dbPTM

DOT1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DOT1L_HUMAN
UniProt AC	Q8TEK3
Protein Name	Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene Name	DOT1L
Organism	Homo sapiens (Human).
Sequence Length	1739
Subcellular Localization	Nucleus .
Protein Description	Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA..
Protein Sequence	MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGVVFNHAVPSASAHPFGARVGRGAACGSATLGPSPLQAAASASASSFQAPASVETRPPPPPPPPPPPLPPPAHLGRSPAGPPVLHAPPPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLPPTSAASLPPANASLSIKLTSLPHKGARPSFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSGVKPR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	ENYVLIDYDTKSFES CCEEEEECCCCCHHH	20.65	30177828
65	Phosphorylation	YVLIDYDTKSFESMQ EEEEECCCCCHHHHH	23.51	30177828
67	Phosphorylation	LIDYDTKSFESMQRL EEECCCCCHHHHHHH	36.02	24719451
70	Phosphorylation	YDTKSFESMQRLCDK CCCCCHHHHHHHHHH	20.43	30177828
78	Phosphorylation	MQRLCDKYNRAIDSI HHHHHHHHHHHHHHH	9.16	20068231
78 (in isoform 1)	Phosphorylation	-	9.16	-
84	Phosphorylation	KYNRAIDSIHQLWKG HHHHHHHHHHHHHCC	18.83	20068231
84 (in isoform 1)	Phosphorylation	-	18.83	-
92	Phosphorylation	IHQLWKGTTQPMKLN HHHHHCCCCCCCCCC	20.66	20068231
93	Phosphorylation	HQLWKGTTQPMKLNT HHHHCCCCCCCCCCC	39.07	20068231
104	Phosphorylation	KLNTRPSTGLLRHIL CCCCCCCCHHHHHHH	34.23	-
209	Phosphorylation	FRKWMKWYGKKHAEY HHHHHHHHCHHHHEE	17.35	26074081
268	Phosphorylation	KEGGRIVSSKPFAPL CCCCEECCCCCCCCC	30.21	23403867
269	Phosphorylation	EGGRIVSSKPFAPLN CCCEECCCCCCCCCE	33.19	23403867
270	Ubiquitination	GGRIVSSKPFAPLNF CCEECCCCCCCCCEE	36.33	-
281	Phosphorylation	PLNFRINSRNLSDIG CCEEEECCCCHHHHH	21.85	20068231
285	Phosphorylation	RINSRNLSDIGTIMR EECCCCHHHHHHEEE	30.63	20068231
285 (in isoform 1)	Phosphorylation	-	30.63	-
289	Phosphorylation	RNLSDIGTIMRVVEL CCHHHHHHEEEEEEC	16.37	20068231
289 (in isoform 1)	Phosphorylation	-	16.37	-
297	Phosphorylation	IMRVVELSPLKGSVS EEEEEECCCCCCCCC	18.06	30266825
297 (in isoform 1)	Phosphorylation	-	18.06	24719451
302	Phosphorylation	ELSPLKGSVSWTGKP ECCCCCCCCCCCCCE	16.05	20068231
302 (in isoform 1)	Phosphorylation	-	16.05	-
304	Phosphorylation	SPLKGSVSWTGKPVS CCCCCCCCCCCCEEE	22.18	20068231
304 (in isoform 1)	Phosphorylation	-	22.18	-
306	Phosphorylation	LKGSVSWTGKPVSYY CCCCCCCCCCEEEEE	28.02	20068231
306 (in isoform 1)	Phosphorylation	-	28.02	-
308	Acetylation	GSVSWTGKPVSYYLH CCCCCCCCEEEEEEE	34.57	26051181
349	Phosphorylation	RRRQQRESKSNAATP HHHHHHHHHHCCCCC	43.50	20873877
351	Phosphorylation	RQQRESKSNAATPTK HHHHHHHHCCCCCCC	40.77	30576142
355	Phosphorylation	ESKSNAATPTKGPEG HHHHCCCCCCCCCCC	29.13	28176443
355 (in isoform 1)	Phosphorylation	-	29.13	27251275
357	Phosphorylation	KSNAATPTKGPEGKV HHCCCCCCCCCCCCC	44.25	20873877
358	Acetylation	SNAATPTKGPEGKVA HCCCCCCCCCCCCCC	73.92	25953088
374	Phosphorylation	PADAPMDSGAEEEKA CCCCCCCCCCHHHHH	33.38	29255136
374 (in isoform 1)	Phosphorylation	-	33.38	24719451
385	Phosphorylation	EEKAGAATVKKPSPS HHHHCCCCCCCCCHH	32.12	23403867
387	Acetylation	KAGAATVKKPSPSKA HHCCCCCCCCCHHHH	55.39	24848091
390	Phosphorylation	AATVKKPSPSKARKK CCCCCCCCHHHHHHH	51.16	23403867
392	Phosphorylation	TVKKPSPSKARKKKL CCCCCCHHHHHHHHH	43.20	26074081
397	Acetylation	SPSKARKKKLNKKGR CHHHHHHHHHCHHHH	57.87	69341
398	Acetylation	PSKARKKKLNKKGRK HHHHHHHHHCHHHHH	61.40	69345
401	Acetylation	ARKKKLNKKGRKMAG HHHHHHCHHHHHHCH	68.02	69349
431	Phosphorylation	RKPKKNQTALDALHA CCCCCCHHHHHHHHH	38.28	20068231
440	Phosphorylation	LDALHAQTVSQTAAS HHHHHHHHHHHHHCC	23.94	20068231
442	Phosphorylation	ALHAQTVSQTAASSP HHHHHHHHHHHCCCH	25.79	30108239
444	Phosphorylation	HAQTVSQTAASSPQD HHHHHHHHHCCCHHH	19.38	28348404
447	Phosphorylation	TVSQTAASSPQDAYR HHHHHHCCCHHHHHC	39.84	22167270
447 (in isoform 1)	Phosphorylation	-	39.84	24719451
448	Phosphorylation	VSQTAASSPQDAYRS HHHHHCCCHHHHHCC	23.12	22167270
448 (in isoform 1)	Phosphorylation	-	23.12	-
453	Phosphorylation	ASSPQDAYRSPHSPF CCCHHHHHCCCCCCC	21.66	22167270
455	Phosphorylation	SPQDAYRSPHSPFYQ CHHHHHCCCCCCCCC	17.81	30108239
455 (in isoform 1)	Phosphorylation	-	17.81	24719451
458	Phosphorylation	DAYRSPHSPFYQLPP HHHCCCCCCCCCCCC	21.79	30108239
461	Phosphorylation	RSPHSPFYQLPPSVQ CCCCCCCCCCCCCCC	16.72	28450419
471	Phosphorylation	PPSVQRHSPNPLLVA CCCCCCCCCCCEEEC	28.67	30266825
471 (in isoform 1)	Phosphorylation	-	28.67	27251275
480	Phosphorylation	NPLLVAPTPPALQKL CCEEECCCCHHHHHH	31.97	25159151
480 (in isoform 1)	Phosphorylation	-	31.97	-
508	Ubiquitination	YTKTPQYKASLQELL HCCCHHHHHHHHHHH	26.67	29967540
519	Ubiquitination	QELLGQEKEKNAQLL HHHHCCHHHHHHHHH	67.13	29967540
521	Ubiquitination	LLGQEKEKNAQLLGA HHCCHHHHHHHHHHH	69.52	29967540
557	Ubiquitination	KLDELGVKALTYNDL HHHHHCCCEECHHHH	35.56	32015554
560	Phosphorylation	ELGVKALTYNDLIQA HHCCCEECHHHHHHH	25.74	20068231
561	Phosphorylation	LGVKALTYNDLIQAQ HCCCEECHHHHHHHH	13.92	20068231
569	Ubiquitination	NDLIQAQKEISAHNQ HHHHHHHHHHHHHHH	61.09	29967540
572	Phosphorylation	IQAQKEISAHNQQLR HHHHHHHHHHHHHHH	25.27	20068231
572 (in isoform 1)	Phosphorylation	-	25.27	-
596	Phosphorylation	NRALRGQSLQLLKAR HHHHHHHHHHHHHHH	22.40	17192257
596 (in isoform 1)	Phosphorylation	-	22.40	-
601	Ubiquitination	GQSLQLLKARCEELQ HHHHHHHHHHHHHHC	42.23	29967540
613	Phosphorylation	ELQLDWATLSLEKLL HHCCHHHHHCHHHHH	16.78	20860994
628	Phosphorylation	KEKQALKSQISEKQR HHHHHHHHHCCHHHH	33.33	-
631	Phosphorylation	QALKSQISEKQRHCL HHHHHHCCHHHHHHH	30.98	-
660	Ubiquitination	QQELLQLKSCVPPDD HHHHHHHHHCCCCCC	28.93	29967540
676	Acetylation	LSLHLRGKGALGREL HHHHHCCCCCCCCCC	34.28	129865
700	Phosphorylation	ELDCTKFSLPHLSSM EEECCCCCCHHHHHC	42.41	26074081
705	Phosphorylation	KFSLPHLSSMSPELS CCCCHHHHHCCHHHH	22.44	26074081
706	Phosphorylation	FSLPHLSSMSPELSM CCCHHHHHCCHHHHC	29.64	26074081
708	Phosphorylation	LPHLSSMSPELSMNG CHHHHHCCHHHHCCC	19.71	26074081
727	Phosphorylation	YELCGVLSRPSSKQN HHHHCEECCCCCCCC	39.47	26074081
730	Phosphorylation	CGVLSRPSSKQNTPQ HCEECCCCCCCCCCC	49.40	26074081
731	Phosphorylation	GVLSRPSSKQNTPQY CEECCCCCCCCCCCH	40.73	26074081
732	Ubiquitination	VLSRPSSKQNTPQYL EECCCCCCCCCCCHH	52.48	29967540
735	Phosphorylation	RPSSKQNTPQYLASP CCCCCCCCCCHHCCC	14.85	22322096
738	Phosphorylation	SKQNTPQYLASPLDQ CCCCCCCHHCCCCCC	12.87	22322096
741	Phosphorylation	NTPQYLASPLDQEVV CCCCHHCCCCCCCCC	24.33	22322096
741 (in isoform 1)	Phosphorylation	-	24.33	24719451
751	Phosphorylation	DQEVVPCTPSHVGRP CCCCCCCCHHHCCCC	23.04	22322096
753	Phosphorylation	EVVPCTPSHVGRPRL CCCCCCHHHCCCCCH	16.80	22322096
764	Phosphorylation	RPRLEKLSGLAAPDY CCCHHHHCCCCCCCC	42.71	23927012
771	Phosphorylation	SGLAAPDYTRLSPAK CCCCCCCCCCCCHHH	7.84	23927012
771 (in isoform 1)	Phosphorylation	-	7.84	-
772	Phosphorylation	GLAAPDYTRLSPAKI CCCCCCCCCCCHHHH	32.30	23401153
775	Phosphorylation	APDYTRLSPAKIVLR CCCCCCCCHHHHHHH	21.37	30266825
775 (in isoform 1)	Phosphorylation	-	21.37	24719451
786	Phosphorylation	IVLRRHLSQDHTVPG HHHHHHCCCCCCCCC	27.69	23401153
786 (in isoform 1)	Phosphorylation	-	27.69	24719451
790	Phosphorylation	RHLSQDHTVPGRPAA HHCCCCCCCCCCCCH	36.36	23927012
798	Phosphorylation	VPGRPAASELHSRAE CCCCCCHHHHHHHHH	42.68	23927012
802	Phosphorylation	PAASELHSRAEHTKE CCHHHHHHHHHHHHH	45.90	23927012
814	Phosphorylation	TKENGLPYQSPSVPG HHHCCCCCCCCCCCC	27.02	26074081
816	Phosphorylation	ENGLPYQSPSVPGSM HCCCCCCCCCCCCCC	17.19	25159151
818	Phosphorylation	GLPYQSPSVPGSMKL CCCCCCCCCCCCCCC	46.31	26074081
822	Phosphorylation	QSPSVPGSMKLSPQD CCCCCCCCCCCCCCC	13.48	18669648
822 (in isoform 1)	Phosphorylation	-	13.48	-
826	Phosphorylation	VPGSMKLSPQDPRPL CCCCCCCCCCCCCCC	18.26	23401153
826 (in isoform 1)	Phosphorylation	-	18.26	27251275
834	Phosphorylation	PQDPRPLSPGALQLA CCCCCCCCCCHHHHC	24.78	19664994
834 (in isoform 1)	Phosphorylation	-	24.78	24719451
845	Phosphorylation	LQLAGEKSSEKGLRE HHHCCCCCCHHHHHH	39.15	26074081
846	Phosphorylation	QLAGEKSSEKGLRER HHCCCCCCHHHHHHH	55.16	26074081
855	Phosphorylation	KGLRERAYGSSGELI HHHHHHHCCCCCCEE	24.62	30576142
857	Phosphorylation	LRERAYGSSGELITS HHHHHCCCCCCEECC	23.61	-
858	Phosphorylation	RERAYGSSGELITSL HHHHCCCCCCEECCC	31.74	30576142
868	Phosphorylation	LITSLPISIPLSTVQ EECCCCEEEECCCCC	19.06	30576142
882	Phosphorylation	QPNKLPVSIPLASVV CCCCCCCEEEEEEEE	19.29	-
892	Phosphorylation	LASVVLPSRAERARS EEEEECCHHHHHHHC	39.71	-
899	Phosphorylation	SRAERARSTPSPVLQ HHHHHHHCCCCCCCC	43.62	22167270
899 (in isoform 1)	Phosphorylation	-	43.62	24719451
900	Phosphorylation	RAERARSTPSPVLQP HHHHHHCCCCCCCCC	23.41	22167270
900 (in isoform 1)	Phosphorylation	-	23.41	27251275
902	Phosphorylation	ERARSTPSPVLQPRD HHHHCCCCCCCCCCC	27.94	22167270
902 (in isoform 1)	Phosphorylation	-	27.94	24719451
913	Phosphorylation	QPRDPSSTLEKQIGA CCCCCCCHHHHHHCC	43.18	21815630
982	Phosphorylation	FATVGSRSSTPQHPL EEEECCCCCCCCCCE	40.02	22167270
983	Phosphorylation	ATVGSRSSTPQHPLL EEECCCCCCCCCCEE	42.89	22167270
983 (in isoform 1)	Phosphorylation	-	42.89	24719451
984	Phosphorylation	TVGSRSSTPQHPLLL EECCCCCCCCCCEEE	28.37	22167270
984 (in isoform 1)	Phosphorylation	-	28.37	24719451
997	Phosphorylation	LLAQPRNSLPASPAH EECCCCCCCCCCHHH	36.69	23927012
997 (in isoform 1)	Phosphorylation	-	36.69	-
1001	Phosphorylation	PRNSLPASPAHQLSS CCCCCCCCHHHHCCC	22.23	29255136
1001 (in isoform 1)	Phosphorylation	-	22.23	24719451
1007	Phosphorylation	ASPAHQLSSSPRLGG CCHHHHCCCCCCCCC	23.38	23401153
1007 (in isoform 1)	Phosphorylation	-	23.38	24719451
1008	Phosphorylation	SPAHQLSSSPRLGGA CHHHHCCCCCCCCCC	53.61	29255136
1008 (in isoform 1)	Phosphorylation	-	53.61	27251275
1009	Phosphorylation	PAHQLSSSPRLGGAA HHHHCCCCCCCCCCC	15.63	29255136
1009 (in isoform 1)	Phosphorylation	-	15.63	24719451
1024	Phosphorylation	QGPLPEASKGDLPSD CCCCCCCCCCCCCCC	35.19	28450419
1030	Phosphorylation	ASKGDLPSDSGFSDP CCCCCCCCCCCCCCC	52.27	25159151
1032	Phosphorylation	KGDLPSDSGFSDPES CCCCCCCCCCCCCHH	46.18	22617229
1035	Phosphorylation	LPSDSGFSDPESEAK CCCCCCCCCCHHHHH	56.64	23401153
1035 (in isoform 1)	Phosphorylation	-	56.64	-
1039	Phosphorylation	SGFSDPESEAKRRIV CCCCCCHHHHHHEEE	48.52	29255136
1048	Phosphorylation	AKRRIVFTITTGAGS HHHEEEEEEECCCCC	13.40	23312004
1050	Phosphorylation	RRIVFTITTGAGSAK HEEEEEEECCCCCCC	19.00	24719451
1050 (in isoform 1)	Phosphorylation	-	19.00	24719451
1051	Phosphorylation	RIVFTITTGAGSAKQ EEEEEEECCCCCCCC	22.60	27174698
1055	Phosphorylation	TITTGAGSAKQSPSS EEECCCCCCCCCCCC	31.58	20068231
1055 (in isoform 1)	Phosphorylation	-	31.58	27251275
1059	Phosphorylation	GAGSAKQSPSSKHSP CCCCCCCCCCCCCCC	26.49	28348404
1059 (in isoform 1)	Phosphorylation	-	26.49	-
1061	Phosphorylation	GSAKQSPSSKHSPLT CCCCCCCCCCCCCCC	58.21	28450419
1062	Phosphorylation	SAKQSPSSKHSPLTA CCCCCCCCCCCCCCC	37.46	28450419
1065	Phosphorylation	QSPSSKHSPLTASAR CCCCCCCCCCCCHHC	25.91	30108239
1068	Phosphorylation	SSKHSPLTASARGDC CCCCCCCCCHHCCCC	23.19	30108239
1070	Phosphorylation	KHSPLTASARGDCVP CCCCCCCHHCCCCCC	17.17	30108239
1093	Phosphorylation	RGRRKRASAGTPSLS HCCHHHHCCCCCCCC	31.12	25159151
1096	Phosphorylation	RKRASAGTPSLSAGV HHHHCCCCCCCCCCC	14.93	23927012
1098	Phosphorylation	RASAGTPSLSAGVSP HHCCCCCCCCCCCCC	34.49	23927012
1100	Phosphorylation	SAGTPSLSAGVSPKR CCCCCCCCCCCCCCC	27.58	30278072
1100 (in isoform 1)	Phosphorylation	-	27.58	-
1104	Phosphorylation	PSLSAGVSPKRRALP CCCCCCCCCCCCCCC	24.64	29255136
1104 (in isoform 1)	Phosphorylation	-	24.64	24719451
1112	Phosphorylation	PKRRALPSVAGLFTQ CCCCCCCCCCCCCCC	26.00	30177828
1118	Phosphorylation	PSVAGLFTQPSGSPL CCCCCCCCCCCCCCC	44.61	30177828
1121	Phosphorylation	AGLFTQPSGSPLNLN CCCCCCCCCCCCCHH	41.93	30177828
1123	Phosphorylation	LFTQPSGSPLNLNSM CCCCCCCCCCCHHHH	30.47	30177828
1129	Phosphorylation	GSPLNLNSMVSNINQ CCCCCHHHHHCCCCC	24.59	30177828
1132	Phosphorylation	LNLNSMVSNINQPLE CCHHHHHCCCCCCEE	24.29	30177828
1141	Phosphorylation	INQPLEITAISSPET CCCCEEEEEECCCCC	14.46	30177828
1144	Phosphorylation	PLEITAISSPETSLK CEEEEEECCCCCCCC	37.06	30177828
1145	Phosphorylation	LEITAISSPETSLKS EEEEEECCCCCCCCC	22.20	30177828
1148	Phosphorylation	TAISSPETSLKSSPV EEECCCCCCCCCCCC	42.62	30177828
1149	Phosphorylation	AISSPETSLKSSPVP EECCCCCCCCCCCCC	31.94	30177828
1152	Phosphorylation	SPETSLKSSPVPYQD CCCCCCCCCCCCCCC	45.21	23401153
1153	Phosphorylation	PETSLKSSPVPYQDH CCCCCCCCCCCCCCC	28.47	25159151
1153 (in isoform 1)	Phosphorylation	-	28.47	27251275
1157	Phosphorylation	LKSSPVPYQDHDQPP CCCCCCCCCCCCCCC	27.14	20873877
1173	Phosphorylation	LKKERPLSQTNGAHY CCCCCCCCCCCCCCC	37.33	30177828
1175	Phosphorylation	KERPLSQTNGAHYSP CCCCCCCCCCCCCCC	32.04	30177828
1180	Phosphorylation	SQTNGAHYSPLTSDE CCCCCCCCCCCCCCC	16.08	30177828
1181	Phosphorylation	QTNGAHYSPLTSDEE CCCCCCCCCCCCCCC	11.99	29449344
1184	Phosphorylation	GAHYSPLTSDEEPGS CCCCCCCCCCCCCCC	37.20	29449344
1185	Phosphorylation	AHYSPLTSDEEPGSE CCCCCCCCCCCCCCC	51.19	29449344
1191	Phosphorylation	TSDEEPGSEDEPSSA CCCCCCCCCCCCCHH	53.22	29449344
1196	Phosphorylation	PGSEDEPSSARIERK CCCCCCCCHHHHEEE	34.28	25841592
1197	Phosphorylation	GSEDEPSSARIERKI CCCCCCCHHHHEEEE	32.08	25841592
1206	Phosphorylation	RIERKIATISLESKS HHEEEEEEEEECCCC	17.99	28122231
1208	Phosphorylation	ERKIATISLESKSPP EEEEEEEEECCCCCC	23.02	30266825
1208 (in isoform 1)	Phosphorylation	-	23.02	27251275
1211	Phosphorylation	IATISLESKSPPKTL EEEEEECCCCCCCCC	43.67	30266825
1213	Phosphorylation	TISLESKSPPKTLEN EEEECCCCCCCCCCC	56.57	30266825
1213 (in isoform 1)	Phosphorylation	-	56.57	24719451
1217	Phosphorylation	ESKSPPKTLENGGGL CCCCCCCCCCCCCCC	45.11	30108239
1228	Acetylation	GGGLAGRKPAPAGEP CCCCCCCCCCCCCCC	44.61	26051181
1240	Acetylation	GEPVNSSKWKSTFSP CCCCCHHHCCCCCCC	59.47	25953088
1243	Phosphorylation	VNSSKWKSTFSPISD CCHHHCCCCCCCHHH	33.30	30266825
1244	Phosphorylation	NSSKWKSTFSPISDI CHHHCCCCCCCHHHH	25.14	30266825
1246	Phosphorylation	SKWKSTFSPISDIGL HHCCCCCCCHHHHCC	22.78	19664994
1246 (in isoform 1)	Phosphorylation	-	22.78	24719451
1249	Phosphorylation	KSTFSPISDIGLAKS CCCCCCHHHHCCCCC	26.93	30266825
1256	Phosphorylation	SDIGLAKSADSPLQA HHHCCCCCCCCCCHH	31.53	28450419
1259	Phosphorylation	GLAKSADSPLQASSA CCCCCCCCCCHHCHH	27.50	28450419
1259 (in isoform 1)	Phosphorylation	-	27.50	27251275
1264	Phosphorylation	ADSPLQASSALSQNS CCCCCHHCHHHHCCC	11.81	28450419
1268	Phosphorylation	LQASSALSQNSLFTF CHHCHHHHCCCCEEE	27.34	-
1307	Phosphorylation	LSGADGLSPGTNPAN CCCCCCCCCCCCCCC	27.15	30576142
1327	Phosphorylation	GGLAADLSLHSFSDG CCHHHCCEEEECCCC	25.28	30576142
1332	Phosphorylation	DLSLHSFSDGASLPH CCEEEECCCCCCCCC	37.84	30576142
1348	Phosphorylation	GPEAAGLSSPLSFPS CCCCCCCCCCCCCCC	29.06	30108239
1348 (in isoform 1)	Phosphorylation	-	29.06	-
1349	Phosphorylation	PEAAGLSSPLSFPSQ CCCCCCCCCCCCCCC	34.60	25159151
1352	Phosphorylation	AGLSSPLSFPSQRGK CCCCCCCCCCCCCCC	38.20	30108239
1355	Phosphorylation	SSPLSFPSQRGKEGS CCCCCCCCCCCCCCC	30.42	30108239
1355 (in isoform 1)	Phosphorylation	-	30.42	-
1359	"N6,N6-dimethyllysine"	SFPSQRGKEGSDANP CCCCCCCCCCCCCCC	62.18	-
1359	Methylation	SFPSQRGKEGSDANP CCCCCCCCCCCCCCC	62.18	23644510
1362	Phosphorylation	SQRGKEGSDANPFLS CCCCCCCCCCCCCCC	34.34	24719451
1362 (in isoform 1)	Phosphorylation	-	34.34	24719451
1369	Phosphorylation	SDANPFLSKRQLDGL CCCCCCCCHHHHHCC	26.60	20068231
1384	Phosphorylation	AGLKGEGSRGKEAGE CCCCCCCCCCCCCCC	33.29	24719451
1384 (in isoform 1)	Phosphorylation	-	33.29	24719451
1402	Acetylation	PLCGPTDKTPLLSGK CCCCCCCCCCCCCCH	55.29	26051181
1403	Phosphorylation	LCGPTDKTPLLSGKA CCCCCCCCCCCCCHH	23.21	-
1409	Acetylation	KTPLLSGKAAKARDR CCCCCCCHHHHHCCC	41.62	25953088
1672	Phosphorylation	SLPPANASLSIKLTS HCCCCCCEEEEEEEC	23.58	24719451
1674	Phosphorylation	PPANASLSIKLTSLP CCCCCEEEEEEECCC	18.38	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DOT1L_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DOT1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DOT1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AF9_HUMAN	MLLT3	physical	16636056
AF17_HUMAN	MLLT6	physical	19864429
NPM_HUMAN	NPM1	physical	20431927
HNRPM_HUMAN	HNRNPM	physical	20431927
AF9_HUMAN	MLLT3	physical	20431927
ENL_HUMAN	MLLT1	physical	20431927
AF10_HUMAN	MLLT10	physical	20431927
H12_HUMAN	HIST1H1C	physical	20431927
DDX21_HUMAN	DDX21	physical	20431927
H2B1B_HUMAN	HIST1H2BB	physical	20431927
GRWD1_HUMAN	GRWD1	physical	20431927
HNRPU_HUMAN	HNRNPU	physical	20431927
H2A1A_HUMAN	HIST1H2AA	physical	20431927
THOC4_HUMAN	ALYREF	physical	20431927
YBOX3_HUMAN	YBX3	physical	20431927
HNRPQ_HUMAN	SYNCRIP	physical	20431927
GNL3_HUMAN	GNL3	physical	20431927
H1X_HUMAN	H1FX	physical	20431927
H11_HUMAN	HIST1H1A	physical	20431927
SIR1_HUMAN	SIRT1	physical	20431927
ENL_HUMAN	MLLT1	physical	20153263
AFF1_HUMAN	AFF1	physical	21030982
H32_HUMAN	HIST2H3C	physical	21726816
STAT1_HUMAN	STAT1	physical	22002246
H31T_HUMAN	HIST3H3	physical	22619169
BAG6_HUMAN	BAG6	physical	22373577
H32_HUMAN	HIST2H3C	physical	22373577
ENL_HUMAN	MLLT1	physical	21873227
AF9_HUMAN	MLLT3	physical	21873227
KMT2A_HUMAN	KMT2A	physical	22094252
AF17_HUMAN	MLLT6	physical	26344197
AF9_HUMAN	MLLT3	physical	26496610
AF17_HUMAN	MLLT6	physical	26496610
MK07_HUMAN	MAPK7	physical	26496610
AF10_HUMAN	MLLT10	physical	26496610
EBP2_HUMAN	EBNA1BP2	physical	26496610
IBTK_HUMAN	IBTK	physical	26496610
NIN_HUMAN	NIN	physical	26496610
PAR16_HUMAN	PARP16	physical	26496610
BRNP1_HUMAN	BRINP1	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DOT1L_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; THR-900; SER-902;SER-1001; SER-1104 AND SER-1246, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-826; SER-834AND SER-1104, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374; SER-471; THR-480;SER-775; SER-822; SER-834; SER-899; THR-900; SER-902; SER-1001 ANDSER-1009, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-596, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1001; SER-1009 ANDSER-1349, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297, AND MASSSPECTROMETRY.	17924679 [Abstract]