FBX30_HUMAN - dbPTM
FBX30_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FBX30_HUMAN
UniProt AC Q8TB52
Protein Name F-box only protein 30
Gene Name FBXO30
Organism Homo sapiens (Human).
Sequence Length 745
Subcellular Localization
Protein Description Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation..
Protein Sequence MEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHSCKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLEMCPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKVSKPREQISVKSSVPEIPHANGLVSVDEESYGALYQATVETTRSLAAALDILNTATRDIGMLNTSVPNDMDEQQNARESLEDQNLKDQDHLYEEEIGAVGGIDYNDTNQNAQSEQNGSSDLLCDLNTSSYDTSALCNGFPLENICTQVIDQNQNLHGDSKQSNLTNGDCVASSDGTSKPSSSLAVAAQLREIIPSSALPNGTVQHILMPDDEGEGELCWKKVDLGDVKNVDVLSFSHAPSFNFLSNSCWSKPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMADIYHIDVGTQTFSLPSAILATSTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSIQGAKIIHDRHLRSFGVQPCVSTVLVEPARNCVLGLHNDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKRKYPEGNSSWQIKEKVWRFSTAFCSVNEWKFADILSMADHLKKCSYNVVEKREEAIPLPCMCVTRELTKEGRSLRSVLKPVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
105UbiquitinationPVSYADRKSYENLSR
CCCHHHHHHHHCCCC		58.9229967540
106PhosphorylationVSYADRKSYENLSRD
CCHHHHHHHHCCCCC		38.2828796482
107PhosphorylationSYADRKSYENLSRDV
CHHHHHHHHCCCCCH		16.3328796482
111PhosphorylationRKSYENLSRDVDEVA
HHHHHCCCCCHHHHH		37.7128102081
144UbiquitinationKVATMMSKATDKVSK
HHHHHHHHHCCCCCC		37.0929967540
173PhosphorylationPHANGLVSVDEESYG
CCCCCCEEECHHHHH		28.97-
179PhosphorylationVSVDEESYGALYQAT
EEECHHHHHHHHHHH		15.0827642862
183PhosphorylationEESYGALYQATVETT
HHHHHHHHHHHHHHH		8.7927642862
192PhosphorylationATVETTRSLAAALDI
HHHHHHHHHHHHHHH		21.9223663014
202PhosphorylationAALDILNTATRDIGM
HHHHHHHHHHCCCCC		26.4328555341
212PhosphorylationRDIGMLNTSVPNDMD
CCCCCCCCCCCCCHH		27.4325159151
213PhosphorylationDIGMLNTSVPNDMDE
CCCCCCCCCCCCHHH		34.2125159151
227PhosphorylationEQQNARESLEDQNLK
HHHHHHHHHHHCCCC		31.3521815630
310PhosphorylationLHGDSKQSNLTNGDC
CCCCCCCCCCCCCCE		37.2324043423
313PhosphorylationDSKQSNLTNGDCVAS
CCCCCCCCCCCEEEC		41.2124043423
320PhosphorylationTNGDCVASSDGTSKP
CCCCEEECCCCCCCC		14.4724043423
321PhosphorylationNGDCVASSDGTSKPS
CCCEEECCCCCCCCC		30.2624043423
324PhosphorylationCVASSDGTSKPSSSL
EEECCCCCCCCCCHH		38.2724043423
325PhosphorylationVASSDGTSKPSSSLA
EECCCCCCCCCCHHH		48.3624043423
369UbiquitinationEGELCWKKVDLGDVK
CCEEEEEEECCCCCC		19.2429967540
530AcetylationCGQLFRRKEFSSHFK
HHHHHHHHHHHHHHH		59.8719807485
537AcetylationKEFSSHFKNVHGDIH
HHHHHHHHHCCCCHH		53.2719807493
572PhosphorylationSQRRFCPSIQGAKII
HHHCCCCCCCCCEEE		28.8223403867
577UbiquitinationCPSIQGAKIIHDRHL
CCCCCCCEEEEHHHH		49.36-
649PhosphorylationLMRDVCGSLLQSRGM
HHHHHHHHHHHHCCC		22.30-
653PhosphorylationVCGSLLQSRGMVILQ
HHHHHHHHCCCEEEE		30.67-
665UbiquitinationILQWGKRKYPEGNSS
EEEECCHHCCCCCCC		69.5129967540
666PhosphorylationLQWGKRKYPEGNSSW
EEECCHHCCCCCCCH		15.5630576142
671PhosphorylationRKYPEGNSSWQIKEK
HHCCCCCCCHHHHHH		43.7530576142
672PhosphorylationKYPEGNSSWQIKEKV
HCCCCCCCHHHHHHH		27.3130576142
705UbiquitinationLSMADHLKKCSYNVV
HHHHHHHHHCCCCHH		48.6029967540
706UbiquitinationSMADHLKKCSYNVVE
HHHHHHHHCCCCHHH		34.4729967540
736PhosphorylationELTKEGRSLRSVLKP
HHHHHCCHHHHHHCC		38.70-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FBX30_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FBX30_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FBX30_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SKP1_HUMANSKP1physical
26087183
MYO6_HUMANMYO6physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FBX30_HUMAN

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Related Literatures of Post-Translational Modification

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