| UniProt ID | DPF3_HUMAN | |
|---|---|---|
| UniProt AC | Q92784 | |
| Protein Name | Zinc finger protein DPF3 | |
| Gene Name | DPF3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 378 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.. | |
| Protein Sequence | MATVIHNPLKALGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKPEVELPLKKDGFTSESTTLEALLRGEGVEKKVDAREEESIQEIQRVLENDENVEEGNEEEDLEEDIPKRKNRTRGRARGSAGGRRRHDAASQEDHDKPYVCDICGKRYKNRPGLSYHYAHTHLASEEGDEAQDQETRSPPNHRNENHRPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSGHPTCLQFTLNMTEAVKTYKWQCIECKSCILCGTSENDDQLLFCDDCDRGYHMYCLNPPVAEPPEGSWSCHLCWELLKEKASAFGCQA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 46 | Phosphorylation | LPFLDSQTGVAQNNC CCEECCCCCCCCCCE | 37.26 | - | |
| 92 | Ubiquitination | LHPPEDPKLRLLEIK CCCCCCCCCCEEEEC | 59.57 | - | |
| 99 | Sumoylation | KLRLLEIKPEVELPL CCCEEEECCCEECCC | 26.25 | 28112733 | |
| 107 | Acetylation | PEVELPLKKDGFTSE CCEECCCCCCCCCCC | 47.05 | 25953088 | |
| 108 | Ubiquitination | EVELPLKKDGFTSES CEECCCCCCCCCCCC | 71.42 | - | |
| 138 | Phosphorylation | VDAREEESIQEIQRV CCCCHHHHHHHHHHH | 32.62 | - | |
| 235 | Phosphorylation | DEAQDQETRSPPNHR CCCCCCCCCCCCCCC | 30.71 | 28348404 | |
| 237 | Phosphorylation | AQDQETRSPPNHRNE CCCCCCCCCCCCCCC | 52.72 | 28348404 | |
| 255 | Phosphorylation | PQKGPDGTVIPNNYC CCCCCCCCCCCCCCC | 23.73 | 29978859 | |
| 261 | Phosphorylation | GTVIPNNYCDFCLGG CCCCCCCCCCCCCCC | 10.47 | 29978859 | |
| 269 | Phosphorylation | CDFCLGGSNMNKKSG CCCCCCCCCCCCCCC | 30.98 | 29978859 | |
| 309 (in isoform 2) | Phosphorylation | - | 12.43 | 24275569 | |
| 316 (in isoform 2) | Phosphorylation | - | 1.67 | 24275569 | |
| 317 (in isoform 2) | Phosphorylation | - | 35.26 | 24275569 | |
| 318 (in isoform 2) | Phosphorylation | - | 20.32 | 24275569 | |
| 319 (in isoform 5) | Phosphorylation | - | 1.36 | 24275569 | |
| 320 (in isoform 2) | Phosphorylation | - | 4.62 | 24275569 | |
| 323 (in isoform 2) | Phosphorylation | - | 28.91 | 24275569 | |
| 326 (in isoform 5) | Phosphorylation | - | 65.60 | 24275569 | |
| 327 (in isoform 5) | Phosphorylation | - | 58.90 | 24275569 | |
| 328 (in isoform 5) | Phosphorylation | - | 40.77 | 24275569 | |
| 330 (in isoform 5) | Phosphorylation | - | 42.82 | 24275569 | |
| 333 (in isoform 5) | Phosphorylation | - | 6.12 | 24275569 | |
| 344 (in isoform 2) | Phosphorylation | - | 4.77 | - | |
| 348 (in isoform 2) | Phosphorylation | - | 16.28 | 24719451 | |
| 350 (in isoform 2) | Phosphorylation | - | 11.26 | - | |
| 354 (in isoform 5) | Phosphorylation | - | 50.51 | - | |
| 358 (in isoform 5) | Phosphorylation | - | 18.81 | 24719451 | |
| 360 (in isoform 5) | Phosphorylation | - | 2.00 | - | |
| 364 (in isoform 3) | Phosphorylation | - | 12.96 | 24275569 | |
| 371 (in isoform 3) | Phosphorylation | - | 13.74 | 24275569 | |
| 372 (in isoform 3) | Phosphorylation | - | 34.89 | 24275569 | |
| 373 (in isoform 3) | Phosphorylation | - | 15.09 | 24275569 | |
| 375 (in isoform 3) | Phosphorylation | - | 11.44 | 24275569 | |
| 378 (in isoform 3) | Phosphorylation | - | 26.01 | 24275569 | |
| 399 (in isoform 3) | Phosphorylation | - | - | ||
| 403 (in isoform 3) | Phosphorylation | - | 24719451 | ||
| 405 (in isoform 3) | Phosphorylation | - | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 348 | S | Phosphorylation | Kinase | CSNK2A1 | P68400 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DPF3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DPF3_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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