PAR16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAR16_HUMAN
• UniProt AC: Q8N5Y8
• Protein Name: Mono [ADP-ribose] polymerase PARP16 {ECO:0000305}
• Gene Name: PARP16 {ECO:0000303|PubMed:20106667, ECO:0000312|HGNC:HGNC:26040}
• Organism: Homo sapiens (Human).
• Sequence Length: 322
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type IV membrane protein .
• Protein Description: Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. [PubMed: 23103912]
• Protein Sequence: MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDVKCQTKKKDSKEIDRRRARIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPPKRASSQLSWFSSHWFTVMISLYLLLLLIVSVINSSAFQHFWNRAKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MQPSGWAAARE ----CCCCHHHHHHH	30.03	-
25	Phosphorylation	LAADLRCSLFASALQ HHHHHHHHHHHHHHH	21.79	24719451
33	Phosphorylation	LFASALQSYKRDSVL HHHHHHHHCCCCCCC	33.21	28555341
34	Phosphorylation	FASALQSYKRDSVLR HHHHHHHCCCCCCCC	9.33	28555341
35	Ubiquitination	ASALQSYKRDSVLRP HHHHHHCCCCCCCCC	55.78	22505724
35 (in isoform 3)	Ubiquitination	-	55.78	-
37	ADP-ribosylation	ALQSYKRDSVLRPFP HHHHCCCCCCCCCCC	38.66	25043379
53	Ubiquitination	SYARGDCKDFEALLA HHCCCCCCCHHHHHH	70.91	29967540
64	Ubiquitination	ALLADASKLPNLKEL HHHHCHHHCCCHHHH	70.46	29967540
69	Ubiquitination	ASKLPNLKELLQSSG HHHCCCHHHHHHHCC	53.62	29967540
70	ADP-ribosylation	SKLPNLKELLQSSGD HHCCCHHHHHHHCCC	58.86	25043379
74	Phosphorylation	NLKELLQSSGDNHKR CHHHHHHHCCCCHHH	35.94	24961811
102	Ubiquitination	LTIHSAGKAEFEKIQ EEEECCCHHHHHHHH	44.45	29967540
110	ADP-ribosylation	AEFEKIQKLTGAPHT HHHHHHHHHHCCCCC	52.03	25043379
137	ADP-ribosylation	YFDPANAKFYETKGE EECHHCCEEEECCCC	48.57	25043379
142	Ubiquitination	NAKFYETKGERDLIY CCEEEECCCCCCEEE	47.00	-
232	Phosphorylation	CQTKKKDSKEIDRRR CCCCCCCHHHHHHHH	40.86	19664994
245	Phosphorylation	RRARIKHSEGGDIPP HHHHHHHCCCCCCCC	32.70	30266825
267	Phosphorylation	NQLLRVKYLLVYSQK CCEEEEEEEEEECCC	11.47	29083192
271	Phosphorylation	RVKYLLVYSQKPPKR EEEEEEEECCCCCCC	12.83	29083192
272	Phosphorylation	VKYLLVYSQKPPKRA EEEEEEECCCCCCCC	25.01	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAR16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAR16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAR16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMCL1_HUMAN	GMCL1	physical	25416956
MDN1_HUMAN	MDN1	physical	26186194
DDX20_HUMAN	DDX20	physical	26186194
RAI14_HUMAN	RAI14	physical	26186194
LRP6_HUMAN	LRP6	physical	26186194
LRP5_HUMAN	LRP5	physical	26186194
COG6_HUMAN	COG6	physical	26186194
ECSIT_HUMAN	ECSIT	physical	26186194
VWA8_HUMAN	VWA8	physical	26186194
COG1_HUMAN	COG1	physical	26186194
NEDD1_HUMAN	NEDD1	physical	26186194
COG5_HUMAN	COG5	physical	26186194
VAC14_HUMAN	VAC14	physical	26186194
B3GL2_HUMAN	B3GALNT2	physical	26186194
LRBA_HUMAN	LRBA	physical	26186194
UBE4A_HUMAN	UBE4A	physical	26186194
CREL1_HUMAN	CRELD1	physical	26186194
LRP5_HUMAN	LRP5	physical	28514442
RAI14_HUMAN	RAI14	physical	28514442
NEDD1_HUMAN	NEDD1	physical	28514442
VWA8_HUMAN	VWA8	physical	28514442
LRP6_HUMAN	LRP6	physical	28514442
B3GL2_HUMAN	B3GALNT2	physical	28514442
COG6_HUMAN	COG6	physical	28514442
UBE4A_HUMAN	UBE4A	physical	28514442
MDN1_HUMAN	MDN1	physical	28514442
COG1_HUMAN	COG1	physical	28514442
COG5_HUMAN	COG5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.