GATD1_HUMAN - dbPTM
GATD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GATD1_HUMAN
UniProt AC Q8WUU5
Protein Name GATA zinc finger domain-containing protein 1
Gene Name GATAD1
Organism Homo sapiens (Human).
Sequence Length 269
Subcellular Localization Nucleus .
Protein Description Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me)..
Protein Sequence MPLGLKPTCSVCKTTSSSMWKKGAQGEILCHHCTGRGGAGSGGAGSGAAGGTGGSGGGGFGAATFASTSATPPQSNGGGGGKQSKQEIHRRSARLRNTKYKSAPAAEKKVSTKGKGRRHIFKLKNPIKAPESVSTIITAESIFYKGVYYQIGDVVSVIDEQDGKPYYAQIRGFIQDQYCEKSAALTWLIPTLSSPRDQFDPASYIIGPEEDLPRKMEYLEFVCHAPSEYFKSRSSPFPTVPTRPEKGYIWTHVGPTPAITIKESVANHL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Methylation--MPLGLKPTCSVCK
--CCCCCCCCCCEEE		36.1623644510
6"N6,N6-dimethyllysine"--MPLGLKPTCSVCK
--CCCCCCCCCCEEE		36.16-
10PhosphorylationLGLKPTCSVCKTTSS
CCCCCCCCEEECCCC		32.7828857561
21"N6,N6-dimethyllysine"TTSSSMWKKGAQGEI
CCCCHHHHCCCCCEE		32.46-
21MethylationTTSSSMWKKGAQGEI
CCCCHHHHCCCCCEE		32.4623644510
34PhosphorylationEILCHHCTGRGGAGS
EEEEECCCCCCCCCC		26.0922115753
41PhosphorylationTGRGGAGSGGAGSGA
CCCCCCCCCCCCCCC		33.2528857561
46PhosphorylationAGSGGAGSGAAGGTG
CCCCCCCCCCCCCCC		25.4028857561
52PhosphorylationGSGAAGGTGGSGGGG
CCCCCCCCCCCCCCC		37.1322115753
55PhosphorylationAAGGTGGSGGGGFGA
CCCCCCCCCCCCCCC		35.2922115753
64PhosphorylationGGGFGAATFASTSAT
CCCCCCCEEEECCCC		21.1422115753
67PhosphorylationFGAATFASTSATPPQ
CCCCEEEECCCCCCC		20.7822115753
68PhosphorylationGAATFASTSATPPQS
CCCEEEECCCCCCCC		20.9630576142
69PhosphorylationAATFASTSATPPQSN
CCEEEECCCCCCCCC		27.8722115753
71PhosphorylationTFASTSATPPQSNGG
EEEECCCCCCCCCCC		34.9628857561
75PhosphorylationTSATPPQSNGGGGGK
CCCCCCCCCCCCCCH		43.1228857561
84PhosphorylationGGGGGKQSKQEIHRR
CCCCCHHHHHHHHHH		39.5323403867
92PhosphorylationKQEIHRRSARLRNTK
HHHHHHHHHHHHHCC		20.0727282143
108AcetylationKSAPAAEKKVSTKGK
CCCCHHHHCCCCCCC		54.477380089
109AcetylationSAPAAEKKVSTKGKG
CCCHHHHCCCCCCCC		32.687380099
186PhosphorylationCEKSAALTWLIPTLS
CCHHHHHHHHCCCCC		17.3120068231
191PhosphorylationALTWLIPTLSSPRDQ
HHHHHCCCCCCCHHH		32.0726270265
193PhosphorylationTWLIPTLSSPRDQFD
HHHCCCCCCCHHHCC		40.5520068231
194PhosphorylationWLIPTLSSPRDQFDP
HHCCCCCCCHHHCCC		27.3721815630
232PhosphorylationAPSEYFKSRSSPFPT
CCHHHHHCCCCCCCC		27.7428985074
234PhosphorylationSEYFKSRSSPFPTVP
HHHHHCCCCCCCCCC		49.8325159151
235PhosphorylationEYFKSRSSPFPTVPT
HHHHCCCCCCCCCCC		29.4725159151
239PhosphorylationSRSSPFPTVPTRPEK
CCCCCCCCCCCCCCC		39.2223186163
248PhosphorylationPTRPEKGYIWTHVGP
CCCCCCCCEEEECCC		12.35-
262SumoylationPTPAITIKESVANHL
CCCCEEEHHHHHHCC		34.9728112733
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GATD1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GATD1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GATD1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EMSY_HUMANC11orf30physical
20850016
PHF12_HUMANPHF12physical
20850016
SIN3B_HUMANSIN3Bphysical
20850016
MO4L1_HUMANMORF4L1physical
20850016
KDM5A_HUMANKDM5Aphysical
20850016
HDAC1_HUMANHDAC1physical
20850016
MO4L2_HUMANMORF4L2physical
20850016
HDAC2_HUMANHDAC2physical
20850016
RBBP7_HUMANRBBP7physical
20850016
HDAC1_HUMANHDAC1physical
26496610
HDAC2_HUMANHDAC2physical
26496610
KDM5A_HUMANKDM5Aphysical
26496610
RBBP7_HUMANRBBP7physical
26496610
MTA2_HUMANMTA2physical
26496610
MO4L1_HUMANMORF4L1physical
26496610
SIN3B_HUMANSIN3Bphysical
26496610
EMSY_HUMANC11orf30physical
26496610
PHF12_HUMANPHF12physical
26496610
HERP2_HUMANHERPUD2physical
26496610
MO4L1_HUMANMORF4L1physical
26841866
FA60A_HUMANFAM60Aphysical
26841866
SP130_HUMANSAP130physical
26841866
KDM5A_HUMANKDM5Aphysical
26841866
BAHC1_HUMANBAHCC1physical
26841866
BRMS1_HUMANBRMS1physical
26841866
TNC18_HUMANTNRC18physical
26841866
RFOX2_HUMANRBFOX2physical
26841866
RFOX1_HUMANRBFOX1physical
26841866
SIN3B_HUMANSIN3Bphysical
26841866
SAP30_HUMANSAP30physical
26841866
ARI4A_HUMANARID4Aphysical
26841866
ZN131_HUMANZNF131physical
26841866
ZN143_HUMANZNF143physical
26841866
FOXK1_HUMANFOXK1physical
26841866
RBBP4_HUMANRBBP4physical
26841866
HDAC1_HUMANHDAC1physical
26841866
NPAT_HUMANNPATphysical
26841866
MO4L2_HUMANMORF4L2physical
26841866
RBBP7_HUMANRBBP7physical
26841866
EMSY_HUMANC11orf30physical
26841866
QSER1_HUMANQSER1physical
26841866
ARI4B_HUMANARID4Bphysical
26841866
BRM1L_HUMANBRMS1Lphysical
26841866
E4F1_HUMANE4F1physical
26841866
BANP_HUMANBANPphysical
26841866
SR1IP_HUMANSREK1IP1physical
26841866
GATD1_HUMANGATAD1physical
26841866
HDAC2_HUMANHDAC2physical
26841866
NF2L1_HUMANNFE2L1physical
26841866
PHF12_HUMANPHF12physical
26841866
SIN3A_HUMANSIN3Aphysical
26841866
ING2_HUMANING2physical
26841866
ZN335_HUMANZNF335physical
26841866
SDS3_HUMANSUDS3physical
26841866
SP30L_HUMANSAP30Lphysical
26841866
ING1_HUMANING1physical
26841866
GPTC8_HUMANGPATCH8physical
26841866
ZN281_HUMANZNF281physical
26841866
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614672Cardiomyopathy, dilated 2B (CMD2B)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GATD1_HUMAN

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Related Literatures of Post-Translational Modification

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