CREST_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CREST_HUMAN
• UniProt AC: O75177
• Protein Name: Calcium-responsive transactivator
• Gene Name: SS18L1
• Organism: Homo sapiens (Human).
• Sequence Length: 396
• Subcellular Localization: Nucleus. Chromosome, centromere, kinetochore. Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity)..
• Protein Description: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity)..
• Protein Sequence: MSVAFASARPRGKGEVTQQTIQKMLDENHHLIQCILEYQSKGKTAECTQYQQILHRNLVYLATIADSNQNMQSLLPAPPTQNMNLGPGALTQSGSSQGLHSQGSLSDAISTGLPPSSLLQGQIGNGPSHVSMQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGSQGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYSQQQAGYQQGAAQQQTYSQQQYPSQQSYPGQQQGYGSAQGAPSQYPGYQQGQGQQYGSYRAPQTAPSAQQQRPYGYEQGQYGNYQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSVAFASAR ------CCCCCCCCC	23.35	19413330
3 (in isoform 5)	Phosphorylation	-	4.98	25072903
5 (in isoform 5)	Phosphorylation	-	5.31	25072903
6 (in isoform 5)	Phosphorylation	-	7.79	25072903
10 (in isoform 5)	Phosphorylation	-	49.44	25072903
391	Phosphorylation	YGYEQGQYGNYQQ-- CCCCCCCCCCCCC--	17.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CREST_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CREST_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CREST_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFX6_HUMAN	RFX6	physical	16189514
CBP_HUMAN	CREBBP	physical	14716005
EP300_HUMAN	EP300	physical	14716005
SMCA4_HUMAN	SMARCA4	physical	19081374
AATF_HUMAN	AATF	physical	20211142
RNF12_HUMAN	RLIM	physical	20211142
TAF9B_HUMAN	TAF9B	physical	20211142
GATD1_HUMAN	GATAD1	physical	20211142
PCGF6_HUMAN	PCGF6	physical	20211142
MED30_HUMAN	MED30	physical	20211142
ANR22_HUMAN	ANKRD22	physical	20211142
CREST_HUMAN	SS18L1	physical	25416956
MISSL_HUMAN	MAPK1IP1L	physical	25416956
RSMB_HUMAN	SNRPB	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.