (in isoform 4)Phosphorylation-44.1527251275
59PhosphorylationSDKFRETSAVLERKI
CHHHHHHHHHHHHHH		16.1828857561
67PhosphorylationAVLERKISTRQSREE
HHHHHHHCCHHHHHH		22.14-
129PhosphorylationNGSVSEKTPPLEEQA
CCCCCCCCCCHHHHH		26.53-
157PhosphorylationPAAPALPPSAPPKPR
CCCCCCCCCCCCCCC		43.9333259812
168PhosphorylationPKPRPKPKPKKSPVP
CCCCCCCCCCCCCCC		75.4933259812
197PhosphorylationVPPIKKNTKAPGKQA
CCCCCCCCCCCCCCC		37.15-
223PhosphorylationTTREAAGSSHSKKTT
CCCHHCCCCCCCCCC		21.8328985074
232PhosphorylationHSKKTTGSKASASPS
CCCCCCCCCCCCCCC		23.9830631047
235PhosphorylationKTTGSKASASPSTSS
CCCCCCCCCCCCCCC		32.7722199227
237PhosphorylationTGSKASASPSTSSTS
CCCCCCCCCCCCCCC		19.5223401153
239PhosphorylationSKASASPSTSSTSSR
CCCCCCCCCCCCCCC		38.1222115753
240PhosphorylationKASASPSTSSTSSRP
CCCCCCCCCCCCCCC		30.0423403867
241PhosphorylationASASPSTSSTSSRPK
CCCCCCCCCCCCCCC		35.6423403867
242PhosphorylationSASPSTSSTSSRPKA
CCCCCCCCCCCCCCC		32.1823403867
243PhosphorylationASPSTSSTSSRPKAS
CCCCCCCCCCCCCCC		30.4123403867
244PhosphorylationSPSTSSTSSRPKASK
CCCCCCCCCCCCCCC		26.7123403867
245PhosphorylationPSTSSTSSRPKASKE
CCCCCCCCCCCCCCC		53.3323403867
248PhosphorylationSSTSSRPKASKETVS
CCCCCCCCCCCCHHH		65.2733259812
248 (in isoform 4)Phosphorylation-65.2724719451
263PhosphorylationSKAGTVGTTKGKRKT
CCCCCCCCCCCCCCC		22.4623403867
264PhosphorylationKAGTVGTTKGKRKTD
CCCCCCCCCCCCCCC		31.6923403867
276PhosphorylationKTDKQPITSHLSSDT
CCCCCCCCCCCCCCC		19.4423312004
277PhosphorylationTDKQPITSHLSSDTT
CCCCCCCCCCCCCCC		24.1323312004
280PhosphorylationQPITSHLSSDTTTSG
CCCCCCCCCCCCCCC		22.2726657352
281PhosphorylationPITSHLSSDTTTSGT
CCCCCCCCCCCCCCC		45.3926657352
283PhosphorylationTSHLSSDTTTSGTSD
CCCCCCCCCCCCCCC		33.6423312004
284PhosphorylationSHLSSDTTTSGTSDL
CCCCCCCCCCCCCCC		24.7723312004
292 (in isoform 4)Phosphorylation-67.2427251275
302PhosphorylationPAETRVESFKLEQTV
CCCHHEEEEEEEEEC		25.4826657352
308PhosphorylationESFKLEQTVPGAEEQ
EEEEEEEECCCCCCC		21.2030242111
317PhosphorylationPGAEEQNTGKFKSMV
CCCCCCCCCCCCCCC		41.2529978859
383PhosphorylationAEEPTNRTTLYSGTG
ECCCCCCCEECCCCC		24.1921945579
384PhosphorylationEEPTNRTTLYSGTGL
CCCCCCCEECCCCCC		22.0621945579
386PhosphorylationPTNRTTLYSGTGLSV
CCCCCEECCCCCCCC		11.7121945579
387PhosphorylationTNRTTLYSGTGLSVN
CCCCEECCCCCCCCC		32.7521945579
389PhosphorylationRTTLYSGTGLSVNRE
CCEECCCCCCCCCCC		29.0721945579
392PhosphorylationLYSGTGLSVNRENAK
ECCCCCCCCCCCCCC		20.7721945579
397 (in isoform 4)Phosphorylation-41.2727642862
403 (in isoform 4)Phosphorylation-19.0627251275
410PhosphorylationTKEELGKTVPQLLTP
CHHHHCCCHHHHHCC		35.3027080861
416PhosphorylationKTVPQLLTPGLMGES
CCHHHHHCCCCCCCC		24.7327080861
423PhosphorylationTPGLMGESSESFSAS
CCCCCCCCCCCCCCC		33.4126657352
424PhosphorylationPGLMGESSESFSASE
CCCCCCCCCCCCCCC		32.7226657352
426PhosphorylationLMGESSESFSASEDE
CCCCCCCCCCCCCCC		26.8427732954
428PhosphorylationGESSESFSASEDEGH
CCCCCCCCCCCCCCC		39.9227080861
430PhosphorylationSSESFSASEDEGHRE
CCCCCCCCCCCCCCC		44.3627080861
438PhosphorylationEDEGHREYQANDSDS
CCCCCCCCCCCCCCC		16.9429485707
443PhosphorylationREYQANDSDSDGPIL
CCCCCCCCCCCCCEE		38.5323917254
445PhosphorylationYQANDSDSDGPILYT
CCCCCCCCCCCEEEC		48.7123917254
451PhosphorylationDSDGPILYTDDEDED
CCCCCEEECCCCCCC		14.6226657352
452PhosphorylationSDGPILYTDDEDEDE
CCCCEEECCCCCCCC		33.2626657352
459UbiquitinationTDDEDEDEDEDGSGE
CCCCCCCCCCCCCCH		62.3424816145
464PhosphorylationEDEDEDGSGESALAS
CCCCCCCCCHHHHHH		52.2729485707
467PhosphorylationDEDGSGESALASKIR
CCCCCCHHHHHHHHH		31.9129485707
470UbiquitinationGSGESALASKIRRRD
CCCHHHHHHHHHHHC		14.4324816145
471PhosphorylationSGESALASKIRRRDT
CCHHHHHHHHHHHCC		29.4829485707
478PhosphorylationSKIRRRDTLAIKLGN
HHHHHHCCCHHCCCC		19.1023312004
480PhosphorylationIRRRDTLAIKLGNRP
HHHHCCCHHCCCCCC		10.0432645325
491PhosphorylationGNRPSKKELEDKNIL
CCCCCHHHHHHCCHH		62.2132645325
522PhosphorylationTKLVRRLSQRPTTEE
HHHHHHHHCCCCHHH		23.4929255136
526PhosphorylationRRLSQRPTTEELEQR
HHHHCCCCHHHHHHH		49.3730266825
527PhosphorylationRLSQRPTTEELEQRN
HHHCCCCHHHHHHHH		30.0930266825
533 (in isoform 4)Phosphorylation-23.8424719451
537UbiquitinationLEQRNILKQKNEEEE
HHHHHHHHHCCHHHH		56.27-
538 (in isoform 4)Phosphorylation-50.8124719451
539UbiquitinationQRNILKQKNEEEEQE
HHHHHHHCCHHHHHH		65.8124816145
548 (in isoform 4)Ubiquitination-31.96-
550UbiquitinationEEQEAKMELKRRLSR
HHHHHHHHHHHHHHH		50.8924816145
556PhosphorylationMELKRRLSRKLSLRP
HHHHHHHHHHHCCCH		26.09-
558MalonylationLKRRLSRKLSLRPTV
HHHHHHHHHCCCHHH		38.7726320211
560PhosphorylationRRLSRKLSLRPTVAE
HHHHHHHCCCHHHHH		25.9323401153
564PhosphorylationRKLSLRPTVAELQAR
HHHCCCHHHHHHHHH		26.3923927012
571PhosphorylationTVAELQARRILRFNE
HHHHHHHHHHHHHCC		17.1432645325
571 (in isoform 4)Phosphorylation-17.1424719451
579PhosphorylationRILRFNEYVEVTDSP
HHHHHCCEEEECCCC		11.7429978859
585PhosphorylationEYVEVTDSPDYDRRA
CEEEECCCCCCHHCC		15.4229496963
590 (in isoform 4)Phosphorylation-29.4727642862
596 (in isoform 4)Phosphorylation-10.3527642862
599 (in isoform 4)Phosphorylation-5.3427642862
600PhosphorylationDKPWARLTPADKAAI
CCCHHHCCHHHHHHH		15.7521815630
604UbiquitinationARLTPADKAAIRKEL
HHCCHHHHHHHHHHH		41.65-
604MalonylationARLTPADKAAIRKEL
HHCCHHHHHHHHHHH		41.6526320211
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHAR2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHAR2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHAR2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
POTEI_HUMANPOTEIphysical
28514442
ACTA_HUMANACTA2physical
28514442
ACTBL_HUMANACTBL2physical
28514442
ACTB_HUMANACTBphysical
28514442
ACTC_HUMANACTC1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHAR2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-25, AND MASSSPECTROMETRY.

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