FWCH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FWCH2_HUMAN
• UniProt AC: Q96CP2
• Protein Name: FLYWCH family member 2
• Gene Name: FLYWCH2
• Organism: Homo sapiens (Human).
• Sequence Length: 140
• Protein Sequence: MPLPEPSEQEGESVKASQEPSPKPGTEVIPAAPRKPRKFSKLVLLTASKDSTKVAGAKRKGVHCVMSLGVPGPATLAKALLQTHPEAQRAIEAAPQEPEQKRSRQDPGTDRTEDSGLAAGPPEAAGENFAPCSVAPGKSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MPLPEPSEQEGESV -CCCCCCCCCCCCCC	50.69	28464451
13	Phosphorylation	PSEQEGESVKASQEP CCCCCCCCCCCCCCC	39.51	25159151
15	Ubiquitination	EQEGESVKASQEPSP CCCCCCCCCCCCCCC	52.15	33845483
17	Phosphorylation	EGESVKASQEPSPKP CCCCCCCCCCCCCCC	29.38	23927012
21	Phosphorylation	VKASQEPSPKPGTEV CCCCCCCCCCCCCCC	44.82	29255136
23	Acetylation	ASQEPSPKPGTEVIP CCCCCCCCCCCCCCC	61.49	26051181
23	Ubiquitination	ASQEPSPKPGTEVIP CCCCCCCCCCCCCCC	61.49	29967540
26	Phosphorylation	EPSPKPGTEVIPAAP CCCCCCCCCCCCCCC	35.29	25159151
40	Phosphorylation	PRKPRKFSKLVLLTA CCCCCCCCEEEEEEE	28.28	29214152
41	Ubiquitination	RKPRKFSKLVLLTAS CCCCCCCEEEEEEEC	45.83	33845483
46	Phosphorylation	FSKLVLLTASKDSTK CCEEEEEEECCCCCC	25.40	23312004
48	Phosphorylation	KLVLLTASKDSTKVA EEEEEEECCCCCCCC	31.59	25159151
49	Ubiquitination	LVLLTASKDSTKVAG EEEEEECCCCCCCCC	53.91	33845483
49	Acetylation	LVLLTASKDSTKVAG EEEEEECCCCCCCCC	53.91	23954790
49	Methylation	LVLLTASKDSTKVAG EEEEEECCCCCCCCC	53.91	-
51	Phosphorylation	LLTASKDSTKVAGAK EEEECCCCCCCCCCC	33.59	23312004
52	Phosphorylation	LTASKDSTKVAGAKR EEECCCCCCCCCCCC	39.41	23312004
53	Ubiquitination	TASKDSTKVAGAKRK EECCCCCCCCCCCCC	33.76	33845483
67	Phosphorylation	KGVHCVMSLGVPGPA CCCEEEEECCCCCHH	11.11	25159151
78	Ubiquitination	PGPATLAKALLQTHP CCHHHHHHHHHHHCH	42.55	29967540
83	Phosphorylation	LAKALLQTHPEAQRA HHHHHHHHCHHHHHH	39.09	28555341
101	Acetylation	APQEPEQKRSRQDPG CCCCHHHHHHCCCCC	51.16	26051181
101	Ubiquitination	APQEPEQKRSRQDPG CCCCHHHHHHCCCCC	51.16	33845483
103	Phosphorylation	QEPEQKRSRQDPGTD CCHHHHHHCCCCCCC	41.13	28555341
115	Phosphorylation	GTDRTEDSGLAAGPP CCCCCCCCCCCCCCC	29.49	28555341
133	O-linked_Glycosylation	GENFAPCSVAPGKSL CCCCCCCCCCCCCCC	21.91	23301498
138	Ubiquitination	PCSVAPGKSL----- CCCCCCCCCC-----	47.74	24816145
138	Acetylation	PCSVAPGKSL----- CCCCCCCCCC-----	47.74	25953088
139	Phosphorylation	CSVAPGKSL------ CCCCCCCCC------	45.27	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FWCH2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FWCH2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FWCH2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RXRB_HUMAN	RXRB	physical	26186194
TBC23_HUMAN	TBC1D23	physical	26186194
TRUB1_HUMAN	TRUB1	physical	26344197
GET4_HUMAN	GET4	physical	21516116
RXRB_HUMAN	RXRB	physical	28514442
TBC23_HUMAN	TBC1D23	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442
HPBP1_HUMAN	HSPBP1	physical	28514442
BAG4_HUMAN	BAG4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASSSPECTROMETRY.
PubMed: 18669648