ADSV_HUMAN - dbPTM
ADSV_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADSV_HUMAN
UniProt AC Q9Y6U3
Protein Name Adseverin
Gene Name SCIN
Organism Homo sapiens (Human).
Sequence Length 715
Subcellular Localization Cytoplasm, cytoskeleton . Cell projection, podosome .
Protein Description Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. [PubMed: 8547642]
Protein Sequence MARELYHEEFARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYNERKGRSELIVVEEGSEPSELIKVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
64UbiquitinationGFTYHLHFWLGKECS
CCEEEEEEEECCCCC		7.8829967540
77UbiquitinationCSQDESTAAAIFTVQ
CCCCCCCEEEEEEEE		12.2729967540
102PhosphorylationQNRELQGYESNDFVS
CCCCCCCCCCCCHHH		11.8321082442
109PhosphorylationYESNDFVSYFKGGLK
CCCCCHHHHCCCCEE		25.5028857561
111UbiquitinationSNDFVSYFKGGLKYK
CCCHHHHCCCCEEEE		4.6429967540
122UbiquitinationLKYKAGGVASGLNHV
EEEEECCHHHCCCHH		3.6129967540
135PhosphorylationHVLTNDLTAKRLLHV
HHHCCCCCHHHHHEE		32.7528857561
137UbiquitinationLTNDLTAKRLLHVKG
HCCCCCHHHHHEECC		38.0429967540
156PhosphorylationRATEVPLSWDSFNKG
EEEECCCCCCCCCCC		23.8318767875
206PhosphorylationYNERKGRSELIVVEE
CCCCCCCCEEEEEEC		45.4828555341
215PhosphorylationLIVVEEGSEPSELIK
EEEEECCCCHHHHHH		50.0028555341
227UbiquitinationLIKVLGEKPELPDGG
HHHHHCCCCCCCCCC		41.8329967540
252PhosphorylationNRKMAKLYMVSDASG
CCCEEEEEEEECCCC		8.5123663014
255PhosphorylationMAKLYMVSDASGSMR
EEEEEEEECCCCCEE		15.7823663014
258PhosphorylationLYMVSDASGSMRVTV
EEEEECCCCCEEEEE		36.0723663014
260PhosphorylationMVSDASGSMRVTVVA
EEECCCCCEEEEEEE		10.8323663014
299SumoylationQIFVWKGKDANPQER
EEEEEECCCCCHHHH		50.36-
299SumoylationQIFVWKGKDANPQER
EEEEEECCCCCHHHH		50.36-
309UbiquitinationNPQERKAAMKTAEEF
CHHHHHHHHHHHHHH		11.7529967540
311UbiquitinationQERKAAMKTAEEFLQ
HHHHHHHHHHHHHHH		39.6029967540
312PhosphorylationERKAAMKTAEEFLQQ
HHHHHHHHHHHHHHH		26.64-
317UbiquitinationMKTAEEFLQQMNYSK
HHHHHHHHHHCCCCC		3.8029967540
320SulfoxidationAEEFLQQMNYSKNTQ
HHHHHHHCCCCCCCC		3.0728183972
322PhosphorylationEFLQQMNYSKNTQIQ
HHHHHCCCCCCCCEE		18.7118452278
324UbiquitinationLQQMNYSKNTQIQVL
HHHCCCCCCCCEEEC		54.3729967540
326PhosphorylationQMNYSKNTQIQVLPE
HCCCCCCCCEEECCC		30.6820068231
337PhosphorylationVLPEGGETPIFKQFF
ECCCCCCCCHHHHHH		25.5920068231
358UbiquitinationDQSDGFGKVYVTEKV
CCCCCCCEEEEEEEE		28.2929967540
360PhosphorylationSDGFGKVYVTEKVAQ
CCCCCEEEEEEEEEE		12.73-
362PhosphorylationGFGKVYVTEKVAQIK
CCCEEEEEEEEEEEE		16.6428857561
369UbiquitinationTEKVAQIKQIPFDAS
EEEEEEEEECCCCHH		30.0529967540
381PhosphorylationDASKLHSSPQMAAQH
CHHHCCCCHHHHHHC		14.3825159151
384SulfoxidationKLHSSPQMAAQHNMV
HCCCCHHHHHHCCCC		3.6628183972
484PhosphorylationKEPVHLLSLFKDKPL
CCCEEEHHHCCCCCE		37.8124719451
489MethylationLLSLFKDKPLIIYKN
EHHHCCCCCEEEEEC		42.17-
500MethylationIYKNGTSKKGGQAPA
EEECCCCCCCCCCCC		56.10-
521 (in isoform 2)Phosphorylation-27.8822210691
523 (in isoform 2)Phosphorylation-16.3122210691
556UbiquitinationSGYIWVGKGASQEEE
CCEEEECCCCCHHHH		41.5029967540
564UbiquitinationGASQEEEKGAEYVAS
CCCHHHHHHHHHHHH		67.7029967540
599PhosphorylationSLGGKKDYQTSPLLE
HCCCCCCCCCCCCCC		23.6721082442
601PhosphorylationGGKKDYQTSPLLETQ
CCCCCCCCCCCCCCC		26.5323312004
602PhosphorylationGKKDYQTSPLLETQA
CCCCCCCCCCCCCCC		9.6828857561
675MalonylationKESLKSAKMYLETDP
HHHHHHHEEEEECCC		34.8626320211
676SulfoxidationESLKSAKMYLETDPS
HHHHHHEEEEECCCC		4.6428183972
680PhosphorylationSAKMYLETDPSGRDK
HHEEEEECCCCCCCC		51.0923403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADSV_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADSV_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADSV_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ACTS_HUMANACTA1physical
12438125
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADSV_HUMAN

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Related Literatures of Post-Translational Modification

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