WDR54_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR54_HUMAN
• UniProt AC: Q9H977
• Protein Name: WD repeat-containing protein 54
• Gene Name: WDR54
• Organism: Homo sapiens (Human).
• Sequence Length: 334
• Protein Sequence: MFRWERSIPLRGSAAALCNNLSVLQLPARNLTYFGVVHGPSAQLLSAAPEGVPLAQRQLHAKEGAGVSPPLITQVHWCVLPFRVLLVLTSHRGIQMYESNGYTMVYWHALDSGDASPVQAVFARGIAASGHFICVGTWSGRVLVFDIPAKGPNIVLSEELAGHQMPITDIATEPAQGQDCVADMVTADDSGLLCVWRSGPEFTLLTRIPGFGVPCPSVQLWQGIIAAGYGNGQVHLYEATTGNLHVQINAHARAICALDLASEVGKLLSAGEDTFVHIWKLSRNPESGYIEVEHCHGECVADTQLCGARFCDSSGNSFAVTGYDLAEIRRFSSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MFRWERSIPLRGSA -CCCCEECCCCCCHH	19.62	24719451
33	Phosphorylation	LPARNLTYFGVVHGP CCCCCCEEEEEEECC	11.08	20090780
103	Phosphorylation	MYESNGYTMVYWHAL EEECCCEEEEEEEEE	11.10	23532336
106	Phosphorylation	SNGYTMVYWHALDSG CCCEEEEEEEEECCC	4.81	23532336
228	Ubiquitination	WQGIIAAGYGNGQVH EEEEEEECCCCCEEE	23.12	-
280	Ubiquitination	DTFVHIWKLSRNPES CCEEEEEEECCCCCC	35.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR54_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR54_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR54_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FWCH2_HUMAN	FLYWCH2	physical	26186194
OSCP1_HUMAN	OSCP1	physical	26186194
OSCP1_HUMAN	OSCP1	physical	28514442
FWCH2_HUMAN	FLYWCH2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-33, AND MASSSPECTROMETRY.
PubMed: 15592455