dbPTM

BCL7B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BCL7B_HUMAN
UniProt AC	Q9BQE9
Protein Name	B-cell CLL/lymphoma 7 protein family member B
Gene Name	BCL7B
Organism	Homo sapiens (Human).
Sequence Length	202
Subcellular Localization
Protein Description	Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1. [PubMed: 25569233 Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation]
Protein Sequence	MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNSSAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPSSEVADEPPTLTKEEPVPLETQVVEEEEDSGAPPLKRFCVDQPTVPQTASES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGRSVRAE ------CCCCCHHHH	42.80	29449344
5	Phosphorylation	---MSGRSVRAETRS ---CCCCCHHHHHHH	21.34	26074081
10	Phosphorylation	GRSVRAETRSRAKDD CCCHHHHHHHHCHHH	32.72	29449344
12	Phosphorylation	SVRAETRSRAKDDIK CHHHHHHHHCHHHHH	43.97	18452278
27 (in isoform 3)	Ubiquitination	-	41.02	21890473
27 (in isoform 1)	Ubiquitination	-	41.02	21890473
27	Ubiquitination	KVMAAIEKVRKWEKK HHHHHHHHHHHHHCE	41.02	-
27	Ubiquitination	KVMAAIEKVRKWEKK HHHHHHHHHHHHHCE	41.02	21890473
34	Ubiquitination	KVRKWEKKWVTVGDT HHHHHHCEEEEECCC	35.07	-
41	Phosphorylation	KWVTVGDTSLRIFKW EEEEECCCEEEEEEE	24.59	-
52	Phosphorylation	IFKWVPVTDSKEKEK EEEEEECCCCCHHHH	28.60	21815630
54	Phosphorylation	KWVPVTDSKEKEKSK EEEECCCCCHHHHHC	33.09	21815630
107	Phosphorylation	VYQLKVDSSTNSSPS EEEEEECCCCCCCCC	41.89	30266825
108	Phosphorylation	YQLKVDSSTNSSPSP EEEEECCCCCCCCCH	27.43	30266825
108 (in isoform 3)	Phosphorylation	-	27.43	-
109	Phosphorylation	QLKVDSSTNSSPSPQ EEEECCCCCCCCCHH	42.97	30266825
111	Phosphorylation	KVDSSTNSSPSPQQS EECCCCCCCCCHHHH	43.65	30266825
112 (in isoform 3)	Phosphorylation	-	31.31	-
112	Phosphorylation	VDSSTNSSPSPQQSE ECCCCCCCCCHHHHC	31.31	23401153
114 (in isoform 3)	Phosphorylation	-	36.97	-
114	Phosphorylation	SSTNSSPSPQQSESL CCCCCCCCHHHHCCC	36.97	29255136
118 (in isoform 3)	Phosphorylation	-	24.73	-
118	Phosphorylation	SSPSPQQSESLSPAH CCCCHHHHCCCCCCC	24.73	22167270
120 (in isoform 3)	Phosphorylation	-	39.12	-
120	Phosphorylation	PSPQQSESLSPAHTS CCHHHHCCCCCCCCC	39.12	29255136
122	Phosphorylation	PQQSESLSPAHTSDF HHHHCCCCCCCCCCC	29.35	29255136
122 (in isoform 3)	Phosphorylation	-	29.35	-
126	Phosphorylation	ESLSPAHTSDFRTDD CCCCCCCCCCCCCCC	31.90	30266825
126 (in isoform 3)	Phosphorylation	-	31.90	-
127 (in isoform 3)	Phosphorylation	-	25.53	-
127	Phosphorylation	SLSPAHTSDFRTDDS CCCCCCCCCCCCCCC	25.53	23927012
131	Phosphorylation	AHTSDFRTDDSQPPT CCCCCCCCCCCCCCC	44.12	30278072
134	Phosphorylation	SDFRTDDSQPPTLGQ CCCCCCCCCCCCCCH	47.61	30278072
138	Phosphorylation	TDDSQPPTLGQEILE CCCCCCCCCCHHHHC	50.64	30108239
148	Phosphorylation	QEILEEPSLPSSEVA HHHHCCCCCCHHHCC	57.08	28176443
151	Phosphorylation	LEEPSLPSSEVADEP HCCCCCCHHHCCCCC	44.41	26657352
152	Phosphorylation	EEPSLPSSEVADEPP CCCCCCHHHCCCCCC	33.86	30108239
160	Phosphorylation	EVADEPPTLTKEEPV HCCCCCCCCCCCCCC	58.75	19690332
162	Phosphorylation	ADEPPTLTKEEPVPL CCCCCCCCCCCCCCC	38.60	28176443
171	Phosphorylation	EEPVPLETQVVEEEE CCCCCCEEEEEEEEC	34.05	30108239
180	Phosphorylation	VVEEEEDSGAPPLKR EEEEECCCCCCCCCE	39.88	25849741
186	Acetylation	DSGAPPLKRFCVDQP CCCCCCCCEECCCCC	49.56	26051181
186	Ubiquitination	DSGAPPLKRFCVDQP CCCCCCCCEECCCCC	49.56	-
194	Phosphorylation	RFCVDQPTVPQTASE EECCCCCCCCCCCCC	38.90	-
198	Phosphorylation	DQPTVPQTASES--- CCCCCCCCCCCC---	26.53	28450419
200	Phosphorylation	PTVPQTASES----- CCCCCCCCCC-----	41.58	28450419
202	Phosphorylation	VPQTASES------- CCCCCCCC-------	42.92	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BCL7B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BCL7B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BCL7B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARI1A_HUMAN	ARID1A	physical	26344197
SMCA4_HUMAN	SMARCA4	physical	26344197
SMRD2_HUMAN	SMARCD2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BCL7B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114; SER-118 ANDSER-122, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114; SER-118 ANDSER-122, AND MASS SPECTROMETRY.	18669648 [Abstract]