dbPTM

PHAR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHAR4_HUMAN
UniProt AC	Q8IZ21
Protein Name	Phosphatase and actin regulator 4
Gene Name	PHACTR4
Organism	Homo sapiens (Human).
Sequence Length	702
Subcellular Localization	Cytoplasm. Cell projection, lamellipodium.
Protein Description	Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity)..
Protein Sequence	MEDPFEEADQPTTEPGMVLDSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIGNARSSSPVQVEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTARFIISTSITTAPAATTAATSLAKTVNLSVTPSPAPRTLPAAPASTNTTATPSLTHMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPLPMTPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11 (in isoform 3)	Phosphorylation	-	41.66	29116813
12	Phosphorylation	FEEADQPTTEPGMVL CCCCCCCCCCCCEEE	37.85	23186163
12 (in isoform 3)	Phosphorylation	-	37.85	25849741
13	Phosphorylation	EEADQPTTEPGMVLD CCCCCCCCCCCEEEC	47.03	23186163
15 (in isoform 3)	Phosphorylation	-	33.80	29116813
21	Phosphorylation	EPGMVLDSVEAGDTT CCCEEECCCCCCCCC	20.07	25850435
27	Phosphorylation	DSVEAGDTTPPTKRK CCCCCCCCCCCCCCC	40.04	30266825
28	Phosphorylation	SVEAGDTTPPTKRKS CCCCCCCCCCCCCCC	31.82	30266825
31	Phosphorylation	AGDTTPPTKRKSKFS CCCCCCCCCCCCCCC	44.69	21955146
32	Methylation	GDTTPPTKRKSKFSG CCCCCCCCCCCCCCC	64.70	115974921
36	Phosphorylation	PPTKRKSKFSGFGKI CCCCCCCCCCCCCCC	46.73	32142685
36	Ubiquitination	PPTKRKSKFSGFGKI CCCCCCCCCCCCCCC	46.73	29967540
38	Phosphorylation	TKRKSKFSGFGKIFK CCCCCCCCCCCCCCC	36.63	32142685
42	Acetylation	SKFSGFGKIFKPWKW CCCCCCCCCCCCCCC	42.58	91391
46	Ubiquitination	GFGKIFKPWKWRKKK CCCCCCCCCCCCCCC	27.42	29967540
54	Phosphorylation	WKWRKKKSSDKFKET CCCCCCCCCCHHHHH	53.28	29214152
55	Phosphorylation	KWRKKKSSDKFKETS CCCCCCCCCHHHHHH	54.41	29214152
59	Ubiquitination	KKSSDKFKETSEVLE CCCCCHHHHHHHHHH	66.86	29967540
61	Phosphorylation	SSDKFKETSEVLERK CCCHHHHHHHHHHHH	30.67	25002506
62	Phosphorylation	SDKFKETSEVLERKI CCHHHHHHHHHHHHH	27.14	21712546
69	Ubiquitination	SEVLERKISMRKPRE HHHHHHHHHCCCCHH	4.98	29967540
70	Phosphorylation	EVLERKISMRKPREE HHHHHHHHCCCCHHH	18.64	15302935
99	Phosphorylation	GEDPGKPSDAMLKNG CCCCCCCCHHCCCCC	41.30	15302935
101	Phosphorylation	DPGKPSDAMLKNGHT CCCCCCHHCCCCCCC	15.00	32142685
102	Phosphorylation	PGKPSDAMLKNGHTT CCCCCHHCCCCCCCC	7.03	32142685
108	Phosphorylation	AMLKNGHTTPIGNAR HCCCCCCCCCCCCCC	35.35	24505115
109	Phosphorylation	MLKNGHTTPIGNARS CCCCCCCCCCCCCCC	13.77	27251275
116	Phosphorylation	TPIGNARSSSPVQVE CCCCCCCCCCCCEEC	32.53	29255136
117	Phosphorylation	PIGNARSSSPVQVEE CCCCCCCCCCCEECC	32.86	29255136
118	Phosphorylation	IGNARSSSPVQVEEE CCCCCCCCCCEECCC	30.27	29255136
119 (in isoform 2)	Phosphorylation	-	23.62	27251275
125	Phosphorylation	SPVQVEEEPVRLASL CCCEECCCCCCHHHH	35.27	32142685
126	Phosphorylation	PVQVEEEPVRLASLR CCEECCCCCCHHHHH	21.58	32142685
126	Ubiquitination	PVQVEEEPVRLASLR CCEECCCCCCHHHHH	21.58	24816145
126 (in isoform 2)	Phosphorylation	-	21.58	21406692
127	Phosphorylation	VQVEEEPVRLASLRK CEECCCCCCHHHHHH	9.91	32142685
127 (in isoform 2)	Phosphorylation	-	9.91	27251275
128	Phosphorylation	QVEEEPVRLASLRKA EECCCCCCHHHHHHH	34.94	32142685
128 (in isoform 2)	Phosphorylation	-	34.94	21406692
131	Phosphorylation	EEPVRLASLRKAIPE CCCCCHHHHHHHCCH	33.04	23401153
141 (in isoform 2)	Phosphorylation	-	8.78	21406692
142	Phosphorylation	AIPEEDLKKRLGSTG HCCHHHHHHHHCCCC	48.44	32142685
142	Ubiquitination	AIPEEDLKKRLGSTG HCCHHHHHHHHCCCC	48.44	24816145
147	Phosphorylation	DLKKRLGSTGSQPNS HHHHHHCCCCCCCCC	33.90	17525332
148	Phosphorylation	LKKRLGSTGSQPNSE HHHHHCCCCCCCCCC	38.77	25159151
149	Ubiquitination	KKRLGSTGSQPNSEA HHHHCCCCCCCCCCC	26.44	24816145
150	Phosphorylation	KRLGSTGSQPNSEAE HHHCCCCCCCCCCCC	42.42	17525332
150	Ubiquitination	KRLGSTGSQPNSEAE HHHCCCCCCCCCCCC	42.42	24816145
152	Ubiquitination	LGSTGSQPNSEAESV HCCCCCCCCCCCCCC	48.27	24816145
154	Phosphorylation	STGSQPNSEAESVPE CCCCCCCCCCCCCCC	44.88	23663014
157 (in isoform 2)	Phosphorylation	-	48.49	-
158	Phosphorylation	QPNSEAESVPENVPK CCCCCCCCCCCCCCC	50.44	23663014
158 (in isoform 2)	Phosphorylation	-	50.44	27251275
160	Ubiquitination	NSEAESVPENVPKPP CCCCCCCCCCCCCCC	36.40	24816145
160 (in isoform 2)	Phosphorylation	-	36.40	-
164 (in isoform 2)	Phosphorylation	-	55.83	27251275
166	Phosphorylation	VPENVPKPPLLPPKR CCCCCCCCCCCCCCC	20.78	32142685
168	Phosphorylation	ENVPKPPLLPPKRPL CCCCCCCCCCCCCCC	17.78	32142685
176	Phosphorylation	LPPKRPLSSSHEASE CCCCCCCCCCCCCCC	32.26	29255136
177	Phosphorylation	PPKRPLSSSHEASEG CCCCCCCCCCCCCCC	43.31	23401153
178	Phosphorylation	PKRPLSSSHEASEGQ CCCCCCCCCCCCCCC	23.21	30266825
182	Phosphorylation	LSSSHEASEGQAKDA CCCCCCCCCCCCCCC	39.00	30266825
186 (in isoform 2)	Phosphorylation	-	23.66	21406692
187 (in isoform 2)	Phosphorylation	-	39.75	21406692
188 (in isoform 2)	Phosphorylation	-	59.08	27251275
190	Phosphorylation	EGQAKDATSSGGTAR CCCCCCCCCCCCCEE	33.29	23312004
191	O-linked_Glycosylation	GQAKDATSSGGTARF CCCCCCCCCCCCEEE	28.80	30059200
191	Phosphorylation	GQAKDATSSGGTARF CCCCCCCCCCCCEEE	28.80	23312004
192	Phosphorylation	QAKDATSSGGTARFI CCCCCCCCCCCEEEE	36.57	23312004
195	Phosphorylation	DATSSGGTARFIIST CCCCCCCCEEEEEEE	20.41	23312004
201	O-linked_Glycosylation	GTARFIISTSITTAP CCEEEEEEECCCCCC	15.99	30059200
201	Phosphorylation	GTARFIISTSITTAP CCEEEEEEECCCCCC	15.99	-
202	O-linked_Glycosylation	TARFIISTSITTAPA CEEEEEEECCCCCCC	17.46	30059200
202	Phosphorylation	TARFIISTSITTAPA CEEEEEEECCCCCCC	17.46	-
203	O-linked_Glycosylation	ARFIISTSITTAPAA EEEEEEECCCCCCCH	15.90	30059200
205	O-linked_Glycosylation	FIISTSITTAPAATT EEEEECCCCCCCHHH	19.37	30059200
216	Phosphorylation	AATTAATSLAKTVNL CHHHHHHHHHHHCCE	22.92	-
220	O-linked_Glycosylation	AATSLAKTVNLSVTP HHHHHHHHCCEECCC	14.71	30059200
224	Phosphorylation	LAKTVNLSVTPSPAP HHHHCCEECCCCCCC	20.81	22199227
226	Phosphorylation	KTVNLSVTPSPAPRT HHCCEECCCCCCCCC	18.05	25159151
228	Phosphorylation	VNLSVTPSPAPRTLP CCEECCCCCCCCCCC	25.07	21815630
233	O-linked_Glycosylation	TPSPAPRTLPAAPAS CCCCCCCCCCCCCCC	35.71	30059200
236 (in isoform 2)	Phosphorylation	-	29.23	27251275
240	O-linked_Glycosylation	TLPAAPASTNTTATP CCCCCCCCCCCCCCC	22.56	30059200
240	Phosphorylation	TLPAAPASTNTTATP CCCCCCCCCCCCCCC	22.56	28348404
241	Phosphorylation	LPAAPASTNTTATPS CCCCCCCCCCCCCCC	38.40	28348404
243	Phosphorylation	AAPASTNTTATPSLT CCCCCCCCCCCCCCC	20.21	28348404
244	O-linked_Glycosylation	APASTNTTATPSLTH CCCCCCCCCCCCCCC	30.51	30059200
244	Phosphorylation	APASTNTTATPSLTH CCCCCCCCCCCCCCC	30.51	28348404
246	Phosphorylation	ASTNTTATPSLTHMV CCCCCCCCCCCCCCC	16.00	25159151
256 (in isoform 2)	Phosphorylation	-	58.21	27251275
270	Phosphorylation	PKPAHRNSNPVIAEL CCCCCCCCCHHHHHH	42.33	22167270
278	Phosphorylation	NPVIAELSQAINSGT CHHHHHHHHHHHHCC	14.74	30108239
280 (in isoform 2)	Phosphorylation	-	10.27	27251275
283	Phosphorylation	ELSQAINSGTLLSKP HHHHHHHHCCCCCCC	27.35	22167270
285	Phosphorylation	SQAINSGTLLSKPSP HHHHHHCCCCCCCCC	25.09	29255136
288	Phosphorylation	INSGTLLSKPSPPLP HHHCCCCCCCCCCCC	45.71	29255136
291	Phosphorylation	GTLLSKPSPPLPPKR CCCCCCCCCCCCCCC	42.77	29255136
301 (in isoform 2)	Phosphorylation	-	34.09	27251275
302	Phosphorylation	PPKRGIPSTSVPTLE CCCCCCCCCCCCCHH	31.24	20068231
303	Phosphorylation	PKRGIPSTSVPTLES CCCCCCCCCCCCHHH	28.52	26074081
304	Phosphorylation	KRGIPSTSVPTLESA CCCCCCCCCCCHHHH	30.36	20068231
307	Phosphorylation	IPSTSVPTLESAAAI CCCCCCCCHHHHHHH	40.79	20068231
312 (in isoform 2)	Phosphorylation	-	14.53	-
326	Phosphorylation	PSDEREKSTCSMGSE CCHHHHHHCCCCCCH	29.87	24114839
327	Phosphorylation	SDEREKSTCSMGSEL CHHHHHHCCCCCCHH	21.48	24114839
332	Phosphorylation	KSTCSMGSELLPMIS HHCCCCCCHHHHCCC	19.21	-
339	Phosphorylation	SELLPMISPRSPSPP CHHHHCCCCCCCCCC	14.17	26074081
342	Phosphorylation	LPMISPRSPSPPLPT HHCCCCCCCCCCCCC	32.87	22167270
344	Phosphorylation	MISPRSPSPPLPTHI CCCCCCCCCCCCCCC	40.16	22167270
349	Phosphorylation	SPSPPLPTHIPPEPP CCCCCCCCCCCCCCC	39.87	23927012
349 (in isoform 2)	Phosphorylation	-	39.87	27251275
350	Phosphorylation	PSPPLPTHIPPEPPR CCCCCCCCCCCCCCC	28.72	32142685
352	Phosphorylation	PPLPTHIPPEPPRTP CCCCCCCCCCCCCCC	21.43	32142685
352 (in isoform 2)	Phosphorylation	-	21.43	21406692
354 (in isoform 2)	Phosphorylation	-	63.68	21406692
358	Phosphorylation	IPPEPPRTPPFPAKT CCCCCCCCCCCCCCC	40.88	22167270
359 (in isoform 2)	Phosphorylation	-	29.79	27251275
365	Phosphorylation	TPPFPAKTFQVVPEI CCCCCCCCEEECCCC	22.77	26074081
366	Phosphorylation	PPFPAKTFQVVPEIE CCCCCCCEEECCCCC	5.24	32142685
368	Phosphorylation	FPAKTFQVVPEIEFP CCCCCEEECCCCCCC	7.29	32142685
368 (in isoform 2)	Phosphorylation	-	7.29	21406692
410	Phosphorylation	FGEPHIPSRLPPLPL CCCCCCCCCCCCCCC	45.93	24719451
416	Phosphorylation	PSRLPPLPLHIRIQQ CCCCCCCCCEEEEHH	27.89	32142685
426	Phosphorylation	IRIQQALTSPLPMTP EEEHHHHCCCCCCCC	31.17	29255136
427	Phosphorylation	RIQQALTSPLPMTPI EEHHHHCCCCCCCCC	25.86	27273156
432	Phosphorylation	LTSPLPMTPILEGSH HCCCCCCCCCCCCCC	12.77	27273156
437 (in isoform 2)	Phosphorylation	-	25.88	27251275
438	Phosphorylation	MTPILEGSHRAHSLL CCCCCCCCCHHHHHH	10.63	29255136
440	Phosphorylation	PILEGSHRAHSLLFE CCCCCCCHHHHHHCC	35.38	32142685
442	Phosphorylation	LEGSHRAHSLLFENS CCCCCHHHHHHCCCC	20.95	32142685
442 (in isoform 2)	Phosphorylation	-	20.95	27251275
443	Phosphorylation	EGSHRAHSLLFENSD CCCCHHHHHHCCCCC	26.28	23401153
448	Phosphorylation	AHSLLFENSDSFSED HHHHHCCCCCCCCCC	43.73	32142685
449	Phosphorylation	HSLLFENSDSFSEDS HHHHCCCCCCCCCCC	27.68	23927012
451	Phosphorylation	LLFENSDSFSEDSST HHCCCCCCCCCCCCC	30.41	23927012
453	Phosphorylation	FENSDSFSEDSSTLG CCCCCCCCCCCCCCC	44.43	23403867
453 (in isoform 2)	Phosphorylation	-	44.43	27251275
456	Phosphorylation	SDSFSEDSSTLGRTR CCCCCCCCCCCCCCC	22.59	23403867
457	Phosphorylation	DSFSEDSSTLGRTRS CCCCCCCCCCCCCCC	39.72	23403867
458	Phosphorylation	SFSEDSSTLGRTRSL CCCCCCCCCCCCCCC	36.86	23403867
461 (in isoform 2)	Phosphorylation	-	30.03	27251275
462	Phosphorylation	DSSTLGRTRSLPITI CCCCCCCCCCCCEEE	23.86	22617229
463 (in isoform 2)	Phosphorylation	-	34.53	27251275
464	Phosphorylation	STLGRTRSLPITIEM CCCCCCCCCCEEEEE	37.57	29255136
468	Phosphorylation	RTRSLPITIEMLKVP CCCCCCEEEEEEECC	14.67	30266825
472	Phosphorylation	LPITIEMLKVPDDEE CCEEEEEEECCCCHH	3.07	32142685
474	Phosphorylation	ITIEMLKVPDDEEEE EEEEEEECCCCHHHH	5.75	32142685
474 (in isoform 2)	Phosphorylation	-	5.75	21406692
478	Phosphorylation	MLKVPDDEEEEEQTC EEECCCCHHHHHCCC	74.76	32142685
484	Phosphorylation	DEEEEEQTCPSTFSE CHHHHHCCCCCCCCC	29.66	28348404
487	Phosphorylation	EEEQTCPSTFSEEMT HHHCCCCCCCCCCCC	44.20	28348404
488	Phosphorylation	EEQTCPSTFSEEMTP HHCCCCCCCCCCCCC	19.14	28348404
490	Phosphorylation	QTCPSTFSEEMTPTS CCCCCCCCCCCCCCC	32.51	26657352
494	Phosphorylation	STFSEEMTPTSVIPK CCCCCCCCCCCHHCC	27.05	26657352
496	Phosphorylation	FSEEMTPTSVIPKLP CCCCCCCCCHHCCHH	26.85	25159151
502	Phosphorylation	PTSVIPKLPQCLREE CCCHHCCHHHHHHHH	2.73	32142685
504	Phosphorylation	SVIPKLPQCLREEEE CHHCCHHHHHHHHHH	49.68	32142685
504 (in isoform 2)	Phosphorylation	-	49.68	27251275
514	Phosphorylation	REEEEKESDSDSEGP HHHHHHCCCCCCCCC	54.18	23927012
516	Phosphorylation	EEEKESDSDSEGPIQ HHHHCCCCCCCCCCC	52.92	23927012
518	Phosphorylation	EKESDSDSEGPIQYR HHCCCCCCCCCCCCC	48.70	23927012
524	Phosphorylation	DSEGPIQYRDEEDED CCCCCCCCCCCCCCC	22.28	21406692
524 (in isoform 2)	Phosphorylation	-	22.28	21406692
526 (in isoform 2)	Phosphorylation	-	59.72	21406692
528 (in isoform 2)	Phosphorylation	-	71.62	-
533	Phosphorylation	DEEDEDESYQSALAN CCCCCCHHHHHHHHH	40.57	21406692
534	Phosphorylation	EEDEDESYQSALANK CCCCCHHHHHHHHHH	12.39	21406692
536	Phosphorylation	DEDESYQSALANKVK CCCHHHHHHHHHHHC	19.60	21406692
544 (in isoform 2)	Phosphorylation	-	45.10	27642862
547	Phosphorylation	NKVKRKDTLAMKLNH HHHCHHHHHHHHCCC	21.32	30576142
557	Phosphorylation	MKLNHRPSEPELNLN HHCCCCCCCCCCCCC	66.78	23401153
565	Phosphorylation	EPELNLNSWPCKSKE CCCCCCCCCCCCCHH	35.25	23403867
567 (in isoform 2)	Phosphorylation	-	18.58	27251275
571	Ubiquitination	NSWPCKSKEEWNEIR CCCCCCCHHHHHHHH	45.18	29967540
581	Ubiquitination	WNEIRHQIGNTLIRR HHHHHHHHHHHHHHH	3.62	29967540
584	Phosphorylation	IRHQIGNTLIRRLSQ HHHHHHHHHHHHHHC	20.53	23403867
590	Phosphorylation	NTLIRRLSQRPTPEE HHHHHHHHCCCCHHH	23.49	29255136
591	Ubiquitination	TLIRRLSQRPTPEEL HHHHHHHCCCCHHHH	61.02	24816145
594	Phosphorylation	RRLSQRPTPEELEQR HHHHCCCCHHHHHHC	45.59	29255136
594 (in isoform 2)	Phosphorylation	-	45.59	-
600 (in isoform 2)	Phosphorylation	-	57.24	21406692
604 (in isoform 2)	Phosphorylation	-	9.00	-
607	Ubiquitination	QRNILQPKNEADRQA HCCCCCCCCHHHHHH	55.23	24816145
612	Phosphorylation	QPKNEADRQAEKREI CCCCHHHHHHHHHHH	44.66	32645325
614	Ubiquitination	KNEADRQAEKREIKR CCHHHHHHHHHHHHH	25.77	24816145
615	Ubiquitination	NEADRQAEKREIKRR CHHHHHHHHHHHHHH	44.29	24816145
617	Ubiquitination	ADRQAEKREIKRRLT HHHHHHHHHHHHHHH	42.23	24816145
624	Phosphorylation	REIKRRLTRKLSQRP HHHHHHHHHHHHCCC	24.77	20736484
625	Ubiquitination	EIKRRLTRKLSQRPT HHHHHHHHHHHCCCC	42.37	24816145
628	Phosphorylation	RRLTRKLSQRPTVAE HHHHHHHHCCCCHHH	27.46	29255136
632	Phosphorylation	RKLSQRPTVAELLAR HHHHCCCCHHHHHHH	34.24	23927012
636	Phosphorylation	QRPTVAELLARKILR CCCCHHHHHHHHHHH	3.06	32645325
638	Phosphorylation	PTVAELLARKILRFN CCHHHHHHHHHHHHH	24.28	32645325
638 (in isoform 2)	Phosphorylation	-	24.28	21406692
642 (in isoform 2)	Phosphorylation	-	6.00	-
647	Phosphorylation	KILRFNEYVEVTDAQ HHHHHHCCEEEECHH	11.74	28796482
651	Phosphorylation	FNEYVEVTDAQDYDR HHCCEEEECHHHCCC	16.47	-
656	Phosphorylation	EVTDAQDYDRRADKP EEECHHHCCCCCCCC	10.16	-
657 (in isoform 2)	Phosphorylation	-	41.71	27642862
665	Phosphorylation	RRADKPWTKLTPADK CCCCCCCCCCCHHHH	25.38	28509920
666 (in isoform 2)	Phosphorylation	-	46.63	27642862
668	Phosphorylation	DKPWTKLTPADKAAI CCCCCCCCHHHHHHH	20.27	21815630
672	Ubiquitination	TKLTPADKAAIRKEL CCCCHHHHHHHHHHH	41.65	-
699	Phosphorylation	ESKHFTRYHRP---- HHHCCCCCCCC----	10.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PHAR4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHAR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHAR4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
IFIT3_HUMAN	IFIT3	physical	28514442
IFIT1_HUMAN	IFIT1	physical	28514442
G3PT_HUMAN	GAPDHS	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHAR4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443 AND SER-557, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118; SER-131; SER-342;SER-344; THR-358; SER-427; THR-432 AND SER-628, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427 AND THR-432, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147 AND SER-150, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-628, AND MASSSPECTROMETRY.	17081983 [Abstract]