CAP2_HUMAN - dbPTM
CAP2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAP2_HUMAN
UniProt AC P40123
Protein Name Adenylyl cyclase-associated protein 2
Gene Name CAP2
Organism Homo sapiens (Human).
Sequence Length 477
Subcellular Localization Cell membrane
Peripheral membrane protein.
Protein Description May have a regulatory bifunctional role..
Protein Sequence MANMQGLVERLERAVSRLESLSAESHRPPGNCGEVNGVIAGVAPSVEAFDKLMDSMVAEFLKNSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPHENDVAALLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTVSAFSVLSSGPGLPPPPPPLPPPGPPPLFENEGKKEESSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPSLRAQGGQTQSPTKSHTPSPTSPKSYPSQKHAPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCEKSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVINSQDIQIQVMGRVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPIPEQFKTAWDGSKLITEPAEIMA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MANMQGLVE
------CCCHHHHHH		21.8722223895
16PhosphorylationERLERAVSRLESLSA
HHHHHHHHHHHHHHH		30.1127251275
20PhosphorylationRAVSRLESLSAESHR
HHHHHHHHHHHHHCC		32.0127251275
22PhosphorylationVSRLESLSAESHRPP
HHHHHHHHHHHCCCC		38.9927251275
25PhosphorylationLESLSAESHRPPGNC
HHHHHHHHCCCCCCC		25.2322210691
45PhosphorylationVIAGVAPSVEAFDKL
EEEECCCCHHHHHHH		23.8922210691
77SulfoxidationDVETHAEMVHSAFQA
CHHHHHHHHHHHHHH		3.2230846556
159SulfoxidationPGPYVKEMNDAATFY
CCCCCHHHHHHHHHH		4.5730846556
175AcetylationNRVLKDYKHSDLRHV
HCHHHHCCCCCCCCH		46.9327452117
186MethylationLRHVDWVKSYLNIWS
CCCHHHHHHHHHHHH		29.18-
256PhosphorylationNEGKKEESSPSRSAL
CCCCCCCCCCCHHHH		48.9522199227
257PhosphorylationEGKKEESSPSRSALF
CCCCCCCCCCHHHHH		30.1230576142
259PhosphorylationKKEESSPSRSALFAQ
CCCCCCCCHHHHHHH		40.5930576142
261PhosphorylationEESSPSRSALFAQLN
CCCCCCHHHHHHHHH		33.3930576142
274PhosphorylationLNQGEAITKGLRHVT
HHHHHHHHHHHCCCC		26.5521406692
275UbiquitinationNQGEAITKGLRHVTD
HHHHHHHHHHCCCCC		50.24-
286PhosphorylationHVTDDQKTYKNPSLR
CCCCCCCCCCCCCHH		33.81-
287PhosphorylationVTDDQKTYKNPSLRA
CCCCCCCCCCCCHHC		18.7922817900
299PhosphorylationLRAQGGQTQSPTKSH
HHCCCCCCCCCCCCC		34.0030266825
301PhosphorylationAQGGQTQSPTKSHTP
CCCCCCCCCCCCCCC		37.6130266825
303PhosphorylationGGQTQSPTKSHTPSP
CCCCCCCCCCCCCCC		50.8830266825
305PhosphorylationQTQSPTKSHTPSPTS
CCCCCCCCCCCCCCC		34.7630266825
307PhosphorylationQSPTKSHTPSPTSPK
CCCCCCCCCCCCCCC		32.3330266825
309PhosphorylationPTKSHTPSPTSPKSY
CCCCCCCCCCCCCCC		41.8022167270
311PhosphorylationKSHTPSPTSPKSYPS
CCCCCCCCCCCCCCC		63.1030266825
312PhosphorylationSHTPSPTSPKSYPSQ
CCCCCCCCCCCCCCC		33.4430266825
314AcetylationTPSPTSPKSYPSQKH
CCCCCCCCCCCCCCC		63.49156661
315PhosphorylationPSPTSPKSYPSQKHA
CCCCCCCCCCCCCCC		45.7321712546
316PhosphorylationSPTSPKSYPSQKHAP
CCCCCCCCCCCCCCC		17.0321712546
320UbiquitinationPKSYPSQKHAPVLEL
CCCCCCCCCCCEEEE		46.18-
346PhosphorylationDRNDLVISETELKQV
CCCCEEEEHHHHHHE		30.8727732954
348PhosphorylationNDLVISETELKQVAY
CCEEEEHHHHHHEEE		39.5727732954
355PhosphorylationTELKQVAYIFKCEKS
HHHHHEEEEEEECCC		14.1822817900
412PhosphorylationMGRVPTISINKTEGC
EEECCEEEEECCCCC		23.68-
450PhosphorylationLIPQDGDYREFPIPE
ECCCCCCCCCCCCCH		19.9927642862
460UbiquitinationFPIPEQFKTAWDGSK
CCCCHHHHCCCCCCC		36.71-
476SulfoxidationITEPAEIMA------
CCCCHHHCC------		2.4530846556
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAP2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAP2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAP2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAP1_HUMANCAP1physical
8761950
ACTG_HUMANACTG1physical
8761950
CSK22_HUMANCSNK2A2physical
22863883
MCM4_HUMANMCM4physical
22863883
NCKP1_HUMANNCKAP1physical
22863883
CAP2_HUMANCAP2physical
25416956
POTEI_HUMANPOTEIphysical
28514442
ACTA_HUMANACTA2physical
28514442
ACTBL_HUMANACTBL2physical
28514442
ACTB_HUMANACTBphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAP2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, AND MASSSPECTROMETRY.

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