| UniProt ID | INT13_HUMAN | |
|---|---|---|
| UniProt AC | Q9NVM9 | |
| Protein Name | Integrator complex subunit 13 {ECO:0000312|HGNC:HGNC:20174} | |
| Gene Name | INTS13 {ECO:0000312|HGNC:HGNC:20174} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 706 | |
| Subcellular Localization | Nucleus . Cytoplasm . Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M. | |
| Protein Description | Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. [PubMed: 23904267] | |
| Protein Sequence | MKIFSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDSGAHVLNSWTQEDQNLQELMAALAAVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRSKKELSPVLTSEVHSVRAGRHLATKLNILVQQHFDLASTTITNIPMKEEQHANTSANYDVELLHHKDAHVDFLKSGDSHLGGGSREGSFKETITLKWCTPRTNNIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLTPFLDPRYKIDGSLEVPLERAKDQLEKHTRYWPMIISQTTIFNMQAVVPLASVIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPISTVGTRGKGPKRDEQYRIMWNELETLVRAHINNSEKHQRVLECLMACRSKPPEEEERKKRGRKREDKEDKSEKAVKDYEQEKSWQDSERLKGILERGKEELAEAEIIKDSPDSPEPPNKKPLVEMDETPQVEKSKGPVSLLSLWSNRINTANSRKHQEFAGRLNSVNNRAELYQHLKEENGMETTENGKASRQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Ubiquitination | ------MKIFSESHK ------CCCCCCCCC | 29967540 | ||
| 34 | Ubiquitination | HVEFDMLVKNRTQGI HCCHHEEECCCCCCE | - | ||
| 35 | Ubiquitination | VEFDMLVKNRTQGII CCHHEEECCCCCCEE | - | ||
| 38 | Phosphorylation | DMLVKNRTQGIIPLA HEEECCCCCCEEECC | 21406692 | ||
| 48 | Phosphorylation | IIPLAPISKSLWTCS EEECCCCCCHHCEEC | 21406692 | ||
| 49 | Ubiquitination | IPLAPISKSLWTCSV EECCCCCCHHCEECH | 21963094 | ||
| 50 | Phosphorylation | PLAPISKSLWTCSVE ECCCCCCHHCEECHH | 25599653 | ||
| 53 | Phosphorylation | PISKSLWTCSVESSM CCCCHHCEECHHHHH | 25599653 | ||
| 55 | Phosphorylation | SKSLWTCSVESSMEY CCHHCEECHHHHHHH | 25599653 | ||
| 59 | Phosphorylation | WTCSVESSMEYCRIM CEECHHHHHHHHHHH | 25599653 | ||
| 62 | Phosphorylation | SVESSMEYCRIMYDI CHHHHHHHHHHHHHH | 25599653 | ||
| 66 | Ubiquitination | SMEYCRIMYDIFPFK HHHHHHHHHHHHCHH | - | ||
| 67 | Phosphorylation | MEYCRIMYDIFPFKK HHHHHHHHHHHCHHH | 24667141 | ||
| 73 | Ubiquitination | MYDIFPFKKLVNFIV HHHHHCHHHHHHHHH | 21890473 | ||
| 73 | Ubiquitination | MYDIFPFKKLVNFIV HHHHHCHHHHHHHHH | 21963094 | ||
| 74 | Ubiquitination | YDIFPFKKLVNFIVS HHHHCHHHHHHHHHC | 22817900 | ||
| 81 | Phosphorylation | KLVNFIVSDSGAHVL HHHHHHHCCCCCCHH | - | ||
| 83 | Phosphorylation | VNFIVSDSGAHVLNS HHHHHCCCCCCHHHC | - | ||
| 87 | Ubiquitination | VSDSGAHVLNSWTQE HCCCCCCHHHCCCCC | - | ||
| 122 | Ubiquitination | ADPECCSILHGLVAA CCHHHHHHHHHHHHH | - | ||
| 123 | Ubiquitination | DPECCSILHGLVAAV CHHHHHHHHHHHHHH | - | ||
| 135 | Ubiquitination | AAVETLCKITEYQHE HHHHHHHHHHHHHHH | - | ||
| 142 | Ubiquitination | KITEYQHEARTLLME HHHHHHHHHHHHHHH | 21963094 | ||
| 148 | Sulfoxidation | HEARTLLMENAERVG HHHHHHHHHHHHHHH | 21406390 | ||
| 167 | Ubiquitination | IICITNAKSDSHVRM EEEEECCCCCHHHHH | 21963094 | ||
| 167 | Acetylation | IICITNAKSDSHVRM EEEEECCCCCHHHHH | 25953088 | ||
| 188 | Ubiquitination | ETIHEHNKLAANSDH HHHHHHCHHHCCCCH | 29967540 | ||
| 194 | Ubiquitination | NKLAANSDHLMQIQK CHHHCCCCHHHHHCC | - | ||
| 210 | Phosphorylation | ELVLIHTYPVGEDSL EEEEEEEECCCCCCC | - | ||
| 210 | Ubiquitination | ELVLIHTYPVGEDSL EEEEEEEECCCCCCC | - | ||
| 218 | Ubiquitination | PVGEDSLVSDRSKKE CCCCCCCCCCCCCCC | 21963094 | ||
| 223 | Ubiquitination | SLVSDRSKKELSPVL CCCCCCCCCCCCCCC | - | ||
| 224 | Ubiquitination | LVSDRSKKELSPVLT CCCCCCCCCCCCCCH | 21963094 | ||
| 227 | Phosphorylation | DRSKKELSPVLTSEV CCCCCCCCCCCHHHH | - | ||
| 236 | Phosphorylation | VLTSEVHSVRAGRHL CCHHHHHHHHCHHHH | - | ||
| 270 | Ubiquitination | TNIPMKEEQHANTSA ECCCCCHHHHCCCCC | 21963094 | ||
| 275 | Phosphorylation | KEEQHANTSANYDVE CHHHHCCCCCCCCCE | 28555341 | ||
| 276 | Phosphorylation | EEQHANTSANYDVEL HHHHCCCCCCCCCEE | 28555341 | ||
| 287 | Ubiquitination | DVELLHHKDAHVDFL CCEECCCCCCCCCHH | 29967540 | ||
| 295 | Ubiquitination | DAHVDFLKSGDSHLG CCCCCHHHCCCCCCC | 21963094 | ||
| 305 | Phosphorylation | DSHLGGGSREGSFKE CCCCCCCCCCCCCCE | 27251275 | ||
| 309 | Phosphorylation | GGGSREGSFKETITL CCCCCCCCCCEEEEE | 25627689 | ||
| 311 | Ubiquitination | GSREGSFKETITLKW CCCCCCCCEEEEEEE | 29967540 | ||
| 335 | Ubiquitination | LHYCTGAYRISPVDV EEECCCCEEECCCCC | - | ||
| 344 | Phosphorylation | ISPVDVNSRPSSCLT ECCCCCCCCCCCHHH | 20363803 | ||
| 368 | Phosphorylation | LLEQPRKSGSKVISH EEECCCCCCCHHHHH | 24719451 | ||
| 395 | Ubiquitination | VLSSSRSILEDPPSI HHHCCCHHHCCCCCC | - | ||
| 406 | Ubiquitination | PPSISEGCGGRVTDY CCCCCCCCCCCCCEE | - | ||
| 421 | Ubiquitination | RITDFGEFMRENRLT EECCHHHHHHHCCCC | 21963094 | ||
| 427 | Ubiquitination | EFMRENRLTPFLDPR HHHHHCCCCCCCCCC | 21963094 | ||
| 436 | Ubiquitination | PFLDPRYKIDGSLEV CCCCCCCCCCCCEEC | 29967540 | ||
| 439 | Ubiquitination | DPRYKIDGSLEVPLE CCCCCCCCCEECCHH | 21963094 | ||
| 445 | Ubiquitination | DGSLEVPLERAKDQL CCCEECCHHHHHHHH | 21963094 | ||
| 456 | Phosphorylation | KDQLEKHTRYWPMII HHHHHHHHCHHCCEE | 25599653 | ||
| 471 | Ubiquitination | SQTTIFNMQAVVPLA ECCEECCCCHHHHHH | 21963094 | ||
| 477 | Ubiquitination | NMQAVVPLASVIVKE CCCHHHHHHHHHCCC | 21963094 | ||
| 494 | Ubiquitination | TEEDVLNCQKTIYNL CHHHHHHHHHHHHHH | - | ||
| 496 | Ubiquitination | EDVLNCQKTIYNLVD HHHHHHHHHHHHHHC | 21963094 | ||
| 502 | Ubiquitination | QKTIYNLVDMERKND HHHHHHHHCHHHCCC | 21963094 | ||
| 507 | Ubiquitination | NLVDMERKNDPLPIS HHHCHHHCCCCCCCC | 29967540 | ||
| 514 | Phosphorylation | KNDPLPISTVGTRGK CCCCCCCCCCCCCCC | 23836654 | ||
| 515 | Phosphorylation | NDPLPISTVGTRGKG CCCCCCCCCCCCCCC | 23836654 | ||
| 518 | Phosphorylation | LPISTVGTRGKGPKR CCCCCCCCCCCCCCH | 23836654 | ||
| 547 | Ubiquitination | VRAHINNSEKHQRVL HHHHCCCHHHHHHHH | - | ||
| 561 | Methylation | LECLMACRSKPPEEE HHHHHHHHCCCCHHH | - | ||
| 584 | Phosphorylation | REDKEDKSEKAVKDY CCCCCHHHHHHHHHH | 23403867 | ||
| 591 | Phosphorylation | SEKAVKDYEQEKSWQ HHHHHHHHHHHHHHH | 27642862 | ||
| 595 | Ubiquitination | VKDYEQEKSWQDSER HHHHHHHHHHHHHHH | 29967540 | ||
| 596 | Phosphorylation | KDYEQEKSWQDSERL HHHHHHHHHHHHHHH | 25159151 | ||
| 604 | Ubiquitination | WQDSERLKGILERGK HHHHHHHHHHHHHHH | 29967540 | ||
| 611 | Ubiquitination | KGILERGKEELAEAE HHHHHHHHHHHHHCE | 29967540 | ||
| 611 | Sumoylation | KGILERGKEELAEAE HHHHHHHHHHHHHCE | 28112733 | ||
| 611 | Sumoylation | KGILERGKEELAEAE HHHHHHHHHHHHHCE | - | ||
| 623 | Phosphorylation | EAEIIKDSPDSPEPP HCEECCCCCCCCCCC | 29255136 | ||
| 626 | Phosphorylation | IIKDSPDSPEPPNKK ECCCCCCCCCCCCCC | 29255136 | ||
| 641 | Phosphorylation | PLVEMDETPQVEKSK CCCCCCCCCCHHHCC | 25159151 | ||
| 648 | Ubiquitination | TPQVEKSKGPVSLLS CCCHHHCCCCHHHHH | - | ||
| 652 | Phosphorylation | EKSKGPVSLLSLWSN HHCCCCHHHHHHHHC | - | ||
| 658 | Phosphorylation | VSLLSLWSNRINTAN HHHHHHHHCCCCCCC | - | ||
| 663 | Phosphorylation | LWSNRINTANSRKHQ HHHCCCCCCCHHHHH | - | ||
| 678 | Phosphorylation | EFAGRLNSVNNRAEL HHHHHHHHHCCHHHH | 25159151 | ||
| 686 | Phosphorylation | VNNRAELYQHLKEEN HCCHHHHHHHHHHHC | 27642862 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of INT13_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of INT13_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of INT13_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ZN655_HUMAN | ZNF655 | physical | 16189514 | |
| NAA15_HUMAN | NAA15 | physical | 22939629 | |
| SWP70_HUMAN | SWAP70 | physical | 22863883 | |
| CG026_HUMAN | C7orf26 | physical | 26344197 | |
| INT6L_HUMAN | DDX26B | physical | 26344197 | |
| INT1_HUMAN | INTS1 | physical | 26344197 | |
| INT2_HUMAN | INTS2 | physical | 26344197 | |
| INT4_HUMAN | INTS4 | physical | 26344197 | |
| INT7_HUMAN | INTS7 | physical | 26344197 | |
| SNX2_HUMAN | SNX2 | physical | 26344197 | |
| INT14_HUMAN | VWA9 | physical | 26344197 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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