INT14_HUMAN - dbPTM
INT14_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INT14_HUMAN
UniProt AC Q96SY0
Protein Name Integrator complex subunit 14 {ECO:0000312|HGNC:HGNC:25372}
Gene Name INTS14 {ECO:0000312|HGNC:HGNC:25372}
Organism Homo sapiens (Human).
Sequence Length 518
Subcellular Localization Nucleus .
Protein Description Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing..
Protein Sequence MPTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYIMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLASTGTSEYAAYDQNITPLHTDFSGSSTERI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3 (in isoform 3)Phosphorylation-30266825
3Phosphorylation-----MPTVVVMDVS
-----CCEEEEEEEE		20068231
5 (in isoform 3)Phosphorylation-30266825
10PhosphorylationTVVVMDVSLSMTRPV
EEEEEEEEECCCCCE		20068231
12PhosphorylationVVMDVSLSMTRPVSI
EEEEEEECCCCCEEC		20068231
14PhosphorylationMDVSLSMTRPVSIEG
EEEEECCCCCEECCC		20068231
28UbiquitinationGSEEYQRKHLAAHGL
CCHHHHHHHHHHHHH		21906983
28 (in isoform 2)Ubiquitination-21906983
64 (in isoform 1)Ubiquitination-21890473
120PhosphorylationLVTDGCLGIGRGSLR
EEECCCCCCCHHHHH		27251275
122PhosphorylationTDGCLGIGRGSLRHS
ECCCCCCCHHHHHHH		-
129PhosphorylationGRGSLRHSLATQNQR
CHHHHHHHHHCCCCC		28555341
137PhosphorylationLATQNQRSESNRFPL
HHCCCCCCCCCCCCC		20873877
139PhosphorylationTQNQRSESNRFPLPF
CCCCCCCCCCCCCCC		20873877
178UbiquitinationCLERLIDLNNGEGQI
HHHHHHHCCCCCCCE		-
187PhosphorylationNGEGQIFTIDGPLCL
CCCCCEEEEECCCHH		-
195UbiquitinationIDGPLCLKNVQSMFG
EECCCHHHHHHHHHH		-
199PhosphorylationLCLKNVQSMFGKLID
CHHHHHHHHHHHHHH		-
249PhosphorylationPIPKVINTDLEIVGF
CCCCEECCCCEEEEE		-
280UbiquitinationVLPIALNKEGDEVGT
EEEEECCCCCCCCCC		21906983
290PhosphorylationDEVGTGITDDNEDEN
CCCCCCCCCCCCCCC		28985074
316 (in isoform 1)Ubiquitination-21890473
339UbiquitinationWHGMLYSQADSKKKS
HHHHHHCCCCHHHCC		21890473
358UbiquitinationSLFEPGPEPLPWLGK
HHCCCCCCCCCCCHH		-
363UbiquitinationGPEPLPWLGKMAQLG
CCCCCCCCHHHHHCC		21890473
368UbiquitinationPWLGKMAQLGPISDA
CCCHHHHHCCCCCCC		-
369PhosphorylationWLGKMAQLGPISDAK
CCHHHHHCCCCCCCC		27251275
373PhosphorylationMAQLGPISDAKENPY
HHHCCCCCCCCCCCC		29978859
376UbiquitinationLGPISDAKENPYGED
CCCCCCCCCCCCCCC		21906983
380PhosphorylationSDAKENPYGEDDNKS
CCCCCCCCCCCCCCC		29978859
387PhosphorylationYGEDDNKSPFPLQPK
CCCCCCCCCCCCCCC		27050516
400UbiquitinationPKNKRSYAQNVTVWI
CCCCCCCCEEEEEEE		-
400AcetylationPKNKRSYAQNVTVWI
CCCCCCCCEEEEEEE		-
411UbiquitinationTVWIKPSGLQTDVQK
EEEECCCCCHHHHHH		-
412 (in isoform 1)Ubiquitination-21890473
417UbiquitinationSGLQTDVQKILRNAR
CCCHHHHHHHHHHHH		-
418UbiquitinationGLQTDVQKILRNARK
CCHHHHHHHHHHHHC		21890473
418AcetylationGLQTDVQKILRNARK
CCHHHHHHHHHHHHC		19608861
418UbiquitinationGLQTDVQKILRNARK
CCHHHHHHHHHHHHC		21890473
424UbiquitinationQKILRNARKLPEKTQ
HHHHHHHHCCCHHHH		-
429UbiquitinationNARKLPEKTQTFYKE
HHHCCCHHHHHHHHH		-
429AcetylationNARKLPEKTQTFYKE
HHHCCCHHHHHHHHH		25953088
435UbiquitinationEKTQTFYKELNRLRK
HHHHHHHHHHHHHHH		-
435AcetylationEKTQTFYKELNRLRK
HHHHHHHHHHHHHHH		26051181
442UbiquitinationKELNRLRKAALAFGF
HHHHHHHHHHHHHHH		21890473
442UbiquitinationKELNRLRKAALAFGF
HHHHHHHHHHHHHHH		2189047
454UbiquitinationFGFLDLLKGVADMLE
HHHHHHHHHHHHHHH		-
469UbiquitinationRECTLLPETAHPDAA
HHHCCCCCCCCCCHH		-
504PhosphorylationAAYDQNITPLHTDFS
CCCCCCCCCCCCCCC		-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INT14_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INT14_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INT14_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GOGA4_HUMANGOLGA4physical
26496610
MCM5_HUMANMCM5physical
26496610
M3K4_HUMANMAP3K4physical
26496610
RPB1_HUMANPOLR2Aphysical
26496610
PEPL_HUMANPPLphysical
26496610
2AAA_HUMANPPP2R1Aphysical
26496610
TNR1A_HUMANTNFRSF1Aphysical
26496610
VDAC1_HUMANVDAC1physical
26496610
ELL_HUMANELLphysical
26496610
TAF1A_HUMANTAF1Aphysical
26496610
ZN609_HUMANZNF609physical
26496610
PKCB1_HUMANZMYND8physical
26496610
INT6_HUMANINTS6physical
26496610
RTEL1_HUMANRTEL1physical
26496610
INT11_HUMANCPSF3Lphysical
26496610
INT10_HUMANINTS10physical
26496610
INT13_HUMANASUNphysical
26496610
INT9_HUMANINTS9physical
26496610
RCC2_HUMANRCC2physical
26496610
INT12_HUMANINTS12physical
26496610
INT2_HUMANINTS2physical
26496610
ICE2_HUMANICE2physical
26496610
INT5_HUMANINTS5physical
26496610
DOT1L_HUMANDOT1Lphysical
26496610
INT4_HUMANINTS4physical
26496610
EME1_HUMANEME1physical
26496610
PDE12_HUMANPDE12physical
26496610
INT1_HUMANINTS1physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INT14_HUMAN

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Related Literatures of Post-Translational Modification

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